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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Detection of HBME-1 and Galectin-3 by Immunohistochemistry in Follicular Lesions Wijdan B. Abid
Journal of Global Pharma Technology .
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Abstract

The main problem established by a discovery of a thyroid nodule is to discriminate between a benign and malignant lesion. Differential diagnosis between follicular thyroid cancer (FTC) and benign follicular thyroid adenoma (FTA) is a great challenge for even an experienced pathologist and requires special effort. A developing number of some encouraging IHC markers for the differential diagnosis of thyroid lesions have emerged, including, Hector Battifora mesothelial (HBME-1) and galectin-3 (Gal-3). There was significant positive correlation between Galectin-3 and HBME-1 in follicular carcinoma and follicular variant of papillary carcinoma (r= 0.380, P= 0.041) and (r= 0.315, P=0.047) respectively. There was no significant correlation between Galectin-3 and HBME-1 in follicular adenoma and follicular hyperplasia. Immunohistochemical expression of Galectin-3(Gal-3) there was highly significant difference (P<0.001) among study groups (FC, FVPC, FA, follicular hyperplasia) while there was no significant difference in mean of immunohistochemical score of Galectin-3 between follicular carcinoma, follicular variant of and papillary carcinoma (P>0.05); however, carcinoma of both types showed significantly higher Galectin-3 score than both follicular adenoma and follicular hyperplasia (P<0.001). In addition, the score of follicular adenoma was significantly greater than that of follicular hyperplasia (P<0.05). Immunohistochemical expression of HBME-1 immunohistochemical expression of HBME-1was highly significance among study groups (FC, FVPC, FA, follicular hyperplasia) while there was no significant difference in mean score between follicular carcinoma and follicular variant of papillary carcinoma (P>0.05); however, carcinoma of both types showed significantly higher HBME-1 score than both follicular adenoma and follicular hyperplasia (P<0.001). In addition, the score of follicular adenoma was significantly greater than that of follicular hyperplasia (P<0.05).Keywords: Galatin-3, HBME-1, Thyroid.
Knowledge and Determinants of Use of Health Supplements among Undergraduates in Ipoh, Perak Malaysia Sook Ching Chan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background Objectives: Research on health supplement usage among Malaysian undergraduate students is still limited although an average of USD17.30 was reported spent for nutritional supplements monthly.This study aimed to determine the usage of health supplements among the undergraduate students in Ipoh, Perak, Malaysia and the relationship between consumption and knowledge of health supplement among these students. Methods: This cross-sectional study was conducted in March to April 2018. Health sciences students and non-health sciences students from four different universities/colleges were selected through cluster sampling and random sampling method. A questionnaire that included socio-demographic data, lifestyle practices, usage of health supplement and assessment of knowledge of health supplements was given to selected students. Data analysis was done using SPSS 22.0 (Trial Version).Results: There were 374 respondents of which 79 students (21%) consumed health supplements. The majority of those who consumed health supplements (82%) were from Health Sciences, female (61%), overweight (44%) and with family income of more than RM5000 (39%). The top three most common reasons for using health supplements were “to maintain good health” (82.3%), “to ensure adequate nutrition” (54.4%) and “to improve immune function” (40.5%). The most common types of health supplements used were vitamins (44%) and minerals (23%).  Fifty seven percent of the consumers had good knowledge compared to 30.5% of non - consumers. Conclusion: The majority of the consumers were from Health Sciences, female, overweight, had family income more than RM5000 and had better knowledge regarding the health supplements as compared to the non-consumers.Keywords: Health supplements, Undergraduates, Knowledge, Use.
