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INDONESIA
Cermin Dunia Kedokteran
Published by PT. Kalbe Farma Tbk.
ISSN : 0125913X     EISSN : 25032720     DOI : 10.55175
Core Subject : Health,
Cermin Dunia Kedokteran (e-ISSN: 2503-2720, p-ISSN: 0125-913X), merupakan jurnal kedokteran dengan akses terbuka dan review sejawat yang menerbitkan artikel penelitian maupun tinjauan pustaka dari bidang kedokteran dan kesehatan masyarakat baik ilmu dasar, klinis serta epidemiologis yang menyangkut pencegahan, pengobatan maupun rehabilitasi. Jurnal ini ditujukan untuk membantu mewadahi publikasi ilmiah, penyegaran, serta membantu meningkatan dan penyebaran pengetahuan terkait dengan perkembangan ilmu kedokteran dan kesehatan masyarakat. Terbit setiap bulan sekali dan disertai dengan artikel yang digunakan untuk CME - Continuing Medical Education yang bekerjasama dengan PB IDI (Pengurus Besar Ikatan Dokter Indonesia)
Articles 24 Documents
Search results for , issue "Vol 44, No 11 (2017): Kardiovaskuler" : 24 Documents clear
Potential use of Purslane (Portulaca oleracea L.) as alternative wound healing therapy Setyowati, Hanny
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.756 KB) | DOI: 10.55175/cdk.v44i11.707

Abstract

Portulaca oleraceae (Indonesian name: Krokot) is a herbaceous succulent annual plant, distributed in tropical region. Chemical constituents such as flavonoids, alkaloids, fatty acids, terpenoids, polysaccharides, vitamins, sterols, proteins, and minerals have been isolated from this plant. The pharmacological properties, based on scientific research, are claimed as antibacterial, antiulcerogenic, anti-inflammatory, antioxidant, and especially for wound-healing. Triterpenoids and flavonoids play an important role, promotes wound contraction and increases epithelialization rate in the wound-healing process.Portulaca oleraceae (nama Indonesia: Krokot) adalah tumbuhan perdu sepanjang musim, tersebar di daerah tropis. Senyawa kimia seperti flavonoid, alkaloid, asam lemak, terpenoid, polisakarida, vitamin, sterol, protein, dan mineral telah diisolasi dari tanaman ini. Aktivitas farmakologis, berdasarkan hasil penelitian, dilaporkan sebagai antibakteri, antiulkus, antiinflamasi, antioksidan, dan terutama untuk penyembuhan luka. Triterpenoid dan flavonoid memiliki peran penting, yakni menstimulasi penyempitan bekas luka dan mempercepat penutupan luka.
Perbandingan Pengaruh Terapi Albumin Teknologi Nano dengan Albumin Kapsul terhadap Peningkatan Kadar Albumin dan Lama Perawatan -, Purwoko; Kurniawati, Diah
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.676 KB) | DOI: 10.55175/cdk.v44i11.698

