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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Aerobic Endurance and Heart Pulse Rate among Male Undergraduate in Iraq after 8-Weeks Speed Play (fartlek) Intervention Program Husam Juma Rachid Al-Rubaie
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

This study aims to investigate whether 8-weeks (fartlek) intervention program could improve aerobic endurance and heart pulse rate to enhance the level of fitness for sedentary male students in Iraq. An 8-weeks (fartlek) intervention program depends on outdoor physical activities.44 sedentary undergraduate male students from Al-Mustansiriya University dorms. Were divided by two groups experimental and control group (n=22 in each group) completed practical tests at pre-test and post-test. The subjects of the groups were tested on 1500m run/walk to measure the aerobic endurance, the heart pulse rate measured at 3 times 1-min before, 1 and 3-min after. The collected data were analyzed statistically though analysis of t-test to find out the significant differences. The results showed that the (fartlek) exercises can positively influence the fitness of the sedentary male students.From the previous findings we can conclude the following conclusions:Fartlek training could be very useful method to develop the fitness variable of Aerobic Endurance.Fartlek training could be very useful method to develop the functional capability which is represented by heart plus rate level (before the effort and after the effort by one and three minute).Keywords: Fartlek, Aerobic Endurance, Heart pulse rate, sedentary undergraduate male students.
Molecularly Imprinted Solid-phase Extraction for the Selective Determination of Ciprofloxacin Designer Drugs in Pharmaceutical Preparations Yehya Kamal Al-Bayati
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

We have developed a new method with high sensitivity, low cost and high stability. Using a functional monomer, this method is based on a molecular polymer (MIP).Which is 2 (Trifluoromethyl) acrylic acid (TFMA), 3 (Trimethoxysilyl) propylmethacrylate (TMSA),suitable cross  linker and ciprofloxacin (CPF) template for the production of monolithic solid  phase micro  extraction (SPME) fiber. Used_ UV. Vis_ as (detector).All these analytical methods used to extract, preconcentration and selective Ciprofloxacin determination (CPF). Competence, The stability and duration of the manufactured fiber plays a fundamental and indispensable role in SPME. The aim of this study is to examine the factors influencing the polymerization and extraction procedures, as well as to explain the selectivity of the manufactured fiber in the CPF solution. Also related and unrelated compound selectivity .Under optimum conditions. For five patients repeated experiments for three measurements the relative standard deviations) RSD percent are range of at (10ـ50)ppm of CPFH)Percentage (2.57ـ3.25). The relative recoveries obtained for CPF are within the range of (95.40 ـ 99.28) in spiked human urine samples.Keywords: Ciprofloxacin / Molecularly imprinted polymer solid-phase extraction / UV. Vis.
The Effect of Echinococcus granulosus on TP53 and CTNNB1genes Sequence Alteration among hepatocellular Carcinoma Patients Zaynab Kh. Rasheed
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Echinococcus granulosus is one of the small tap worms that causes Hydatid cyst.  This study was planned for detection of the incidence among cancer patients at Tumor unit in Baghdad medical city. Eleven samples of liver biopsy out of 40 specimens taken from patients with liver cancer in this study. All patients were suffering from Hydatid cyst infection Patients of migratory encampment in and around Baghdad city Kirkuk, Diyala, and Tikrit Hospitals, suffering from hydatidosis. The present study showed that the predominance of hydatidosis was in the patients whose ages ranged between (≤20-60) years. The sensitivity and specificity of ELISA with hydatid cyst IgG were 96%. While Casoin test (immediate hyper sensitivity skin test) was 100%.  The majority incidence was recorded between (50-60) years. The study showed that the predominance of hydatidosis was higher in females 28(70%), than males12 (30%). Analysis of the gene sequence showed that there were genetic mutations occurred in the hepatic cells, and several locations underwent change in genetic sequence including TCC to TCT in exon 147(5), GGT to AGT in exon 152(5), ACT to CCT in exon 160(5), TAT to TGT in exon 203(6),ATG to CTG in exon 235(7).Keywords: TP53 gene, Mutation, Tumor, Hydatid cyst, Gene sequencing.
Comparison of the Casting Accuracy of Monopren in Two Different Implant Systems Elham Soltanpanah Dorbidi
Journal of Global Pharma Technology .
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Abstract

