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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Performance Training for the Development of the Harmonic Ability and its Impact on the Rapid Force and the Achievement of (50) Meters of Breast for Junior Wadad Kadhim Majid
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

In the introduction and importance of the research, the importance of the muscular ability to harmonize the formation and formulation of specific physical characteristics of many games with motor performance, including swimming, which need to link the strength and speed together to the muscles working in the performance, and the importance of research in the use of training exercises to perform muscle training Harmonic characteristic of the speed of the muscles of the arms and legs to promote the players, which in turn is working on the development of the completion of (50) meters breast. The problem of research is that many players are characterized by good physical and physical ability, but cannot perform any movements that require a certain amount of coherence and compatibility at the same time, the chest swell is far from the normal movements performed by the player in his public life, as well as it needs to High level of motor timing and muscle compatibility, which is the blows of the legs and the blows of the arms and the process of linking them to the breathing process, which are not familiar to the swimmer, especially in the younger ages of them. The aim of the study is to prepare a performance training to develop the musculoskeletal capacity of the two legs and arms of the young swimmers. 2 - Identify the effect of special exercises in the development of the rapid strength of the muscles of the legs and arms and the completion of the 50-meter breaststroke ages (11-13) years. The research hypothesis is that there are statistically significant differences in the effect of adaptive ability exercises in the results of the pretests on the dimension in the development of the rapid strength of the muscles of the legs and arms and the completion of (50) m. The researchers identified the research society and its sample with the specialized school for boys (11-13 years old) and officially registered in the Central Swimming Federation who continue in training and competition in the sports season (2017-2018) of (8) swimmers. Their number (4) players. Four of them were excluded due to repeated absence, thus representing 50% of the research community. The special exercises were carried out within the training curriculum for the sample which lasted eight weeks and three days a week for 24 training units. The researchers found several conclusions that the special compatibility ability exercises led to the development of muscular strength of the arms and legs in the junior swimming pool. Special compatibility resulted in the development of muscular capacity for both arms and legs, which had a good effect in the development of the digital achievement of (50) meters in the sample junior swim.Keywords: Performance training, harmonic ability and rapid force.
Estimation and Comparison of the Levels of Elastase in Saliva, GCF & Serum of Smokers and Non-smokers with Chronic Periodontitis -A Clinico-biochemical Study S. Srinivasan
Journal of Global Pharma Technology Volume 12 Issue 10 (2020) Oct. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: This study was done to estimate and compare the levels of Elastase in Saliva, GCF & Serum of smokers and non-smokers with chronic periodontitis. Materials and Method:125 male subjects in the age group of 21-50 years were enrolled and categorized as Group 1, Non-smoking subjects with healthy periodontium Group 2, Smoking subjects with healthy periodontium Group 3, Non-smoking subjects with Chronic periodontitis Group 4, Smoking subjects (10 Cigarettes/day) with Chronic periodontitis. Plaque Index, Gingival Bleeding Index, Probing Pocket Depth, Clinical Attachment Level, Salivary, GCF and Serum Elastase levels were recorded and evaluated using sandwich ELISA method. Results: The clinical parameters expressed a significant difference between diseased group and healthy group. Elastase levels (Saliva, GCF and Serum) showed significant difference between diseased group and healthy group. In between the diseased group comparison, GCF and Saliva showed Lower Elastase levels in smoking periodontitis group. Whereas, Serum showed higher Elastase levels. Conclusion: Elastase can be used as a reliable biomarker for smokers and non-smokers with chronic periodontitis to denote disease activity. Keywords: Periodontitis; Smoking; Elastase; Saliva; Gingival crevicular fluid.
Investigation of Antioxidant Status in Iraqi Patients with Beta- Thalassemia Major Jamela Jouda
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Oxidative stress is the most common complication in Beta-thalassemia patients due to ironover load that is resulted from long life blood transfusion leading to growth retardation, delay of sexualmaturation, and later involvement of the liver, heart, and endocrine system. Aim of study: Assess of someantioxidant parameter status in serum and saliva of patients with beta-thalassemia major in comparisonwith control subjects. Methodology: Total antioxidant (TAO), glutathione (GSH), uric acid (UA), urea (U)and albumin were investigated in serum and saliva samples of all subjects. Results: Albumin level inserum is significantly (P ˂ 0.00001) decreased in patients group (3.27 ± 0.17 g/dl) from that in controlgroup (3.59 ± 0.13 g/dl). However, TAO level was significantly elevated (P = 0.031) from (3.14 ± 1.38U/ml) in the saliva of control group up to (4.09 ± 1.76 U/ml) in the saliva of patients group as well assignificant difference (P = 0.02) in salivary fraction index (Sf) only for TAO which is elevated from 0.47 incontrol group up to 0.56 in patients group. Conclusion: The findings of this study indicated that theserum level of albumin can be used as a good marker to reflect the liver status in TM patient in additionto other conventional markers. Also this study suggested that saliva can be act as an alternative sampleto assess the antioxidant status in TM patients but need further investigation.Keywords: Beta thalassemia major, Iron overload, Antioxidant, Saliva.
PHYTOCHEMICALS AND ANTIMICROBIAL STUDIES ON COSTUS SPECIOSUS Dash, Deepti Prangya; Mohanty, Rajashree; Ray, Jassaswi
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

