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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Grafting onto Different Rootstocks Influences Yield, Quality, Chemical Composition, and Bioactivities of Tomato Fruits under Greenhouse Conditions Howaida I. Abd-Alla
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: Grafting is a possible chemical free solution that shows several changes in plants, with the aid of vigorous rootstock. Methods: The influence of grafting on the yield and fruit quality of tomato cultivars grown under greenhouse condition was conducted during two successive seasons of 2016 and 2017. The metabolic composition of fruits of tomato Solanum lycopersicum L. Nefret hybrid (T1) grafted onto four rootstocks were identified by gas chromatography coupled to mass spectrometry (GC-MS). The levels of aspartate and alanine aminotransferases and alkaline phosphatase were analyzed for the determination of liver functions. The levels of oxidative stress markers; malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were determined in the rat's liver tissue. Kidney function parameters of serum urea and creatinine levels were also measured. Histologic examinations of the liver and kidney tissues were also performed. Results: The effects of grafting on the vegetative growth, yield, and fruit quality characteristics, i.e., fruit weight, length, diameter, total soluble solids content and titratable acidity of T1, grafted onto four rootstocks have showed great variability.  The vegetative growth, i.e., plant height of T2, was increased when S. lycopersicum L. var. VFN (T2) was used as a rootstock.  T2 has showed no adverse effects in all biochemical parameters under investigation compared by the other treatments. Aldehydes, ketones, esters, fatty acids, terpenoids, carotenoids, phenolics and alkaloids were the main identified components and the major compound was β-ionone (13.37%) in T2. Conclusion: The nutritional content of T2 and that it has showed no alteration in oxidative stress markers, liver and kidney function tests and their histopathological patters support its safety. While, un-grafting or grafting onto Solanum melongena L. cv. Balady (T3) may be a tool to improve the crop quality. Keywords: Greenhouse-grown tomato, Grafting, GC-MS, Carotenoids, Lycopene, Polyphenols, Liver, Kidney, Histopathology.
Synthesis and Characterization of Some Bis Heterocyclic Compounds from (Dapson and 3-Amino Phenol) Faez Abdul-Hussein Al-Rammahi
Journal of Global Pharma Technology .
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This study involves synthesized of diheterocyclic compounds of the reaction of (4,4-diamino diphenylsulphon (DDS) and 3-Aminophenol with (benzoin, 2-Hydroxy-1,2-diphenylethanone); These compounds were characterized by melting point and FT-IR spectroscopy and the biologicl activity was evaluated against four kinds of bacteria two positive and two negative.Keywords: Heterocyclic compounds, Schiff base, Oxazepine, Imidazolidine, benzoin, Dapson.
The Influence of Health Education and Simulation Methods on The Improvement of Mother’s Knowledge and Skill in Handling Injury Toward Children at Home Abd. Hady J; Andi Agustang; Arlin Adam; Simunati Simunati; Hariani Hariani; Nuraeni Mustari
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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This research aimed to analyze the influence of providing health education and simulation method on the mothers’s knowledge and skill in handling first aid toward children at home. This research was a quasi-experimental research by utilizing two group pretest-posttest design. The sample size were 65 mothers, selected using purposive sampling. Data collection was carried out in the pre test and post test phases. In this case, the data were collected through questionnaires, observations and interviews. After the data has been collected, then analyzed using paired sample t-test. Regarding the knowledge, the statistical test result was obtained p-value of 0.000 (
CPCR Results in Cardiac Arrested Patients in Motahari Hospital Affiliated to Jahrom University of Medical Sciences, Iran, 2011-2015 Mohsen Hojat
Journal of Global Pharma Technology .
