cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
 1   2   3   4   5 
Search results for , issue "." : 1,092 Documents clear
Synthesis and Characterization of SM (III), Ce (III), Ni (II) AND Cu (II) Dinuclear Complexes Derived from Terephthaldehyde Qassim. Ksuadi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A new ligands  (H2L1, H2L2) and Theirs Binuclear  complexes with (SmIII ,CeIII, NiII and CuII  ). Both ligands  prepare in two steps, the first step dissolution  of terephthaldehyde in methanol and reacted under refluxe with O- phenylen diamine  to give N1,N1,-(1,4-Phenylenebis (methanylylidene) bis(benzene-1,2-diamine)  which reacted in the second step with  O-Vanillin to give the ligand6,6,-((1E,1,E)-((((1,4-Phenylenebis (methanylylidene)) bis(azanylylidene)) bis(2,1- phenylene) ) bis(azanylylidene  bis(methanylylidene)  bis(2- meth oxyphenol) (H2L1) and reacted with 2-Hydroxy-1- naphthaldehyde to give the ligand  1,1,-((1E)-((((1,4-phenylenebis (methanylylidene)) bis(azanylylidene)) bis (2,1- phenylene)) bis(azanylylidene))bis(methanylylidene)bis(naphthalene-2-ol (H2L2 ).The four complexes manufacture by immediate reaction of the ligands with appropriate metal chloride. The ligands and Theirs  complexes were characterize by spectroscopic methods ,Elemental Analysis (C.H.N),Infrared Spectroscopy (FT-I.R), Nuclear Magnetic Resonance Spectroscopy (1H-NMR),  Mass Spectra , Magnetic sensitivity and Molar conductivity .  The data of these measurements suggest a Sequare planer geometry for (CuII , NiII) ,  Monocapped octahedron for Ce III and Sm III  complexes .Keywords: Binuclear complexes, Terephthaldehyde, Schiff base, Inner-transition metals.
Cystatin C, E-glomerular Filtration Rate and Creatinine are Considered as a Marker in Iraqi Patients with Chronic Kidney Disease Mohammed Qasim Waheeb
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

People with diminished glomerular filtration rate (GFR) are at more serious hazard for cardiovascular disease and different comorbidities. Creatinine-based conditions are utilized to estimate GFR, recognize patients with potential kidney disease, and arrange them into various stages since serum creatinine is uncaring to changes in the GFR.The aim of study to assess analytic execution of serum cystatin C e-glomerular filtration rate and creatinine as markers of kidney function in patients. Sixty cases at various stages of renal disability and 30 healthy control groups were tried. serum cystatin C were higher in stage 2 chronic kidney disease (CKD) when contrasted with the control gathering (p<0.05). For stages 3– 5 the median levels of cystatin C and creatinine were observed to be essentially higher than the control group.Keywords CKD, EGFR, Cystatin, Creatinine.
Potential of Pomelo Fruit (Citrus Maxima) Extract on T47D, WiDr, and HepG2 Cancer Cells Vevi Maritha; Aris Hartono; Mega Arianti Putri
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.146 KB)

