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All Journal International Journal of Public Health Science (IJPHS) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Journal of Medical Physics and Biophysics JBN (Jurnal Bedah Nasional) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Journal of Global Pharma Technology The Hip and Knee Journal Indonesian Journal of Biomedicine and Clinical Sciences

Rahadyan Magetsari

Division Of Orthopaedics And Traumatology, Department Of Surgery, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada

Author-ID : 2410819

Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

Published : 18 Documents Claim Missing Document

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Structural evaluation and animal implantation of porous eggshell wastederived hydroxyapatite graft as bone substitution Rahadyan Magetsari, Yudha Mathan Sakti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 04 (2013)
Publisher : Universitas Gadjah Mada

The development of hydroxyapatite graft with high economically value is needed for orthopedicÂ practice in developing countries. Eggsell waste is well known as natural substance for calciumÂ resource. It has been used as raw material in producing hydroxyapatite. This study was conductedÂ to synthesize porous hydroxyapatite from eggshell waste and evaluate its activity as boneÂ substitution. The porous hydroxyapatite graft was manufactured from eggshell and sugar as aÂ raw material using hydrothermal process. The porous eggshell waste-derived hydroxyapatiteÂ (EW-HAP) graft was characterized using X ray difractometer (XRD) and analytical scanningÂ electron microscope (SEM) and compared with commercial hydroxyapatite (HAP) JCPDS 09-432Â graft (BangrosÂ®) as standard. The porous EW-HAP graft obtained was then implanted on criticallyÂ sized femoral defects surgically created in the right thigh of male Wistar rats (Rattus norvegicus)Â with BangrosÂ® as control. Radiological examination using XRD and histological examinationÂ using hematoxyline-and-eosin staining of the bone femour were performed at 28 days afterÂ implantation. The results showed that the XRD pattern for EW-HAP was likely similar with theÂ HAP standard. However, the SEM examination showed that the pasticle size of EW-HAP graftÂ (2.5-3 Î¼m) was higher than those HAP standard graft (1.5-2 Î¼m). Radiographs according to theÂ International of Limb Salvage (ISOLS) radiological evaluation system between EW-HAP graftÂ (6.1 Â± 1.45) and HAP control graft (6.9 Â± 2.10) was not significantly different (p>0.05).Â Moreover, histological examination according to Lane and Shandu scoring system between theÂ both graft (4.0 Â± 0.94 versus 4.4 Â± 0.92) was also not significantly different (p>0.05). It canÂ be concluded that the structure EW-HAP graft is similar with HAP graft standard. The bothÂ grafts have also equal outcome as bone substitution.

Accuration of Fine Needle Aspiration Biopsy in Musculoskeletal Tumour Rahadyan Magetsari; Hengkie Marseno; Zikrina Lanodiyu; Punto Dewo
International Journal of Public Health Science (IJPHS) Vol 5, No 2: June 2016
Publisher : Intelektual Pustaka Media Utama

Fine needle aspiration biopsy (FNAB) has been reported to be the preferable choice of biopsy for musculoskeletal tumour. While FNAB appears to have advantages to core biopsy in the aspect of simplicity and cost, the diagnostic accuracy should be the most critical parameter in determining the choice of biopsy. This research was designed to evaluate the diagnostic accuracy of fine needle aspiration in musculoskeletal tumour in Sardjito Hospital from 2010 until 2014. This was a descriptive study from medical record in Sardjito Hospital from 2010 until 2014. The inclusion criteria are musculoskeletal tumours in all age level that has been performed FNAB with subsequent operative treatment and confirmation of histopathology examination in Sardjito Hospital. There were 41 elligible subjects in this study. Concordance diagnosis of FNAB and histopathological examination in all musculoskeletal tumor cases was found to be 86%. In addition, the concordance in soft tissue tumor cases was 94% with the detail as follows: giant cell tumor was 86%, synovial sarcoma was 50% and liposarcoma was 50%. In bone tumours, the accuracy was found to be 60% with the detail as follows: distribute osteosarcoma was 60%, osteochondroma was 50% and chondrosarcoma was 50%. Our data showed that accuracy of FNAB for diagnosis of musculoskeletal tumours was 86% with soft tissue tumour 94%, bone tumour 60% and others 93%. Therefore, Fine needle aspiration biopsy is still important diagnosis tool in musculoskeletal tumours.