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Introduction Cardiopulmonary resuscitation (CPR) in hospital has received much attention over the last decade. Computing international indices of CPR in hospital can be a guideline for researchers and managers in determining the executive and research priorities. So this study was designed and implemented to evaluate the results of CPR in Motahari Hospital in Jahrom. Materials and Methods this study was a cross-sectional and analytic study that designed and implemented in Motahari Hospital affiliated with the Jahrom University of Medical Sciences during 2011-2015. All patients receiving resuscitation were evaluated each year and in each section as the census regardless of the background factors; and information was collected through cardiopulmonary resuscitation checklist which was filled by clinical supervisor and hospital resident doctor per shift. Content and face validity was calculated according to opinion of 5 professors, content validity index (0.77), and the content validity ratio (0.83); reliability of the tool was calculated through education of clinical supervisors and acquisition of Kappa coefficient to researchers (96%). Data were analyzed by SPSS16 software. Results In this study, resuscitation was annually performed on 353 patients from 389 cases during 2011-2015, that the patients were 78.61% males and 21.39% females with an age range of 1-98 years and an average age of 55.6 years. Of the total cases conducted resuscitation, successful resuscitation was 56.29% at 24 hours and return of spontaneous blood circulation was 63.03% at first 20 minutes. Average total of duration of resuscitation was reported 59.58 minutes. Conclusion the results of this study are consistent with the results of European and America countries. It also shows that the faster resuscitation start and quick and correct use of defibrillator can improve short-term and long-term indicators of resuscitation.Keywords: Cardiopulmonary resuscitation (CPR), ROSC - S to D.
Evaluation of Antioxidant and Anticancer Activity of Kohautia Aspera (Heyne Ex Roth) Bremek Kavitha G; Sivakkumar T; Elessy Abraham
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The purpose of present study was to investigate the antioxidant and anticancer activities of selected extracts of Kohautia aspera (Heyne ex Roth) Bremek. The chloroform, water and ethanolic extracts which are rich in phytoconstituents were subjected to DPPH photometric assay and standard MTT assay. The percentage of growth inhibition in antioxidant study increased with increasing concentration of extracts. The ethanolic extract showed better antioxidant activity followed by other extracts. The anticancer potential of plant was investigated by standard MTT assay against SK-MEL 28 skin cancer cells. In vitro cytotoxic activity of plant increased with increasing concentration of extracts. The results clearly indicated that the extracts of the study species has potential inhibition of free radicals and powerful anticancer activity against skin cancer cells.
Substantiation of use of Photodynamic Therapy in Experimental Research in Vitro with Strains of Periodontopathogenic Bacteria and Fungi Candida Vadim O. Samusenkov
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Photodynamic therapy is used for the treatment of inflammatory periodontal diseases. This study was aimed at determining the effectiveness of the treatment of periodontitis and gingivitis with the use of a photosensitizer that interacts with the light flux, has the ability to adsorption on the surface of the bacterial cell. To determine the sensitivity of photodynamic effects, the following priority strains of microorganisms were selected: Aggregatibacter actinomycetemcomitans, Streptococcus constellatus, Candida glabrata. For the cultivation of microorganisms in the bioreactor, two types of tubes were used: 50 ml tubes with a membrane filter (TubeSpin) and 50 ml tubes of Falcon type with a lid without a membrane. 20 ml of nutrient medium was added to each tube. A. actinomycetemcomitans (37°C; RPM: 500 min‒1; measurement freq.: 3 h-1; Rev. spin period: 1 sec.; volume: 15-16 ml; λ: 850 nm); S. constellatus (37°C; RPM: 1500 min‒1; measurement freq.: 3 h-1; Rev. spin period: 2 sec.; volume: 15-16 ml; λ: 850 nm); C. albicans (37°C; RPM: 1300min‒1; measurement freq.: 3 h-1; Rev. spin period: 3sec.; volume: 15-16 ml; λ: 850 nm). After bacterial suspension inoculations, the samples were irradiated with semiconductor laser devices with different wavelengths-630 nm and 662 nm, at a power of 100 j/cm2. The basis of experimental studies was automated cultivation of isolated strains of microorganisms with control of growth curves of microbial populations using different modes of exposure and photosensitizers.Keywords: Periodontopathogenic microorganisms, Photodynamic effects, Photosensitizers, Gingivitis, periodontitis.
Effect of Resistance Exercises by Means of Aids with Doses of Vitamin D3 in Some Biomechanical Variants to Develop the Spike Skill of Volleyball for Female Students Mohammed Jasim Mohammed Al-Khalidi
Journal of Global Pharma Technology .
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The research focused on several axes focused on these axes to know the impact of resistance exercises using the aids with doses of vitamin D3 to develop the skill of beating overwhelming volleyball and try to reach the best achievement, as the use of different aids shapes and sizes, taking into account differences in lengths and abilities for sample members to help Students to master this skill as required. The experimental group was trained on the skill of beating overwhelming by using aids with a dose of (1g) daily of vitamin D3 within 6 weeks at the rate of two training units per week and after the end of this period the results were collected for the two groups and the comparison between them (experimental group, control group) The statistic exceeds the experimental group on the control group.Keywords: Resistance exercises, Vitamin D3, biomechanical variants and spike skill.
