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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 5 Documents
 1 
Search results for , issue "Vol 14, No 2 (2020): June" : 5 Documents clear
Over-Expression of Osteopontin as Potential Predictive Biomarker for Bladder Cancer Treatment Andy Zulfiqqar; Indrawarman Soerohardjo; Sumadi Lukman Anwar
Indonesian Journal of Cancer Vol 14, No 2 (2020): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v14i2.709

Abstract

Background: Current options for management of bladder cancer (BCa) still depend on traditional clinical determinants of stage and histological grade which often do not reflect the biological entity of the tumors. Therefore, new biomarkers are required to better determine suitable treatments for different types of bladder cancers. Recent research has shown osteopontin (OPN) expressions correlate with clinic-pathological variables and outcomes of bladder cancer. This study aimed to evaluate the expression of OPN in the Indonesian population, and it’s potential role as an immune-targeting therapy of BCa. Methods: Total RNAs from formalin-fixed paraffin-embedded tissues were extracted from 49 patients with bladder cancer consisting of normal histopathology (n = 4), chronic cystitis (n = 15), non-muscle-invasive bladder cancer (NMIBC, n = 15), and muscle-invasive breast cancer (MIBC, n = 15). The expression of OPN was measured using reverse transcription-polymerase chain reaction. Results: The baseline clinical and histo-pathological characteristics were not statistically different. The expression of OPN was statistically higher in bladder cancer compared to normal histology tissues (P < .001). The expression of OPN was statistically higher in MIBC compared to NMIBC (P < .001). Conclusions: The expression of OPN was significantly higher in bladder cancer and compared to NIMBC, the OPN expression in MIBC was significantly higher rendering the potential role of OPN expression as a surrogate biomarker marker to determine suitable treatment options for patients with bladder cancer.
The Proportion of Radiation Pneumonitis among Lung Cancer Patients in Persahabatan Hospital Dini Rizkie Wijayanti; Jamal Zaini; Achmad Hudoyo; Aziza Ghanie; Westi ATW
Indonesian Journal of Cancer Vol 14, No 2 (2020): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.765 KB) | DOI: 10.33371/ijoc.v14i2.701

Abstract

Background : Radiation-induced pulmonary toxicity occurs in patients with lung cancer who received irradiation. The objective of this study was to determine the proportion of radiation pneumonitis among lung cancer patients that were exposed to radiation treatment in Persahabatan Hospital. There is no data about proportion of radiation pneumonitis in Indonesia.Methods: This was a retrospective study conducted in Persahabatan Hospital during June 2013– July 2015 using the medical record of lung-cancer patients who received irradiation.Results: 33 lung-cancer patients fulfilled the inclusion criteria. Most of them were male (66.7%), in age ≥ 51 years (63.6%), had a smoking history (75.8%) with moderate Brinkman Index (60%), were given irradiation doses of 3,000–4,000 (60.6%) with irradiation fractions of 10–19 (60.6%), had no history of chemotherapy (54.5%), and were diagnosed with adenocarcinoma (66.7%) and stage-IV cancer (84.84%). The proportion of radiation pneumonitis based on chest X-ray (CXR) was 39.4%; which consisted of hazy ground-glass opacities, hazy ground-glass opacities, and fibrosis, and only fibrosis. There were significant differences in age, radiation doses, and history of chemotherapy with the proportion of radiation pneumonitis (p < .05).Conclusion: The proportion of radiation pneumonitis based on CXR was 39.4%. There were significant differences in age, radiation doses, and history of chemotherapy with the proportion of radiation pneumonitis. 
Giant Breast Hypertrophy in Juvenile: A Rare Case Dila Junita; Edmond Rukmana Wikanta
Indonesian Journal of Cancer Vol 14, No 2 (2020): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.956 KB) | DOI: 10.33371/ijoc.v14i2.700

Abstract

Introduction: Juvenile hypertrophy of the breast (JHB) is a benign condition that can lead to gigantomastia in adolescence. The development of breast enlargement in adolescence can cause both physical and psychosocial problems. Therefore, appropriate investigation and proper management at an early stage of the disease are very important. One of the treatment modalities is breast reduction surgery which ideal and offers an improvement in the quality of life. Case Presentation: A 13-year-old female with massive bilateral breast enlargement for a period of 8 months. The patient also complained of severe back pain and neck discomfort since her breast progressively enlarged. Psychosocial problems were recorded. Right breast reduction was performed and closed with inverted-T mammoplasty. The post-operative period was uneventful, and the patient was discharged on day 5 after the operation. Conclusions: Reduction mammoplasty is well accepted by adolescents with juvenile breast hypertrophy and can improve physical and psychological outcomes.
COVID-19 and Cancer Care in Indonesia: What we have done in Dharmais Cancer Center Hospital Hendi Setiadi; Fifi Dwijayanti; Martya Rahmaniati Makful
Indonesian Journal of Cancer Vol 14, No 2 (2020): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.526 KB) | DOI: 10.33371/ijoc.v14i2.747

Abstract

At the end of 2019, the novel coronavirus (CoV) of severe acute respiratory syndrome (SARS), named SARS- CoV-2 was approved as a microbial agent that causes viral pneumonia in patients who are linked epidemiologically to the seafood market in Wuhan (Wuhan) Hubei province, China [1]. The World Health Organization (WHO) stated the coronavirus or COVID-19 as a pandemic because it has spread globally in the world since March 11, 2020 [2]. There have been more than 8 million cases reported with more than 450 thousand deaths around the world until June 19, 2020 [3]. Indonesia reported the first cases of COVID-19 in early March 2020 and currently 43,803 cases with 2,373 deaths [4]. Indonesia has the highest cases of COVID-19 in Southeast Asia [5]. WHO stated that according to the current evidence, coronavirus is transmitted among people through respiratory droplets and contact routes [6-8]. Droplet transmission is different from airborne disease. Droplet transmission occurs when a person closely contacted (within 1 m) with someone who has respiratory symptoms (e.g. coughing or sneezing,) and was therefore at risk of having his/her mucosae (mouth and nose) or conjunctiva (eyes) exposed to potentially infective respiratory droplets. Droplet transmission may also occur through fomites in the immediate environment around the infected person [9]. Increasing cases occur continuously become alert for our institution as health care providers.
Diabetes Mellitus as One of the Risk Factors Contribute to Carcinogenesis Noorwati Sutandyo
Indonesian Journal of Cancer Vol 14, No 2 (2020): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (526.981 KB) | DOI: 10.33371/ijoc.v14i2.703

Abstract

Diabetes mellitus (DM) and cancer are both global diseases whose numbers continue to grow. Higher risk of developing cancer in diabetic patients, especially in liver, endometrial, pancreatic, kidney, colorectal, bladder, and breast cancer, was already shown in several previous studies. This review will explain the possible DM pathogenesis that plays a role in carcinogenesis using the simple but thorough concept of insulin resistance, hyperglycemia, and chronic inflammation. By knowing the link, it is hoped that this review can be useful in developing cancer prevention plans for those with diabetes.

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