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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Effect of Repetition Training in Develop the Physical Fitness and Improve the Sense-Kinetic Perception for the players of Volleyball Labeeb Zouyan Moseekh
Journal of Global Pharma Technology .
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Abstract

This study aims at finding out the impact of a Repetition training on developing the kinetic sensory perception of Al-Anbar University players for the academic year 2017-2018, where, (14) player of Volleyball team in college of physical education and sports science_ have been subjected to this  training program. The researchers utilize the empirical method depending on the prior and post measurement for one group in order to determine the range of the physical fitness program effectiveness on developing some of the kinetic sensory perception variables. The results show that the conducted program actively affected on the sense of the muscular grip, of time, and of distance which contributes at improving the student's physical fitness level, as well as, at developing the kinetic sensory perception variables. Moreover, the results also show the decreasing of assessment fault of these variables of the sample. The researchers recommend the necessity of emphasizing the importance of physical fitness before the starting the motor skills and using the proposed program for developing the kinetic sensory perception variables.Keywords: Repetition Training, Physical Fitness and Sense-Kinetic Perception.
Ability of Manufacturing of Bioformulations using Trichoderma spp for Biological Control of Some Plant Pathogenic Fungi Ahmed Mshari
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The aims of this study were to Ability of manufacturing of bioformulation using Trichoderma spp, Seven isolation of Trichoderma spp are evaluated as antagonist of five soil-borne fungal diseases, in dual culture, antagonistic activity of T. harzianum (Th3) was showed highest percentage inhibition compare with the other Trichoderma species, which caused 100, 79.16, 69.23, 63.88 and 58.33 % inhibition mycelial growth of Fusarium solani , Fusarium oxysporum f. sp. lycopersici, Fusarium oxysporum f. sp. melonis, Macrophomina phaseolina and Rhizoctonia solani  respectively. Among five groats grains used as substrate for Th3,  Corn substance  has  recorded  the maximum colony forming unit (CFU) produce  27 x 108 g or ml  followed  by  Millet, Barley, Wheat and Rice which record 20,66, 16, 10,33 and 8,66 respectively. Prepared nine different Trichoderma formulations and tested for their shelf life up to 150 day the result showed formulation which has higher shelf life and stress protection was ThT and ThS which record 20.33x108 and 19.66 x108 CFU/ ml respectively and followed by ThG, STCG, CTCG and LTCG which record 11.33 x108, 4.33 x108, 3.33 x108 and 3 x108 CFU/ ml while minimum CFU was  by  ST ,LT, and CT to 1.33 x108 CFU/ ml, 1 x108 CFU/ ml, and 0.66 x108 CFU/ ml respectively.Keywords: Bioformulation, Soil-borne fungal diseases, Antagonistic, Substance, Shelf life.
Antimicrobial Effect of Bacillus Spp. on MRSA Samarah Jafar Alwash; Zahraa A. Jabur; Maha Mohammad; Saad Sabah Fakhry; Farqad Farhan Abdulhammed
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

