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Zidnal Falah
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INDONESIA
Jurnal Sehat Indonesia (JUSINDO)
Published by Publikasi Indonesia
ISSN : 27753077     EISSN : 27750892     DOI : 10.36418
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Ruang lingkup dan fokus penelitian terkait bidang kajian dengan penekanan pada pendekatan, yang meliputi: Kesehatan Masyarakat, Kesehatan dan Keselamatan Kerja (Kesehatan Kerja; Hyperkes), Kebijakan Kesehatan (dan Analis Kesehatan), Ilmu Gizi, Epidemiologi, Teknik Kesehatan Lingkungan, Promosi Kesehatan, Asuransi Jiwa dan Ilmu Kesehatan, Kesehatan Lingkungan, Ilmu Olah Raga, Ilmu Keperawatan, Kebidanan, Administrasi Rumah Sakit, Entomologi (Kesehatan, Fitopatologi), Ilmu Biomedis, Ergonomi, Fisiologi Kerja, Fisioterapi, Analis Medis, Fisiologi (Olahraga ), Reproduksi (Biologi dan Kesehatan), Akupunktur, Rehabilitasi Medis.
Arjuna Subject : Profesi Kesehatan - Menejmen Informasi Kesehatan
Articles 450 Documents
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Differential Expression Analysis Identifies Novel Regulatory Genes in Endometriosis Pranandi, Ian
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Endometriosis is a chronic estrogen-dependent inflammatory disorder associated with pelvic pain and infertility. Despite its high prevalence, the molecular regulatory mechanisms underlying disease progression remain incompletely understood. Objective: This study aimed to identify differentially expressed genes (DEGs) and prioritize key regulatory candidates involved in endometriosis pathogenesis using integrative bioinformatics analysis. Methods: Publicly available human transcriptomic datasets comparing endometriotic lesions and normal endometrial tissues were analyzed. Data were normalized and subjected to differential expression analysis using adjusted p-value < 0.05 and |log2 fold change| ≥ 1 as thresholds. Functional enrichment analysis and protein–protein interaction (PPI) network construction were performed to identify enriched pathways and hub genes. Results: A total of 326 significant DEGs were identified, including 189 upregulated and 137 downregulated genes. Enrichment analysis revealed predominant involvement of inflammatory signaling, angiogenesis, extracellular matrix remodeling, and steroid hormone response pathways. Network analysis identified IL6, STAT3, VEGFA, and MMP9 as central upregulated hub genes, while PGR and HOXA10 were among the key downregulated regulators associated with progesterone resistance. Conclusion: Endometriosis exhibits coordinated activation of inflammatory–angiogenic networks and suppression of steroid signaling pathways. The identified hub genes represent potential biomarkers and therapeutic targets, warranting further experimental validation.
The Role of Vitamin D in Endometrial Receptivity for Successful Implantation Nur Fadilah
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.497

Abstract

Successful embryo implantation depends on endometrial receptivity during the implantation window, which involves gene regulation, decidualization, and local immune modulation. Vitamin D has received attention due to the expression of the vitamin D receptor (VDR) in the endometrium and its role in regulating receptor gene transcription. To review the scientific evidence regarding the association of vitamin D levels with endometrial receptivity and implantation outcomes in assisted reproductive technology (ART). A literature review was conducted through a systematic search of PubMed, Google Scholar, and ScienceDirect (2020–2026). Observational human studies assessing vitamin D levels on endometrial parameters or pregnancy outcomes were included; eight studies met the criteria. Vitamin D plays a role in the regulation of HOXA10, HAND2, decidualization, and the tolerogenic immune balance. However, clinical outcomes are heterogeneous; some studies show benefits primarily in deficiency states, while others find no significant associations with implantation rate or live birth rate. Vitamin D has the potential to be a permissive factor in endometrial receptivity, but it is not a primary determinant of implantation success.
Short-Chain Fatty Acids and Neurodegeneration in Alzheimer's Disease: A Narrative Review Sumadewi, Komang Trisna; Astini, Dewa Ayu Agung Alit Suka; Evayanti, Luh Gde; Manuaba, Ida Ayu Laxmi Ananda Dewi; Dewi, Ni Made Gita Kusuma
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.498

