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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 13 Documents
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Search results for , issue "Vol 17, No 2 (2023): June" : 13 Documents clear
Incidental Findings of Duodenal-Type Follicular Lymphoma by Endoscopic Screening: A Case Report Herman Saputra; Ni Putu Sriwidyani; Putu Erika Paskarani; Silvia Khosasi
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.965

Abstract

Introduction: Follicular Lymphoma (FL) is a B-cell neoplasm arising from the germinal center. Gastrointestinal FL is a rare case, accounting for less than 4% of all primary lymphoma of the gastrointestinal tract. Duodenal-type Follicular Lymphoma (DTFL) was included in an entity of primary intestinal FL. However, in the 2017 World Health Organization (WHO) Classification, this entity was included in a specific variant called DTFL. In this article, we report a case of DTFL in a 56-year-old man which was incidentally found during upper gastrointestinal endoscopy Case Presentation: : We report a case of incidentally found DTFL in a 56-year-old man during an endoscopy. The endoscopic finding showed a small, hypertrophic, or nodular lesion on part two duodenum. Microscopic evaluation of duodenal mucosa consists of proliferative atypical lymphoid cells arranged in follicular architecture. The lesion was confined to the lamina propria. The atypical lymphoid cells were dominated by monotonous centrocyte-like cells, small-sized, with scant cytoplasm, and cleaved nuclei. There were some scattered larger centroblast-like cells with multiple nucleoli. No mantle zone and tingible body macrophage were found. The immunohistochemical evaluation showed positivity for CD 20, CD 10, Bcl-6, and Bcl-2 in the follicular structure. CD 21 was dominantly stained at the periphery of the follicular structure, and Ki-67 was low. Conclusions: According to clinical data, endoscopic findings, and histopathological and immunohistochemical findings, the patient was diagnosed with DTFL. 
Comparative Prostate Cancer Detection Rate of Transrectal Ultrasonography Guided versus Finger Guided Prostate Biopsy Rizki Abri Laksono; Tanaya Ghinorawa; Aria Danurdoro
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.689

Abstract

Background: Prostate biopsy was used to diagnose and establish a therapy for prostate cancer (PCa). Instead of using conventional finger-guided prostate biopsy (FGPB) to approximate prostatic architecture, transrectal ultrasonography-guided biopsies of the prostate (TRUSGB) have become more popular nowadays because of offer direct visualization. However, the lack of availability of transrectal ultrasound probes in less-developed regions raises concerns regarding the need to diagnose patients with PCa. Moreover, different conclusions have been found from prior studies that examined the efficacy of both methods. This study aims to compare the accuracy of TRUSGB to FGPB in prostate cancer.. Methods: This study was done retrospectively from 50 medical records of PCa in the Urology Division of Sardjito Hospital from January 2009 until December 2013. Patients’ age, PSA value, digital rectal examination, and histopathological examination were analyzed. Results: The mean age was 65.18 ± 7.76 years in FGPB and 67.52 ± 10.79 years in TRUSGB group. The median PSA was 65.01 (range: 16.33–114.72) ng/mL in FGPB and 71.75 (range: 19.86– 123.47) ng/mL in TRUSGB. Abnormal DRE was found in 75.75% of patients in FGPB group and 70.58% in TRUSGB. Comparable cancer detection rates were found in the FGPB and TRUSGB groups (45.45% vs. 52.94%) (p = 0.136).Conclusions: The cancer detection rates for FGPB and TRUSGB procedures are comparable. This supports using FGPB as the first-line diagnostic technique, especially in low-resource situations where ultrasonography is unavailable.
Left Hindquarter Amputation due to High-Grade Pleomorphic Sarcoma of the Groin: A Case Report M. Zaki Abdul Hafiz; Bayu Brahma; Rian Fabian Sofyan
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.957