Statement of the problem the correct fit of implant-supported frameworks is obtained through taking a precise master cast which is quite similar to the patient’s intraoral orientation. The accuracy of implant casts depends on several factors including the impression technique and material, tray, implant angulations and depth, impression coping, the geometry of implant torque, and cast expansion. Purpose: this study aimed to evaluate the accuracy of open-tray and closed-tray impressions in two implant systems. Materials and method: two master casts of edentulous mandible were made of transparent acrylic resin. Bio horizon (n=30) and dio of implants (n=30) were inserted in either cast at 0 and 20° angles. Open- and closed-tray impressions were taken by using monopren material, and were poured with type iv stone cast. The related abutments were installed on the prepared casts. Digitizer in association with the 3d scanning system of atos software created point cloud of the casts and master casts. Finally, a comprehensive report of the deviations in x, y, and z axes were presented. Results: both the impression technique and implant system affected the impression accuracy significantly (p=0). but, the effect of implant angulations was statistically insignificant (p=0.793). Moreover, the interaction of implant system and impression technique was significant (p=0). However, no significant interaction was noted between the implant angulations and system or between the implant angulations and impression technique (p=0.944).conclusion: the impression technique and implant system play the key roles in the implants impression accuracy.Keywords: Impression accuracy; Impression technique; Implant system; Implant angulation; Impression material.
E-Prescription in Nigeria: A Survey Adebayo Omotosho; Justice Emuoyibofarhe; Peace Ayegba; Christoph Meinel
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Electronic prescribing or Electronic prescription (EP) is the computer-based electronic generation and transmission of a prescription.  EP systems help to increase accuracy and safety of patient prescription and reduce costs through improved legibility and electronic delivery. The motivation for EP is greater safety of drug use and to counter the current unacceptable levels of adverse drug events. This study evaluated the feasibility of hospitals in Nigeria to adopt an EP system. A survey was conducted in four hospitals in Nigeria to determine the economic, technical and organisational feasibility of adopting e-prescribing. Respondents included 42 medical practitioners - doctors, pharmacists, pharmacy technicians and assistants - working at the hospitals at the time of the survey. Respondents felt that implementation of an EP system is economically feasible (p=0.031) and organisationally feasible (p=0.032) but were ambivalent as to whether it is technically feasible (p=0.446). However, inadequate funding by the government does not provide for the health sector to acquire the necessary resources and training skills.
Investigation on the Effect of Origin of Carbon Steel Reinforcing Bar on the Corrosion Behavior in Artificial Concrete Solution Abdulkareem M.A. Al-Sammarraie
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The corrosion of steel reinforcing bar in concrete is very important point in fractures and damage of concrete building structures, many factors play important role in this problem. This research focuses on the effect of the origin of the carbon steel reinforcing bar on the corrosion parameters in simulate concrete solution (artificial), consisted of (Ca (OH) 2 (2gm), KOH (22.44mg), Noah (8mg). Two familiar types in the Iraqi local markets were followed, namely; locally produced sample and Ukrainian imported samples. Tafel plots and cyclic polarization procedures were conducted to estimate the corrosion parameters and pitting susceptibly of the two types using three electrodes potentiostat.The effect of temperature and some thermodynamic functions were measured in the range 20 to 50ᴼC. The microstructure and morphology was imaged using optical and atomic force microscope (AFM) respectively.Keywords: Steel reinforcing, Concrete solution, Artificial, Tafel.
Cardioprotective Activity of Polyphenolic Extract of Tubers of Cyperus Rotundus and Taurine against Isoproterenol - induced Myocardial Infraction in Rats: Troponin-I and Histological Findings Alyaa Majid
Journal of Global Pharma Technology .
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Abstract