Abstract

Latar Belakang: Pada hipoalbuminemia akan terjadi gangguan fisiologi tubuh, sehingga menghambat penyembuhan dan pemulihan. Beberapa cara untuk meningkatkan kadar albumin darah yaitu parenteral dan peroral. Tujuan: Untuk mengetahui efektivitas albumin teknologi nano dibandingkan kapsul albumin dalam meningkatkan kadar albumin penderita dan mengurangi lama perawatan. Metode: Randomized Controlled Trial di ICU RSUD Dr. Moewardi Surakarta sejak Juni hingga Agustus 2014 atas 30 sampel, terbagi menjadi dua kelompok. Kelompok pertama diberi albumin teknologi nano selama 3 hari dengan dosis 2 x 1 (a 5 g) sachet, kelompok kedua diberi kapsul albumin selama 3 hari dengan dosis 4 x 5 (a 500 mg) kapsul. Data dianalisis dengan uji Mann-Whitney U. Hasil: Kadar albumin kelompok albumin teknologi nano naik rata-rata 1,26+0,30 mg/dL, sedangkan yang mendapat kapsul albumin naik rata-rata 0,86+0,52 mg/dL (p<0,05). Lama rawat di ICU kelompok albumin teknologi nano (3,60+1,06 hari) dibandingkan kelompok kapsul albumin (4,13+1,19 hari) lebih singkat tetapi tidak bermakna (p>0,05).Simpulan: Albumin teknologi nano lebih efektif dibandingkan kapsul albumin untuk meningkatkan kadar albumin darah, namun tidak mempengaruhi lama perawatan pasien hipoalbuminemia di ICU.Background: Hypoalbuminemia is associated with increased complication risk, wound healing time, and hospitalization. Several methods to increase albumin levels are parenteral and oral albumin supplementation. Objectives: To compare the effectiveness of albumin nanotechnology to albumin capsules in increasing the albumin levels and in reducing length of hospital stay. Methods: Randomized Controlled Trial trial in ICU dr. Moewardi Hospital, Surakarta, during June until August 2014. The 30 study samples were divided into two groups. The first group were given nanotechnology albumin sachets for 3 days with a dose 2x1 (a 5g) sachet, second group was given albumin capsules for 3 days with a dose 4 x 5 (a 500 mg) capsules. Data was analyzed with Mann-Whitney U test. Results: Albumin levels in nanotechnology group has an average increase of 1.26+0.30 mg/dL, while an average increase in the other group was 0.86+0.52 mg/dL (p<0.05). The length of stay in the ICU was shorter in the nanotechnology group (3.60+1.06 days) compared to albumin capsule group (4.13+1.19 days), with no significant difference (p>0.05). Conclusion: Albumin nanotechnology was more effective than albumin capsules in increasing blood albumin levels, but does not affect the length of stay in the ICU in hypoalbuminemia patients.
Identifikasi Faktor Risiko Eksogen Maternal Orofacial Cleft Non-sindromik Tobing, Jessica Nadia
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (367.763 KB) | DOI: 10.55175/cdk.v44i11.712

Abstract

Orofacial Clefts (OFC) non-sindromik merupakan kelainan kongenital wajah berupa bibir sumbing, celah palatum (langit mulut), atau keduanya, tanpa kelainan pembentukan organ lain. Etiologi multifaktorial, kombinasi faktor endogen (genetik) dengan faktor eksogen yang dipengaruhi lingkungan. Tulisan ini membahas faktor risiko eksogen maternal pada OFC non-sindromik dengan metode studi jurnal epidemiologi. Rokok merupakan faktor risiko eksogen yang paling berhubungan dengan OFC.Non-syndromic Orofacial Clefts (OFC) is a facial congenital malformation, presented as isolated cleft lip, isolated cleft palate, or both, without other accompanying organ malformation. The etiology is multifactorial, combination of endogenous (genetic) and exogenous (environmental) factors are necessary. The discussion is on maternal exogenous risk factor identification for non-syndromic OFC through epidemiological journal study. Cigarette smoking is the most related risk factor to OFC.
Sepsis Neonatorum Awitan Dini -, Anastasia
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (187.879 KB) | DOI: 10.55175/cdk.v44i11.703

Abstract

Sepsis awitan dini tetap menjadi salah satu penyebab paling umum morbiditas dan mortalitas neonatal pada populasi prematur. Identifikasi neonatus berisiko untuk sepsis awitan dini sering didasarkan pada gabungan faktor risiko perinatal yang tidak sensitif maupun spesifik. Pengobatan optimal bayi dengan dugaan awal sepsis adalah agen antimikroba spektrum luas (ampisilin dan aminoglikosida). Setelah patogen diidentifikasi, terapi antimikroba harus disesuaikan. Laporan kasus bayi lahir preterm dgn usia gestasi 25-26 minggu. BBL 1310 gram.Bayi menunjukkan gejala sepsis awitan dini dengan gangguan koagulasi intravaskular diseminata dan trombositopeni. Pemberian antibiotik dimulai dengan antibiotik empiris dan dilanjutkan sesuai hasil kultur. Bayi mengalami perbaikan dan pada kontrol menunjukkan perkembangan yang baik.Early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality among preterm population. The identification of neonates at risk for early-onset sepsis is frequently based on a constellation of perinatal risk factors that are neither sensitive nor specific; and diagnostic tests for neonatal sepsis have a poor positive predictive accuracy. The optimal treatment of infants with suspected early-onset sepsis is broad-spectrum antimicrobial agents (ampicillin and an aminoglycoside). Once a pathogen is identified, antimicrobial therapy should be specified. Antimicrobial therapy should be discontinued after 48 hours if the probability of sepsis is low. This is a case report of preterm infant, gestational age of 25-26 weeks with body weight 1310 grams. The baby showed symptoms of early onset sepsis wih DIC (Disseminated Intravascular Coagulation). Therapy started with empirical antibiotic and continued according to culture results. The baby improved and follow up showed good growth.
Laporan Kasus Berbasis Bukti Manfaat Pelembap pada Dermatitis Atopi Fitriana, Eva; Christiani Siregar, Ricka
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (830.581 KB) | DOI: 10.55175/cdk.v44i11.704