Abstract

Introduction:Hindquarter amputation or known as hemipelvectomy is a surgical technique that is primarily used for the eradication of malignant primary soft tissue and bone tumors of the pelvis, hip, and upper thigh regions. Occasionally, hindquarter amputation has been employed in the treatment of severe trauma, metastases, and infection. This case report aims to give a lesson in the case of the High-Grade Pleomorphic Sarcoma of the Groin because this is a very rare case and most patients are not willing to undergo amputation.Case Presentation: A 54-year-old male patient came with a complaint of a lump in the thigh. Initially, the lump was as big as a marble and has been getting bigger since last year. The size of the lump was approximately 30 x 30 x 30 cmConclusions: The most common indications for amputation in patients with the primary localized disease were extensive involvement of the limb-girdle, multiple muscle compartment involvement, multifocality, and unsuitability for limb-sparing surgery, typically due to lack of a salvage option. Hindquarter amputation was used as a treatment for 13% of all pelvic bone sarcomas where there is a realistic chance of control of symptoms or long-term survival.comas.
The Pattern of Prostate Cancer Screening and Diagnosis among Indonesian Urologists: A Questionnaire Survey Muhammad Firman; Fakhri Rahman; Agus Rizal Ardy Hariandy Hamid; Chaidir Arif Mochtar
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.970

Abstract

Background: Prostate cancer (PCa) screening and diagnosis are mandatory to deliver optimal management in the early phase. Even though it has been discussed in many guidelines, the implementation of PCa screening and diagnosis in Indonesia remains unknown. This study aims to evaluate the pattern of PCa screening and diagnosis among Indonesian urologists and their adherence to guidelines. Methods: This cross-sectional study was conducted between February and July 2019. Respondents were Indonesian urologists registered as members of the Indonesian Urological Association (IUA) and had already practiced for at least six months. Data were collected using questionnaires, which were distributed at a national urology symposium and electronically via Google Form. Data were presented descriptively, and all data were processed using SPSS version 23. Results: Of 458 urologists, 195 (42.6%) gave full responses. Most of the respondents, 181 (92.8%) urologists, used the IUA guidelines. Among the 103 (52.8%) respondents who performed screening, nearly half (42.7%) agreed to screen patients aged ≥ 50 years or ≥ 45 years with a family history of PCa. Moreover, 76.8% would repeat screening annually, and 35.6% would stop when the patient’s age reached 70 years old. Digital rectal examination (DRE) was frequently performed for screening (74.5%), while prostate-specific antigen (PSA) tests were only performed in 52.3% of cases. The PSA test was available in 74.8% of hospitals. Transurethral resection of the prostate (TURP) was still used by 67.2% of respondents for diagnosis. Only 52.3 % of participants used transrectal prostate biopsy for diagnosis, using anesthesia (78.1%) during the procedure, and increased PSA level (98%) as its indication. However, Transrectal Ultrasound (TRUS) was only available in 49% of hospitals. This study found that Indonesian urologist adherence level toward guidelines was 63.3% (9–100%). Conclusions: PCa screening and diagnosis are still varied among Indonesian urologists, which might arise due to the different availability of diagnostic modalities.
The Profile of Oncologic Orthopedic Surgery in 2 Years of COVID-19 Pandemic: A Single-Centered Study in Orthopedic Hospital Mujaddid Idulhaq; Fajar Baskoro Gardjito; Musa Fasa Roshada
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.926

Abstract

Background: COVID-19 pandemic has led to a difficult condition for healthcare providers to maintain their service without risking their safety. Generally, patients were canceling their hospital visits as they feared COVID-19 transmission. This has led to a general decline in the number of patient visits, attending doctors, and elective surgeries. However, this may not be the same for oncologic orthopedic cases which are allowed to continue elective surgeries, and the patients still perceive their condition as urgently in need of treatment. This article aimed to compare the number of oncologic orthopedic surgeries before and during the COVID-19 pandemic and describe the profile of oncologic orthopedic surgery two years of the pandemic.Methods: This was a retrospective study comparing the total number of oncologic orthopedic patients undergoing elective surgery in a single center, Prof. Dr. R. Soeharso Orthopedic Hospital, Surakarta, Indonesia, from March 2019 to February 2022. The number of surgeries per month before the pandemic, in the first and second years of the COVID-19 pandemic, was described and compared with one-way ANOVA. The surgical procedures performed in these three years were also described.Results: The total of oncologic orthopedic surgeries before the COVID-19 pandemic was 390 cases in comparison to 374 cases in the first year and 355 cases in the second year of the pandemic. The average number of cases per month was 32.5 ± 6.4 before the pandemic compared to 31.2 ± 7.8 in the first year and 29.5 ± 6.4 cases per month in the second year of the pandemic. There was no significant difference (p = 0.59, Confidence Interval 95%). Sophisticated reconstruction surgery such as arthroplasty and megaprosthesis still took place during the pandemic. Conclusions: The trend in the number of oncologic orthopedic surgeries did not decline significantly during the COVID-19 pandemic.
Atypical Radiology Imaging of Squamous Cell Lung Carcinoma: A Case Report and Narrative Review Nunki Puspita Utomo; Brenda Miriane Rustam; Sudharmadji Sudharmadji
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.958

