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Murdani Abdullah
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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia
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INDONESIA
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Published by The Indonesian Society for Digestive Endoscopy
ISSN : 14114801     EISSN : 23028181     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.
Arjuna Subject : Kedokteran - Ilmu Pencernaan
Articles 7 Documents
 1 
Search results for , issue "VOLUME 9, ISSUE 1, April 2008" : 7 Documents clear
Cause of Upper Gastrointestinal Tract Bleeding in Dengue Hemorrhagic Fever Patient Elza Febria Sari; Ari Fahrial Syam; Leonard Nainggolan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/91200830-34

Abstract

Dengue fever is an acute mosquito-transmitted disease caused by the dengue fever virus which had clinical manifestations range from fever to severe hemorrhage, shock, and death.1  There were 500,000 cases of dengue hemorrhagic fever and 25,000 deaths due to dengue annually worldwide. Bleeding is one of the major problems encountered in dengue fever. The reported prevalence of upper gastrointestinal bleeding in dengue patients varies from 5% to 30%. The pathogenesis of hemorrhage could be multifactor and include vasculopathy, platelet deficiency, and dysfunction, and blood coagulation defects. We presented here a case of 27 years-old male patient who had clinical manifestation of hematemesis on his third day of fever.   Keywords: GI tract, bleeding, DHF
Intractable Diarrhea due to Secondary Gastrointestinal Amyloidosis in a Patient with History of Leprosy Chyntia Olivia MJ; Tito Ardi; Evy Yunihastuti; Ari Fahrial Syam; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/91200824-29

Abstract

Amyloidosis is not a single disease but a term for diseases that share a common feature: the extracellular deposition of pathologic insoluble fibrillar proteins in organs and tissues. In both primary and secondary amyloidosis, the most commonly involved organ system is the gastrointestinal system, with the colon being the most frequently involved organ. A 30 years-old male, complained of diarrhea since 4 months prior to admission. The colonoscopy examination revealed pancolitis, ileitis, and the result from histopathological examination showed chronic destructive ileocolitis with 40-70% amyloidosis of mucosa. The abdominal ultrasonography showed chronic cholecystitis, multiple cholelithiasis and minimally ascites. The esophagogastroduodenoscopy revealed candida esophagitis, erosive pangastritis grade V, pyloring gapping, erosive duodenitis, bile reflux gastritis and esophagitis, and the result from histo-pathological examination showed amyloidosis on gastric mucosa.The immunofixation electrophoresis was negative for monoclonal light chains, and the serum protein electrophoresis showed normal pattern. Enteral and parenteral nutritional therapy were given. Secondary infection was treated by antibiotics. Complication and organ failure occured lately. This chalenging case demonstrated complicated management of gastestinal amyloidosis. Keywords: gastrointestinal amyloidosis, intractable diarrhea, leprosy
Endoscopic Findings and Histopathological Pattern in Patients with Chronic Dyspepsia at Panti Rapih Hospital Jogjakarta Haryanto Rahardjo; Siti Nurdjanah; Putut Bayupurnama
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/9120084-6

Abstract

Background: To determine the relationship between clinical manifestation of chronic dyspepsia and endoscopic findings along with histopathological pattern by descriptive analysis. Methods: This study was a retrospective study. Subjects were patients with chronic dyspepsia who underwent endoscopic examination and gastric biopsy between June 2005 and July 2006. Result: There are 10.17% normal endoscopic results of 79 patients with chronic dyspepsia and almost 90% show abnormal result in endoscopic examination. The histopathological pattern is normal in 2.53% and 97.47% demonstrate abnormal result. The prevalence of Helicobacter pylori due to gastric ulcer is 1.26% and chronic atrophic gastritis is 3.80%. Conclusion: Most of chronic dyspepsia patients have abnormal endoscopic and histopathologic result. Keywords: chronic dyspepsia, endoscopic findings, histopathological pattern, Helicobacter pylori
Gastroesophageal Reflux Disease in Obesity Hotmen Sijabat; Marcellus Simadibrata; Murdani Abdullah; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/91200810-15

Abstract

Incidence of gastroesophageal reflux disease (GERD) has been significantly increased, and nearly 25% of the population has experienced GERD. It appears to be correlated to an increasing number of obesity in the population (BMI 30 kg/m2). Mechanism of the GERD is affected by multifactor. Increased intra-abdominal pressure is considered as one of risk factors for GERD. The development of GERD is virtually associated with a down turning of lower esophageal sphincter tonus, increased transient lower esophagus sphincter relaxation (TLESR), and decreased capacity of esophageal clearance. Management of GERD in obesity includes weight loss treatment, pharmacotherapy by using prokinetics, H2 -receptor antagonists, proton pump inhibitor and surgical approach including fundoplication, gastric banding and vertical banded gastroplasty. Keywords: GERD, obesity, BMI, TLESR, weight loss, abdominal pressure
The Role of Insulin Resistance in Diabetic Patients with Chronic Liver Disease Neneng Ratnasari; Siti Nurdjanah; Putut Bayupurnama; Sutanto Maduseno
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/9120081-3

