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Narra J
Published by PT Narra Sains Indonesia
ISSN : -     EISSN : 28072618     DOI : https://doi.org/10.52225/narraj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Narra J is a multidisciplinary journal and it is published three times (April, August, December) a year. The objective is to promote articles on infection, public health, global health, tropical infection, one health and diseases in tropics. Narra J publishes original research work across all disciplines of medicine and allied sciences, related to infection, public health, global health, tropical infection, one health and diseases in tropics. The journal publishes Original articles, Short Report, Review articles, and Letters to the Editor. All articles published in Narra J are peer-reviewed and published online for immediate access and citation. Narra J publishes the primary research papers, review articles, short communications and letters on topics but not limited to: Public health Global health Infection Tropical diseases One health Biomedical sciences Epidemiology and clinical epidemiology Molecular biology Environmental health Microbiology Pharmacological sciences Diseases in tropics
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol. 6 No. 2 (2026): August 2026" : 5 Documents clear
Psychometric properties of the Burmese version of Self-Stigma Scale: A study among older Myanmar migrants in Thailand Shun Lei Oo; Moe Moe Yu; Wongpakaran, Tinakon; Griffiths, Jiranan; Lerttrakarnnon, Peerasak; O’Donnell, Ronald R.; Wongpakaran, Nahathai
Narra J Vol. 6 No. 2 (2026): August 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i2.3076

Abstract

Self-stigma is a major barrier to mental health help-seeking among marginalized populations, including older Myanmar migrants in Thailand. Despite its importance, this issue has been little studied in this population, and no validated Burmese-language instrument has been available to date. This study evaluated the psychometric properties of the Burmese version of the Self-Stigma Scale–Short Form (SSS-SF), with particular emphasis on its factor structure, reliability, and validity among older Myanmar migrants in Thailand. Participants (n=211) aged ≥60 years were recruited through online platforms and community outreach initiatives. The SSS-SF was translated and culturally adapted in accordance with international guidelines. Confirmatory factor analysis was used to test multiple structural models, and reliability was assessed using Cronbach’s alpha. Convergent and discriminant validity were examined through correlations with the depression and anxiety subscales of the Outcome Inventory-21 (OI-21), the Mental Help-Seeking Intention Scale (MHSIS), and the Extraversion domain of the Zuckerman-Kuhlman-Aluja Personality Questionnaire-20 (ZKA-20). Initial analyses indicated that the 9-item bifactor model provided the best representation of the data, although overall fit remained only modest. After removal of four misfitting items, a shortened 5-item version demonstrated improved fit as a unidimensional model. Reliability was good for the 9-item scale (α=0.855) and acceptable for the 5-item scale (α=0.828). Convergent validity was supported by significant positive correlations between self-stigma and OI-21 depression (r=0.55, p<0.01), OI-21 anxiety (r=0.54, p<0.01), and MHSIS (r=0.15, p<0.05). Discriminant validity was supported by a weak, non-significant association with ZKA-20 Extraversion (r=0.11, ns). These findings suggest that, although the original 9-item Burmese SSS-SF showed limitations in model fit, the refined 5-item version offers a more concise measure with initial evidence of promising psychometric properties for assessing self-stigma among older Myanmar migrants. This shorter version may be useful for rapid screening in community and clinical settings, although further validation in other Burmese populations is warranted.
Impact of colchicine on hs-CRP, neutrophil levels, neutrophil-to-lymphocyte ratio and major adverse cardiac events (MACEs) in Thai patients with acute coronary syndrome undergoing percutaneous coronary intervention Wattanasiriporn, Wittawat; Rattanasidha, Paruj; Munirwan, Haris; Arayangkoon, Chantisa
Narra J Vol. 6 No. 2 (2026): August 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i2.3079