Abstract

Introduction: Multiple well-circumscribed round nodules, also known as “Cannonball” appearance in the lungs, are typically associated with specific pulmonary metastases. However, limited reports denote the finding, especially if correlated with primary squamous cell lung carcinoma in the younger population. This is the first case report in Indonesia of a 19-year-old male with primary squamous cell carcinoma in the lung and chest radiograph image mimicking a “Cannonball” appearance Case Presentation: A 19-year-old male was presented with a history of progressing hemoptysis for two weeks with no other abnormal respiratory symptoms but a reduction of vocal fremitus. The subject is an occasional smoker and had a history of lung tuberculosis in 2009 and a suprarenal or adrenal mass. X-ray imaging revealed multiple bilateral pulmonary nodules, mimicking the “Cannonball” appearance. A fine needle aspiration (FNA) biopsy of a nodule was done and interpreted to be primary squamous cell carcinoma. Symptomatic treatment was given and the subject was discharged on the fifth day. Conclusions:  A “Cannonball” appearance or its mimic is not always typical to certain carcinoma based on what this case report finds. In the case of a tumor, radiograph findings should also be correlated with other supporting tests such as biopsy and clinical presentation.
A Comparison of Cancer Incidences Between Dharmais Cancer Hospital and GLOBOCAN 2020: A Descriptive Study of Top 10 Cancer Incidences Bob Andinata; Adang Bachtiar; Puput Oktamianti; Jeremy Romeo Partahi; Mazaya Shafa Ainan Dini
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.982

Abstract

Background: : Cancer is one of the main causes of death and increased morbidity in every country in the world. According to Global Cancer Observatory (GLOBOCAN) 2020 data, it is estimated that 19.3 million new cancer cases and nearly 10.0 million cancer deaths occurred in the world in 2020. Based on the same data, it is estimated that 396,914 new cancer cases and nearly 234,511 cancer deaths are estimated to occur in Indonesia. Dharmais National Cancer Hospital (DNCH) as a national cancer center is a miniature of cancer data in Indonesia. For this reason, researchers want to compare whether the data on the number and types of cancer in DNCH are the same as those in GLOBOCAN 2020.Methods: This research is a descriptive analysis with secondary data collection methods taken from medical records. The sampling technique was total sampling, univariate data analysis, namely new cases of cancer patients for the January-December 2021 period which are 2,382 cases.Results: The results showed that the same order in both data was only found in the first, second, and seventh order, namely breast cancer, cervical cancer, and non-Hodgkin’s lymphoma, respectively. However, the percentage of new cases of breast cancer in RSKD is much higher (2.5-folds) than in GLOBOCAN.Conclusion: There are several differences between the data on new cancer cases in the two data, which can be caused because DNCH has complete facilities, both for diagnostic and curative purposes, and examinations such as IHC and bone scans are only available at certain hospitals and one of them is DNCH.
Limb Salvage Surgery in Large and Fungating Giant Cell Tumors of Distal Radius: A Case Series Muhamad Naseh Sajadi Budi; Arief Abidin
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.963