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Abstract

The aim of the present study was to investigate antimicrobial activity of methanolic extract of Costus Speciosus (CS). The percentage yield and physical status of the methanolic leaf extract (MECS) and chloroform (CSC) and aqueous fractions Costus Speciosus (CS) are showed. The antibacterial activity of a compound is expressed in terms of its ability to inhibit the growth of bacteria in nutrient broth or agar media. The bacterial growth inhibition can be measured by two methods (Cup plate method and Serial dilution method ) . Nutrient broth has been used for the preparation of inoculum of the bacteria and nutrient agar is used for the evaluation of antibacterial activity. All the Extracted compounds (BMC & BMQ), were found to be effective antibacterial agents. Antifungal activity evaluation against C. Albicans showed that compound BMH also did not possess significant antifungal properties. The study confirms that Costus Speciosus (CS) and all possess antimicrobial activity with different potency against variety of selected microorganisms. The differentiating activities of these extracts encourage developing an ovel broad spectrum antimicrobial herbal formulation in future. Costus Speciosus (CS), Antimicrobial Activity, Antifungal Activity, MECS, BMC & BMQ, BMH, Albicans.
PREVALENCE OF HELICOBACTER PYLORI IN OBESE PATIENT Altaee, Mohammed J.; Mohammed, Bilal; Jasim, Ahmed S.; Abdulkadhm, Hasanin
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Helicobacter pylori is a widely recognized pathogen that exhibits a high prevalence among the global population. The infection caused by H. pylori poses significant health risks due to its association with various gastrointestinal disorders, including gastric ulcers, duodenal ulcers, chronic gastritis, and gastric carcinoma. The regulation of gastric hormones, such as ghrelin and leptin, plays a crucial role in energy homeostasis. Ghrelin, secreted by P/D1 cells in the stomach during periods of hunger, stimulates appetite and promotes food consumption. Conversely, leptin, released by P cells in the stomach and adipocytes after food intake, reduces appetite and fosters a sense of fullness. Individuals infected with H. pylori tend to have lower plasma levels of both ghrelin and leptin compared to those who are not infected. Consequently, the reduced serum leptin levels can delay the sensation of satiety during meals, leading to increased energy intake and a potential development of obesity. Aim: Our study has been proposed and structured to achieve the below objectives: Prevalence of H. pylori associated with overweight. Presence or absence of some clinical signs among patient. Prevalence of infection among age group. Methods: Blood seem were collected from 30 person during the period from February to April 2023 and both gender were participate in this study with age ranging from 20-50 years old.Blood tests were used to measure the antibodies against H pylori. The sample were collected and small amount of it applied in to well In the test line area, anti-human IgG is rendered immobile. Following its addition to the device's specimen well, the specimen reacts with the test's H. pylori antigen-coated particles. This mixture interacts with the immobilized anti-human IgG and migrates chromatographically over the course of the test. A colored line will show up in the test line region, signifying a positive result, if the samples contain H. pylori antibodies. A colored line indicating a negative result won't show up in this area if the specimen is devoid of H. pylori antibodies. To act as a methodical. Result: Our study shows that Middle age group were the highest percentage among other age group (35 %). In another hand the overweight patient suffering from H. pylori infection constitutes about 36.7 %. Keywords: Helicobacter Pylori, Obese Patient, Infection.
BIOLOGICALS AND BIOSIMILAR: ADVANCING HEALTHCARE THROUGH INNOVATION AND ACCESSIBILITY Pal, Pradeep; Chorasiya, Anjali; Jawani, Akanshag; Rathore, Chalsy; Panwar, Mangal Singh
Journal of Global Pharma Technology Volume 17 Issue 02 (2025) Feb. 2025
Publisher : Journal of Global Pharma Technology

