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Nikki Aldi
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Jurnal Kedokteran Raflesia
Published by Universitas Bengkulu
ISSN : 24773778     EISSN : 26228343     DOI : 10.33369
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JKR (Jurnal Kedokteran Raflesia) is a peer-reviewed professional journal with the editorial board of scholars mainly in medicine, biomedic and health sciences. It is published by UNIB Press, Universitas Bengkulu, Indonesia with the ISSN (online): 2622-8343; and ISSN (print): 2477-3778. The journal seeks to disseminate research to educators around the world and is published twice a year in the months of June and December. The newest template has been published since Volume 6(2): December 2020.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 5 Documents
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Search results for , issue "Vol. 7 No. 2 (2021)" : 5 Documents clear
Profil Hasil Pemeriksaan GeneXpert Real Time Polymerase Chain Reaction (RT-PCR) Terhadap Mycobacterium tuberculosis pada Pasien Tuberkulosis Paru di Rumah Sakit Bhayangkara Polda Bengkulu Periode Januari-Desember 2018 Sariyanti, Mardhatillah
JURNAL KEDOKTERAN RAFLESIA Vol. 7 No. 2 (2021)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v7i2.15892

Abstract

Background: Tuberculosis (TB) is an infection that caused by Mycobacterium tuberculosis (MTB) and the droplets can be transmitted by the air. Mycobacterium tuberculosis mainly infected the lungs, but also and infected other organs like, glands, bones, and nervous system. World Health Organization reported that there are 10 million TB cases in 2017 and 1,3 million death caused by this disease. Based on the data from Health’s Profile in Bengkulu city in 2015 there are 18.982 lung tuberculosis suspects. GeneXpert is a brand new innovation to diagnose TB based on molecular examination that uses  Real Time Polymerase Chain Reaction (RT-PCR) which targeting the gene rpoB hotspot in MTB integrated and automatically processing the sample’s Deoxyribo Nucleic Acid (DNA) in disposable catridge. Method: This is an analytic description research. This research took secondary data (medical record) from the result of sputum examination by GenExpert tools from the lung tuberculosis patients at Bhayangkara Polda Bengkulu Hospital in January-December 2018 to acknowledge the result of MTB’s examination. Results: From this research, there were 150 male patients (70,1%) and 64 female patients (29,9%). The most patients in this research was from the age range 45-65 years old which is 102 patients (47,7%). The proportion of MTB rifampicin sensitive is 22 patients (10,3%). The proportion of MTB rifampicin resistance is 1 patient (0,05%). And the proportion of MTB not-detected is 191 patients (89,2%). Conclusion: Profile of the result of Genexpert examination in lung tuberculosis patients at Bhayangkara Polda Bengkulu Hospital is sensitive to rifampicin
Pengaruh pemberian teh hitam (camellia sinensis) terhadap gambaran histopatologi gaster tikus putih (Rattus norvegicus) jantan Sprague dawley yang diinduksi minyak jelantah Akbar, Novrian
JURNAL KEDOKTERAN RAFLESIA Vol. 7 No. 2 (2021)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v7i2.19031

Abstract

Latar Belakang: Minyak jelantah atau minyak goreng bekas adalah minyak yang digunakan secara berulang tanpa penambahan minyak goreng baru. Pemakaian minyak berulang kali dapat merusak struktur kimia dan menghasilkan radikal bebas. Hasil dari proses tersebut adalah senyawa toksik seperti hidroperoksida. Teh mengandung enam kelompok bioflavanoid catechins, theaflavins, the arubigins, oxyaromatic acids, flavonols, flavones, dan derivac gallic acid yang dapat menghambat radikal bebas, melindungi organ dari stress oksidatif. Teh hitam selain mengandung katekin juga mengandung theaflavin dan thearubigin sebagai hasil dari proses oksidasi enzimatik yang lebih tinggi dibandingkan dengan teh hijau. Metode: Penelitian ini menggunakan metode penelitian eksperimental post test only control grup design dengan menggunakan 24 tikus Sprague dawley jantan dibagi dalam 6 kelompok secara acak dan diberi perlakuan selama 7  minggu. K0 (control) (diberi aquadest), K1 (diberi  minyak jelantah 12 kali penggorengan  1,5 ml/hari, 1 jam kemudian diberi aquadest), K2 (diberi infusa teh hitam dengan dosis 0,50 gr/200grBB), K3 ( diberi infusa teh hitam dengan dosis 0,75 gr/200grBB), K4(diberi minyak jelantah 12 kali penggorengan  1,5 ml 1 jam kemudian diberi infusa teh hitam dengan dosis 0,50 gr/200grBB) K5 (diberi minyak jelantah 12 kali penggorengan  1,5 ml 1 jam kemudian diberi infusa teh hitam dengan dosis 0,75 gr/200grBB), setiap hari selama 6 minggu. Pada akhir penelitian tikus dilakukan terminasi dan diambil lambungnya untuk pembuatan preparat histopatologi dengan pewarnaan Hematoksilin Eosin. Data dianalisis dengan uji Kruskal-Wallis dan uji Post Hoc Mann-Whitney. Hasil: Hasil uji Kruskal-Wallis diperoleh nilai p=0,063, yang artinya tidak terdapat perbedaan bermakna dari skor histopatologi antar kelompok. Hasil uji Post Hoc Mann-Whitney menunjukkan tidak terdapat perbedaan bermakna K0 terhadap K1 yang berarti pemberian minyak jelantah 12 kali pemanasan tidak merusak  gambaran histopatologi lambung ditinjau secara statistik. Perbandingan antara K0 dengan K2 dan K3 tidak terdapat perbedaan bermakna yang artinya dosis yan diberikan tidak merusak gambaran histopatologi lambung. Perbandingan antara K0 dengan K4 dan K5 menunjukkan tidak terdapat perbedaan bermakna yang artinya pemberian infusa teh hitam (Camellia sinensis) dosis 0,50 gr/200 grBB dan dosis 0,75 gr/200 grBB tidak terjadi perbaikan terhadap kerusakan gaster tikus putih. Kesimpulan: Penelitian membuktikan bahwa Induksi minyak jelantah dengan 12x pemanasan berulang tidak menyebabkan kerusakan pada gaster tikus Rattus norvegicus dan pemberian infusa teh hitam (Camellia sinensis) dosis 0,50 gr/200 grBB dan dosis 0,75 gr/200 grBB tidak terjadi perbaikan terhadap kerusakan gaster tikus putih.
Diagnostic Description of Ischemic Stroke Patients with Type 2 Diabetes Mellitus in Royal Prima Medan General Hospital Halim, Michael
JURNAL KEDOKTERAN RAFLESIA Vol. 7 No. 2 (2021)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v7i2.19087

