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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Effect of Sensory Kinetic Exercises in the Development of Some of the Functional Abilities and the Accuracy and Strength of Serving Skill in Tennis Hameed Hammad Khalaf
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The problem lies in the apparent decrease in the accuracy and strength of the serving performance of theAnbar University team in tennis and the lack of focus on the mental abilities and linking them to thephysical and skillful aspects, which necessitated the researchers to go into this problem through thedevelopment of sensory - kinetic exercises to address this decline. The research aims at identifying theeffect of sensory-kinetic exercises in the development of the functional abilities, and the accuracy andstrength of serving in tennis. The researchers hypothesized that the impact of exercises has a statisticalsignificance on the functional abilities and the accuracy and strength of the skill of serving in tennis.They used the experimental approach to design the two equal groups and on a sample of (12) players.The field procedures of the research were by conducting the pretests on Wednesday, 4/10/2017 at 11amon the outdoor tennis court and the closed hall at the college. The sensory-kinetic exercises were carriedout over 6 weeks at three units per week. On Sunday, 12/11/2017 at 11 am the post-tests were conductedin the same court and conditions similar to the conducting of the pretests. The researchers concludedthat the controlling and experimental groups developed but the experimental group that used sensorykineticexercises was more advanced in the post-tests. They recommend the emphasis on using thesensory-kinetic exercises to develop the skill of serving, other tennis skills, and other individual andteam sports.Keywords: Sensory, Kinetic exercises, Functional abilities, Accuracy and Serving skill.
Modest Simultaneous Determination of Acetylsalicylic Acid and Salicylic Acid in Plasma by High Performance Liquid Chromatography UV Detection Yahdiana Harahap
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: Acetylsalicylic acid (ASA) is one of the drugs used in antiplatelet therapy. ASA is rapidly hydrolyzed to salicylic acid (SA) and has low levels in plasma. Analysis of ASA and SA in plasma has been done using LC-MS/MS, UHPLC, and HPLC with hydrolysis and fluorescence detector. Compared to those methods, HPLC equipped with UV detector is less expensive. The method using HPLC with UV detector also has been done but not sensitive enough according to the LLOQ. Therefore a sensitive and selective analysis method needs to be developed. This study aims to develop an analytical method of ASA and SA in human plasma using HPLC with UV detector.Method: The method used in this study is Reversed Phase - High Performance Liquid Chromatography using C18 column (Waters, Reliant™ 5 μm; 250 x 4.6 mm) with UV-Vis detector and was detected at wavelength of 230 nm. This method was developed using furosemide as internal standard (IS). Human plasma containing ASA and SA was extracted after protein precipitaion method using 15% perchloric acid with a liquid-liquid extraction method using ethyl acetate.Result: The method obtained was linear (r ≥ 0.99) at concentration range of 0.05 – 1.5 μg/mL for ASA and concentration range of 0.2 – 5.0 μg/mL for SA. The validation result of ASA and SA analytical method fulfilled the validation requirement of EMEA Bioanalytical Guideline in the year 2011. Therefore the method provides modest, sensitive, and selective measurements of ASA and SA concentrations.
Role of Leptin in Iraqi Male Infertility Batool A. Al-Haidary
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: Many etiological factors participate in initiation and development of males’ infertility. Leptin is an adipokine that play a crucial role in obesity and many other biological effects. One of these its effects are on Hypothalamus and Pituitary glands to which males’ infertility may be attributed.  Aims of Study: This study was designed to investigate the role of Leptin and its’ receptor in development of infertility among Iraqi males Materials & Methods: Seventy sub-fertile males were included in this investigation to estimate Leptin and its receptor levels in seminal plasma by ELISA techniques. All patients had been diagnosed as a sub-fertile male under the supervision of consultant physician.  Seminal fluid analysis was performed for each patient. Body mass index for each patient was calculated besides sera LH, FSH and testosterone hormones determinations and the results of the above tests were compared with those for 30 normal fertile men who matched the patients in their ages. All data has been analyzed statistically. Results: The results revealed highly significant decline in the mean of leptin levels (27.283±3.034ng/ ml) among patients in comparison with healthy fertile control group (47.975±7.152 ng/ ml) (P=0.002). Moreover, LH hormone showed an increment in its mean level (34.699±1.594) in highly significant manner in comparison with control group (14.859±1.947) (P= 0.001). This study referred to highly significant correlation between leptin receptor and BMI (P=0.0001), in addition to significant correlation with testosterone (P=0.046). Meanwhile significant correlation was observed between leptin and FSH (P=0.027). Conclusion: In view of the above results it can be concluded that there is an association between Leptin and FSH which in turn significantly correlated with sperms’ count and theirs ’motility.Keywords: Leptin, Obesity, Sex hormones, LH, FSH, Testosterone, Seminal fluid analysis.
Effects of Emodin on CCl4 Induced Liver Fibrosis in Mice Model Mohannad Falah Hassan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Many compounds demonstrated an anti-fibrotic activity, but none have been used in the clinics. The current study aims to assess the in-vivo emodin anti-fibrotic activity in liver fibrosis. Thirty-two mice were divided into four groups; the first group is composed of eight healthy mice to be a negative control group, while the remaining twenty-four mice had received intraperitoneal carbon tetrachloride 1ml/kg twice weekly for six weeks. Then, eight of these mice were sacrificed to be a positive control group, while the remaining sixteen mice were divided into two groups; one received six intraperitoneal doses every other day of emodin 40 mg/kg and the other received silymarin 20 mg/kg. Mice livers have taken and examined histopathologically to confirm the diagnosis of liver fibrosis and to assess the antifibrotic effects of emodin, then immunohistochemical evaluation was done for collagen III and Interleukin-4 secretion. Statistics used are ANOVA test followed by Tukey’s post HOC analysis. Emodin reduces fibrosis significantly in histopathologic sections, collagen content and Interleukin-4 content (in which p˂0.0001 was significant). There is no significant difference between emodin and silymarin in lowering fibrosis grade (p=0.1411), collagen III level (p=0.958729), and interleukin-4 level (p=0.144028). Emodin anti-fibrotic effects is related to lowering nuclear factor-ĸB leading to IL-4 lowering, decrease of epithelial mesenchymal transition by increasing E-cadherin, suppression of TGF-ß1 Smad signaling, Up-regulation of metastasis‑ associated gene 3, inhibits the Toll-like receptor-4 (TLR-4) pathway, and blocking the migration and proliferation of HSCs induced by platelet derived growth factor. Emodins have anti-fibrotic activity comparable to that of silymarin and can alleviate liver cirrhosis.Keywords: Liver fibrosis, Collagen III, Emodin, Interleukin-4, Silymarin.
Nurses Awareness Regarding Detection of Tuberculosis Cases in Babylon Hospitals Hayder Mohammed
Journal of Global Pharma Technology .
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Abstract