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Abstract

“Biologics” considered one of the fastest growing sectors of the pharmaceutical industry; “Biologics” have introduced many new treatments for life-threatening and rare diseases. The first generation of bio pharmaceutical products produced using recombinant technologies was launched in the 1980s and is now on the way to patent expiration. As a result, research and generic pharmaceutical companies are seizing the opportunity to develop “generic” substitutes for original biologics, referred to here as biosimilars. However, the process of introducing an innovator's biosimilar product is much more complex than the relatively straightforward process of introducing a generic equivalent of an innovator's product based on a new chemical entity. Biologics are produced by cells in culture or whole organisms, which are inherently more variable than chemical synthesis methods. Therefore, unlike generic drugs, it is not possible to create an identical or identical copy of the innovator product. In this way, biosimilars are "similar but not the same" or in other words biosimilars are "a twin but not a clone" of the original biologic innovator product. The field of biosimilars therefore presents several important challenges, including i) validation of similarity, ii) interchangeability of biosimilar and innovative products, iii) possible need for a unique nomenclature to distinguish different bio pharmaceutical products, iv) regulatory framework, v) business opportunities as well as guidance for assistance to manufacturers in product development, vi) intellectual property rights and vii) public safety. Keywords: Biosimilars, Biological drugs, Innovative product, Pharmacovigilance.
PHYTOCHEMICALS AND ANTIMICROBIAL STUDIES ON COSTUS SPECIOSUS Dash, Deepti Prangya; Mohanty, Rajashree; Ray, Jassaswi
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of the present study was to investigate antimicrobial activity of methanolic extract of Costus Speciosus (CS). The percentage yield and physical status of the methanolic leaf extract (MECS) and chloroform (CSC) and aqueous fractions Costus Speciosus (CS) are showed. The antibacterial activity of a compound is expressed in terms of its ability to inhibit the growth of bacteria in nutrient broth or agar media. The bacterial growth inhibition can be measured by two methods (Cup plate method and Serial dilution method ) . Nutrient broth has been used for the preparation of inoculum of the bacteria and nutrient agar is used for the evaluation of antibacterial activity. All the Extracted compounds (BMC & BMQ), were found to be effective antibacterial agents. Antifungal activity evaluation against C. Albicans showed that compound BMH also did not possess significant antifungal properties. The study confirms that Costus Speciosus (CS) and all possess antimicrobial activity with different potency against variety of selected microorganisms. The differentiating activities of these extracts encourage developing an ovel broad spectrum antimicrobial herbal formulation in future. Costus Speciosus (CS), Antimicrobial Activity, Antifungal Activity, MECS, BMC & BMQ, BMH, Albicans.
PREVALENCE OF HELICOBACTER PYLORI IN OBESE PATIENT Altaee, Mohammed J.; Mohammed, Bilal; Jasim, Ahmed S.; Abdulkadhm, Hasanin
Journal of Global Pharma Technology Volume 16 Issue 12 (2024) Dec. 2024
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Helicobacter pylori is a widely recognized pathogen that exhibits a high prevalence among the global population. The infection caused by H. pylori poses significant health risks due to its association with various gastrointestinal disorders, including gastric ulcers, duodenal ulcers, chronic gastritis, and gastric carcinoma. The regulation of gastric hormones, such as ghrelin and leptin, plays a crucial role in energy homeostasis. Ghrelin, secreted by P/D1 cells in the stomach during periods of hunger, stimulates appetite and promotes food consumption. Conversely, leptin, released by P cells in the stomach and adipocytes after food intake, reduces appetite and fosters a sense of fullness. Individuals infected with H. pylori tend to have lower plasma levels of both ghrelin and leptin compared to those who are not infected. Consequently, the reduced serum leptin levels can delay the sensation of satiety during meals, leading to increased energy intake and a potential development of obesity. Aim: Our study has been proposed and structured to achieve the below objectives: Prevalence of H. pylori associated with overweight. Presence or absence of some clinical signs among patient. Prevalence of infection among age group. Methods: Blood seem were collected from 30 person during the period from February to April 2023 and both gender were participate in this study with age ranging from 20-50 years old.Blood tests were used to measure the antibodies against H pylori. The sample were collected and small amount of it applied in to well In the test line area, anti-human IgG is rendered immobile. Following its addition to the device's specimen well, the specimen reacts with the test's H. pylori antigen-coated particles. This mixture interacts with the immobilized anti-human IgG and migrates chromatographically over the course of the test. A colored line will show up in the test line region, signifying a positive result, if the samples contain H. pylori antibodies. A colored line indicating a negative result won't show up in this area if the specimen is devoid of H. pylori antibodies. To act as a methodical. Result: Our study shows that Middle age group were the highest percentage among other age group (35 %). In another hand the overweight patient suffering from H. pylori infection constitutes about 36.7 %. Keywords: Helicobacter Pylori, Obese Patient, Infection.
BIOLOGICALS AND BIOSIMILAR: ADVANCING HEALTHCARE THROUGH INNOVATION AND ACCESSIBILITY Pal, Pradeep; Chorasiya, Anjali; Jawani, Akanshag; Rathore, Chalsy; Panwar, Mangal Singh
Journal of Global Pharma Technology Volume 17 Issue 02 (2025) Feb. 2025
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

