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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Age Aspect of Etiopathogenetic and Clinico-morphological Features of Chronic Gastritis Anna Berestova
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Chronic gastritis (CG) is a histopathologic entity characterized by chronic inflammation of the gastric mucosa with loss of gastric glandular cells. CG, pathological regeneration of the gastric mucosa, intestinal metaplasia (IM), and intraepithelial neoplasia or epithelial dysplasia (ED) of the stomach are common and are associated with an increased risk of gastric cancer. 800 patients (aged 8 to 80) were examined during the period of 2012-2017. Patients with CAG were diagnosed by endoscopy then underwent histological, bacteriological and cytological examinations. The Enzyme-Linked Immunosorbent Assay (ELISA) was used to detect antibodies to H+/K+ -ATPase and to Castle factors of parietal cells of the gastric mucosa in serum.Keywords: Helicobacter pylori (H. pylori) infection; Enzyme-Linked Immunosorbent Assay; gastric glandular cells.
A Review on Electrospun Nanofibres for Drug Delivery Kamala Kumari
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Electrospinning is most widely used technique for fabrication of nanofibres. It is cost effective, simple and versatile process. The resulting nanofibres possess unique properties such as a high surface-area-to-volume and aspect ratio, low density, and high pore volume. These properties make the nanomaterials more advantageous than conventional materials in energy harvesting, conversion, and storage devices. There are different aspects of electrospinning, but the current discussion is based on the use of electrospun fibrous matrices for drug delivery. The article explains about all the available approaches to incorporate drugs onto or within electrospun fibrous matrices, along with their release mechanisms and about the applications of such drug carrying fibrous matrices for regeneration of various tissues, such as neural, vascular, cardiac, skin, and bone.
Mixed Effects of Marketing with Approach of Information Technology for Promotion of Customer's Loyalty in Hamadan Province Clubs Ali Akbar Zohrevand
Journal of Global Pharma Technology .
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Abstract

The present study is Descriptive method type study from its application essence and in consideration to its objective, that has been conducted in the form of survey research. Statistical population is all the users of sports gymnasiums in Hamadan province that according to report from sports insurance control is reported to be 1000.statisticalsample was predicted to be 382 based on Morgan table easement tool includes ( consists of) mixed local marketing glue stingier (1389) and technical information Questionnaire (1395) .validity and reliability was obtained to be 0.80 for mix marketing element and 0.91 for technical information Questionnaire respectively by using Cranach Alpha. To analyze the data’s, discretional and interferential. Statistics such as Kolmogorov - Simonov test (test k-s), one sample t test, and freedman test was used. the results of this study showed that, there is a significant difference between the observed and imaginary average’s in mixed marketing elements ( t= 29/12 , p<0/001) .in the other word , situation of mixed marketing elements in sample study is little bet term than assumed or imaginary elements. Freedman test results showed that, the highest ranking average is for employee’s elements (4.46) and the lowest ranking is for product (2.72). It is recommended that all of employees or staff in sport clubs achieve the required or necessary skills. In using the internet, and also know the applied software packages which are related to their work area and have a special skills in utilizing then.Keywords: mixed marketing, Information technology, Customer’s loyalty. Clubs in Hamadan province.
POTENTIAL OF ASTAXANTHIN FROM ASIAN TIGER SHRIMP (Penaeus monodon) SHELL EXTRACT AS AN ANTIBACTERIAL AND ANT INFLAMATORY sukmawati syarif
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Asian tiger shrimp (Penaeus monodon) shell is an industrial waste which becomes one of the sources of carotenoids in the form of astaxanthin (3.3’-dihydroxy-β, β′-carotene-4.4′-dione) which has a very potential biological activity because it can work on target molecules. Astaxanthin in Asian tiger shrimp shell is well known to be lipophilic, being insoluble in water but soluble in organic solvents, one of which acetonitrile. The characteristics of astaxanthin were obtained through qualitative and quantitative analyses using FTIR (Fourier Transform Infra-Red) and HPLC (High Performance Liquid Chromatography). Furthermore, antibacterial and anti-inflammatory activities had been tested. Based on the research results done on the inhibition of Asian tiger shrimp (Penaeus monodon ) shell extract on the 5th growth of the test bacteria, the tiger shrimp shell extract had antibacterial activity on Eschericia coli., Streptococcus mutans, Pseudomans auriginosa, Salmonella typhi, Staphylococcus aureus which was characterized by the presence of clear zone / inhibition zone / Oligodynamic zone which showed the effect of tiger shrimp shell extract in killing and inhibiting the growth of test bacteria. Besides, An anti-inflammatory testing through extracting chemical components with acetonitrile solvent with several concentrations showed that the anti-inflammatory activity with a concentration of 1000 ppm with % stability on erythrocyte membrane obtained 60.516%, indicating that the higher the concentration used, the better was the anti-inflammatory effect.
Evaluation of Hirschsprung’s Disease in a Pediatric Hospital in Southern Iran During 2005-2013 Farzaneh Dehghan
Journal of Global Pharma Technology .
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Abstract