Abstract

AbstractStroke is a focal cerebral dysfunction that occurs for 24 hours or more, which can cause disability or death due to spontaneous bleeding or inadequate blood supply. The stroke itself can be divided into ischemic and hemorrhagic. Ischemic stroke is a sudden loss of blood circulation in the brain area. Diabetes mellitus is a metabolic disease characterized by hyperglycemia that occurs due to abnormalities in insulin, insulin action, or both. Diabetes mellitus is divided into type 1, type 2, and gestational. Type 2 diabetes mellitus is a metabolic disorder usually characterized by increased blood sugar due to a decrease in insulin by pancreatic beta cells and insulin resistance. The purpose of this study was to determine the diagnostic picture of ischemic stroke patients with type 2 diabetes mellitus and to determine the distribution of proportions based on sociodemographic characters, procedures for diagnosis, management, and complications of the disease. This research is descriptive, retrospective with a case study design and a sample of 30 medical records at Royal Prima Hospital, which will then be analyzed using the SPSS application. The results showed the distribution of the proportion of ischemic stroke patients with T2DM in the elderly, male gender, blood sugar levels 200-300 mg/d, cholesterol above 200, and previous disease history. Based on the research results that have been done, it is concluded that people who have had an ischemic stroke almost always have a history of diabetes mellitus, both type 2 and vice versa, and have congenital supporting diseases such as hypertension. Keywords: Stroke, ischemic stroke, type 2 diabetes mellitus  AbstrakStroke merupakan disfungsi serebral fokal yang terjadi selama 24 jam, bahkan lebih. Sehingga dapat menyebabkan disabilitas atau kematian karena terjadi pendarahan spontan atau pasokan darah yang tidak memenuhi. Stroke sendiri dapat dibagi menjadi iskemik dan hemoragik. Stroke iskemik merupakan hilangnya sirkulasi darah didaerah otak secara tiba-tiba. Diabetes mellitus merupakan penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan insulin, kerja insulin atau keduanya. Diabetes mellitus dibagi menjadi DM tipe 1, DM tipe 2, gestasional. Pengertian dari diabetes mellitus tipe 2, yaitu merupakan gangguan metabolik yang biasanya ditandai dengan kenaikkan gula darah akibat penurunan insulin oleh sel beta pankreas dan resistensi insulin. Tujuan penelitian ini adalah untuk mengetahui gambaran diagnostik pasien stroke iskemik terhadap diabetes mellitus tipe 2, serta untuk mengetahui distubusi proporsi berdasarkan karakter sosiodemografis, tata cara diagnosis, penatalaksanaan dan komplikasi penyakit. Penelitian ini bersifat deskriptif, retrospektif dengan desain studi kasus dan jumlah sampel sebanyak 30 data rekam medis di RSU Royal Prima yang selanjutnya akan dianalisa menggunakan aplikasi SPSS. Hasil penelitian didapatkan distribusi proporsi pasien stroke iskemik dengan DMT2 pada usia lansia, jenis kelamin laki-laki, kadar gula darah 200-300mg/d, kolestrol diatas 200 dan memiliki riwayat penyakit sebelumnya. Berdasarkan hasil penelitian, dapat disimpulkan hasil: orang yang pernah terkena stroke iskemik hampir selalu memiliki riwayat penyakit diabetes mellitus baik tipe 2 dan sebaliknya, serta memiliki penyakit bawaan pendukung seperti hipertensi.                                                                                          Kata kunci: Stroke, stroke iskemik, diabetes mellitus tipe 2
RELATIONSHIP OF PATIENT CHARACTERISTICS WITH THE SEVERITY OF COVID-19 IN HOSPITALIZED PATIENTS IN ROYAL PRIMA HOSPITAL MEDAN JANUARY- MARCH 2021 Millenny Zai, Theodora Destry
JURNAL KEDOKTERAN RAFLESIA Vol. 7 No. 2 (2021)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v7i2.19620