Trajectory and Determinant of Functional Independence among Patient with Traumatic and Non-Traumatic Spinal Cord Injury Yudha Mathan Sakti; Astri Ferdiana; Dananjaya Putramega; Zikrina A. Lanodiyu; Galih Prasetya Sakadewa; Rahadyan Magetsari
International Journal of Public Health Science (IJPHS) Vol 7, No 2: June 2018
Publisher : Intelektual Pustaka Media Utama

The level of functional independence was directly proportional to life satisfaction and quality of life in patients with spinal cord injury. By knowing the determinants that predict changes in functional independence, medical treatment and rehabilitation can be better planned to improve the patient’s quality of life. We conducted a prospective cohort study on 49 patients with spinal cord injury at Dr. Sardjito general hospital Yogyakarta from April to June 2016. The data were taken before patient underwent surgery, before discharged from the hospital, and 3 months after underwent surgery. We found that most common spinal cord injury was at the level of lumbar vertebra with 28 patients (58%). There was a positive trajectory of the patients with spinal cord injury with ASIA grade B-E classification. However, patients with spinal cord injury with ASIA classification grade A have a neutral trajectory.We conclude there was a positive trajectory between functional independence and traumatic or non-traumatic spinal cord injury except in patients with ASIA grade A classification spinal cord injury. The determinants that affected the trajectory of patients with spinal cord injury were the level of the injured vertebra and severity of the neurological deficit.

Load displacement simulation of CP-Ti/UHMWPE hip implant Handoko Handoko; Suyitno Suyitno; Rini Dharmastiti; Rahadyan Magetsari
Journal of Medical Physics and Biophysics Vol 8, No 1 (2021)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Hip implant made from titanium is special due to its lower modulus of elasticity to avoid stress shielding with the human bone. One type of load the material designed to withstand is a gradually increased compressive force which happened when the patient change his/her position from sitting to standing. This study examined the capability of a metal on polymer (MOP) implant made from commercially pure titanium (CP-Ti) and ultra-high molecular weight polyethylene (UHMWPE) loaded up to 3 kN according to ISO 14242 standard. Two CP-Ti/UHMWPE MOP models with femoral diameter of 22 mm and 32 mm were simulated with finite element. The results expressed in load displacement curves were validated with compressive load experimental tests. Both materials are capable to withstand the load. Simulation data are in good agreement with the experiments.

Structural evaluation and animal implantation of porous eggshell wastederived hydroxyapatite graft as bone substitution Yudha Mathan Sakti; Rahadyan Magetsari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 04 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The development of hydroxyapatite graft with high economically value is needed for orthopedic practice in developing countries. Eggsell waste is well known as natural substance for calcium resource. It has been used as raw material in producing hydroxyapatite. This study was conducted to synthesize porous hydroxyapatite from eggshell waste and evaluate its activity as bone substitution. The porous hydroxyapatite graft was manufactured from eggshell and sugar as a raw material using hydrothermal process. The porous eggshell waste-derived hydroxyapatite (EW-HAP) graft was characterized using X ray difractometer (XRD) and analytical scanning electron microscope (SEM) and compared with commercial hydroxyapatite (HAP) JCPDS 09-432 graft (Bangros®) as standard. The porous EW-HAP graft obtained was then implanted on critically sized femoral defects surgically created in the right thigh of male Wistar rats (Rattus norvegicus) with Bangros® as control. Radiological examination using XRD and histological examination using hematoxyline-and-eosin staining of the bone femour were performed at 28 days after implantation. The results showed that the XRD pattern for EW-HAP was likely similar with the HAP standard. However, the SEM examination showed that the pasticle size of EW-HAP graft (2.5-3 μm) was higher than those HAP standard graft (1.5-2 μm). Radiographs according to the International of Limb Salvage (ISOLS) radiological evaluation system between EW-HAP graft (6.1 ± 1.45) and HAP control graft (6.9 ± 2.10) was not significantly different (p>0.05). Moreover, histological examination according to Lane and Shandu scoring system between the both graft (4.0 ± 0.94 versus 4.4 ± 0.92) was also not significantly different (p>0.05). It can be concluded that the structure EW-HAP graft is similar with HAP graft standard. The both grafts have also equal outcome as bone substitution.