Abstract

Background: Alzheimer Disease remains the most prevalent cause of dementia worldwide, representing a major and escalating global health challenge. Objective: This study aims to examine the role of short chain fatty acids in the pathogenesis and progression of Alzheimer Disease within the framework of the microbiota gut brain axis. Methods: The research employed a qualitative design with a descriptive approach through a narrative literature study. Data were collected through systematic searches of peer reviewed scientific articles published between 2015 and 2026, focusing on gut microbiota dysbiosis, short chain fatty acids, neuroinflammation, amyloid pathology, and cognitive decline in Alzheimer Disease. Document analysis was conducted using thematic identification, data reduction, conceptual categorization, and inductive interpretation to generate a comprehensive synthesis of the evidence. Results: The findings indicate that Alzheimer Disease is consistently associated with reduced abundance of short chain fatty acid producing bacteria and altered circulating and fecal short chain fatty acid profiles, which are linked to impaired blood brain barrier integrity, microglial activation, increased neuroinflammation, amyloid beta accumulation, and tau pathology. Mechanistic insights demonstrate that short chain fatty acids regulate inflammatory signaling pathways, epigenetic modulation, mitochondrial bioenergetics, and metabolic homeostasis. Conclusion: In conclusion, short chain fatty acids function as key metabolic mediators in Alzheimer Disease and represent promising targets for preventive and therapeutic strategies, contributing to a systems biology perspective and supporting microbiome based precision approaches in cognitive health management.
Single-Visit Root Canal Treatment on a Mandibular First Premolar with Three Root Canals Junaidi, Achmad; Sari, Annisa Fitria
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.500

Abstract

Background: In root canal treatment, accurate diagnosis of root canal morphology is crucial for treatment success. Vertucci reported that in mandibular premolars, 74% have one canal, 25.5% have two canals, and 0.5% have three canals. Therefore, pre-treatment radiography, careful examination, and appropriate techniques are essential to identify root canal orifices, especially in cases with canal variations. The purpose of this case report is to demonstrate the importance of knowledge about the morphology of the root canal system and how to manage root canal care in the first premolar tooth of the lower jaw with three root canals. Case: A 57-year-old female patient with a complaint of a large cavity of the left lower jaw premolar tooth, no pain and wants to be treated. The radiographic results showed that the tooth pulp was open and the morphology of the root canal showed that there were three root canals. Management: Access opening and search of three root canals is carried out using ultrasonic tips and magnification assistance with a dental microscope. The root canal is prepared with rotary NiTi fileby irrigation using 5.25% sodium hypochlorite, 17% EDTA. Obturation using thermal fill and the use of dental crowns as final restoration will be done at the next visit. Conclusion: An understanding of the morphology of the root canal system and the proper use of tools and materials will influence success in the treatment of complex root canals in premolar teeth with three root canals.
Acute Low-Tone Sensorineural Hearing Loss Presenting With Non-Rotatory Vestibular Prodrome in a High-Risk Patient: A Comprehensive Case Report on Aggressive Systemic Corticosteroid Management and Prognostic Evaluation Marsella Lulu Aulia; Gustav Syukrinto
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.503