Abstract

Latar belakang. Beberapa penelitian membuktikan manfaat pelembap pada terapi dermatitis atopi yaitu memperbaiki gejala klinis serta menunda kejadian relaps. Tujuan. Mengevaluasi kegunaan pelembap pada dermatitis atopi berdasarkan bukti ilmiah.Metode. Penelusuran pustaka database elektronik: Pubmed, Research Gate, Medical Journals. Simpulan. Pelembap (moisturizer) terbukti bermanfaat memperbaiki gejala klinis, nilai SCORAD, TEWL, hidrasi stratum korneum, sertu menunda relaps.Background. Several clinical trials showed that moisturizer is effective in reducing clinical symptoms and delays relapse of atopic dermatitis. Objective. To evaluate the evidence for moisturizer use in atopic dermatitis treatment. Methods. Literature search using electronic database: Pubmed, Research Gate, Medical Journals. Conclusions. Moisturizer is effective by reducing clinical symptoms, SCORAD score, TEWL, stratum corneum hydration, and delaying relapse. 
Teknik Reduksi untuk Parafimosis Kusumajaya, Christopher
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.985 KB) | DOI: 10.55175/cdk.v44i11.709

Abstract

Parafimosis merupakan kasus kegawatdaruratan urologi jika kulit prepusium, setelah diretraksi, tidak dapat dikembalikan menutupi glans penis, menyebabkan nyeri pada penis. Penanganan cepat di Unit Gawat Darurat dibutuhkan karena keterlambatan penanganan akan menyebabkan iskemi glans penis. Dalam sebagian besar kasus, teknik non invasif reduksi manual sangat efektif. Berbagai macam teknik reduksi dapat menjadi pilihan.Paraphimosis is a urologic emergency, if the foreskin retracted over the glans penis is irreducible, potential for serious penile injury if left unattended. Paraphimosis must be treated immediately in the emergency department. In most cases, manual reduction, a noninvasive technique, is effective. A variety of reduction techniques are available
Evidence for Graft versus Tumour Effect after Allogeneic Stem Cell Transplantation for Leukaemia and Lymphoma Ayuputeri Kumaheri, Meutia
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (461.145 KB) | DOI: 10.55175/cdk.v44i11.700

Abstract

Haematopoietic Stem Cell Transplantation (HSCT) has been commonly used in the treatment of haematopoietic malignancy as a rescue regiment to prevent bone marrow toxicity subsequent to high dose chemotherapy.The harmful effects are leading to Graft versus Host Disease (GVHD). However, studies have shown that GVHD, T-Cell dependent mechanisms, and NK cells in allogeneic stem cell transplantation contributed to a lower risk of disease relapse by a mechanism known as Graft versus Tumour (GVT) effect. Evidence of Graft Versus Tumour (GVT) effect has allowed development of cancer therapy with less toxic chemotherapy to allow tumour eradication. This essay aims to discuss evidences of GVT effect after allogeneic stem cell transplantation in both leukaemia and lymphoma and examine future prospects of maximizing GVT effect in the treatment of both diseasesTransplantasi dengan sel punca hematopoietis umumnya digunakan untuk pengobatan keganasan darah sebagai pencegahan toksisitas kemoterapi dosis tinggi terhadap sumsum tulang. Efek negatif dikenal sebagai graft rejection dan Graft versus Host Disease (GVHD). Meskipun demikian, para ilmuwan menemukan efek Graft versus Tumour (GVT) yang dapat menurunkan risiko relaps melalui efek GVHD, mekanisme dependen sel T dan sel NK. Efek GVT ini memungkinkan pengembangan terapi kanker yang lebih aman. Tulisan ini membahas bukti efek GVT setelah tranplantasi sel punca alogenis pada leukemia dan limfoma serta propek masa depan untuk memaksimalkan efek GVT pada terapi leukemia dan limfoma.
Pengaruh Anti-VEGF pada Diabetic Retinopathy Adrian, Dicky
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.927 KB) | DOI: 10.55175/cdk.v44i11.705