Abstract

Currently, alternative therapies are needed for breast, colon, and liver cancer patients. Those therapies are therapies that can selectively kill cancer cells without damaging other cells that have high development, such as hair and nails. One of those alternative therapies is the use of plants in cancer therapy. Pomelo has the potential as an anti-cancer agent because it contains phytochemical compounds, one of which is lycopene. Lycopene is a free anti-radical compound found in pomelo (citrus maxima). The lycopene content in pomelo fruit is more than in other parts, such as in leaves and fruit skin. Lycopene works by suppressing the proliferation or multiplication of cells through mutations in the initiation and progression phase of cancer. In cervical cancer patients, cell multiplication occurs quite rapidly, so that with the presence of lycopene, cervical cancer cell growth can be inhibited. Lycopene compounds can minimize the oxidation process and reduce the presence of free radicals in the body. Free radical compounds interact with DNA and reduce physiological functions that can increase cervical cancer cell growth. Lycopene is a compound that can counteract these free radicals and is also able to slow down or even prevent the oxidation process of other molecules and eliminate free radicals in the body that can cause cell damage. Through these two mechanisms, namely suppressing cell multiplication and eliminating free radicals, lycopene can be used as a cancer therapy. The cytotoxic activity test of pomelo fruit extract was carried out using the MTT method on T47D, WiDr, and HepG2 cells. The pomelo fruit was extracted by maceration method using 96% ethanol solvent. Cancer cell cultures were transferred as many as 1x104 cells/well in culture media consisting of FBS, penicillin-sterptomycin, amphoterizin-B, and RPMI 1640 into 96-well plates and incubated in a 5% CO2 incubator overnight. Furthermore, the test samples were given a series of levels and replications were made three times (triplo), and then they were incubated again overnight. On the third day of testing, MTT reagent was added, and after 4 hours, formazan crystals in living cells would be formed. Furthermore, SDS stoper was added to stop the MTT reaction. Then, the absorbance reading was carried out using an elisa reader at a wavelength of 595nm and the determination of the IC50 value was then carried out as well. The results showed that the IC50 value of pomelo extract in T47D 50 cells was 954.34 µg/mL, in WiDr cancer cells was 130.70 µg/mL, and in HepG2 cancer cells was 1,660.257 µg / mL. This shows that pomelo extract has the potential as an anti-cancer agent for breast and colon cancer, but not for liver cancer. This research could contribute to the development of breast and colon cancer drugs.
Effectiveness of Reconstruction Methods in Compressive Sensing for Biomedical Images Urvashi Ji
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

For the effectual storage and transmission of signal in telemedicine, compression of medical images is one of the indispensable operations. Acquisition speed is always an issue in medical images like magnetic resonance imaging and computed tomography images. Compressed sensing came up as an inkling that achieves sparse signal with under sampled Nyquist rate. Compressed sensing is always astounding because only few samples can perfectly recover the entire signal is indeed a big achievement. In this paper different performance parameters peak signal to noise ratio, compression ratio, structural similarity in dearer evaluated for medical images by reconstruction algorithms like basic pursuit (l1), least square (l2), or thogonal matching pursuit. From these recovery algorithms, it is pointed thatl1norm minimization is most established convex optimization approach to achieve better quality image. Performance metric speak signal to noise ratio and root mean square error are observed at different measurement samples and it is seen that peak signal to noise ratio increases with increased measurement and root mean square error decreases. Keywords:Compressed Sensing, Sparsity, Compression Ratio, Structural Similarity Index, Root Mean Square Error, Performance Root Mean Square Error Difference.
Cosmos caudatus Leaf Ethanol Extract Inhibit Growth and Viability through Membrane Permeability and Apoptosis in Candida albicans Agustina Tri Endharti
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.119 KB)

Abstract

Objective: Candidiasis is the most common fungal gynecological disease in humans. Essentially, the use of antifungal such as Fluconazole has reportedly increased resistance to candidiasis by 7%. The flavonoid has been shown to be used as an antifungal in Candida albicans. Cosmos caudatus contains 51% of Quercetin. To prove the influence of the use of flavonoid antifungal of quercetin group on the growth, viability, membrane permeability, and apoptosis of the C. albicans. Methods: The SV-1148 coded C. albicans isolate was obtained from the Microbiology Laboratory of Brawijaya University, Malang, Indonesia. Initially, the isolate was grown in Sabouraud Dextrose Agar (SDA) medium. The samples were divided into negative and positive control groups of fluconazole (60µg/ml) and difference concentrations (5%, 10%, 20%, and 40%) of leaves ethanol extract of C. caudatus. Results:  Concentration of 40% ethanol extract C. caudatus has Minimum Inhibitory Concentration (MIC) of 30%. This result showed that 40% ethanol extract C. caudatus was able to provide the best growth resistance which was characterized by the absence of colonies from C. albicans. The data of Influx Assay Iodide increased membrane permeability of C. albicans to disrupt cell membranes and induce apoptosis. The percentage of apoptosis increased after treatment of 40% ethanol extract C. caudatus in the culture of C. albicans. Conclusion: C. caudatus has antifungal activity and can be used as an herbal drug in C. albicans infection.
Effect of Isolate Catechin GMB4 in Expression of GRP78 and Tunel Assay in Rat Cataract Model Nugraha Wahyu Cahyana
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.296 KB)

