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Nur Samsu
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Jl. JA Suprapto No. 2 Kec. Klojen Malang 65112, Indonesia. Laboratory of Internal Medicine, Department of Internal Medicine, Faculty of Medicine, dr. Saiful Anwar General Hospital, IRNA 1 Building 2nd Floor
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INDONESIA
CRJIM (Clinical and Research Journal in Internal Medicine)
Published by Universitas Brawijaya
ISSN : 27235130     EISSN : 27235122     DOI : https://doi.org/10.21776/ub.crjim
Core Subject : Health, Science, Education,
Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other
Clinical and Research Journal in Internal Medicine is the official open access journal of Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. It publishes articles two times per year. It is a peer reviewed publication of Indonesian Internal Medicine journals and accepting articles for publication from around the world. CRJIM only publishes articles in the English version. The objective of this journal is to publish the selected clinical and basic research relevant to Internal Medicine. It covers the following topics, nephrology, endocrinology, metabolic, and diabetes, rheumatology, geriatrics, tropic infection, hematology oncology. CRJIM publishes original researches, reviews, brief reports, editorial, case series, case reports, and commentary. Additionally, it also considers publishing animal studies relevant to Internal Medicine topic. It is an international journal dedicated to providing new information that could give new insight for alternative solutions, diagnosis, therapy and prevention for researchers and practitioners in Internal Medicine.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 123 Documents
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The Efficacy of Oral Cannabinoids for Neuropathy: A Systematic Review and Meta Analysis Rakhman, Muhammad Farid; Djamil, Putri Amelia; Aghna, Zhalif Zhafir
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.10

Abstract

Background: Neuropathic pain remains difficult to treat despite multiple pharmacological options. Cannabinoids have been proposed as therapeutic agents, yet the efficacy of oral formulations remains uncertain. Aim: The aim of this study was to evaluate the efficacy of oral cannabinoids in reducing pain intensity among patients with peripheral neuropathic pain through a systematic review and meta-analysis. Methods: This study employed systematic review and meta-analysis designed in accordance with PRISMA 2020 reporting guidelines. PubMed, ScienceDirect, Scopus, and IEEE Xplore were searched through January 2026. Randomized controlled trials evaluating oral cannabinoids for peripheral neuropathic pain were included. Pain intensity was standardized to a 0-10 scale and pooled using mean differences. Results: Four randomized controlled trials comprising 174 participants met inclusion criteria. Individual studies reported variable analgesic effects. Pooled analysis demonstrated no statistically significant reduction in pain intensity compared with placebo (Mean difference -057; 95% CI -1.26 to 0.12) Moderate heterogeneity was observed (I2= 74.4%). Conclusion: Current evidence does not support oral cannabinoids as first line therapy for peripheral neuropathic pain. Larger, methodologically rigorous trials are required to clarify their clinical role.
Asthma in Patients with Chronic Kidney Disease Undergoing Dialysis: A Narrative Review Rifai, Achmad; Nahak, Malisa Sherly Theresia
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.11

Abstract

Asthma and chronic kidney disease (CKD) are chronic disorders with substantial morbidity and increasingly recognized overlap. This narrative review summarizes the current evidence on the relationship between asthma and CKD, with emphasis on patients undergoing dialysis. Available data indicate that asthma, particularly when severe or poorly controlled, is associated with a higher risk of CKD, whereas CKD more consistently modifies pulmonary physiology and worsens control of pre-existing asthma than clearly causing new-onset asthma. The interaction is supported by several mechanisms, including systemic inflammation, immune dysregulation, endothelial injury, oxidative stress, disordered acid-base balance, and fluid overload. In advanced CKD, anemia, uremia, metabolic disturbances, and volume excess may mimic or aggravate respiratory symptoms, while dialysis adds further complexity through rapid intravascular volume shifts, complement activation, membrane bioincompatibility, and electrolyte changes that can influence lung mechanics and airway reactivity. Management generally follows standard asthma therapy based on inhaled corticosteroids and bronchodilators, but treatment must be individualized according to kidney function, dialysis status, polypharmacy, and the risk of medication-related adverse effects. Careful integration of respiratory assessment, renal monitoring, and volume management is therefore essential in this population.
Infectious Granuloma at the Peritoneal Dialysis Catheter Exit Site: A Case Report of MRSA-Associated Complication in a Young CAPD Patient Rifai, Achmad; Manugan, Reizal Audi
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.13

Abstract

Introduction: Exit-site infection (ESI) is one of the most frequent complications in CAPD patients and can progress to peritonitis if inadequately managed. Granulomatous ESI caused by MRSA remains sparsely reported in the literature. Case Presentation: A 20-year-old woman with end-stage kidney disease secondary to lupus nephritis, on CAPD for two years, presented with a five-day history of a moist, erythematous nodule (±1 cm) at the Tenckhoff catheter exit site with purulent discharge. The modified Schaefer exit-site score was ≥7, confirming active infection. There was no peritoneal involvement. Management and Outcome: Gram staining revealed Gram-positive cocci (3+), and culture confirmed MRSA susceptible to levofloxacin and TMP-SMX. Empirical oral ciprofloxacin 500 mg twice daily and topical gentamicin were initiated. Clinical improvement was observed at day seven. Therapy was then transitioned to oral TMP-SMX (cotrimoxazole 480 mg once daily) for an additional seven days. MRSA carrier screening via nasal and throat swabs was planned. Discussion: Empirical ciprofloxacin deviated from ISPD guidelines recommending anti-staphylococcal penicillin or first-generation cephalosporin. Transition to TMP-SMX post-culture was appropriate and guideline-concordant. The favorable outcome highlights the importance of microbiological confirmation and targeted therapy. Conclusion: MRSA-associated infectious granuloma at the CAPD exit site can present in young patients without systemic features. Timely microbiological workup, guideline-directed antibiotic therapy, and MRSA decolonization are essential to prevent progression to peritonitis.

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