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All Journal Universa Medicina Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Juminten : Jurnal Manajemen Industri dan Teknologi JKKI : Jurnal Kedokteran dan Kesehatan Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Leonard Nainggolan
Department Of Internal Medicine, Faculty Of Medicine Universitas Indonesia- Dr. Cipto Mangunkusumo National Hospital
Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Inverse correlation between serum albumin and serum lactate in adults with dengue Mauleti, Ifael Yerosias; Suhendro, Suhendro; Nainggolan, Leonard; Rumende, Martin
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.75-80

Abstract

BACKGROUNDDengue infection is an acute viral infection, in the natural history of which plasma leakage may occur, resulting in shock followed by tissue hypoxia, with death as the final outcome if not treated properly. The purpose of this study was to determine the correlation of the hematocrit, serum albumin concentration, and the presence of pleural effusion or ascites, with hyperlactatemia in adult dengue patients.METHODSA cross-sectional study was conducted on 62 subjects. The inclusion criteria were: diagnosed dengue viral infection, age >14 years, fever during three consecutive days, and hyperlactatemia. Serum albumin was measured on an Advia 1800 analyzer using the bromocresol green method. The lactate oxidase method was used to determine serum lactate levels. Pleural effusion and/or ascites was determined using an ultrasound scanner (Xario SSA-660 A, Toshiba, Japan). The Pearson correlation test was used to analyze the data. RESULTSThere was no significant correlation between the hematocrit (r=0.11; p=0.301), serum albumin (r=0.003;p=0.981), and pleural effusion or ascites (r=0.75; p=0.692) with serum lactate levels. However, in patients aged >30 years there was a significant inverse correlation between serum albumin and lactate levels (r =- 0.663;p=0.026). CONCLUSIONThis study demonstrated a significant inverse correlation between albumin and serum lactate levels in dengue patients aged > 30 years. This can aid in the early recognition and prompt management of at-risk patients to reduce morbidity and mortality.
Pengembangan Produk Alat Pencuci Pakaian Secara Manual dengan Metode Design For Assembly (DFA) Emon Leonardo Nainggolan; Akmal Suryadi; Tranggono Tranggono
JUMINTEN Vol 1 No 5 (2020): Juminten: Jurnal Manajemen Industri dan Teknologi
Publisher : UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.948 KB) | DOI: 10.33005/juminten.v1i5.169

Abstract

Pada dasarnya proses desain merupakan langkah awal dari proses manufaktur. Sebagaian besar biaya produksi ditentukan dalam proses desain dan perancangan. Jumlah komponen dan sistem perakitan yang diguanakan sangat berpengaruh terhadap biaya perakitan dan lama waktu perakitan. Setiap produk memiliki komponen – komponen penyusunnya. Antara lain dari bagian pertama merupakan dasar bentuk, ukuran dan tujuannya. Pada bagian kedua terdapat spesifikasi dari produk itu antara lain harga, bahan kemasan, kualitas, nama, jenis. Pada tahap pengembangan alat pencuci pakaian secara manual peneliti menggunakan analisis dengan metode DFA (Design For Assembly). Kesimpulan dari penelitian didapatkan hasil pengembangan produk alat pencuci secara manual diperoleh harga sebesar Rp. 544.000,00 sedangkan untuk produk awal sebelumnya dikembangkan memiliki harga relatif murah dari produk sebelumnya dengan selisih harga Rp. 26.500,00 atau 8,90 % dan berdasarkan pengembangan kapasitas pakaian pada produk sebelumnya kapasitas menampung pakaian 3 kg, maka pada produksi inovasi mampu menampung pakain 9 kg.
Cause of Upper Gastrointestinal Tract Bleeding in Dengue Hemorrhagic Fever Patient Elza Febria Sari; Ari Fahrial Syam; Leonard Nainggolan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/91200830-34

Abstract

Dengue fever is an acute mosquito-transmitted disease caused by the dengue fever virus which had clinical manifestations range from fever to severe hemorrhage, shock, and death.1  There were 500,000 cases of dengue hemorrhagic fever and 25,000 deaths due to dengue annually worldwide. Bleeding is one of the major problems encountered in dengue fever. The reported prevalence of upper gastrointestinal bleeding in dengue patients varies from 5% to 30%. The pathogenesis of hemorrhage could be multifactor and include vasculopathy, platelet deficiency, and dysfunction, and blood coagulation defects. We presented here a case of 27 years-old male patient who had clinical manifestation of hematemesis on his third day of fever.   Keywords: GI tract, bleeding, DHF
Diagnosis of Acute Pancreatitis as a Compilation of Weil's Disease Rabbinu Rangga Pribadi; Christy Efiyanti; Rio Zakaria; Ari Fahrial Syam; Leonard Nainggolan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 3, Desember 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.133 KB) | DOI: 10.24871/1332012181-184