Objective: The polyphenolic extract of tuberus of cyperus rotundus and taurine was studied for the cardio protective activity using isoproterenol induced myocardial infraction in female rats. Materials and Methods: Sixty of female rats (Rattus norvegicus) were used in the present study. Animals were divided into 10 groups ( 6 for each group). MI was induced in rats with ISO (85 mg/kg) twice at an interval of 24 hrs. ISO produced significant alterations in the troponin-I and necrosis in the heart. The effect of polyphenolic extract of tuberus of cyperus rotundus oral treatment for 21 days at two doses (15 mg and 30 mg/kg, body weight) and taurine at two doses (100 mg and 200 mg/kg, body weight) was evaluated against ISO- induced cardiac necrosis. Results: Significant myocardial necrosis and increase in serum levels of troponin-I were observed in ISO- treated animals as compared with the normal control animals. Polyphenolic extract of tubers of cyperus rotundus and taurine showed a significant cardio protective activity by lowering the levels of serum troponin-I and less myocardial necrosis. Conclusion: These findings the synergistic cardio protective effects of polyphenolic extract of tubers of cyperus rotundus and taurine during ISO-induced myocardial infraction in rats.Keywords: Isoproterenol, Cardiac troponin I, Myocardial necrosis, Histology, Cyperus rotundus, Taurine.
Study of Some Hormonal and Genetic Variants in Women with Polycystic Ovaries Syndrome in Baghdad City/Iraq Noor Thamer Hamood Al-Dolaimy
Journal of Global Pharma Technology .
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Abstract

The study was carried out to determine the impact of the levels of sexual hormones represented by (LH, FSH, Prolactin and Testosterone) and also to assess the damage in the genetic material of DNA (comet assay) through the standards which are represented by (Tail length, DNA in tail, and Tail moment). Hormonal levels were examined on the second day of the menstrual period for 50 women infected with polycystic ovary syndrome (patients) and 20 women without polycystic ovary syndrome (control). In addition to that, the hereditary caudate test was tested for 34 patients with polycystic ovary syndrome compared to 50 women in the control group. The results showed a significant increase in the level of Testosterone and a significant decrease in the level of Prolactin hormone levels of LH and FSH hormones were within normal values as well as the genetic instability of DNA is more common in women with polycystic ovary syndrome PCOS compared with control group women.Keywords: Sexual hormones, PCO and comet assay.
Temperature Discrepancy and its Relation to the Most Important Physiological (Hormonal) Variants According to Teaching Climate in Handball Lesson Nazar Hussein al-Naffakh
Journal of Global Pharma Technology .
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Abstract

The study includes several aspects focused on the importance of identifying hormones levels in the blood of (female) students according to the climate of teaching at different temperatures and recognizing the dysfunction of students. The method was through dividing the samples into three groups each group contains six students and the blood sample is withdrawn before, during, and after the lesson, each group within a certain climatic period, divided into a moderate period, a cold period, and a hot period, where the specialist took blood samples from students at different temperatures in the environment of teaching handball. The first period of the climate is the moderate period where the specialist took blood samples and examined them in vitro. The results were recorded. In the second period, the cold weather, blood samples were also taken from the students. They were examined and the results were obtained. Finally, the hot period, the specialist also drew blood from the students, examined them and obtained the results. After finalizing the field work, the results of the three groups were collected and statistically compared.Keyword: Temperature Discrepancy, Physiological, Teaching Climate and Handball Lesson.
Marital Satisfaction, Anxiety, and Health-Related Quality of Life in Myocardial Infarction Patients Devi Wulandari
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Anxiety is predictor of cardiac incidents and mortality, its relationship with Health-Related Quality of Life (HRQL) remains unclear, especially in married couples, yet a marital relationship as part of the immediate environment that can be a source of support or stress. The objective of this study is to shed light on the relationship between anxiety and HRQL by adding marital satisfaction as an independent predictor and moderator. A cross-sectional study was conducted on 214 myocardial infarction patients. The patients completed three questionnaires (McNew Health-Related Quality of Life, Couple Satisfaction Index, Cardiac Anxiety Questionnaire), analysed using a four-step moderated hierarchical multiple regression. In conclusion, anxiety and marital satisfaction significantly predict patients’ HRQL. There were no significant interaction effects between anxiety and marital satisfaction in predicting HRQL. These findings could spur further research in addressing the limitations of this study and similar studies, which in turn may direct future policies in healthcare.

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