There are many antimicrobial peptides produced by Bacillus species, which have a bacteriostatic and/or bactericidal activity. The aim of this study is to investigate the antimicrobial activity of Bacillus spp. against methicillin-resistant Staphylococcus aureus (MRSA) by analyzing 59 Bacillus spp. isolated from rice and spices using the agar well diffusion method in terms of their general inhibition effects on some MRSA isolates. Nine isolates were found to be effective against MRSA and their effects were compared with some antibiotics. The study showed that many Bacillus spp. has antimicrobial effect against MRSA3 which is resistant to all antibiotics except vancomycin. It has been found that Bacillus lentus is more effective against MRSA when compared with some antibiotics. Further studies may be required to assess the use of Bacillus lentus as therapeutic and bio preservative in food processing industry.Keywords: MRSA, Bacillus lentus, Antimicrobial peptides, Antibiotic, API-CHB-50.
Epidemiology of Staphylococcus Aureus Clinical Isolates Causing Skin and Soft Tissue Infections Among Patients in the Community Settings At Primary Healthcare Centres in Sidoarjo Region-East Java, Indonesia Sugiharto .
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objectives To determine percentage of case finding of Staphylococcus aureus, methicillin resistant Staphylococcus aureus (MRSA) and panton–valentine leukocidin (PVL)-positive Staphylococcus aureus (S. aureus) isolated from skin and soft tissue infections in the community settings at Primary Healthcare Centres in Sidoarjo region, Indonesia and the relationship of risk factors of Staphylococcal skin and soft tissue infections. Methods S. aureus isolates from clinical cultures of patients in 2 Primary Healthcare Centres were included. Wound cultures were performed to identify the MRSA phenotypically using VITEK® 2 system. The mecA gene and genes encoding PVL were detected using Polymerase Chain Reaction (PCR). Clinical data including gender, age, hospitalization history in primary health care center and hospital, comorbidity (diabetes mellitus) history and antibiotic history, were collected from questionnaires and medical record. Statistical analysis was done by Chi-square-Fisher’s exact test. Results In total, 45 patients involved in this study. The 20 patients consisted Staphylococcal strain, and 25 patients did not. Of the 20 Staphylococcal strains, 3 samples were Staphylococcus coagulase negative, 1 sample was Staphylococcus gallinarum and another sample was Staphylococcus haemolyticus. There were 15 patients (33.3%) were infected by S. aureus. Of these, 13 isolates were MRSA-positive (28,9%) and 1 isolate was PVL-positive (2,2%). Analysis showed no relationship between the risk factors and finding of S. aureus, neither MRSA and PVL in all patients (p > 0.05).Conclusions S. aureus is common in the community. The MRSA is clinical importance in Indonesia, not only in hospitals, but also in the community settings. High case of MRSA was found in this study. However, the case of PVL-positive S. aureus was low. It is very important to promote case finding by detecting MRSA in the community settings. A national surveillance system should be set-up for further monitoring this.Keywords Methicillin-resistant S. aureus, Panton–valentine leukocidin, Staphylococcus aureus, community setting, Prevalence.
Comparing Autoimmune Hypothyroidism Patients with Normal Subjects in Terms of Serum Vitamin D Alireza Mehdizadeh
Journal of Global Pharma Technology .
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Abstract

Introduction Autoimmune diseases of the thyroid known as Graves and Hashimoto are the most common autoimmune diseases that vitamin D levels of these patients is different from that of healthy individuals. In this study, we examine vitamin D level in patients with Hashimoto's thyroiditis and compare them with the healthy group. Method This research is a case-control study. In this study, 65 patients with Hashimoto thyroiditis and 60 healthy people were randomly selected. Hashimoto thyroiditis patients diagnosed recently and not treated with any hormone were referred to laboratory to examine the 25-hydroxy-vitamin D and the results were analyzed using SPSS16.Results The results of this study showed that there is no significant difference between two groups of study and control in terms of variables such as age, height, weight, 25-hydroxy D3, BMI and TSH, and gender.Discussion and conclusion there is no correlation between 25-hydroxy D3 and TSH and Anti TPO, and most of other studies confirm this result.Keywords: Autoimmune, Vitamin D, Patients.
A Brief Review Self Nanoemulsifying Mouth Dissolving Film: Formulation and Applications in Herbal Medicine Lusi Nurdianti
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The use of herbal medicines is increasing, because of the belief that natural medicines have fewer side effects than synthetic drugs. But many herbal products show low therapeutic action due to problems with solubility and improper molecular size which have an impact on low bioavailability despite having good potential. The development of self nanoemulsion (spontaneous nanoemulsion) in fast-dissolving intraoral film preparations is one alternative formulation that can be used, to improve the limitations of bioavailability and increase patient acceptance and compliance because the application of developments is effortless, given through the oral cavity, so that direct absorption occurs in the cavity mouth and enter the systemic circulation without experiencing the effects of the first cross metabolism. This study aims to explain the concepts and techniques of self nanoemulsion formulation in intraoral (mouth dissolving film) preparations to increase the bioavailability of natural active compounds in extracts with low solubility in water and their characterization and evaluation.Keyworlds: Self nanoemulsifying, Mouth dissolving fim, Herbal medicine, Bioavailability.
Synthesis and Characterization of New Schiff Bases Derivative from 2, 5ـ Dimarcaptothiadiazole Israa Taha Ibraheem
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