Clinical Applications of Doppler Ultrasound in Obstetrics Rowshan Jawad Azeez
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Ultrasound images of flow, whether color flow or spectral Doppler, are essentially obtained from measurements of movement. In ultrasound scanners, a series of pulses is transmitted to detect movement of blood. Echoes from stationary tissue are the same from pulse to pulse. Echoes from moving scatters exhibit slight differences in the time for the signal to be returned to the receiver. These differences can be measured as a direct time difference or, more usually, in terms of a phase shift from which the ‘Doppler frequency’ is obtained. They are then processed to produce either a color flow display or a Doppler sonogram.
Biosynthesis, Characterization and Antibacterial effect of Zno Nanoparticles Synthesized by Lactobacillus Spp Jehan Abdul Sattar Salman
Journal of Global Pharma Technology .
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Biosynthesis of Zinc oxide (ZnO) nanoparticles using a probiotics bacteria Lactobacillus spp. which isolated from different sources was studied. The formation of ZnO nanoparticles was checked using X-ray diffraction (XRD) technique, Atomic Force Microscopy (AFM), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopic (SEM) and Energy-dispersive X-ray analysis (EDX) spectra. The characterization results showed that the biosynthesized nanoparticles are hexagonal ZnO crystal structure, spherically shaped with a diameter of about (30.3 - 38) nm. The antibacterial effect of the synthesized ZnO nanoparticles was determined through the minimum inhibitory concentration (MIC) against pathogenic bacteria isolated from skin infections included Pseudomonas aeruginosa, Acinetobacter baumanii, Klebsiella pneumonia , and Staphylococcus aureus. The synthesized ZnO nanoparticles were effective against all the tested pathogenic bacteria at different degrees. The best effect has been shown against A. baumannii with MIC recorded at 12.5mg/ml, but the lowest effect has been recorded on P. aeruginosa(50mg/ml).Keywords: Biosynthesis, ZnO nanoparticles, Lactobacillus spp., Antibacterial activity, Skin infections.
The Dual Role of Gentamicin in Gene Expression of Fibronectin Binding Proteins in Staphylococcus Aureus Hind Tahseen Ibrahim
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Abstract

Objectives: The current work aimed to reveal the impact of gentamicin on the fibronectin binding proteins (fnbp) gene expression and its relation to biofilm and agr type in Staphylococcus aureus.  Materials and Methods: A total of 25 S. aureus isolates were enrolled in this study previously isolated from different specimens. Identification confirmation and methicillin resistance were achieved by amplification of 16SrRNA and mecA. Multiplex polymerase chain reaction (PCR) based assay was employed to evaluate the agr typing. The gene expression of fnbA and fnbB genes was tested by real-time PCR technique. Minimum inhibitory concentration was estimated by micro broth dilution methodology. Microtiter plate method was performed to determine the adhesiveness of to human fibronectin, with and without gentamicin. Results: Here we revealed a weak inverse correlation was observed between gene expression of either fnbA or fnbB with each of biofilm forming capacity and agr type. Whereas there was a strong correlation between fnbA and fnbB gene expression. Furthermore, gentamicin affected the bacterial genome in a way that down-regulates one of the genes in question; meanwhile, up-regulates the other one. Moreover, the current study found that polysaccharides production in 48% of isolates significantly (P<0.05) reduced by increasing fibronectin concentration. Conclusion: gentamicin has dual impacts on fnb genes expression. Albeit much work is needed; however, it is strongly suggested that gentamicin should be omitted from antibiotic regimen in treating S. aureus isolates.Keywords: Gentamicin, Fnba, Fnbb, Biofilm, Staphylococcus arueus.