Background: Hirschsprung’s disease (HD) is a congenital absence of ganglion cells in the lining of the large intestine that can cause functional intestinal obstruction. Objective: The aim of this study was to investigate the incidence of Hirschsprung's disease in patients referring to a pediatric hospital in south of Iran over a period of 9 years. Methods: This retrospective research was carried out on all neonates, infants and children who referred to the largest pediatric Hospital of Hormozgan in Bandar Abbas, Southern of Iran due to suspected signs and symptoms of hirschsprung’s disease during the 9 years from March, 2005 to March, 2013.Demographic data and clinical symptoms of these patients were extracted from medical records available in hospital archives by a checklist. Results: Among the 85177 hospitalized patients in koodakan hospital of Bandar Abbas, a total of 425 cases had Hirschsprung’s disease (HD) with an overall male-to-female incidence ratio of 1.72. An overall increasing trend was observed in studied time. Chronic constipation (92.2%) and abdominal distension (91.1%) were the most common complaints. There were 21 deaths (4.9%) in cases with HD but none of the deaths in this population were attributable to HD. Conclusions: Based on the result the incidence of hirschsprung’s disease was elevated in recent years. However, more studies in several provinces are required to determine the exact value of incidence and further associations.Keywords: Hirschsprung’s disease, neonates, infants, children
Synthesis new Trifluoperazine Selective Liquid Electrodes Depending on Molecularly Imprinted Polymers Based on PVC Membrane for Determination of Trifluoperazine from Pharmaceutical Samples Ahmed Mohsen Dhari
Journal of Global Pharma Technology .
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Abstract

Liquid electrodes of polymers imprinted with Trifluoperazine were synthesized based on Mechanics polymerization of precipitation. The molecularly imprinted polymer (MIP) and non-imprinted polymers (NIP) It was manufactured using (TFP) as a template. In polymerization process, 2-Hydroxy ethyl meth acrylate (2-HEMA) and 2-Vinyl Pyridine (2-VP) were used as monomers.  Divinylbanzene (DVB) was used as cross-linkers and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted membranes and the molecularly non-imprinted membranes were synthesized utilize DibutylSebacate (DBS) and Nitro benzene (NB) as plasticizers in PVC matrix.  Detection limit and Slopes of the liquid electrodes are ranged at (3 × 10-6– 8 × 10-6) M and (21.83– 23.03) mV/decade, respectively. Response time was 60 seconds. The electrodes were filled with liquid of 10-1 M standard solution of drug and observed stable response for a pH ranged from 1.5 to 12 and with good selectivity for more than several types. The new synthesis electrodes were successfully used for the analyte estimated in preparation pharmaceutical sample without any time consuming pretreatment steps.Keywords: Molecularly imprinted electrodes; Trifluoperazine; Potentiometric method; (2-HEMA); (2-VP) monomers
Synthesis and Characterization of Some New Di-amines Derived from Di-amines Supplemented with Di-heterocyclic Five Membered Rings and Some Aromatic Aldehydes Noor S. Noori
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