Tuberculosis consider one problem that threaten a public health in world and specially in developing countries, the detection of TB cases is very important in eliminate the prevalence rate of this disease among society and also lead to success the treatment regime of TB. The  nursing staff has crucial role in given the appropriate care for patients and also direct contact with patients in various sites of health facilities, therefore the improve the nurses awareness regarding detection of TB cases is important to control and decrease the risk of spread this disease. Quantitative research, descriptive design cross sectional study consisting of 80 nurses working in different site at Al-Hilla General Teaching Hospital. The result show the number of male (52.5%) higher than the number of female (47.5%), more nurses with secondary certificate as educational level (44.0%), the assessment of response rate of study sample for knowledge and awareness related TB is moderate level (40.0%) as higher percentage while the attitude and practice related TB is equal assessment between low and moderate level (47.5%).  Keywords: Nurses, Awareness, Detection of Tuberculosis, Babylon Hospitals.
Tuberculosis Correlation with Age and Gender in Kirkuk City-Iraq Ibrahim Mohammed Saeed Hussein
Journal of Global Pharma Technology .
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Abstract

The study performed from 1st of January 2017 to 1st of April 2018. It was included (1042) patients data were collected from patients attending the Consultant Clinic for Chest and Respiratory Diseases in Kirkuk City. Results of the diagnostic procedure performed by direct microscopically technique using Ziehl-Neelsen (ZN) stain method for detecting Mycobacterium tuberculosis. The data showed that 523 of them were male and 519 of them were female patients. The examination results registered 83(7.96%) positive cases, 37(3.55%) of them were male whereas 46(4.41%) were female patients. According to the age group the results indicated that the age ranges of (15-24 years) showed the highest percentage of tuberculosis infection 18(21.68%) of the total positive cases, 7(8.43%) occurred in males and 11(13.25%) occurred in females. It was concluded that the highest proportion of positive TB cases were among the age group of (15-24 years) in both males and females..Keywords: Active PTB, Tuberculosis, Age & sex.
Insilico and Electron Microscope Study about Attachment of Mesenchymal Stem Cell Derived from Stromal Vascular Fraction to Scaffold (Bovine Bone Cancellous, Hydroxyapatite-Calcium Sulphate, Calcium Phosphate) Panji Sananta
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Objective: Insilico study using molecular docking with Hex had already surpassed all of the other previous approach in assessment of molecular binding to scaffold. The combination of insilico study to investigate the molecular binding to scaffold and electron microscope to assess the population density of adipocyte derivative stem cells by measuring the number of cluster cells could show the inter cell communication between adipocyte derived stem cell and scaffold. The aim of this study is to prove the attachment of mesenchymal stem cell (MSC) from stromal vascular fraction (SVF) to scaffold.Methods: The research is true experimental research using molecular docking with HEX version 8.0. Electron microscope used to measure the density and number of cluster cells of adipocyte derivative stem cells.Results: The strongest bound to scaffold is between MSC from SVF to hydroxyapatite in both receptor which was Integrin Alpha V to Hydroxyapatite which need a total energy of -89.24 (J/Mol) and Integrin Beta 2 to Hydroxyapatite which need a total energy of -177.8 (J/Mol). The highest impact obtained from hydroxyapatite-calcium phosphate with an average value of 12.66 cluster cells counting per 100 µm2 scaffold material observed by electron microscope.Conclusion: This study showed that MSC from SVF could attach to scaffold with stronger binding between Integrin Alpha V and Integrin Beta 2 to hydroxyapatite. From microscope electron study we can prove that MSC can make a cluster cell in those scaffolds with hydroxyapatite-calcium sulphate having the biggest cluster cell counting.Keywords: Hydroxyapatite; Integrin Alpha V; Integrin Beta 2; Mesenchymal stem cell; Scanning electron microscope; Stromal vascular fraction.