Myristica fragrans and Chronic Toxoplasmosis; In Vivo Parasitological, Histopathological and SEM Study Noha Madbouly Taha; Maysa Mohamed Kamel Sobhy; Rabab Sayed Zalat; Mohamed Sherif Ismail Negm; Eman Ahmed EL-wakil; Dina M. H. El Akkad
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Toxoplasma gondii (T.gondii) is one of the most important protozoa causing abortion in pregnant women and fatal manifestations in immunocompromized individuals. The present study was conducted to assess the effect of Myristica fragrans (M.fragrans) alone and loaded on Chitosan nano particles (CS NPs) on chronic toxoplasmosis as a more effective safe candidate in comparison with spiramycin. One hundred and ten laboratory bred Swiss albino mice were infected by oral inoculation of T.gondii tissue cysts, treated for 14 days starting from the 4th week post infection (p.i) and sacrified at the 10th week p.i. The effect of drugs was assessed by counting the number of tissue cysts in homogenized brain tissues, histopathological examination and SEM of brain tissue. There was a significant decrease in the number of tissue cysts detected in the brain between the control group and all treated groups (P<0.001). Histopathological examination revealed marked improvement of inflammation in all treated groups and the SEM of brain tissues revealed remarkable changes in the shape and structure of the T.gondii tissue cysts.
Histopathological and Some Hematological Analysis in Iraqi Patients with Osteoarthritis Nabaa S. Abdul Sahib Abdul Sahib
Journal of Global Pharma Technology .
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Osteoarthritis (OA) is a biomechanical process in which the joints respond pathologically to mechanical stress, leading to articular cartilage damage and changes in other knee tissue. The present study focuses on some haematological and biochemical test in both patients and control and histopathological change with knee OA patients. Tissue samples (Synovial membrane and Cartilage) obtained from 50 knee OA patients (35 females and 15 males) during total knee replacement for histological study. Blood sample were obtained from 50 knee OA patients and 25 control. The tissue sample and blood were collected during the period from October 2015 to June 2016. In the present study, the Histological study of knee OA tissues (Synovial membrane and Cartilage) expressed many histopathological changes such as fibrin deposition, congestion blood vessels and infiltration of inflammatory cells.Assessment of differential white blood cell (WBC) level in blood revealed that both neutrophils and monocytes levels elevated significantly in total knee OA patients (male and female) in compared with that of healthy controls, but there was no significant difference in neutrophils and monocytes levels of knee OA male patients compared with that of female patients. Also, no significant difference in WBC level of knee OA patients compared with healthy control, but there was a significant difference in WBC level between male and female knee OA patients. On the other hand, no significant difference in lymphocyte level of knee OA patients compared with healthy control for both male and female. Our results showed significant elevation in erythrocyte sedimentation rate (ESR) in females as compared with males with in the patients group. Also there was significant elevation difference in ESR between total patients and controls in males and females. While, no significant difference in platelets level of female with knee OA compared with healthy, but there was highly significant elevation difference in level of platelets in knee OA male compared with control, and between knee OA female and control but there was a significant elevation in platelets level of knee OA patient male as compared with knee OA female. On the other hand, no significant difference in Hemoglobin (Hb) level between male and female knee OA patients as compared with control, and between both males and females.Keywords: Osteoarthritis, Synovial Membrane, Cartilage, Knee joint.