Abstract

Acute coronary syndrome (ACS) is strongly associated with inflammation, which contributes to plaque instability, thrombosis, and adverse cardiovascular outcomes. High-sensitivity C-reactive protein (hs-CRP), neutrophil count, and neutrophil-to-lymphocyte ratio (NLR) are inflammatory markers that have been associated with poor prognosis in patients with ACS. Colchicine has emerged as a potential adjunctive anti-inflammatory therapy in cardiovascular disease. This study aimed to evaluate the effects of colchicine on inflammatory markers and clinical outcomes in Thai patients with ACS undergoing percutaneous coronary intervention (PCI). This single-center, retro-prospective observational cohort study included adult patients with ACS who underwent PCI at Rajavithi Hospital, Bangkok, Thailand, in 2024. Patients were classified into colchicine and non-colchicine groups based on treatment exposure after PCI. Hs-CRP, neutrophil count, and NLR were assessed at baseline, 1 month, and 3 months. Major adverse cardiac events (MACE) during follow-up were also recorded. A total of 56 patients were included, comprising 38 in the colchicine group and 18 in the non-colchicine group. Compared with the non-colchicine group, the colchicine group showed significantly greater reductions from baseline to 3 months in hs-CRP levels (2.29±3.37 vs 0.45±1.03; p=0.044), neutrophil count (21.86±10.62 vs 4.13±12.92; p=0.001), and NLR (2.98±2.93 vs 1.68±3.60; p=0.025). No significant differences in MACE were observed between the two groups. This study highlighted that colchicine was associated with greater reductions in inflammatory markers during the early post-PCI period, although no significant difference in short-term clinical outcomes was identified. Larger prospective studies are needed to confirm these findings.
Association of interleukin-6 and C-reactive protein with in-hospital mortality in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention Rachman, Adelia U.; Saputra, Firandi; Bagaswoto, Hendry P.; Setianto, Budi Y.
Narra J Vol. 6 No. 2 (2026): August 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i2.3085

Abstract

Inflammation contributes substantially to the pathogenesis of acute coronary syndromes (ACS), and interleukin-6 (IL-6) and C-reactive protein (CRP) have been proposed as biomarkers of adverse outcomes. The aim of this study was to evaluate the associations of IL-6 and CRP with in-hospital mortality among patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). This prospective cohort study enrolled adult patients with STEMI who underwent primary PCI at Dr. Sardjito General Hospital, Yogyakarta, Indonesia, in 2023. A single blood sample for IL-6 and CRP measurement was collected within 24 hours after PCI. In-hospital mortality was recorded during hospitalization. Receiver operating characteristic analysis identified optimal cut-off values, and multivariable logistic regression was performed to adjust for potential confounders. In-hospital mortality occurred in 6 patients (12.8%). In univariate analysis, higher IL-6 and CRP levels were associated with in-hospital mortality. IL-6 ≥84.60 pg/mL showed an area under the curve (AUC) of 0.776, sensitivity of 66.7%, and specificity of 82.9% (p=0.007), whereas CRP ≥31.35 mg/L showed an AUC of 0.748, sensitivity of 83.3%, and specificity of 68.3% (p=0.015). However, after adjustment for confounding variables in separate multivariable models, neither IL-6 nor CRP remained independently associated with in-hospital mortality. These findings indicate that although elevated IL-6 and CRP levels were associated with in-hospital mortality in unadjusted analyses, their independent prognostic value was not retained after accounting for other clinical and laboratory factors. Further studies with larger sample sizes are needed to clarify the role of these inflammatory biomarkers in risk stratification among patients with STEMI.
Translational evaluation of magnetized saline water combined with ciclopirox olamine and piroctone olamine against Malassezia species and scalp seborrheic dermatitis Rivetti, Nicolò; Lista, Simone; García-Chico, Celia; Khoramipour, Kayvan; Santos-Lozano, Alejandro; Minoretti, Piercarlo
Narra J Vol. 6 No. 2 (2026): August 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i2.3090