Abstract

Acute Low-Tone Hearing Loss (ALHL) is often recognized as the clinical manifestation of cochlear-restricted endolymphatic hydrops (EH), making it highly prone to recurrence and subsequent conversion into definitive Menière's Disease (MD). Given this risk, necessitate immediate and aggressive therapeutic intervention to stabilize inner ear function. This research aims to study the therapy and observation in patients with ALHL. Case Report A 27-year-old female presented with acute unilateral tinnitus, aural fullness and new-onset subtle, non-rotatory dizziness, unsteadiness and an episode of nausea and vomiting. Pure tone audiometry, showed a low tone sensorineural hearing loss. What do we have to consider in treatment of patient with ALHL to avoid worsening progression and achieve complete recovery? Literature research was carried out through PubMed and Google Scholar with keywords "Acute Low Tone Hearing Loss" AND "Sudden Sensorineural Hearing Loss" AND "Therapy". Based on the search, we found recommendations in managing patient of ALHL, such as high-dose corticosteroids, pure-tone audiometric evaluation, anti-hydrops agents, and other supportive management. There are several considerations in ALHL therapy in patients that should be carried out carefully and with comprehensive, prolonged audio vestibular surveillance.
Management of Otomycosis in Pregnancy: A Case Study Fierda Ovita Azhari; Gustav Syukrinto
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.504

Abstract

Otomycosis is a fungal infection of the external auditory canal that commonly occurs in tropical and humid regions such as Indonesia. Pregnancy is a unique physiological condition characterized by hormonal and immunological changes that may increase susceptibility to fungal infections while simultaneously limiting therapeutic options due to concerns regarding fetal safety. This report details the clinical management of a 25-year-old pregnant patient (G1P0A0) at 24 weeks gestation who presented with complaints of severe pruritus and aural fullness in the right ear.  Clinical examination revealed characteristic fungal debris with a "white fluffy" appearance. Management included aural toilet followed by the topical solution, a treatment selected for its high efficacy and established safety during pregnancy. The successful resolution of the infection without maternal or fetal complications reinforces the efficacy of combined mechanical debridement and topical therapy. This case underscores the importance of specialized ENT care in secondary referral hospitals for managing infections in high-risk populations.
Effectiveness of Balloon Sinuplasty Compared to Functional Endoscopic Sinus Surgery in The Management of Chronic Rhinosinusitis Cecilia Gritce Widjaja, Maria; Fauzi, Ahmad
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.499

Abstract

This study addresses the growing clinical interest in minimally invasive surgical approaches for managing chronic rhinosinusitis (CRS), particularly the use of Balloon Sinuplasty (BSP) as an alternative to Functional Endoscopic Sinus Surgery (FESS). While FESS remains the gold standard for severe CRS, BSP has gained attention due to its reduced invasiveness and faster recovery. The purpose of this study is to compare the effectiveness of BSP and FESS in improving clinical outcomes among CRS patients. This research employed a descriptive-analytical literature review approach by analyzing scientific articles from databases such as PubMed, Scopus, and Google Scholar. Selected studies include randomized controlled trials, cohort studies, and meta-analyses that meet established inclusion criteria. Key variables assessed include symptom improvement, quality of life, complication rates, sinus patency, and recovery time. The findings indicate that both BSP and FESS significantly improve symptoms and quality of life, with comparable outcomes in selected patient populations. BSP demonstrates advantages in terms of lower complication rates, reduced intraoperative bleeding, and shorter recovery time, while FESS remains more effective in severe or complex cases involving nasal polyps. In conclusion, both procedures are effective treatment options for CRS, and the choice of intervention should be individualized based on disease severity, anatomical factors, and patient characteristics to achieve optimal clinical outcomes
Concurrent Intratonsillar, Peritonsillar, and Retropharyngeal Abscesses: Case Report of Multiple Deep Neck Space Infection Hamdani, Yovita; Widyastuti, Henny
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.506

Abstract

Deep neck space infections are potentially life-threatening conditions due to their proximity to vital structures such as the airway, major blood vessels, and cranial nerves. These infections may spread rapidly and lead to severe complications, including airway obstruction and sepsis. This study aims to describe a rare case of concurrent intratonsillar, peritonsillar, and retropharyngeal abscesses, as well as to evaluate the effectiveness of conservative management using intravenous antibiotics. This research employed a descriptive qualitative case report approach involving a 32-year-old male patient presenting with progressive throat pain, dysphagia, neck swelling, and a muffled voice. Data were collected through clinical examination, laboratory tests, and radiological imaging, followed by continuous observation during hospitalization. The findings revealed elevated leukocyte levels and radiographic evidence of retropharyngeal space widening. The patient was treated with intravenous cefotaxime and metronidazole, along with supportive therapy. Significant clinical improvement was observed within 48 hours, with resolution of symptoms by the fifth day without surgical intervention. In conclusion, early diagnosis and prompt antibiotic therapy can effectively manage selected cases of multiple deep neck abscesses. Conservative treatment may be considered in stable patients, potentially avoiding invasive procedures while ensuring favorable clinical outcomes
A Comprehensive Systematic Review of the Association Between Vitamin D Deficiency and Alopecia Areata Rania, Salsabilla Gina; Bangsawan Puteri, Nanda Khirana
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.477

Abstract

Alopecia areata (AA) is a non-scarring hair loss disorder commonly considered an autoimmune condition in which the immune system attacks the hair follicle during the anagen phase. Vitamin D is a fat-soluble hormone primarily known for regulating calcium homeostasis via the vitamin D receptor (VDR), which is expressed in various cells including immune cells and hair follicles. This systematic review aims to examine the association between vitamin D deficiency and alopecia areata. The study followed the PRISMA 2020 guidelines. A literature search was conducted using databases including PubMed, SagePub, and ScienceDirect for articles published between 2014 and 2024. Review articles, duplicates, and incomplete studies were excluded. Results: From 1,751 initially identified articles, only eight studies met the inclusion criteria after a three-step screening process. All eight full-text articles were analyzed in depth. Vitamin D levels demonstrate an inverse relationship with the severity, extent, and pattern of alopecia areata. Thus, vitamin D deficiency may serve as a contributing factor in the pathogenesis of AA or may exacerbate the existing condition.
Analysis of Infection-Causing Factors and Antibiotic Sensitivity to the Degree of Ulcers in Diabetes Mellitus Patients Ramadhan, Ahmad Rizqi; Niamuzisilawati, Eva; Susilawati, Tri Nugraha; Harioputro, Dhani Redhono
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.501

Abstract

The diabetic foot ulcer prevalence was 6.3% globally and 7.3% in Indonesia. This study analyzes the relationships between the type of germs and antimicrobial susceptibilities to the Wagner’s degree of diabetic-foot-ulcers on patients with type-2 diabetes mellitus admitted to Dr. Moewardi regional hospital. The method used in this observational analysis is a cross-sectional approach. The variables used were the type-of-germs, antimicrobial susceptibilities, and the degree of diabetic-foot-ulcers with the data extracted from 149 inpatients between the period of 2021-2022 and tested with Fisher’s-exact and multinomial-logistic-regressions. Data for the 4-most-frequent germs on the diabetic-foot-ulcers are Pseudomonas aeruginosa (17.4%; 26/149), Escherichia coli (12.8%; 19/149), Klebsiella pneumoniae ss. Pneumoniae (11.4%, 17/149) and Proteus mirabilis (10.7%; 16/149). Data for the 4-most-frequent antimicrobial susceptibilities are ampicillin (20,8%; 31/149), sulfamethoxazole (20,8%; 31/149), gentamicin (18,8%; 28/149) and amikacin (16,1%; 24/149). Data for the 3-most-frequent degree of diabetic-foot-ulcers are the 4th (39.6%; 59/149), 3rd (31.5%; 47/149) and 2nd (19.5%; 29/149) degrees. There is no relationship between the type-of-germs and the degree of diabetic-foot-ulcers (p=0.111). There is a relationship between antimicrobial susceptibilities and the degree of diabetic-foot-ulcers (p=0.009). There is a relationship between the type-of-germs and antimicrobial susceptibilities (p=0,0001). There is a simultaneous relationship between the type-of-germs (p=0.029) and antimicrobial susceptibilities (p=0.032) to the degree of diabetic-foot-ulcers (p=0.005). Therefore, it is necessary to conduct microbial culture and antimicrobial susceptibility tests on all patients with diabetic foot ulcers.

Page 44 of 45 | Total Record : 450

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