This research includes synthesis of new heterocyclic containing Schiff bases derivatives of 2, 5ـdimarcapto thiadiazole. The preparation process started by the reaction of  2,5ـdimercaptoـ1,3,4ـthiadiazole (1) with ethyl chloroacetate to give diethyl 2,2`-(1,3,4-thiadiazole-2,5-diyl)bis(sulfanediyl)diacetate (2). Compound (1) reacted with hydrazine hydrate to give 2, 5ـbis (mercaptoـacetichydrazide) 1, 3, 4ـthiadiazole (3). The reacted with various substituted benzaldehydes in the presence of glacial acetic acid as catalyst in absolute ethanol to obtain new Schiff bases derivatives (4-13).Keywords: 2, 5ـ dimercaptoـ1, 3, 4ـthiadiazole, Schiff bases.
Evaluation Some Immunological Markers in Patients Infected with Hydatid Cysts Saleem Khteer Al-Hadraawy
Journal of Global Pharma Technology .
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Abstract

A hydatid cyst is the important disease reported parasite worldwide. The aim of this study was to investigate the PGE2, GM-CSF, TGF- β1 and IL-13 concentration in patients infected with hydatid cyst. We registered 60 patients with Hydatidosis which separated as30 male and 30 female and the control groups consisted of healthy subjects 30 separated as 15 male and 15 female. The results demonstrated that there was a significant increase (P < 0.05) in the PGE2, GM-CSF, TGF- β1 and IL-13 levels, Hydatidosis patients as compared to the healthy group.Key words: Hydatid cyst disease, IL-13, TGF- β1and GM-CSF.
Serum Zinc Level Correlation with urinary Arginase in Patients with Bladder Cancer in Babylon Governorate Ahmed F.F. Al-Baaj
Journal of Global Pharma Technology .
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Abstract

The present study aims to determine the level of serum zinc and its correlation with urinary arginase level in patients with bladder cancer compared to healthy control group. The type of present study is a case-control study. Forty-five patients with bladder cancer and forty-five healthy persons as a control in Babylon province /Iraq participated in this study. Results of the present study were shown significant decreases in serum zinc and significant increases in the urinary arginase levels in patients with bladder cancer when compared with control group, especially in muscle-invasive bladder cancer. Also, there was significance negative correlations of serum zinc level and urinary arginase level, In conclusions, present study propose that patients with bladder cancer in Babylon province have low zinc level comparing to normal subjects and this level decrease extremely as the cancer progress to higher stage. As regard zinc have antioxidant and immune boosting properties, zinc is a cofactors for a wide range of enzymes, zinc deficiency leads to decrease superoxide dismutase activity and that may be an important cause for initiating oxidative stress and worsen the prognosis of bladder cancer. The present study also proposesthat Increased level of urinary arginase in bladder cancer patients is related to increased production of polyamine and this will promote cancer growth and development to a higher stage. Keywords: Bladder cancer, Zinc, Urinary arginase.
Detection of Colorectal Cancer Specific APC Deletion in Peripheral Blood Culture in Iraqi Population by FISH Technique Haidar J. Muhammed
Journal of Global Pharma Technology .
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Abstract

Colorectal cancers (CRC) are classified as tumor phenotypes based on molecular profiles in which the most common defect is inactivation of adenomatous polyposis coli (APC) gene. This study included (20) patients male and female suffered from tumor of CRC range aged less than 20 and farther 60 years compared with (5) healthy individuals as a control. Samples collected from colonoscopy unit from Baghdad Teaching hospital and National Center Hospital for early detection of cancer related to Ministry of Iraqi Health. Deletion of APC gene was further verified on chromosomal level on metaphase spreads by peripheral blood lymphocytes (PBLs) culture so as value screening by using fluorescence in situ hybridization (FISH) technique. The results described the identification of classical familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP) and  sporadic colorectal cancer as in58.3%, 25%,and 16.7 % respectively which were showed significant differences (P≤0.01) compared with healthy control, so as a deletion of arm specific 5q of APC gene which showed significant differences (P≤0.01). In conclusion of this study explained the APC gene alteration localized on 5q arm have an essential role in prognosis and prognostic of colorectal cancer.Keywords: APC gene, 5q arm chromosome, AFAP and FAP gene incolorectal cancer. 

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