Effects of Soursop (Annona muricata ) Lea f Water Extract (SLWE) on Body Weight, Leptin and TNF α Plasma Levels of Rats with High Fat and High Fructose (HFHF) Diet. Dini Sri Damayanti
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract Background: Soursop leaves believed to be able to lose weight. The aim of the study was to prove that SLWE had an effect on body weight, leptin and TNF α plasma level in mice with the HFHF diet . Methods:The study used post test group design only. Male Wistar rats aged 8-10 weeks weighing 175-200g, healthy, 25 were divided into 5 groups by simple random sampling. Normal groups (N) , Positive groups (P) were given a HFHF 10% diet, treatment group  (T1), T2, and T3 ( HFHF diet + SLWE at dose of 100 mg / kg bw, 200 mg / kg bw, and 400 mg / kg bw). The diet and extract were given for 10 weeks. Measurement of body weight and weighing the amount of food consumed were carried out every week. Measurement of plasma leptin and TNF α levels using the ELISA method. Statistical analysis using ANOVA and Kruskal Wallis test with a confidence level p <0.05. Results : SLWE at all doses increased the amount of intake compared to P and N groups (p <0.05).Giving SLWE at dose of 400 mg/kgbw causes a slowdown in weight gain (p> 0.05),  increase levels of plasma leptin than P group. There was a tendency to decrease TNF α plasma levels with an increase in the dose of the extract (p>0.05). Conclution : Giving SLWE in HFHF diet-induced mice increased appetite, increased Leptin levels, and tendency to decreased weight gain and TNF α levels.Keyword : Soursop leaf, Weight gain, Leptin, TNF α, High Fat-High Fructose Diet
Synergistic Hurdle Effect of Physical and Chemical Treatments for Non-thermal Pasteurization of Guava (Psidium guajava) Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Guava (Psidium guajava) is commonly known for its food and nutritional values throughout the world. It has high fermentable sugar composition when mature and ripe .It’s known for its sweet and tangy flavor and many uses. It is a fruit with good nutritional attributes but has short shelf-life under the ambient conditions. Dimethyl dicarbonate is a microbial control agent inhibitor widely applied in the food industry. Various current and potential applications of ultrasound in the fruit processing have been identified. Consumers prefer to safe, nutritious, high quality guava juices without thermal treatment. In our research, synergistic or hurdle effectiveness by ultrasound combined dimethyl dicarbonate was studied on guava juice. Different parameters of ultrasonic duration (10, 15, 20, 25, 30 min), dimethyl dicarbonate addition (10, 15, 20, 25, 30 µL/100mL) was examined on guava juice in respect of microbial inactivation. Log10 reductions of total plate count and coliform were evaluated to define the optimal variables. Our results revealed that microbial loads in guava juice would be decreased dramatically by ultrasonic treatment in 25 minutes at frequency 37 kHz with 20 µL/100mL supplementation of dimethyl dicarbonate to create a synergistic hurdle effect for a significant microbial reduction. It could be considered as an excellent non-thermal pasteurization for a better fruit juice quality, not only for guava but also for other tropical fruits to enhance their added value.Keywords: Guava juice, Synergistic, Hurdle, Ultrasound, Dimethyl dicarbonate, Microbial reduction.
Prediction of Scoring Skills from the Persistence of Basketball in Terms of Cognitive-kinetic Abilities of School Children Aged 11 Years Zahraa Ihsan Abd Aoun
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The introduction and problem of research on childhood, which is one of the most important stages in human life, has been manifested by its great impact on its future life because it is the basis on which the rest of its life is built and through which the basic concepts are formed, as well as the proper planning of the educational and educational process because it Comprehensive studies of all aspects of the child involved (mental, motor, physical, emotional), where the growth of those aspects intersect, each one is affected by the other. Cognitive-kinetic abilities are the ones that the specialists sought to study and reveal their levels and the objective of the study was to:To recognize the level of cognitive-kinetic abilities and the skill of correction from the constant basketball of schoolchildren in the center of Kerbala Governorate aged 11 years.To identify the contribution ratios of cognitive-kinetic skills for the correction of the school attendance of schoolchildren in the center of Kerbala Governorate.Forecasting of the skill of the correction of a basketball constant in the meaning of cognitive-kinetic abilities of schoolchildren in the center of Kerbala Governorate.The researchers used the descriptive method of surveying and mutual studies (correlation and comparison), the researcher identified her research community for elementary school pupils in the center of Kerbala Governorate. The selection of her research sample was made with a simple random sampling method and (260 pupils), used Statistical pouch Researcher (SPSS).One of the most important conclusions:There are significant percentages of some cognitive - motor abilities in the skill of correction of the stability of basketball in primary school students.The development of predictive equations for the skill of correction of the stability of the basketball in terms of cognitive abilities - kinetic to elementary school pupil's model.Keywords: Prediction, Scoring skills, Cognitive-kinetic abilities and schoolchildren.

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