“Biologics” considered one of the fastest growing sectors of the pharmaceutical industry; “Biologics” have introduced many new treatments for life-threatening and rare diseases. The first generation of bio pharmaceutical products produced using recombinant technologies was launched in the 1980s and is now on the way to patent expiration. As a result, research and generic pharmaceutical companies are seizing the opportunity to develop “generic” substitutes for original biologics, referred to here as biosimilars. However, the process of introducing an innovator's biosimilar product is much more complex than the relatively straightforward process of introducing a generic equivalent of an innovator's product based on a new chemical entity. Biologics are produced by cells in culture or whole organisms, which are inherently more variable than chemical synthesis methods. Therefore, unlike generic drugs, it is not possible to create an identical or identical copy of the innovator product. In this way, biosimilars are "similar but not the same" or in other words biosimilars are "a twin but not a clone" of the original biologic innovator product. The field of biosimilars therefore presents several important challenges, including i) validation of similarity, ii) interchangeability of biosimilar and innovative products, iii) possible need for a unique nomenclature to distinguish different bio pharmaceutical products, iv) regulatory framework, v) business opportunities as well as guidance for assistance to manufacturers in product development, vi) intellectual property rights and vii) public safety. Keywords: Biosimilars, Biological drugs, Innovative product, Pharmacovigilance.
COMPARARIVE STUDY OF EFFECT OF SUBSTITUENTS PRESENT ON CEPHALOSPORIN RING ON THE ANALYTICAL METHOD AND STATISTICAL PARAMETERS OF VARIOUS GENERATION DRUGS Dilip M. Chafle
Journal of Global Pharma Technology Volume 17 Issue 11 (2025) Nov.2025
Publisher : Journal of Global Pharma Technology

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Abstract

Cephalosporin are very important class of antibiotic drugs which frequently prescribed by medical practitioners in modern allopathy for treatment of bacterial infections. In the present study Cefadroxil, Cefalexin, Cefaclor, Cefuroxime, Cefixime, Cefotaxime, Cefepime and Cefpirome drugs of various generation cephalosporin were selected. The spectrophotometric technique was used to study the effect of substituents of cephalosporin ring on the analytical method and statistical parameters of varios generation cephalosporin drugs. In the proposed method Fe (III) is reduced to Fe (II) by reacting with cephalosporin drug and then complexed with 1, 10 Phenanthroline. The reaction conditions for each drug such as maximum wavelength of absorption, time for complexation of reaction, volume of Fe (III) solution, volume of 1, 10 Phenanthroline solution and volume of phosphoric acid are optimized. The other parameters such as Beer’s law limit, molar absorptivity, Sandell’s sensitivity, regression equation and correlation coefficient have been determined. Lastly correlation of the substituent present on cephalosporin rings in various generations and their effect on analytical method and statistical parameters have been evaluated. Keywords: Spectrophotometry, Cephalosporin, Comparative study, Generation, Substituents.

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