cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
harapan@unsyiah.ac.id
Phone
+62895600103060052
Journal Mail Official
harapan@unsyiah.ac.id
Editorial Address
School of Medicine Universitas Syiah Kuala Darussalam, Banda Aceh, 23111 Indonesia
Location
Kota banda aceh,
Aceh
INDONESIA
Narra J
Published by PT Narra Sains Indonesia
ISSN : -     EISSN : 28072618     DOI : https://doi.org/10.52225/narraj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Narra J is a multidisciplinary journal and it is published three times (April, August, December) a year. The objective is to promote articles on infection, public health, global health, tropical infection, one health and diseases in tropics. Narra J publishes original research work across all disciplines of medicine and allied sciences, related to infection, public health, global health, tropical infection, one health and diseases in tropics. The journal publishes Original articles, Short Report, Review articles, and Letters to the Editor. All articles published in Narra J are peer-reviewed and published online for immediate access and citation. Narra J publishes the primary research papers, review articles, short communications and letters on topics but not limited to: Public health Global health Infection Tropical diseases One health Biomedical sciences Epidemiology and clinical epidemiology Molecular biology Environmental health Microbiology Pharmacological sciences Diseases in tropics
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 632 Documents
 60   61   62   63   64 
Comparison of interleukin-6 and serum creatinine levels in preeclampsia and normal pregnancy patients: A cross-sectional study in Indonesia Dewi, Syerli R.; Yeni, Cut M.; Munizar, Munizar; Dewi, Tgk. Puspa; Utami, Niken A.; Rusnaidi, Rusnaidi
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3016

Abstract

Preeclampsia (PE) is a complication of pregnancy with high morbidity and mortality, characterized by endothelial dysfunction, systemic inflammation, and impaired renal function. Interleukin-6 (IL-6) and serum creatinine have potential as biomarkers for early detection of PE; however, data from Indonesia are limited. The aim of this study was to compare IL-6 and serum creatinine levels between pregnant women with PE and normotensive controls, as well as their diagnostic performance in identifying PE. A cross-sectional study involving pregnant women with PE and normotensive controls was conducted at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. Serum IL-6 and creatinine levels were measured using the ECLIA method. Levels were compared using the Mann–Whitney test; diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis, and multivariable logistic regression was used to evaluate combined diagnostic contribution. A total of 68 pregnant women were included, comprising 34 patients with PE and 34 normotensive controls. Median IL-6 levels were significantly higher in the PE group (16.05 pg/mL) than in the control group (3.71 pg/mL). Receiver operating characteristic analysis demonstrated excellent diagnostic performance of IL-6, with an are under the curve (AUC) of 0.831 (95%CI: 0.734–0.929). At an optimal cutoff value of 5.52 pg/mL, IL-6 achieved a sensitivity of 73.53%, specificity of 76.47%, and diagnostic accuracy of 86.76%. Median serum creatinine levels were also significantly elevated in the PE group (0.56 mg/dL) compared with controls (0.44 mg/dL; p<0.001). The AUC for serum creatinine was 0.806 (95%CI: 0.700–0.912), indicating good diagnostic performance. At a cutoff value of 0.475 mg/dL, serum creatinine demonstrated a sensitivity of 70.59%, specificity of 73.53%, and accuracy of 72.06%. Multivariable logistic regression confirmed that IL-6 (B=0.123; p=0.005) and serum creatinine (B=9.306; p=0.023) were independently associated with PE, explaining 57.5% of PE variability (Nagelkerke R²=0.575). These findings indicate that serum IL-6 and creatinine are significantly associated with PE, and their combined assessment shows potential as a predictive biomarker with good diagnostic performance.
Prevalence of malnutrition in patients with acute coronary syndrome undergoing coronary angiography in Thailand: A retrospective observational study Wattanasiriporn, Wittawat; Sunawin, Methat; Arayangkoon, Chantisa
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3077

Abstract

Malnutrition is an important prognostic factor in patients with acute coronary syndrome (ACS), but it remains under-recognized in routine practice, particularly in Thailand, where local data are limited, and no population-specific nutritional screening tool has been validated. The Prognostic Nutritional Index (PNI) and Nutritional Risk Index (NRI) have been associated with mortality and major adverse cardiovascular events (MACEs) in patients with ACS, but their clinical usefulness in Thai patients remains unclear. This study aimed to determine the prevalence of malnutrition among patients with ACS undergoing coronary angiography (CAG) at Rajavithi Hospital, Bangkok, Thailand, and to assess the clinical usefulness of PNI and NRI in this setting. The secondary objective was to evaluate 1-year all-cause mortality and the occurrence of MACEs according to nutritional status. This study included 244 adult patients with ACS who were admitted between January 2023 and December 2024, underwent CAG, and completed a 1-year follow-up. Nutritional status was assessed using PNI and NRI, and categorized as severe, moderate, or no malnutrition. The primary outcome was 1-year all-cause mortality, while the secondary outcome was MACEs, defined as a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, hospitalization for heart failure, and hospitalization for unstable angina. Associations between nutritional status and outcomes were examined using logistic regression. According to PNI, 43.8% of patients were malnourished, including 27.0% with severe malnutrition and 16.8% with moderate malnutrition. In contrast, NRI classified 99.6% of patients as severely malnourished. The 1-year all-cause mortality rate was 28.3%, and the MACE rate was 28.7%. Based on PNI, severe and moderate malnutrition were associated with higher mortality than no malnutrition (62.1% and 31.7% vs 10.9%, respectively). Severe malnutrition was associated with 13.34-fold higher odds of death (odds ratio (OR) 13.34; 95%CI: 6.41–27.71), while moderate malnutrition was associated with 3.78-fold higher odds (OR 3.78; 95%CI: 1.61–8.82). Severe and moderate malnutrition were also associated with higher odds of MACEs (OR 2.65; 95%CI: 1.38–5.06 and OR 2.89; 95%CI: 1.36–6.11, respectively). Malnutrition was common among Thai patients with ACS undergoing CAG and was strongly associated with adverse 1-year outcomes. Compared with NRI, PNI provided more clinically meaningful stratification in this cohort. Although formal comparative performance analyses were not performed, PNI may be a practical tool for nutritional risk assessment in routine ACS care.

Page 64 of 64 | Total Record : 632

 60   61   62   63   64 

Filter by Year

2021 2026


Reset
Filter By Issues
All Issue Vol. 6 No. 1 (2026): April 2026 Vol. 5 No. 3 (2025): December 2025 Vol. 5 No. 2 (2025): August 2025 Vol. 5 No. 1 (2025): April 2025 Vol. 4 No. 3 (2024): December 2024 Vol. 4 No. 2 (2024): August 2024 Vol. 4 No. 1 (2024): April 2024 Vol. 3 No. 1 (2023): April 20223 (In Press) Vol. 3 No. 3 (2023): December 2023 Vol. 3 No. 2 (2023): August 2023 Vol. 3 No. 1 (2023): April 2023 Vol. 2 No. 3 (2022): December 2022 Vol. 2 No. 2 (2022): August 2022 Vol. 2 No. 1 (2022): April 2022 Vol. 1 No. 3 (2021): December 2021 Vol. 1 No. 2 (2021): August 2021 Vol. 1 No. 1 (2021): April 2021 More Issue