Correlation between vascular endothelial growth factor (VEGF) expression with histopathological findings in osteosarcoma Fikar Arsyad Hakim; Yuni Artha Prabowo Putro; Yudha Mathan Sakti; Rahadyan Magetsari; Irianiwati Widodo; Ery Kus Dwianingsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 2 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Vascular endothelial growth factor (VEGF) expression is associated with malignancy progression, metastasis, and poor prognosis in many malignancies, including osteosarcoma. However, studies concerning correlations between VEGF expression and histopathological prognostic factors ofosteosarcoma are limited. This study aimed to evaluate the correlations between VEGF expression and histopathological findings in osteosarcoma’spatients.This was a cross-sectional study using formalin-fixed paraffin embedded (FFPE) samples of 32 osteosarcoma’s patients from Dr. Sardjito General Hospital, Yogyakarta. Histopathological findings of specimens were re-evaluated by two independent observers, recorded for the subtypes, invasiveness, grading, mitotic counts, and tumor infiltrating lymphocytes (TIL). Expression of VEGF was determined based on immunostaining and evaluated using immunoreactivity score (IRS).Chi-square and Spearman correlation test were used to analyze the association between variables. Range of VEGF expression score was 0 to 11, with mean 5.09. Significant negative correlation between the VEGF expression and TIL was observed (p=0.046). However, there was no significant correlations between the VEGF expression and osteosarcomas subtypes, invasion, grading or mitotic counts (p> 0.05). In conclusion, the VEGF expression is associated with TIL. Further study is needed to evaluate the roles of VEGF and lymphocytes in osteosarcoma development dan progression in order to better understand of the role of VEGF in immunotherapy of osteosarcoma.

Comparison of diagnostic accuracy between clinical examination and magnetic resonance imaging (MRI) in diagnosing anterior cruciate ligament (ACL) rupture on Indonesian population Luthfi Hidayat; Aditya Fuad Robby Triangga; Muhamad Afrizal Farkhan; Bernadeta Fuad Paramita Rahayu; Rahadyan Magetsari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 2 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Anterior cruciate ligament (ACL) injury is the most common knee ligament injured. Anterior drawer and Lachman tests are the most common physical examinations for helping diagnose ACL injuries, while magnetic resonance imaging (MRI) is the first choice of supporting examination for evaluating any internal abnormality of the knee. However, studies concerning the accuracy of those examinations in the Indonesian population are limited. This study aimed to compare the accuracy between the anterior drawer test, Lachman test, and MRI in diagnosing ACL injury in Javanese patients. This retrospective study used medical records data of patients who underwent knee arthroscopy in the Department of Orthopaedics and Traumatology, Dr. Sardjito General Hospital, Yogyakarta in 2018. The MRI and the clinical examination results were compared to the arthroscopy results as the gold standard. The study showed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for the anterior drawer test were 86.67% (95%CI: 69.28-96.24%), 80% (CI: 44.39-97.48%), 92.86% (CI: 78.88-97.84), 66.67% (CI: 43.28-83.98%), and 85% (CI: 70.16-94.29%), respectively. Lachman test had 96.67% (CI: 82.78-99.92%) sensitivity, 90% (CI: 55.50-99.75%) specificity, 96.67% (CI: 81.86-99.47%) PPV, 90% (CI: 56.44-98.43%) NPV, and 95% (CI: 83.08-99.39%) accuracy. The diagnostic parameters of MRI were 83.33% (CI: 65.28-94.36%) for sensitivity, 60% (CI: 26.24-87.84%) for specificity, 86.21% (CI: 74.21-93.14%) for PPV, 54.55% (CI: 31.77-75.57%) for NPV, and 77.50% (CI: 61.55-89.16%) for accuracy. In conclusion, the Lachman test has better accuracy than the anterior drawer test. Both the anterior drawer and Lachman tests had higher accuracy compared to the MRI.