Abstract

ABSTRACTWeil’s disease is a severe form of leptospirosis and caused by pathogenic strain of Leptospira. Weil’s disease affects many organs including pancreas. Acute pancreatitis in leptospirosis is quite rare. Diagnosis of acute pancreatitis in Weil’s disease is based on clinical features, biochemical, and radiologic examination. Sometimes histopathological examination is urged to confirm diagnosis. Management of acute pancreatitis in severe leptospirosis comprise of antibiotic for leptospirosis and supportive treatment for the acute pancreatitis. Early and appropriate treatment is mandated as it was studied to significantly decrease mortality riskWe reported a case of 42 year old man suffering Weil’s disease with multi organ complications. Patient complained diffuse abdominal pain. Although the abdominal ultrasonography did not show any abnormalities of the pancreas, the amylase and lipase showed striking results. He recovered uneventfully. This case report demonstrated acute pancreatitis as one of severe leptospirosis complications. Keywords: acute pancreatitis, Weil’s disease, severe leptospirosis
Association between Early Antibiotic Administration and In-Hospital Mortality in Moderate and Severe COVID-19 Patients Chen, Lie Khie; Nathanael, Jason; Shakinah, Sharifah; Pasaribu, Adeline; Sinto, Robert; Nainggolan, Leonard; Susilo, Adityo
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 4
Publisher : UI Scholars Hub

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Abstract

Introduction. Patients with moderate and severe COVID-19 generally receive antibiotic therapy with consideration of the possibility of co-infection or secondary bacterial infection which clinically is difficult to distinguish from COVID-19 symptoms. Overuse of antibiotics can lead to an increased risk of bacterial resistance to antibiotics which is associated with poor outcomes in COVID-19 patients. This study aimed to assess the effect of early antibiotic administration on mortality in moderate and severe COVID-19 patients. Methods. An observational study with a retrospective cohort design was conducted at Dr. Cipto Mangunkusumo Hospital. Data were obtained from medical records of patients admitted from March to September 2020. Patients who received early antibiotics were defined as patients who received antibiotics hospital, 108 subjects were included in this study, 74 (68.5%) with moderate degrees and 34 (31.5%) with severe degrees. Early antibiotics were administered to 79 (73.1%) subjects with a median start time of one day. The results of the bivariate analysis did not find a significant effect of early antibiotic administration on mortality in moderate or severe COVID-19 patients (p=0.42). Subgroup analysis based on the degree of disease also found no significant results. Conclusion. There is no relationship between early antibiotic administration and mortality of moderate and severe COVID-19 patients.
Pain Management in Advanced Hepatocellular Carcinoma:A Case Study Fitrianti, Fita; Shatri, Hamzah; Faisal, Edward; Putranto, Rud; Agung, Ratih Arianita; Nainggolan, Leonard; Kalista, Kemal Fariz; Irawan, Cophiadi
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Hepatocelullar carcinoma (HCC), the most common primary liver malignancy is the fifth most common cancer and the third most frequent cause of cancer related death globally. Pain comprises one the most common symptoms of HCC and may have severely negative effects on patient’s quality life. Furthermore, patients with HCC often presented with a cirrochis,so to control pain in this patient poses a clinical challenge. This case report discuss about a young 26-years-old male patient who presented with a four-month history of right upper quadrant abdominal pain and weight loss. HbsAg positive and serum alpha-fetoprotein level was high. Computed tomography (CT) and liver biopsy confirmed the presence of primary hepatocellular carcinoma.,with lung metastatic from the radiologic x-ray. Patient came with a loss of consciousness due to hypoglicemia. During hospitalization, patient complaint of abdominal pain and was given morphine intermediate release (MIR) to control the pain. By administering measurable and well-controlled opioids, the patient’s suffering can be reduced, thus improving the patient’s quality of life
Coronavirus Disease 2019: Review of Current Literatures Susilo, Adityo; Rumende, C. Martin; Pitoyo, Ceva W; Santoso, Widayat Djoko; Yulianti, Mira; Herikurniawan, Herikurniawan; Sinto, Robert; Singh, Gurmeet; Nainggolan, Leonard; Nelwan, Erni J; Chen, Lie Khie; Widhani, Alvina; Wijaya, Edwin; Wicaksana, Bramantya; Maksum, Maradewi; Annisa, Firda; Jasirwan, Chyntia OM; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Comparison of Absolute Neutrophil Count between Hospital and Community Acquired Methicillin-Resistant Staphylococcus aureus Infection Kurniyanto, Kurniyanto; Santoso, Widayat Djoko; Nainggolan, Leonard; Kurniawan, Juferdy
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 4
Publisher : UI Scholars Hub