Abstract

Yeasts of the Malassezia genus are implicated in numerous skin conditions, including seborrheic dermatitis, pityriasis versicolor, and folliculitis. While ciclopirox olamine (CPO) and piroctone olamine (OCT) are effective anti-Malassezia agents, the activity of magnetized water against pathogenic yeasts remains unclear. The aim of this study was to examine the in vitro efficacy of magnetized saline water (MSW), alone or combined with CPO plus OCT, against three Malassezia species (M. furfur, M. globosa, and M. restricta) using broth microdilution to determine minimal inhibitory concentrations (MICs). A proof-of-concept study evaluating a shampoo containing MSW 30% + CPO 0.5% + OCT 1.0% in 20 patients with scalp seborrheic dermatitis (SSD) was subsequently conducted. Participants applied the shampoo four times per week for 12 weeks; efficacy was assessed by changes in a validated 16-point SSD severity score. The triple combination demonstrated additive-to-synergistic activity, with MIC values of 3.91 mg/L across all three species, representing a 2.0- to 4.0-fold MIC reduction compared to CPO + OCT alone, and synergy (FIC=0.31) for M. furfur. The total SSD score decreased by 33.9% after 12 weeks (p<0.001), with improvements in pruritus (49.0%), erythema (54.3%), and scaling (24.2%); all p values remained significant after Bonferroni correction (α=0.0125). These findings support MSW as a vehicle to potentiate the anti-yeast activity of CPO and OCT while reducing the chemical load, potentially offering a novel strategy for Malassezia-associated skin disorders. The open-label, single-arm design limits causal attribution, and larger controlled trials are needed.
Global longitudinal strain and left ventricular ejection fraction for early detection of chemotherapy-related cardiac dysfunction in breast cancer: A prospective comparison of doxorubicin-based and paclitaxel–carboplatin regimens Faradilla, Rizka; Heriansyah, Teuku; Novita, Novita; Munirwan, Haris; Fitra, Maha
Narra J Vol. 6 No. 2 (2026): August 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i2.3095

Abstract

Left ventricular ejection fraction (LVEF) is widely used in routine practice to assess cardiotoxicity; however, reductions in LVEF often reflect relatively advanced myocardial damage. Global longitudinal strain (GLS) quantifies myocardial deformation and has demonstrated greater sensitivity for identifying early systolic dysfunction, yet comparative evidence on myocardial strain changes between doxorubicin-based regimens and non-anthracycline chemotherapy in breast cancer patients remains limited. The aim of this study was to compare changes in left ventricular GLS and LVEF between breast cancer patients receiving doxorubicin-based chemotherapy and those treated with paclitaxel–carboplatin regimens. A prospective cohort study was conducted among 106 women with histopathologically confirmed breast cancer, who were allocated to receive either a doxorubicin-based regimen (n=53) or a paclitaxel–carboplatin regimen (n=53). Transthoracic echocardiography was performed within seven days before chemotherapy initiation and repeated after four months. Left ventricular GLS was measured using two-dimensional speckle-tracking echocardiography from apical views and analyzed offline using the 17-segment model. Baseline GLS values did not differ significantly between the doxorubicin and paclitaxel–carboplatin groups (−20.47±0.45 vs −20.38±0.53; p=0.410). After four months, GLS was significantly reduced in the doxorubicin group compared with the paclitaxel–carboplatin group (−15.04±0.35 vs −19.54±0.50; p<0.001). The change in GLS (ΔGLS) was also greater in the doxorubicin group (5.43±0.12 vs 0.84±0.11; p<0.001). No significant differences were observed in LVEF before chemotherapy (55.26±1.78 vs 55.39±1.99; p=0.720), after chemotherapy (51.32±1.51 vs 51.60±1.64; p=0.359), or in ΔLVEF (p=0.484). In conclusion, doxorubicin-based chemotherapy was associated with early subclinical systolic dysfunction detectable by GLS before measurable LVEF decline, whereas paclitaxel–carboplatin was associated with relatively preserved myocardial deformation. These findings support the incorporation of strain imaging into routine cardiac surveillance for earlier identification and management of chemotherapy-related myocardial injury.

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