Abstract

Diabetic retinopathy adalah gangguan mata berupa perdarahan retina akibat komplikasi mikrovaskular diabetes, yang sifatnya kronis dan progresif. Diabetic retinopathy disebabkan peningkatan jumlah Advanced Glycation Endproducts (AGEs), aktivasi jalur polyol, aktivasi jalur stres oksidatif, peningkatan Vascular Endothelial Growth Factor (VEGF), dan peningkatan protein kinase-C. VEGF merupakan faktor kunci penyebab neovaskularisasi retina, dan terjadinya perdarahan retina. Anti VEGF dianggap dapat menurunkan progresifitas diabetic retinopathy. Anti VEGF dapat berupa antibodi terhadap reseptor VEGF atau VEGF itu sendiri, VEGF Trap Eye, dan aptamer VEGF.Diabetic retinopathy is a chronic and progressive retinal bleeding as a microvascular complication of diabetes. Diabetic retinopathy is caused by increased of Advanced Glycation Endproducts (AGEs), activation of polyol pathway, activation of oxidative stress pathway, increased of Vascular Endothelial Growth Factor (VEGF), and increased of protein kinase-C. VEGF is the key factor in retinal neovascularization and retinal hemorrhage. Anti-VEGF can reduce neovascularization, it can be an antibody to either VEGF or VEGF receptor, VEGF Trap-Eye, and VEGF aptamer.
Hand and Foot Mouth Disease Murasmita, Alamanda; Mulianto, Nurrachmat; Mochtar, Moerbono
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.16 KB) | DOI: 10.55175/cdk.v44i11.701

Abstract

HFMD adalah penyakit infeksi virus, yang sering disebabkan oleh virus coxsackie A16 dan enterovirus 71 dan pada umumnya dijumpai pada anak-anak. Penyakit hand-foot-mouth didiagnosis berdasarkan anamnesis seperti riwayat kontak, gejala klinis, serta pemeriksaan penunjang identifikasi virus. Kebanyakan kasus HFMD dapat sembuh sendiri dan hanya membutuhkan terapi simptomatik, HFMD berat memerlukan terapi lebih intensif.HFMD is a viral infection disease, often caused by coxsackie A16 virus and enterovirus 71 and commonly found in children. Hand-foot-mouth disease is diagnosed by anamnesis such as contact history, clinical symptoms, and virus identification. Most cases of HFMD can heal itself and require only symptomatic therapy, severe HFMD requires more intensive therapy.
Penyakit Arteri Ekstremitas Bawah - Tinjauan Klinis Aziz, Melisa
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.68 KB) | DOI: 10.55175/cdk.v44i11.706

Abstract

Penyakit arteri ekstremitas bawah atau lower extremities artery disease (LEAD) diderita oleh hampir 202 juta jiwa di seluruh dunia. Presentasi klinis LEAD beragam mulai dari asimptomatik, claudicatio intermittent, hingga keluhan nyeri saat istirahat. Faktor risiko meliputi merokok, hipertensi, diabetes melitus, hiperkolesterolemia, dan inflamasi. Metode diagnostik yang mudah diakses dan non-invasif adalah pemeriksaan ankle-brachial index (ABI). Terapi farmakologis termasuk obat anti-hipertensi, obat penurun kadar lipid, dan antiplatelet.Lower extremities artery disease (LEAD) affects nearly 202 million people worldwide. Clinical presentations of LEAD range from asymptomatic, claudicatio intermittent, to pain at rest. Risk factors include smoking, hypertension, diabetes mellitus, hypercholesterolemia, and inflammation. The easily accessible and noninvasive diagnostic method is ankle-brachial index (ABI) examination. Pharmacologic therapy includes anti-hypertensive drugs, lipid-lowering drugs, and antiplatelets.

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