Abstract

Coronavirus Disease 19 (COVID-19) is an infectious ailment as a consequence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Symptoms that get up due to SARS-CoV-2 infection are the most common with in the form of fever, fatigue, and dry cough, similarly to some of the symptoms and symptoms that patients may also moreover experience, are headache, conjunctivitis, sore throat, diarrhea, loss of sense of smell and skin rash. Serious signs can also additionally consist of issue respiration or shortness of breath, chest pain, and issue speak me or moving. Covid-19 is split into numerous types, specifically asymptomatic, mild, moderate, severe, and crucial that have a courting with affected person traits. This has a look at is a retrospective cohort have a look at. The general quantity of samples become 372 affected person clinical facts with information taken with inside the shape of age, gender, blood pressure, weight, height, Hb, urea, creatinine, SGOT, SGPT, blood glucose, smoking records, hypertension, coronary heart attack, kidney disorders, and radiological results. The results of this study showed that there were several patient characteristics related to the severity of Covid-19 (p<0.05), namely Body Mass Index (BMI), urea, GFR, X-Ray Radiology examination, CT-Scan examination, and the patient's initial symptoms. On the other hand, other characteristics did not show an association with the severity of Covid-19 (p>0.05), namely: age, gender, blood pressure, creatinine, SGOT, SGPT, Hb, blood glucose, smoking history, history of hypertension, history of heart attack, and history of renal impairment.Coronavirus Disease 19 (COVID-19) adalah penyakit menular yang disebabkan oleh Sindrom Pernafasan Akut Parah Coronavirus 2 (SARS-CoV-2). Gejala yang timbul akibat kontaminasi SARS-CoV-2 adalah yang paling umum berupa demam, kelelahan, dan batuk kering, serta beberapa gejala yang mungkin juga dialami penderita, yaitu sakit kepala, konjungtivitis, nyeri tenggorokan, diare, kehilangan indra penciuman dan ruam kulit.. Gejala serius yang dapat terjadi berupa kesulitan bernapas atau sesak napas, nyeri pada dada, dan kesulitan berbicara atau bergerak. Covid-19 dibedakan menjadi beberapa type yaitu tanpa gejala, ringan, sedang, berat, dan kritis yang memiliki hubungan dengan karakteristik pasien. Penelitian ini merupakan penelitian cohort retrospective. Jumlah sampel total berjumlah 372 rekam medis pasien dengan data yang diambil berupa usia, jenis kelamin, tekanan darah, berat badan, tinggi badan, Hb, ureum, kreatinin, SGOT, SGPT, KGD, riwayat merokok, hipertensi, serangan jantung, gangguan ginjal, dan hasil pemeriksaan radiologi. Pada hasil penelitian ini menunjukkan adanya beberapa karakteristik pasien yang berhubungan dengan derajat keparahan Covid-19 (p<0.05), yaitu Indeks Massa Tubuh (IMT), ureum, GFR, pemeriksaan Radiologi X-Ray, pemeriksaan CT-Scan, serta gejala awal pasien. Sebaliknya karakteristik lainnya tidak menunjukkan adanya hubungan dengan derajat keparahan Covid-19 (p>0.05), yaitu: umur, jenis kelamin, tekanan darah, kreatinin, SGOT, SGPT, Hb, KGD, riwayat merokok, riwayat hipertensi, riwayat serangan jantung, dan riwayat gangguan ginjal .
CASE REPORT: AN ASCARIASIS CASE IN A MALE KIDS ON SEMARANG Zulaikhah, Siti Thomas
JURNAL KEDOKTERAN RAFLESIA Vol. 7 No. 2 (2021)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v7i2.19821

Abstract

Soil-transmitted Helminths (STH) often cause slightly high numbers of comorbids, especially in developing countries. Ascaris lumbricoides is the STH that most often causes infection, which is called Ascariasis. The high rate of STH infection is caused by poor environmental sanitation and poor habits of Clean and Healthy Lifestyle (PHBS) of the population. In Indonesia, STH infection is one of the main public health problems with prevalence ranged between 45% to 65%. Indeed the prevalence can reach 80% in areas with poor sanitation. The high prevalence of helminthiasis cases in Indonesia, especially in the work area of the Pusekesmas Bangetayu Semarang, the authors are interested in further exploring the diarrhea case in An. AR at Pusekesmas Bangetayu Semarang with an epidemiological triangle approach

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