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Jurnal Kedokteran Raflesia
Published by Universitas Bengkulu
ISSN : 24773778     EISSN : 26228343     DOI : 10.33369
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JKR (Jurnal Kedokteran Raflesia) is a peer-reviewed professional journal with the editorial board of scholars mainly in medicine, biomedic and health sciences. It is published by UNIB Press, Universitas Bengkulu, Indonesia with the ISSN (online): 2622-8343; and ISSN (print): 2477-3778. The journal seeks to disseminate research to educators around the world and is published twice a year in the months of June and December. The newest template has been published since Volume 6(2): December 2020.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 5 Documents
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Search results for , issue "Vol. 6 No. 1 (2020)" : 5 Documents clear
Ekspresi CD30 pada pasien Diffuse Large B-cell Lymphoma di RSUP Dr. Kariadi Semarang winoto, jessica
JURNAL KEDOKTERAN RAFLESIA Vol. 6 No. 1 (2020)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v6i1.11072

Abstract

EKSPRESI CD30 PADA PASIEN DIFFUSE LARGE B-CELL LYMPHOMA DI RSUP DR. KARIADI SEMARANG Jessica Winoto1; Udadi Sadhana2; Dik Puspasari2; Siti Amarwati2; Devia Eka Listiana2; Hermawan Istiadi2 Residen Departemen Patologi Anatomi, Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia1; Staf pengajar Departemen Patologi Anatomi, Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia2 Corresponding email: jessicawin11@gmail.com AbstrakLatar Belakang: Diffuse Large B-Cell Lymphoma (DLBCL) merupakan penyakit heterogen dengan berbagai morfologi, sifat biologi dan klinis, yang memiliki respon terapi bervariasi. Beberapa penelitian melaporkan adanya ekspresi CD30 pada DLBCL berhubungan dengan ketahanan hidup yang lebih baik. Namun hal ini masih perlu dilakukan penelitian lebih lanjut. Tujuan penelitian ini untuk mengevaluasi ekspresi CD30 pada pasien DLBCL di RSUP Dr. Kariadi.Metode penelitian: Penelitian ini mengevaluasi ekspresi CD30 pada 35 pasien DLBCL di RSUP Dr. Kariadi periode Januari 2017 hingga Desember 2017 menggunakan cut off >0%. Data klinik yang diambil yaitu usia saat terdiagnosis, lokasi tumor, stadium penyakit, subtipe sel asal, dan ketahanan hidup 2 tahun. Analisis data menggunakan uji chi square.Hasil: Dari 35 kasus, CD30 diekspresikan oleh 13 kasus (37.1%). Ekspresi CD30 lebih tinggi pada pasien dengan usia ?60 tahun (P=0.03), lokasi ekstranodal (P=0.78), stadium awal (P=0.89), dan subtipe non-GCB (P=0.97). Kelompok CD30 positif memiliki ketahanan hidup yang lebih baik dibandingkan CD30 negatif (P=0.90).Kesimpulan: Ekspresi CD30 memiliki hubungan yang bermakna dengan usia ?60 tahun. Pasien DLBCL dengan CD30 positif memiliki ketahanan hidup yang lebih baik dibandingkan CD30 negatif, namun tidak bermakna. Kata Kunci : DLBCL, CD30, ketahanan hidup    CD30 EXPRESSION IN DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS  IN KARIADI GENERAL HOSPITAL SEMARANG Jessica Winoto1; Udadi Sadhana2; Dik Puspasari2; Siti Amarwati2; Devia Eka Listiana2; Hermawan Istiadi2 Resident of Anatomical Pathology Department, Faculty of Medicine Diponegoro University, Semarang Indonesia1; Lecturer of Anatomical Pathology Department, Faculty of Medicine Diponegoro University, Semarang Indonesia2 Corresponding email: jessicawin11@gmail.com AbstractBackground: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogenous disease containing morphology, biologically dan clinically distinctive subgroups that show variable response to therapy. Many studies showed that CD30 expression in DLBCL is associated with superior overall survival. However, prognostic value of CD30 expression in DLBCL still needs further studies. The aim of this study was to determine the expression of CD30 in DLBCL patients in Kariadi General Hospital.Methods: This study identified CD30 expression in 35 cases of DLBCL diagnosed between January 2017 and December 2017, using cut off values >0%. Clinical data collected including age of diagnosis, tumour location, stage of disease, cell of origin subtype, and two-year overall survival. Data were analyzed using chi square test. Results: CD30 expression was found in 13 (37.1%) cases. CD30 positivity was higher in age ?60 years (P=0.03), extranodal location (0.78), early stage (P=0.89), and non-GCB subtype (P=0.97). CD30-positve DLBCL had a better survival than CD30-negative DLBCL (P=0.90).Conclusion: CD30 positivity was significantly associated with age ?60 years. CD30-positve DLBCL had a better survival than CD30-negative DLBCL, but not significant. Keywords: DLBCL, CD30, overall survival
HIPERTIROIDISMEE GRAVES DISEASE:CASE REPORT Srikandi, Putri Rahayu
JURNAL KEDOKTERAN RAFLESIA Vol. 6 No. 1 (2020)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v6i1.10986