Penatalaksanaan Giant Cell Tumor pada Distal Radius: Sebuah Laporan Kasus Yuliaji Narendra Putra; Rahadyan Magetsari
JBN (Jurnal Bedah Nasional) Vol 3 No 1 (2019): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Latar belakang: giant cell tumor adalah suatu tumor jinak tulang yang meskipun jarang menyebabkan kematian, tetapi berpotensi untuk menjadi agresif dan mempunyai kemampuan untuk bermetastasis. Kasus: seorang perempuan berusia 20 tahun datang ke rumah sakit dengan keluhan terdapat benjolan di pergelangan tangan sebelah kiri yang telah berlangsung selama 6 bulan. Benjolan tersebut semakin lama dirasakan semakin membesar dan nyeri namun tidak mengganggu pergerakan dari pergelangan tangan. Pada pemeriksaan fisik ditemukan massa solid berukuran 5x3x2 cm dengan kesan terfiksir tulang tanpa tanda peradangan. Range of motion sendi pergelangan tangan masih dalam batas normal. Pada pemeriksaan radiologi ditemukan ekspansil, osteolitik ekstraosseus, serta lesi radiolusen tanpa batas sklerotik, dan reaksi periosteal pada akhir distal radius. Pasien ini didiagnosis dengan giant cell tumor radius distal kiri, kemudian dilakukan penanganan berupa eksisi tumor dan rekonstruksi dengan auto bone graft dari fibula. Evaluasi rutin selama 5 tahun menunjukkan hasil yang baik yang mana tidak tampak tanda-tanda rekurensi, tidak ada reaksi penolakan graft, dan range of motion sendi pergelangan tangan tetap dalam batas normal. Simpulan: tatalaksana giant cell tumor dengan eksisi dan rekonstruksi menggunakan auto bone graft menunjukkan hasil yang baik dan memuaskan.

Correlation between the effect of increasing body weight with plantar pressure and ankle-knee radiographic angle parameters changes Dimas Triaryo; Luthfi Hidayat; Rahadyan Magetsari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art5

Background: Understanding the biomechanical structure of the body is important to preventing and treating the musculoskeletal system problems. The increase in body mass index contributes to the elevated peak plantar pressure and decreased longitudinal arch of the foot. This condition, consequently, may cause mal-alignment of the lower extremity, leading to promote cartilage breakdown, osteophyte formation, subchondral bone hypertrophy, lead to progression of knee joint destruction and functional deficits. Objective: The aim of the study was to examine the correlation between body weight, plantar pressures, ankle and knee angle measurement parameters.Methods: The research study sample included 30 female who met inclusion and exclusion criteria. In order to evaluate the structural characteristic of plantar foot, we used the blueprint method on bare-foot and also when carrying 15 and 25 kilogram of load. Furthermore, to measure knee-angle parameters, we also performed a bilateral standing radiograph approach of lower extremity. Results: This study showed a significant correlation between BMI/Body mass index and HW/heel width (p = 0,00) with low positive correlation for both sides. Furthermore, BMI and PAW/plantar arch width (p = 0,00) showed a moderate positive correlation for both sides. In contrast to that, BMI and MFA/mid-foot area (p = 0,00) showed a moderate positive correlation for the right side but low positive correlation for the left side. Another measurement such as BMI and AI/arch index (p = 0,00) had a strong positive correlation on the right side and moderate positive correlation on the left side. Moreover, BMI and AAL/Ankle angle alignment (p = 0,00) revealed a strong positive correlation for both sides, BMI and XCTP/trans-condylar tibial plateau angle (p < 0,05) had a low positive correlation for both sides, meanwhile BMI and AA/ankle angle (p = 0,00) showed a low positive correlation for both sides. Conclusion: Increasing axial load was statistically significant correlated with increasing plantar pressure and ankle-knee radiographic angle parameter. The results also revealed that increasing axial load was found to have strong correlation to the arch index (AI) and ankle angle alignment (AAL). It was a compensatory phenomenon, which can cause structural disturbances and function of the lower limb.