Evaluation of In Vitro Antioxidant Activity of Ethanolic Extract from Vallaris solanacea Leave Pitchaimuthu Pandian
Journal of Global Pharma Technology Volume 13 Issue 01 (2021) Jan. 2021
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Abstract

Several methods employed in evaluating antioxidant activities on varied samples gives varying results depending on the specificity of the free radical or oxidant used as a reactant. This study investigated the antioxidation /radical scavenging properties since ethanolic extraction on Vallaris solanacea leaves. Antioxidant capacity on Vallaris solanacea leaves were evaluate near measuring a DPPH photometric assay, Superoxide radical scavenging activities, Iron chelating activities, Hydroxyl radical scavenging activity, Nitric oxide radical scavenging activities, Total antioxidant activities, Ferric Reducing Ability Power (FRAP) assay, full phenol content overall flavonoids content. A concentration was 125, 250, 500, 1000 μg/ml. The standard was used according to their methods. All values are expressed for mean ± SEM for three determinations with percentage of activity (±SEM) of IC50 values. The result revealed that DPPH as 625μg/ml, Superoxide radical scavenging as 459μg/ml, Iron chelating activity as 639μg/ml, Hydroxyl radical scavenging as 556μg/ml, Nitric oxide original scavenging as 683μg/ml, Total antioxidant as 638 μg/ml, FRAP as 543μg/ml and the total phenolic , flavonoids content was 3.980±0.007 and 2.651±0.077. The findings from the study reveal that the antioxidative potentials of Vallaris solanacea leaves of ethanolic extract and could serve as free radical inhibitors, phenolic and flavonoids as possibly acting as principal antioxidantsKeywords: Vallaris solanacea antioxidant, phenols, flavonoids, free radical.
The Effectiveness of Positive Psychology on Improving the Happiness of Women Heading the Family Aliakbar Nakhaei Shahmahmoud
Journal of Global Pharma Technology .
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Abstract

The present study was conducted as a quasi-experimental research with pre-test and post-test with unequal experimental and control groups to evaluate the effectiveness of positivistic psychology on improving happiness among the women who were heads of the family. The statistical population of the present study consisted of all women heading the family whose specifications had been recorded in Birjand Social Welfare Organization and Birjand Imam Khomeini (RA) Relief Committee, and were the heads of the families resulted from divorce that among them 30 people were selected through convenience sampling method and assigned to experimental group (n=15) and control group (n=15). In order to measure happiness, Oxford Happiness Questionnaire was used. Also, to study the effectiveness of positivistic psychology, intervention method was used so that the experimental group received ten 90-minute sessions of training over a period of three months. To analyze data, covariance analysis and multivariate analysis of covariance were used. The results showed that the positivistic psychology effects on increasing of happiness of mother-child among female-headed families.Keywords: Positivistic psychology, Happiness, Women heading the family.
Calendula Officinalis: an Important Herb with Valuable Therapeutic Dimensions -An overview Arun K Mishra
Journal of Global Pharma Technology Volume 02 Issue 10: (2010) Oct.2010
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Calendula Officinalis: an Important Herb with Valuable Therapeutic Dimensions -An overview

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