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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 13 Documents
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Search results for , issue "Vol. 9, No. 1" : 13 Documents clear
Identification of Community Knowledge on Lead Contamination and Analysis of Lead Level in Fish Nurwulan, Sita; Damayanti, Sophi; Amalia, Lia
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Poisoning is an event of human exposure to poisonous substances that are harmful to the body at certain doses. Lead is a heavy metal that can cause toxicity, including neurotoxic effects, hypertension, digestive system disorders, bone and tooth growth disorders, immune system disorders, infertility, and fetal disorders. Fish is a source of nutrients that are often consumed by people, however can also accumulate lead. This study aimed to analyze the lead level in fish and identify the community knowledge level regarding lead contamination in fish. Identification of community knowledge levels regarding lead. Identification of community knowledge levels regarding lead contamination in fish was conducted on three hundred respondents consisting of School of Pharmacy (SF) Institut Teknologi Bandung (ITB) one hundred students, one hundred community, and one hundred housewives. This study also analyzed lead levels in six fish samples using Graphite Furnace Atomic Absorption Spectroscopy (GFAAS). As the result, SF ITB students had the highest level of knowledge in the definition of lead (97%), lead poisoning (98%), fish lead accumulation (75%), the poisoning effects of lead, and sources of lead. However, all of the respondents had a low level of knowledge regarding regulations about lead levels in fish. The lead levels analysis on fish showed that three out of six samples had lead levels that exceeded the limit of lead contamination (>0.2 g/kg). The study indicated that respondents’ knowledge regarding lead contamination in fish is still low and lead-contaminated fish is still being sold on the market.
In vitro Antibacterial and Antifungal Activities of Sorindeia madagascariensis and Albizia harveyi Stem Barks Makoye, Paul Malaba; Mrutu, Sunday; Daniel, Innocent John; Mbunde, Mourice Nyangabo; Sempombe, Joseph; Mugoyela, Veronica
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

The emerging multi-drug-resistant pathogens urge continuous searches for new antimicrobial agents. This study investigated the in vitro antibacterial and antifungal activities of the stem barks of two plants, Sorindeia madagascariensis and Albizia harveyi. Broth microdilution assay was used to determine the minimum inhibitory concentrations (MICs) of hydroethanolic extracts of the stem barks against selected bacteria and fungi. Both plant extracts exhibited activity against all tested microorganisms and their minimum inhibitory concentrations (MICs) against bacteria and fungi were from 1.67 to 5.00 mg/mL and from 1.67 to 10.00 mg/mL, respectively. This study reports the antibacterial and antifungal activities of the hydroethanolic extracts of the stem barks of both plants. Antifungal activity of A. harveyi is being reported for the first time. We therefore suggest further investigation of bioactive compounds from stem barks of A. harveyi and S. madagascariensis with antibacterial and antifungal activities.
Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose Eff, Aprilita Rina Yanti; Ayu Pertiwi, Reza; Ehe Hurit, Hermanus; Rahayu, Sri Teguh; Eden, Yonatan
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given at the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (pJamu B at dose of 0.12 g/kg BW; 0.24 g/kg BW; and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant.

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