Nanotechnology Applications in the Single-Cell Analysis for Cancer and Therapy Ali Hamad Abd Kelkawi
Journal of Global Pharma Technology Volume 11 Issue 6.
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Understanding the molecular, cell, genetic, and functional heterogeneity of tumors at the cell level has become a major challenge to cancer research. Microfluidic technology has emerged as an important tool that offers advantages in single-cell analysis with the ability to integrate labor-intensive, labor-intensive experimental procedures, such as single-cell capture into a single small device at ease and in high productivity. Single-cell processing and analysis can be performed within a microfluidic multifunctional device for various applications in cancer research. Here, we present recent developments in microfluidic devices for single-cell analysis related to cancer biology, diagnosis, and treatment. First, we briefly present several microfluidic pads used to analyze one cell, followed by different microfluidic techniques to manipulate a single cell. Next, we highlight their various applications in cancer research, with a focus on cancer biology, diagnosis, and treatment. Current limitations and potential trends of one microfluidic cell analysis are discussed in the end.Keywords: Microfluidic lab-on-a-chip, Single cell analysis, Cancer biology, Cancer diagnosis, Cancer therapy, Cancer research.
Effect of Spraying Salicylic Acid and Collection Dates of Corn Silk (Zea mays L.) on Growth, Yield and Content of Some Antioxidant Compounds Maher H.S. Al-Mohammad
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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A filed experiment was conducted during the autumn season of 2016 to study the effect of foliar application salicylic acid (SA) at concentrations 0, 50, 100 and 200 mg.L-1 and collection dates (CD) at 14, 28 and 32 days after flowering and their interactions on growth parameters (plant length, total leaves number, leaf area and total chlorophyll), yield (Fresh and dry weight, plant yield and dry productivity) and some antioxidant compounds(total phenol compounds, flavonoids, anthocyanins, carotene, ascorbic acid and glutathione) of corn silk (Zea mays L.). Results of analysis of variance showed that SA affect were given increased   significantly impact (P<0.05)  when increased concentrations on all growth parameters of plant and yield, while late CD were increased leaf area, plant yield and dry productivity of corn silk, but the early CD decreased total chlorophyll and fresh weight of corn silk. The interaction between SA 200 mg.L-1×CD 14 days were given high amount of total phenol compounds, carotene, ascorbic acid and glutathione (140.53, 8.96 mg.Kg-1 DW, 115.34 and 16.71 mg.Kg-1 FW) respectively, and treat of SA 200 mg.L-1×CD 32 days were given high amount of total flavonoids and anthocyanin (48.57 and 5.93 mg.Kg-1 DW).  Keywords: Corn silk, Salicylic acids, Collection dates, Antioxidant compounds.
Determinants of Stigma Attitude Among People Living with HIV Nursalam .
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: Human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) is still a stigma in the community and becomes a barriers in dealing with HIV. This study aimed to identify the determinants of stigma attitude among people living with HIV/AIDS (PLWHA).Methods: This study used a cross-sectional design. Sample collection was carried out by simple random sampling involving 135 Housewife suffered by HIV in Surabaya. The independent variables were policy support, patient characteristics (including age, sex, education level, marital status, occupation, HIV status, first being diagnosed with HIV), family factors (including family burden and family resilience). The dependent variables were stigma. Data were collected using a questionnaire. The analysis used binary logistic regression with a significance level of p ≤0.05. Results: The results showed there are five factors related to stigma in PLWHA, namely policy support (p = 0.019), marital status (p = 0.039), first being diagnosed with HIV (p = 0.006), family burden (p = 0.000) and family resilience (p = 0.041). Out of five variables, only four had a significant effect on stigma, namely marital status (OR = 0.009; 95% CI 0.000 – 0.697), first being diagnosed with HIV (OR = 7,464; 95% CI 1,820 - 30,617), family burden (OR = 0.075; 95% CI 0,017 - 0.329), and family resilience (OR = 0.010; 95% CI 0.000 - 0.381).Conclusion: The determinants of stigma attitude among PLWHA include policy support, marital status, first being diagnosed with HIV, family burdens and family endurance. Tackling stigma on HIV which involves various sectors including society, family, private and government.Keywords: HIV/AIDS; PLWHA, Stigma attitude.

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