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Zidnal Falah
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INDONESIA
Jurnal Sehat Indonesia (JUSINDO)
Published by Publikasi Indonesia
ISSN : 27753077     EISSN : 27750892     DOI : 10.36418
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Ruang lingkup dan fokus penelitian terkait bidang kajian dengan penekanan pada pendekatan, yang meliputi: Kesehatan Masyarakat, Kesehatan dan Keselamatan Kerja (Kesehatan Kerja; Hyperkes), Kebijakan Kesehatan (dan Analis Kesehatan), Ilmu Gizi, Epidemiologi, Teknik Kesehatan Lingkungan, Promosi Kesehatan, Asuransi Jiwa dan Ilmu Kesehatan, Kesehatan Lingkungan, Ilmu Olah Raga, Ilmu Keperawatan, Kebidanan, Administrasi Rumah Sakit, Entomologi (Kesehatan, Fitopatologi), Ilmu Biomedis, Ergonomi, Fisiologi Kerja, Fisioterapi, Analis Medis, Fisiologi (Olahraga ), Reproduksi (Biologi dan Kesehatan), Akupunktur, Rehabilitasi Medis.
Arjuna Subject : Profesi Kesehatan - Menejmen Informasi Kesehatan
Articles 436 Documents
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Differential Expression Analysis Identifies Novel Regulatory Genes in Endometriosis Pranandi, Ian
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Endometriosis is a chronic estrogen-dependent inflammatory disorder associated with pelvic pain and infertility. Despite its high prevalence, the molecular regulatory mechanisms underlying disease progression remain incompletely understood. Objective: This study aimed to identify differentially expressed genes (DEGs) and prioritize key regulatory candidates involved in endometriosis pathogenesis using integrative bioinformatics analysis. Methods: Publicly available human transcriptomic datasets comparing endometriotic lesions and normal endometrial tissues were analyzed. Data were normalized and subjected to differential expression analysis using adjusted p-value < 0.05 and |log2 fold change| ≥ 1 as thresholds. Functional enrichment analysis and protein–protein interaction (PPI) network construction were performed to identify enriched pathways and hub genes. Results: A total of 326 significant DEGs were identified, including 189 upregulated and 137 downregulated genes. Enrichment analysis revealed predominant involvement of inflammatory signaling, angiogenesis, extracellular matrix remodeling, and steroid hormone response pathways. Network analysis identified IL6, STAT3, VEGFA, and MMP9 as central upregulated hub genes, while PGR and HOXA10 were among the key downregulated regulators associated with progesterone resistance. Conclusion: Endometriosis exhibits coordinated activation of inflammatory–angiogenic networks and suppression of steroid signaling pathways. The identified hub genes represent potential biomarkers and therapeutic targets, warranting further experimental validation.
The Role of Vitamin D in Endometrial Receptivity for Successful Implantation Nur Fadilah
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.497

Abstract

Successful embryo implantation depends on endometrial receptivity during the implantation window, which involves gene regulation, decidualization, and local immune modulation. Vitamin D has received attention due to the expression of the vitamin D receptor (VDR) in the endometrium and its role in regulating receptor gene transcription. To review the scientific evidence regarding the association of vitamin D levels with endometrial receptivity and implantation outcomes in assisted reproductive technology (ART). A literature review was conducted through a systematic search of PubMed, Google Scholar, and ScienceDirect (2020–2026). Observational human studies assessing vitamin D levels on endometrial parameters or pregnancy outcomes were included; eight studies met the criteria. Vitamin D plays a role in the regulation of HOXA10, HAND2, decidualization, and the tolerogenic immune balance. However, clinical outcomes are heterogeneous; some studies show benefits primarily in deficiency states, while others find no significant associations with implantation rate or live birth rate. Vitamin D has the potential to be a permissive factor in endometrial receptivity, but it is not a primary determinant of implantation success.
Short-Chain Fatty Acids and Neurodegeneration in Alzheimer's Disease: A Narrative Review Sumadewi, Komang Trisna; Astini, Dewa Ayu Agung Alit Suka; Evayanti, Luh Gde; Manuaba, Ida Ayu Laxmi Ananda Dewi; Dewi, Ni Made Gita Kusuma
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.498