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Abstract

Introduction. The virulence factors from community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) mainly due to toxins like Panton Valentin Leukocidin (PVL) and Phenol Soluble Modulin (PSM). Both of toxins cause decrease of value through neutrophil lysis. This study aimed to identify different value of absolute neutrophil count between hospital and community acquired MRSA. Methods. A cross sectional was conducted which included subjects who were infected by MRSA and hospitalized during 2012-2017. Classification of MRSA were divided due to its sensitivity and resistance to non-beta lactam antibiotics. Isolate that resistance to ≤ 2 antibiotics were classified as CA-MRSA. The others with resistance to ≥ 3 antibiotics were classified as hospital acquired MRSA. Absolute neutrophils count (ANC) were collected 24 hours from the positive MRSA culture. Data were analyzed by using independent T test and Mann-Whitney test. Results. We collected 62 subjects infected by MRSA which 35 subjects were HA-MRSA and 27 subjects were CA-MRSA. The median of ANC from CA-MRSA was 7,410.7 (1,147.3-26,560.2) and HA-MRSA was 16,198.0 (3,921.6-28,794.1) with p value < 0.001. Conclusion. There was a different value of absolute neutrophil count in infections due to community and hospital acquired MRSA.
Penilaian Domain Pengkajian Paripurna Pasien Geriatri (P3G) sebagai Faktor yang Berpengaruh terhadap Kejadian Pneumonia Nosokomial pada Pasien Usia Lanjut yang Dirawat di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo Victor, Hildebrand Hanoch; Wahyudi, Edy Rizal; Rumende, C. Martin; Soejono, C. H.; Rooshoeroe, A. G.; Shatri, Hamzah; Nainggolan, Leonard; Irawan, Cosphiadi
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. Nosocomial pneumonia is a lung infection that occurs after the patient is hospitalized for more than 48 hours, without any signs of pulmonary infection at the time of treatment. When compared with young individuals, elderly individuals are more likely to have community-sourced and nosocomial infections with worse outcomes. Comprehensive Geriatric Assessment (CGA) domains are expected to explain the factors that contribute to nosocomial pneumonia in elderly patients. This study aimed to determine the proportion of elderly treated at Dr. Cipto Mangunkusumo National Central General Hospital who experienced nosocomial pneumonia and whether the CGA domains influence the occurrence of nosocomial pneumonia. Methods. A retrospective cohort study was conducted by analyzing the medical records of patients aged 60 years or older who were hospitalized in the medical ward of Geriatric Internal Medicine at Dr. Cipto Mangunkusomo National Central General Hospital in January – September 2019. We also collected secondary data from the geriatric division’s research. The sample consisted of inpatients aged ≥60 years who were hospitalized for more than 48 hours. Those who died within the first 48 hours of hospitalization and subjects with incomplete CGA domain data were excluded from the study. The criteria for nosocomial pneumonia used in this study followed the CDC’s pneumonia criteria for geriatric patients. Data processing was conducted using the application of Statistical Product and Service Solutions (SPSS) 16. Results. Of 228 subjects, the proportion of nosocomial pneumonia in elderly patients hospitalized was 31,14%. The mean age was 69 years with the subject’s age range between 60-89 years. Nutritional status (OR 2.226; CI95% 1.027-4.827) and functional status (OR 3.578; 95%CI 1.398-9.161) are factors that influence the incidence of nosocomial pneumonia in elderly patients who are hospitalized at Dr. Cipto Mangunkusumo National Central General Hospital. Conclusions. The proportion of elderly patients with nosocomial pneumonia was 31.14%. Nutritional status and functional status are factors that influence the incidence of nosocomial pneumonia in elderly patients who are hospitalized at Dr. Cipto Mangunkusumo National Central General Hospital. Keywords: Comprehensive geriatric assessment, elderly, nosocomial pneumonia
Cut-off Value of HSPG for Early Marker of Plasma Leakage in Adult Dengue Patient Settrin Chenderawasi; Rahajuningsih Dharma; Herdiman T. Pohan; Beti Ernawati Dewi; Rianto Setiabudy; Suhendro Suhendro; Aryati Aryati; Hardi Darmawan; Leonard Nainggolan; Agustin Iskandar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2221