Abstract

AbstractThis research is to explore glucose-regulated protein 78 (GRP78) expression and Tunel assay, signs of stress of endoplasmic reticulum (ER) and apoptosis in rat cataract model. Cataract was formed by inducing a subcutaneous injection of 19 µmol/kg sodium selenite to ten-day-old Wistar rats. The neonatal rats were divided into five groups randomly (n=5 in each group): a control group, and four cataract-induction groups, treated with either 0, 50, 100, 200 mg/kg catechin Isolate From GMB4 Clone Green Tea. We performed slit-lamp biomicroscopic analysis, immunohistochemistry for GRP78 and Tunel. Both eyes of all rats in Group 1 did not exhibit cataract formation. In Group 2, one out of five (20%) developed grade 3 cataracts and the remaining four out of five (80%) developed grade 4 cataracts. The grade of cataract formation decreased in groups 3, 4 and 5. The difference in exhibited cataract in the lens of all rats between Group 2 and any eyes of groups 3 or 4 and 5 were significant (P = 0.022, 0,001, 0,001). The mean amount of Tunel cells and GRP78 of group II rats were significantly (P < 0.01) higher than the levels in Group I, Group III, Group IV and Group V. Stress of Endoplasmic reticulum and apoptosis in the lens that increased following cataract formation in rats was suppressed by catechin Isolate From GMB4 Clone Green Tea.
Compare the Forms of ACE Gene According to Maximum Oxygen Consumption before and After the Lactic Voltage in 1500 Meters Running Players Alia Abdulkhader Safah
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The objective of the study was to identify the forms of ACE gene in mid-distance runners as well as to identify maximum oxygen consumption and the pre-voltage and post-voltage lactation threshold of 1500 meters and to determine the differences between the groups according to the two periods before and after the voltage according to the forms of the ACE gene. The research problem was to identify which alleles of the ACE gene were better in the physiological abilities of the players and included the imposition of research. There were differences in the maximum oxygen consumption and the lactic threshold in the two stages before and after voltage according to the gene shapes of 1500 meters running athletes. The researcher used the descriptive method in the survey method. The sample was randomly selected. They were players of Al-Qadisiyah clubs for the field and field players. The sample consisted of 16 players. The sample divided three groups according to the forms of the gene (II, ID, DD). The researcher concluded that the preferred form is the genetic makeup (II), which gives the physiological potential of players running 1500 meters.Keywords: ACE gene, Maximum oxygen consumption and lactic threshold.
Mycoplasma gallisepticum Infection and Efficacy of Inactivated Poultry Viral Vaccines Marwa Fathy
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.865 KB)