Estimasi Prevalensi Kecelakaan Lalu Lintas dengan Metode Capture-Recapture Sayekti Udi Utama, Rahadyan Magetsari, Vitalis Pribadi
Berita Kedokteran Masyarakat (BKM) Vol 24, No 1 (2008)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Background: Accident is a global health problem. In 2002 the major cause of accident leading to death is road accident (22.8%). In 2003–2005 the number of road accidents in the Province of Yogyakarta Special Territory is decreasing; however the fatality and ratio of road accident and the number of victims are increasing. In Indonesia there are two kinds of reporting made whenever there is a road accident. When the accident is handled by the police, data are kept at the police office and hospital; however, when it is not handled by the police, data are kept only at the hospital, not at the police office. In the Province of Yogyakarta Special Territory data of road accident are based on the report of Traffic Office of Yogyakarta Special Territory Regional Police so that they may not reflect the actual road accidents.Objective: To estimate the prevalence of road accidents by combining data sources from both the police and hospital at the Province of Yogyakarta Special Territory 2006.Method: This was a descriptive study with survey design. It was carried out at the Province of Yogyakarta Special Territory from May to August 2007. Analysis was made using capture-recapture method. Data entry and calculation were carried out using web-based computer program with Personal Home Page language programming and the database was maintained in MySQL.Result: There were as many as 1,721 data from 5 district police office/big city police office and 5,422 data from 22 hospitals and there were as many as 751 similar data. Data from the police office were 100% complete and from hospitals were not as complete as those from the police office. Coverage of data from the police office was 13.9% and from hospitals was 43,7%. The result of the study showed that the prevalence of road accident based on data from the police office was 51 per 100,000 people and from the hospital was 161 per 100,000 people; whereas the prevalence of the result of estimation using capture-recapture method was 369 per 100,000 people (12,417 cases – 95% CI:11.799-13.035) with highest prevalence for male of 16–25 years old, living and having road accidents at Sleman District.Conclusion: The estimation of the prevalence of road accident using capture-recapture method at the Province of Yogyakarta Special Territory in 2006 was 369 per 100,000 people, 2.28 times greater than data of hospitals and 7.2 times greater than data of the police office with under reporting as much as 724% at the police office and 229% at hospitals.Keywords: road accident, capture-recapture method, prevalence

Co-Authors Aditya Fuad Robby Aditya Fuad Robby Triangga Astri Ferdiana Bernadeta Fuad Paramita Rahayu Dananjaya Putramega Dimas Triaryo Ery Kus Dwianingsih Fikar Arsyad Hakim Galih Prasetya Sakadewa Handoko Handoko Hengkie Marseno Hilmi Muhammad Irianiwati Widodo Luthfi Hidayat Meirizal Hasan Muhamad Afrizal Farkhan Prisilla Desfiandi Punto Dewo Rezky Saraswaty Rini Dharmastiti Sakti, Yudha Mathan Suyitno Suyitno Triangga, Aditya Fuad Robby Yossie Atyandhari Yuliaji Narendra Putra Yuni Artha Prabowo Putro Zikrina Lanodiyu

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