Abstract

Plasma leakage is a state of increased vascular permeability due to loss of interendothelial junction and focal adhesion. Endothelium glycocalyx plays a major role in the pathogenesis of plasma leakage. Proteoglycans glycocalyx consists of heparan sulfate (HSPG) around 50-90%. Plasma leakage in dengue infection can be fatal and early detection is essential. This study aimed to determine the optimal cut-off value of HSPG levels for early marker of plasma leakage in dengue infection. The study was a retrospective cohort study as a part of the Community Based Dengue Study of the Faculty of Medicine, University of Indonesia, which was conducted between February 2010 and January 2011. Subjects were recruited by consecutive sampling. Dengue infection was confirmed by conventional PCR serotyping. Subjects were categorized into 2 groups, i.e. those with and without plasma leakage. Plasma leakage was confirmed by hemoconcentration or hypoalbuminemia or USG results. The level of HSPG was measured using the ELISA method from the first until the third day of the hospital admission. A total of 40 subjects were involved in this study, consisting of 21 with leakage and 19 without leakage. The optimal cut-off level of HSPG as a marker of early plasma leakage in dengue infection patients on the 1st day, 2nd day, and 3rd day was was 2179.73 pg/mL, 2538.66 pg/mL, and 1294.06 pg/mL, respectively. HSPG could as an early marker of plasma leakage in dengue infection with an optimal cut-off value for each of the first 3 days of the patient's fever. A pediatric study was recommended to obtain the optimal cut-off value for HSPG.
Co-Authors Aditya Wardhana Adityo Susilo, Adityo Agung, Ratih Arianita Agustin Iskandar Akmal Suryadi Aldo Ferly Alvina Widhani, Alvina Andreas Pekey, Andreas Annisa, Firda Ari Fahrial Syam Aryati Aryati Beti E. Dewi Beti Ernawati Dewi Bramantya Wicaksana C. Martin Rumende, C. Martin Ceva W. Pitoyo Christy Efiyanti Cleopas M Rumende, Cleopas M Cleopas Martin Rumende Cleopas Martin Rumende Cophiadi Irawan Cosphiadi Irawan Cynthia Olivia Maurine Jasirwan Dadang Makmun Dante S Harbuwono Deka Larasati Dicky L. Tahapary E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edward Faisal Edwin Wijaya Edwin Wijaya, Edwin Edy Rizal Wahyudi Elza Febria Sari Elza Febria Sari Em Yunir, Em Eppy Eppy Erni J Nelwan, Erni J Erni Juwita Nelwan, Erni Juwita Esthika Dewiasty, Esthika Evy Yunihastuti Faisal, Edward Firda Annisa Fita Fitrianti Fithriyah Fitrianti, Fita Gurmeet Singh Gurmeet Singh Hardi Darmawan Herdiman T. Pohan Herikurniawan Herikurniawan Herikurniawan, Herikurniawan Irawan, Cophiadi Irsan Hasan Jasirwan, Chyntia OM Juferdy Kurniawan Kemal Fariz Kalista, Kemal Fariz Khie Chen Kumalawati, July Kurniyanto Kurniyanto Kurniyanto, Kurniyanto Maksum, Maradewi Maradewi Maksum Marcellus Simadibrata Mauleti, Ifael Yerosias Mira Yulianti Mira Yulianti, Mira Nadira Prajnasari Sanjaya Nathanael, Jason Nugraheni, Enny Pasaribu, Adeline Pradana Soewondo Putranto, Rud Rabbinu Rangga Pribadi Rahajuningsih Dharma Ratih Arianita Agung Rianto Setiabudy Rio Zakaria Rio Zakaria Robert Sinto Robert Sinto Rooshoeroe, A. G. Rudi Putranto Rumende, Martin Rustam, Musfardi Settrin Chenderawasi Shakinah, Sharifah Soejono, C. H. Suhendro Suhendro Suhendro Suhendro TJAHJANI MIRAWATI SUDIRO Tranggono Tranggono Veronica, Raja Merlinda Victor, Hildebrand Hanoch Wicaksana, Bramantya Widayat Djoko Santoso Widayat Djoko Santoso Widayat Djoko Santoso, Widayat Djoko Wiguna, Candra