Abstract

Background: The association between diabetes and chronic liver disease has been well documented. However, the mechanism remains unknown. The aim of this study was to investigate the insulin resistance in chronic liver disease and normal liver in diabetic patient. Method: A total of 31 diabetic, non-alcoholic patients with multiple oral hypoglycemic drugs, either with or without lipid abnormalities were enrolled in this study. Subjects were recruited from outpatient clinic of Department of Endocrine at Dr. Sardjito Hospital, Jogjakarta, Indonesia from May-June 2004. This was a cross sectional study. Fasting insulin and glucose level, liver function test, body mass index, and the presence of fatty liver by ultrasound were examined. Insulin resistance was estimated by calculating fasting insulin and glucose plasma level as the homeostasis model assessment (HOMA) index ratio. Data was described with mean ± SD and analyzed by independent sample t-test. Results: Thirty one patients were enrolled to the study, i.e. 8 patients with normal liver and 23 patients with fatty liver. Only 14 patients agreed to continue the study including 10 patients with fatty liver and 4 patients with normal liver. Mean of age was 59.1 ± 8.7 and mean value of BMI was 24.62 ± 3.05. The liver function test revealed normal Results. Triglyceride, cholesterol, fasting glucose level, and HOMA index (2.77 ± 1.95 vs. 1.66 ± 1.02) in patients with fatty liver were higher than patients with normal liver. No correlation was found between fasting insulin level as well as HOMA index and mean value of BMI (obese and non-obese) as well as hypertension. There was significant correlation between triglyceride level and fasting insulin among fatty liver patients (p = 0.048; CI 95% -7.404; -0.032). Conclusion: The non-alcoholic fatty liver disease in diabetic patients with normal liver enzymes and multiple oral hypoglycemic drugs appear to be related with insulin resistance and hypertriglyceridemia. Keywords: fatty liver, diabetic, insulin resistance
Diagnostic Tests for Helicobacter pylori Infection Tonny Loho
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/91200816-23

Abstract

Helicobacter pylori is a spiral-shaped Gram negative bacterium, has 4-6 flagella, live in microaerophillic condition, has urease, oxidase and catalase enzymes. Helicobacter pylori (H. pylori) infection                                       is etiologically involved in dyspepsia, gastric ulcer, duodenal ulcer, gastric adenocarcinoma and primary gastric B-cell lymphoma. Transmissions of H. pylori is by fecal-oral and oral-oral.4 Diagnostic tests for H. pylori infection can be divided into 2 categories, invasive and non invasive methods. Invasive methods to diagnose H. pylori infection are performed by endoscopy and biopsy. Gastric biopsies are then tested with culture, histologic assessment, urease test and PCR test. Non-invasive methods to diagnose H. pylori infections consist of urea breath test (UBT), 15NH + excretion test, serologic detection of IgG and IgA in the blood, fecal antigen detection and fecal PCR detection. All these tests have its own advantages and limitations. But non-invasive tests have several advantages compared to invasive tests as cheaper, more convenient and easier to perform. To apply these tests accurately, it is very important to understand the principle of the test, how to perform the test, the sensitivity, specificity, positive predictive value, negative predictive value and to recognize all the sources of error which can happen with each test and accurate interpretation. Keywords: Helicobacter pylori infection, diagnostic tests, invasive methods, non-invasive methods
Prevalence of Hapatitis Prevalence of Hepatitis C Virus and Human Immunodeficiency Virus Co-infection in Dr. Mintohardjo Navy Hospital, Jakarta Suyanto Sidik
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/9120087-9

Abstract

Background: Today HIV/AIDS has become a major global health problem due to high rate of morbidity and mortality. Epidemiological data showed that many HIV-infected patients were co infected by hepatitis C virus (HCV) since both of these viruses share similar routes of transmission, with the most frequent modes of acquiring the infections are by sexual, parenteral, and perinatal transmission. The objective was to describe the profiles of HCV and HIV co-infection patients in Mintohardjo hospital Jakarta. Methods: This was a cross-sectional study in HIV patients who were treated in Internal Medicine Department of Mintohardjo hospital Jakarta from January 2006 to July 2007. Patient’s record was retrieved from Medical Record Department and we sought event rate of hepatitis C co-infection. Results: There were 114 patients were diagnosed as HIV positive in a several clinical staging treated during period of 1st January 2006 to 31st July 2007, 80.7% were men and their median age was 27 years old. The peak age group was 26-30 years old. Intravenous drug users (IDUs) were found in 73.7% of cases. Anti-HCV total antibody was found in 31.6% cases, including 1 non-IDUs. Sex was significantly correlated with the risk factor of HIV infection (r = 0.580, p 0.01), and educational background was also significantly correlated with the risk factor of HIV infection (r = 0.229, p 0.05). Conclusion: The prevalence of HCV and HIV co-infection in Dr. Mintohardjo Navy Hospital was 31.6%. There were a correlation between HCV infection and IDU, sex and risk factors, and also between educational background and risk factors. Keywords: HIV infection, hepatitis C infection, IDUs

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