Abstract

Introduction: A Giant Cell Tumor (GCT) is a benign tumor, but often aggressive with recurrence or metastasis tendency. Often, distal radius GCT is presented in relatively small or medium sizes. Large and fungating distal radius GCT is characterized by its higher ability to infiltrate, destruct, and compromise its surrounding tissue. Therefore, it increases the risk of complications including amputation. The treatment requires more complex surgery and reconstruction than usual GCT. In this case series, we prefer to perform the limb salvage surgery with wide en bloc resection, followed by reconstruction of the bone and soft tissue, instead of amputation. Case Presentation: We report 4 patients with massive GCT at the distal radius. All complained about pain and a lump in the wrist. The tumors are large in dimension with the size of 12 x 8 x 6 cm, 10 x 10 x 8 cm, 11 x 9 x 9 cm, and 17 x 14 x 8 cm respectively, fungating and compromised surrounding soft tissue. Limb salvage procedures are performed with wide en-bloc resection, bone cement spacer insertion, K-wire fixation, dissection, and tendon reconstructions followed by soft tissue defect closure using distant flap and primary suture. Follow-up post-surgery was variable within 2 to 36 months. All patients had a reduced scale of VAS, increased functional outcome measured with quick DASH score, no major complications, and no sign of recurrence or metastasis during the follow-up period. Conclusion: Large and fungating GCT of distal radius managed by limb salvage surgery and complex reconstruction deliver a good result. Thus, it can give other options other than amputation. 
The Symptomatic Improvement of Metastatic Brain Tumor Patients Based on Clinical and Distress Thermometer in Adjunctive Psychotherapy Tiara Aninditha; Dian Oktaria Safitri; Henry Riyanto Sofyan; Sylvia Detri Elvira; Irmia Kusumadewi; Feranindhya Agiananda
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.961

Abstract

Background: Along with the increasing incidence of primary cancer, metastatic brain tumors are becoming more common. Metastatic brain tumor patients go through a great deal of distress. Therefore, providing adequate standard therapy can alleviate patients’ clinical symptoms and improve their overall quality of life. This study aimed to investigate the role of symptomatic treatments and adjunctive psychotherapy in patients with metastatic brain tumors. Methods: We conducted a randomized, single-blind, parallel design without matching and pragmatic clinical trial at Cipto Mangunkusumo Hospital from August 2019 – June 2020. A total of 30 metastatic brain tumor patients were divided into 2 groups: (1) The treatment group which received a combination of symptomatic and adjunctive psychotherapy, and (2) The control group which was given symptomatic therapy only. The patients’ distress level was evaluated using a distress thermometer (DT). Data analysis was carried out using the Chi-square test, Fisher exact’s, and binominal test.Results: All patients in the treatment group experienced a significant improvement in overall DT scores before and after adjunctive psychotherapy (p=0.01). Symptomatic therapy alleviates headaches and seizures significantly by 100% with or without psychotherapy. Conclusions: The standard symptomatic treatment of metastatic brain tumors can alleviate clinical symptoms in both groups, especially for headaches and seizures. An adjunctive psychotherapy may significantly improve the overall DT.
The Potency of Herbal Active Compounds as Immune Modulators for Cancer Therapy Septelia Inawati Wanandi; Maria Maghdalena
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.956

Abstract

Cancer was the second leading cause of death globally in 2018. On the other hand, immunotherapy is one of the most promising and effective therapies to fight against cancer. This area of research has highly increased over the last decade. Immunotherapy will modulate and initiate an effective immune response. Hence, the immune system in the body will be more potent in combating cancer. Cancer immunotherapy can utilize herbal products to modulate the immune system with low toxicity. In addition, the usage of herbal products has also proven to decrease the side effects of conventional cancer therapy. Some herbal products have been proven to have biological and pharmacological activity, such as anti-inflammatory, anticancer, and chemopreventive. Indonesia, with its immense biodiversity of herbal products, can use this advantage to develop these sources in the health sector. We showcase some active compounds such as quercetin, andrographolide, curcumin, resveratrol, capsaicin, epigallocatechin-3-gallate, genistein, 6-shogaol, and 6-gingerol. We further highlight the mechanism and signaling pathways that can occur in these active compounds to suppress cancer progression and development. This review discusses the mechanism and potency of herbal products as a modulator in cancer immunotherapy to combat cancer. In summary, this review summarizes herbal products’ active compounds and future promise within the field of immunotherapy.

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