Abstract

Objective: This study was designed to evaluate the effect of Mycoplasma gallisepticum (MG) infection on the antibody titers of viral vaccines in fourteen-day-old specific pathogen-free (SPF) chicks. Methods: Five types of inactivated poultry viral vaccines-Newcastle disease viral vaccine (NDVV), avian influenza viral vaccine (AIVV), infectious bronchitis viral vaccine (IBVV), infectious bursal disease viral vaccine (IBDVV) and Reo-Virus Vaccine were used to vaccinate five hundred chicks. The chicks were divided into twenty groups at the age of 14 days; five groups were infected with MG. At day twenty-one, all the groups were vaccinated (four groups for each vaccine one of them previously infected by MG and one simultaneously infected by MG). At day twenty-seven, five vaccinated non-infected groups were infected. Results: All pre-infected groups showed highest antibody titers against NDV, AIV, IBV, IBDV, and Reo V (7.4 log2, 7.1 log2, 20EU, 20EU, and 17EU, respectively) 28 days post-vaccination. The lowest titer appeared in non-infected vaccinated groups with NDV, AIV, IBV, IBDV, and Reo V (6.5 log2, 6.5 log2, 12EU, 14EU, and 11EU, respectively). Conclusion: This study highlighted the outcome of poultry vaccination with inactivated virus vaccines by using serological immune response especially in the presence or absence of Mycoplasma infection of chicks.Keywords: Mycoplasma gallisepticum, Poultry, Vaccine evaluation, SPF chicks, Serological immune response.
A Comparison between the Effects of Nasal Lavage with Hypertonic, Isotonic and Hypotonic Saline Solutions for the Treatment of Chronic Sinusitis Nader Saki
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background and Objectives Nasal lavage is an adjuvant treatment used for sinonasal diseases like sinusitis. There is no general consensus on the superiority of one of the three common solutions of hypertonic saline, hypotonic saline, and isotonic saline for the treatment of sinusitis’s symptoms. Furthermore, the majority of past studies have focused on two solutions of isotonic saline and hypertonic saline. In addition, no study has been published on the effect of hypotonic saline in the treatment of sinusitis symptoms. More importantly, in Iran no study has been conducted on this area. Due to the high importance of sinusitis disease and spending a lot every year for the treatment of the disease and its complications arising from it for patients and the country’s health system and with regard to the auxiliary use of saline solution is an inexpensive and easy treatment, we decided to conduct this study. Methods & Materials: This clinical trial study was conducted on 185 patients with chronic sinusitis referred to Imam and Apadana Hospitals (Ahvaz, Iran). With a diagnosis of chronic sinusitis by an ear, nose and throat specialist and using the CT scan, the patients have been selected. For collecting the data the necessary symptoms and information on the patients were recorded in a standard information gathering questionnaire. The patients were randomly divided into four groups. The first group received medication the second group medication as well as nasal lavage or hypertonic saline; the third group received medication in addition to nasal lavage or isotonic saline; the fourth group received medication plus nasal lavage or hypotonic saline. Results The results show the nasal lavage has an optimal therapeutic effect on headache symptoms, discharge from the nose and throat, coughing, nasal obstruction, olfactory problems, feeling of fullness in the face and according to all the criteria the isotonic saline has a useful treatment effect and is more effective than the hypertonic saline and has improved the nasal obstruction in about 50% of patients. Conclusion our findings showed better therapeutic features for isotonic saline solution with no serious side effects compared with the use of this solution is of greater priority.Keywords: Nasal lavage, Chronic Sinusitis, Isotonic, Hypotonic, Hypertonic Saline.
Primitive Neuroectodermal Tumor (PNET) at the Level of Thoracic Spine: A Case Report Magetsari Rahadyan
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.441 KB)

Abstract

Introduction Primitive neuroectodermal tumors (PNET) are malignant tumors thought to arise from the neural ectoderm and comprise of undifferentiated small round cells that affect soft tissue and bone. These tumors occur primarily in children and adolescents (thirteen to sixteen years old), with a tendency to recur quickly and metastasize especially to lungs, bone marrow, brain and lymph nodes. PNET are uncommon malignancies that are increasingly reported in the literature and located in the spine are extremely rare. In this study we present a case of 14 years old girl with PNET of the thoracic spine which recur after initial resection. Case Report a 14 years old girl presented with low back pain and progressive weakness of both of lower limbs of three months duration. On physical examination, motor and sensory function was lost, motoric strength in the lower limbs was grade 1/5 with hypoesthesia below L1 level. Magnetic resonance imaging (MRI) of the spine showed burst pathologic fracture of the 12th thoracic spine with suspicious malignant lesion in the 12th thoracic spine. Initially the condition was treated with laminectomy, decompression, stabilization and open biopsy. Histopathology and immunohistochemistry of the lesion revealed the diagnosis of PNET. During the early postoperative course, she had instance neurological recovery and was able to walk unassisted. But, 1 month later the neurologic deficit recurred and she was treated with extended laminectomy with tumor debulking. Then the patient received chemotherapy and planned for radiotherapy. Conclusion Primitive neuroectodermal tumors (PNET) are extremely rare and are aggressive with poor outcomes. Good modalities play a significant role in the identification of the feasibility of surgical excision of the tumors, detection of distant metastasis, and evaluation of the efficacy of therapeutic interventions.Keywords:  Primitive neuroectodermal tumor (PNET), Malignant Tumor, Rare Tumor, Spinal Tumor.

Page 2 of 110 | Total Record : 1092

 1   2   3   4   5 

Filter by Year

2010 2025


Reset
Filter By Issues
All Issue Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue