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Septian Adi Permana
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Solo Journal of Anesthesi, Pain and Critical Care
Published by Universitas Sebelas Maret
ISSN : 27761770     EISSN : 27970035     DOI : https://doi.org/10.20961
Core Subject : Health, Engineering,
Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Nursing Public Health
Case Report, Original Research and Review Article in the scope of : Life Support Emergency and Trauma Cardiovascular Anesthesia Pediatric Anesthesia Neuro Anesthesia Pain Management Intensive Care Obstetry Anesthesia Geriatric and Oncology Anesthesia Regional Anesthesia Ambulatory Anesthesia
Arjuna Subject : Kedokteran - Anesthesiology and Pain Medicine
Articles 43 Documents
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Erector Spinae Block vs Paravertebral Block in Breast Cancer Surgery: A Systematic Review and Meta-analysis Rizky Rahmad Tri Cahyo; Doso Sutiyono; Intan Karmila; Ismini Aufakamilia
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 5, No 2 (2025): October 2025
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v5i2.67351

Abstract

 Background :The paravertebral block (PVB) is the gold standard for postoperative analgesia in breast surgery, but it easily causes pneumothorax. Erector spinae plane block (ESPB) is considered as alternative to PVB because its less invasive so relative safer. However, evidence in favor of these techniques is lacking. Method :A search of PubMed Central, Cochrane Library, Wiley Online Library, and ClinicalTrials.gov to identify the latest 20 years studies comparing ESPB and PVB in breast cancer surgery was conducted. Our endpoints were: intraoperative fentanyl consumption, total postoperative morphine, and time to first analgesic request. Result :A total of 6 studies (394 patients) were included for this meta-analysis. The pooled analysis showed there is -3.03 (MD = -3.03: 95% CI: -7.47– 1.42) mean difference with insignificant overall effect (P = 0.18) for intraoperative fentanyl consumption on ESPB patient after breast cancer surgery compared against PVB procedure. There is an insignificant between ESPB and PVB regarding total postoperative morphine with 0.46 (MD = 0.46: 95% CI: -0.94 – 1.85) mean difference with insignificant overall effect (P =0.52). There is a significant difference between ESPB and PVB regarding time to first analgesic request with 0.23(MD = 0.23: 95% CI: 0.01– 0.44) risk ratio with statistically significant overall effect (P = 0.04). Both intraoperative fentanyl consumption and total postoperative morphine consumption showed heterogeneity. Meanwhile, time to the first analgesic request showed no heterogeneity. Conclusion : PVB is superior to ESPB regarding time to first analgesic request, but ESPB can serve as analternative to PVB with a similar analgesic effect   
Regenerative Pain Therapy Using Platelet-Rich Plasma Compared with Steroid Injection for Spinal Disc Herniation: A Meta-Analysis Alfan Rizki Nur Rohman; Taufiq Agus Siswagama; Probo Yudha Pratama Putra
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 5, No 2 (2025): October 2025
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v5i2.103270

Abstract

Background: Radicular pain resulting from spinal conditions remains one of the most challenging problems for clinicians. This meta-analysis aimed to compare the interventional pain outcomes of platelet-rich plasma (PRP) injection versus steroid injection in patients with disc herniation.Methods: A systematic review was conducted following PRISMA guidelines using PubMed, Science Direct, Cochrane Library, and RevMan 5.3. Three RCTs were analyzed.Results: A total of 204 patients were included (PRP n = 101; control n = 103). There was no significant difference between the PRP and steroid for VAS (Visual Analog Scale), ODI (Oswestry Disability Index), and SF-36 scores at 3 and 6 months.Conclusion: PRP provides similar pain reduction compared with steroid injection, with the additional advantage of potential regenerative effects. Further studies are warranted to evaluate structural regeneration
Dexmedetomidine vs. Other Sedatives in Mechanically Ventilated Sepsis Patients: Updated Meta-analysis Rizky Eka Putera; Rafael Bagus Yudhistira; Livilia Abigail Onggowasito; Nathania Ella Sudiono
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 5, No 2 (2025): October 2025
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v5i2.106536

Abstract

Introduction. Globally, the incidence of sepsis is estimated at over 400 cases per 100,000 population annually, making it a major public health concern.  .   In this setting, sedation is essential to ensure patient-ventilator synchrony and reduce physiological stress. Dexmedetomidine is a selective α₂-agonist often used instead of traditional sedatives because it provides light sedation, lowers the risk of delirium, and may reduce inflammation. However, clinical outcomes remain inconsistent across studies. To assess the clinical effects of dexmedetomidine compared to other sedatives in mechanically ventilated sepsis patients.Methods. A comprehensive literature search of Pubmed, Scopus, Cochrane Central, Scilit, and Epistemonikos was performed to identify studies published from 2020 to 2025. Inclusion criteria included Randomized Controlled Trial (RCT) studies that directly compared dexamethomidine as sedation and involving sepsis patients with mechanical ventilation. Risk of Bias was estimated using RoB2.0 and meta analysis was using Revman 5.4.Results. Eight randomized control trials (n = 1119) were included. Compared to other sedatives, dexmedetomidine prolonged hospital LOS significantly (MD = 1.47; 95% CI: 0.59 to 2.34; p = 0.001), reduced ICU LOS significantly (MD = -0.91; 95%CI = -1.51 to -0.29; p = 0.004), not improving the event of mortality insignificantly (OR = 0.99; 95% CI: 0.71–1.37; p = 0.95), reduced ventilator-free days insignificantly (MD = –0.85; 95% CI = –1.94 to 0.25; p = 0.13), and improved lactate clearance insignificantly (MD = 0.54; 95%CI = -0.41 to 1.49; p = 0.21)Conclusion. Dexmedetomidine reduces ICU length of stay and may offer early mortality benefits at 28 days in mechanically ventilated sepsis patients. However, its effects on hospital stay, lactate clearance, and ventilator-free days remain uncertain, and further standardized trials are needed.

Page 5 of 5 | Total Record : 43

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