It has been documented that imines and heterocyclic compounds with five membered rings and their derivatives, have enormous biological activity in various area as medicinal and pharmaceutical. Therefore, supplementing the di imines with five -membered heterocyclic rings, perhaps enhance the biological activity characters of the resulting products. Consequently, the target of present work involve the developing of new imines derived from selected di amines after connecting a five membered heterocyclic rings of the type di thiazole and di oxazole to the parent molecules via the reaction of the previous di amines with chloroacetyl chloride yield the corresponding amides [A1-A3] , then subsequent reaction of the later  with of thiourea and urea give substantially new di thiazol [th1-th3] and di oxazole [Ox1-Ox3] respectively .Reaction of these new developed di amines with selected aromatic aldehydes result a pavantly in the formation of the desired bis imines [Sc1-Sc10]. On the other hand the structures of all the synthesized compounds were confirmed by their physical properties, such as colors and melting points and spectroscopic measurements FT-IR, 1H-NMR and 13C-NMR for selected compounds.Keywords: Di imines, Chloroacetyl chloride, Thiazole-2, 4-diamines, oxazole-2, 4-diamines.
Cytotoxicity of Xanthium Strumarium against Breast Cancer Cell Lines Atheer S. Alsabah
Journal of Global Pharma Technology .
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Abstract

Objective: This study aimed to investigate the possible in vitro cytotoxicity of Xanthium strumarium.  Methods: The dried leaves powder was extracted with chloroform. Extract alone and combined with Doxorubicin have been evaluated by MTT assay for cytotoxicity against AMN3, AMJ13, MCF7 breast cancer cell lines and normal REF cell line.   Results: Chloroform extract has potent cytotoxicity in a dose dependent manner, against AMN3, AMJ13, MCF7 cell lines and less toxic effect on normal REF cell line; where IC50 (2.93µg/ml), (2.99µg/ml), (2.67µg/ml), and (15.84µg/ml) respectively. The cytotoxicity of extract combined with Doxorubicin showed a synergistic activity on AMN3, AMJ13, MCF7 cell lines, and dose dependent effect on normal REF cell line (synergism at 3.125-6.25µg/ml, addition at 12.5µg/ml, and antagonism at 25-100µg/ml). Conclusion: Chloroform extract has potent cytotoxicity against breast cancer cell lines and less toxic effect on normal REF cell line. In addition to synergistic activity in combination with Doxorubicin on breast cancer cell lines and dose dependent effect on REF cell line.  Keywords: Chloroform extract, Xanthium strumarium, Cytotoxicity, MTT assay, cell line.
Removal of Pharmaceutical (Paracetamol) by using CNT/ TiO2 Nanoparticles Aseel M. Aljeboree
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Paracetamol has been the highly usage drug in the world which increased environmental pollution, it has been effected in human life, flora and fauna in the world. Adsorption technique was used to remove paracetamol from water using CNT/TiO2 nanoparticles; the TiO2 was developed from CNT/TiO2 nanoparticles. The experiments were carried out to drug uptake by CNT/TiO2 nanoparticles and effect of some experimental factors like temperature, initial drug concentration, adsorbent dosage, , and particle size in solution, also the adsorption equilibrium was characterized using Langmuir and Freundlich isotherm models. The results have shown immense potential, it was found that correlation coefficient value deal with of the drug, while Langmuir equation was found a good correlation of drug.Keywords: Adsorption, Pharmaceutical, Paracetamol, TiO2, Isotherm models, CNT.
Synthesis and Identification of Some New Derivatives of Benzoxazole Bearing Pyrazole and 1, 2, 4-Triazine Rings Ahmed S. Hamed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this work, new derivatives of benzoxazole bearing two types of heterocyclic rings; pyrazole and 1,2,4-triazine have been described. This work involved preparation hydrazide derivative 5 as a key material in the synthetic route, which was obtained over five sequence steps. Reaction of 2-aminophenol with CS2 under basic conditions afforded 2-mercaptobenzoxazole 1 in 61% yield.  Michael addition of 1 to ethyl acrylate provided the desired ester 2 in a good yield (74%). Thereafter, hydrolysis of the ester group at 2 using basic conditions yielded the corresponding acid 3. The acid 3 was then converted to acid chloride 4, followed by nucleophilic addition of hydrazine hydrate was performed in a one-pot reaction and provided the desired hydrazide 5 in a 71% yield. Pyrazole derivatives 6-11 were then obtained via reaction of 5 with 1, 3-dicarbonyl compounds. Whereas, treatment of 5 with 1, 2-dicarbonyl compounds and NH4OAc in the presence of K2CO3 as a base gave the desired 1, 2, 4-triazine derivatives 12-17.        Keywords: Benzoxazole, Anticancer, 1, 2, 4-Triazine ring, Heterocyclic.

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