Abstract

AbstractAbstrak:Hipertiroid adalah kondisi klinis yang disebabkan peningkatan sintesis dan sekresi hormone oleh kelenjar tiroid, sedangkan tirotoksikosis mengacu pada manifestasi klinis.  Penyakit graves merupakan penyebab hipertiroid yang paling sering ditemukan sekitar 60-80% dari semua kasus tirotoksikosis di seluruh dunia. Pada laporan kasus ini akan dibahas pasien Ny. NMS berusia 56 tahun datang dengan keluhan dada berdebar-debar yang dirasakan sejak 3 minggu yang lalu dan pada pemeriksaan fisik didapatkan adanya pembesaran kelenjar tiroid dan indeks Wayne pada kasus ini didapatkan  21. Pada pemeriksaan laboratorium didapatkan kadar Tyroid Stimulating Hormone (TSH) 0,005 uIU/ml, , dan free Tiroksin (fT4) 7,77mg/dl. Penatalaksanaan pada kasus ini yaitu pasien diberikan tyrozol  3x10 mg sehari dan propanolol 3x10mg. Kata kunci: graves, hipertiroidism, tirotoksikosis AbstractHipertiroidisme is a clinical condition caused by increased synthesis and secretion of hormones by the thyroid gland. Thyrotoxicosis is defined as clinical manifestations related to increased thyroid hormone levels. Graves' disease (GD) persists as the most frequently encountered etiology of hipertiroidisme causing approximately 60-80% of all cases of thyrotoxicosis worldwide. In this case report we will discuss woman patient Mrs.NMS aged 56 years with complaints of palpitations felt since three weeks ago and physical examination found enlargement of the thyroid gland and Wayne index in this case obtained 21. In laboratory tests found levels of TSH 0.005 uIU/ml and T4 7.77 mg/dl. Principle in the treatment of hipertiroidisme is suppressing the production of thyroid hormone by using antithyroid drugs. Management in this case that the patient is given 3x10 mg Thyrozol and propranolol 3x10 mg. Keywords: graves, hipertiroidisme, thyrotoxicosis
THE EFFECTIVENESS OF CORIANDER (Coriandrum sativum L.) EXTRACTS ON REDUCING THE BLOOD SUGAR LEVELS OF ALLOXAN INDUCED WISTAR MALE RATS (Rattus norvegicus L.) Dersing, Kalvin
JURNAL KEDOKTERAN RAFLESIA Vol. 6 No. 1 (2020)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v6i1.10979

Abstract

AbstractBackground : Diabetes mellitus is the most common metabolic syndrome in the whole world with an incidence of 1-8%. This disease arises when insufficient insulin is produced or insulin cannot function properly.The ability of coriander juice water extract is expected to reduce blood glucose levels because the action is similar to insulin and can stimulate insulin release. Purpose : Knowing effectiveness coriander extract (Coriandrum sativum L.)to decline blood sugar levels in male white rats (Rattus norvegicus L.) wistar strain induced by alloxan. Method : This is a pure experimental study (true-experiment) using a pre and post test design with control group design using subjects namely white rats (Rattus norvegicus L.) male Wistar strain aged 10-12 weeks with a weight of 150-200 grams. By looking at changes in blood sugar levels during administration of alloxan and administration of coriander extract. Results : There were significant changes in some groups induced alloxan (p <0.05), but the effect of coriander extract was not very significant (p> 0.05). Conclusion : Coriander extract can control blood sugar levels to be stable or normal, but it takes longer and more research.  Keywords : coriander extract, blood sugar levels, alloxan
EKSPRESI PD-L1 PADA MENINGIOMA janah, raudatul
JURNAL KEDOKTERAN RAFLESIA Vol. 6 No. 1 (2020)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v6i1.9350

Abstract

ABSTRAKMeningioma merupakan tumor yang paling umum terjadi pada sistem saraf pusat (SSP), berasal dari sel meningothelial lapisan arakhnoid. Programmed Death Ligand 1 (PD-L1) merupakan protein immune checkpoint yang akan menyebabkan imun antitumor tersupresi. Pada meningioma high grade, sel T regulator dan ekspresi PD-L1 meningkat yang disebabkan karena immunosuppressive tumor microenvironment sehingga tumor menjadi agresif. Tingkat ekspresi PD-L1 tidak ditetapkan dalam meningioma. Tergantung pada tingkat ekspresi, anti-PD-L1, mungkin merupakan pengobatan yang efektif untuk meningioma.Kata Kunci : meningioma, PD-L1, Anti PD-L1
Analysis of Environmental Sanitation With The Occurrence of Malaria in The Work Area of Sidomulyo Health Center, Gading Cempaka District, Bengkulu City Taurustya, Hernita
JURNAL KEDOKTERAN RAFLESIA Vol. 6 No. 1 (2020)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v6i1.10295

Abstract

Background: Malaria is a disease that is re-emerging (transmitted massively) and causes a mortality rate of 10-50% of the total cases of severe malaria that are hospitalized. This disease is transmitted through the bite of the Anopheles mosquito which carries the parasite Plasmodium sp. Bengkulu Province is a malaria endemic area, and malaria cases are evenly found throughout the province every month. This study aims to analyze the relationship of environmental sanitation with malaria in the working area of the Sidomulyo Health Center in Bengkulu City.Method: This study uses a cross sectional research design. The study was conducted in the working area of the Sidomulyo Health Center in Bengkulu City in July 2016. The selection of samples was carried out based on simple random sampling. Primary data collection using questionnaires and secondary data from medical records. Data analysis with chi-square test (x 2) at a significance level of 95% (a0.05).Results: From 82 respondents in this study, there were 50 people with poor environmental sanitation, 9 people were malaria positive and 41 people were negative. While out of 32 people with good sanitation, 14 were malaria positive and 18 were negative.Conclusion: There is a significant relationship between environmental sanitation and malaria in the working area of Sidomulyo Health Center, Gading Cempaka District, Bengkulu City with p = 0.022, c = 0.011.  Keywords: Environmental Sanitation, malaria incidence 

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