Abstract

Background: Alzheimer Disease remains the most prevalent cause of dementia worldwide, representing a major and escalating global health challenge. Objective: This study aims to examine the role of short chain fatty acids in the pathogenesis and progression of Alzheimer Disease within the framework of the microbiota gut brain axis. Methods: The research employed a qualitative design with a descriptive approach through a narrative literature study. Data were collected through systematic searches of peer reviewed scientific articles published between 2015 and 2026, focusing on gut microbiota dysbiosis, short chain fatty acids, neuroinflammation, amyloid pathology, and cognitive decline in Alzheimer Disease. Document analysis was conducted using thematic identification, data reduction, conceptual categorization, and inductive interpretation to generate a comprehensive synthesis of the evidence. Results: The findings indicate that Alzheimer Disease is consistently associated with reduced abundance of short chain fatty acid producing bacteria and altered circulating and fecal short chain fatty acid profiles, which are linked to impaired blood brain barrier integrity, microglial activation, increased neuroinflammation, amyloid beta accumulation, and tau pathology. Mechanistic insights demonstrate that short chain fatty acids regulate inflammatory signaling pathways, epigenetic modulation, mitochondrial bioenergetics, and metabolic homeostasis. Conclusion: In conclusion, short chain fatty acids function as key metabolic mediators in Alzheimer Disease and represent promising targets for preventive and therapeutic strategies, contributing to a systems biology perspective and supporting microbiome based precision approaches in cognitive health management.
Single-Visit Root Canal Treatment on a Mandibular First Premolar with Three Root Canals Junaidi, Achmad; Sari, Annisa Fitria
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.500

Abstract

Background: In root canal treatment, accurate diagnosis of root canal morphology is crucial for treatment success. Vertucci reported that in mandibular premolars, 74% have one canal, 25.5% have two canals, and 0.5% have three canals. Therefore, pre-treatment radiography, careful examination, and appropriate techniques are essential to identify root canal orifices, especially in cases with canal variations. The purpose of this case report is to demonstrate the importance of knowledge about the morphology of the root canal system and how to manage root canal care in the first premolar tooth of the lower jaw with three root canals. Case: A 57-year-old female patient with a complaint of a large cavity of the left lower jaw premolar tooth, no pain and wants to be treated. The radiographic results showed that the tooth pulp was open and the morphology of the root canal showed that there were three root canals. Management: Access opening and search of three root canals is carried out using ultrasonic tips and magnification assistance with a dental microscope. The root canal is prepared with rotary NiTi fileby irrigation using 5.25% sodium hypochlorite, 17% EDTA. Obturation using thermal fill and the use of dental crowns as final restoration will be done at the next visit. Conclusion: An understanding of the morphology of the root canal system and the proper use of tools and materials will influence success in the treatment of complex root canals in premolar teeth with three root canals.
Acute Low-Tone Sensorineural Hearing Loss Presenting With Non-Rotatory Vestibular Prodrome in a High-Risk Patient: A Comprehensive Case Report on Aggressive Systemic Corticosteroid Management and Prognostic Evaluation Marsella Lulu Aulia; Gustav Syukrinto
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.503

Abstract

Acute Low-Tone Hearing Loss (ALHL) is often recognized as the clinical manifestation of cochlear-restricted endolymphatic hydrops (EH), making it highly prone to recurrence and subsequent conversion into definitive Menière's Disease (MD). Given this risk, necessitate immediate and aggressive therapeutic intervention to stabilize inner ear function. This research aims to study the therapy and observation in patients with ALHL. Case Report A 27-year-old female presented with acute unilateral tinnitus, aural fullness and new-onset subtle, non-rotatory dizziness, unsteadiness and an episode of nausea and vomiting. Pure tone audiometry, showed a low tone sensorineural hearing loss. What do we have to consider in treatment of patient with ALHL to avoid worsening progression and achieve complete recovery? Literature research was carried out through PubMed and Google Scholar with keywords "Acute Low Tone Hearing Loss" AND "Sudden Sensorineural Hearing Loss" AND "Therapy". Based on the search, we found recommendations in managing patient of ALHL, such as high-dose corticosteroids, pure-tone audiometric evaluation, anti-hydrops agents, and other supportive management. There are several considerations in ALHL therapy in patients that should be carried out carefully and with comprehensive, prolonged audio vestibular surveillance.
Management of Otomycosis in Pregnancy: A Case Study Fierda Ovita Azhari; Gustav Syukrinto
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.504

Abstract

Otomycosis is a fungal infection of the external auditory canal that commonly occurs in tropical and humid regions such as Indonesia. Pregnancy is a unique physiological condition characterized by hormonal and immunological changes that may increase susceptibility to fungal infections while simultaneously limiting therapeutic options due to concerns regarding fetal safety. This report details the clinical management of a 25-year-old pregnant patient (G1P0A0) at 24 weeks gestation who presented with complaints of severe pruritus and aural fullness in the right ear.  Clinical examination revealed characteristic fungal debris with a "white fluffy" appearance. Management included aural toilet followed by the topical solution, a treatment selected for its high efficacy and established safety during pregnancy. The successful resolution of the infection without maternal or fetal complications reinforces the efficacy of combined mechanical debridement and topical therapy. This case underscores the importance of specialized ENT care in secondary referral hospitals for managing infections in high-risk populations.

Page 44 of 44 | Total Record : 436

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