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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Synthesis, Characterization of Di-1, 3-Oxazepine and Evaluation of their Antimicrobial Activity against Molecular Diagnostic Bacterial Isolates Nadia A. Salih
Journal of Global Pharma Technology .
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Abstract

This work presents Two Schiff bases derived from 4, 4'-Diaminodiphenylmethane, distinguished by the para substituted halogen of benzaldehyde. These Schiff bases used to synthesis of four compounds of di-1, 3-oxazepine by direct condensation with tetrachloro phthalic anhydride and tetrabromophtalic anhydride. All structures were characterized by using spectroscopic techniques such as FT- IR, 1H-NMR, 13C-NMR. The synthesized compounds were screened as an anti-bacterial agent against bacterial strains (Gram positive S. aureus and Gram-negative P. aeruginosa and K. pneumonia) which were diagnosed using high specific method “genetic method for S. aureus and P. aeruginosa and Vitec 2 for K. pneumonia.Keywords: Schiff bases, 1, 3-Oxazepine, Tetrachlorophthalic anhydride, Antibacterial activity.
Hospitalized Adults with Acute Bacterial Meningitis: Etiology and Antimicrobial Susceptibility Profiles Zainab Khamees Abbas
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Eeffective management of acute bacterial meningitis depending on the diagnosis of bacteria that cause disease, as well as, identification of the effective antibiotic or antibiotics against most of these causative agents, the objective of this study was to detect the causative agents of acute bacterial meningitis isolated from C.S.F of inpatients adults. Since June 2017 and July 2018; 135 C.S.F. specimens were collected, 53 (39.26 %) were positive for C.S.F culture, and 71 specimens were negative. Of 53 acute meningitis patients, there were 66% male and 34% female, predominant causative agents was S. pneumoniae (20.8%), followed by N. meningitides (18.9%) and K. pneumoniae (15.1%). Antimicrobial susceptibility profiles differ depending on the causative agents, the results shows a high sensitivity to Amikacin, Vancomycin, Gentamicin, and  Ciprofloxacin, S. pneumoniae were high sensitive to Vancomycin, Gentamicin, Chloramphenicol, as well as, Ciprofloxacin, While H. influenzae  and N. meningitides exhibited considerable susceptibility to Chloramphenicol.Key words: Meningitis; C.S.F; Antibiotics.
Synthesis and Characterization of Mixed Ligand Complexes Contain Curcumin, Schiff Base and Azide (N3‾) with Some Metal ions and Evaluation their Antibacterial Activity Sagid M. Lateef
Journal of Global Pharma Technology .
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Abstract

The research included the synthesis and characterization of new Schiff Base (L3) by reaction 2-aminopyridine and isatin , also included synthesis and characterization of mixed Ligand  complexes using curcumin (essential "HL1", Schiff base (secondary Ligand "L3"), and Azide ion (N3‾) ( secondary Ligand)  with some metal ions and evaluation of antibacterial activity in general formula:  [M(L1)(L3)(N3)H2O]  where : M = [Co(II) , Ni(II) , Cu(II)]  M (L1) (L3) (N3)]       where:  M= [Mn (II), Zn (II), Cd (II), Hg (II)]  With M: L1: L3, 1:1:1 Mole ratio using ethanol as a solvent. The complexes were characterized by using physical methods and spectroscopic (FT -IR, UV-Vis, mass)  along with C.H.N. ,the chloride content and designate the percentage of the metal in addition to measurements of  molar conductivity From the above data we suggested an octahedral geometry for all complexes. Antibacterial activity of ligands and  their complexes was estimated for four types of   bacterial Staphylococcus aureu, Bacillus subtilis, Eterobactern, Escherichia Coli, the results of antibacterial activity showed that their compounds prepared effective against bacteria.Keywords: Curcumin, Schiff base, Mixed ligands complexes.
Effect of Different Solvent on Total Phenolic, Total Flavonoid, and Sun Protection Factor of Belimbing Wuluh (Averrhoa Bilimbi linn.) Fruits Fraction Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Ultraviolet (UV) radiation is related with a variety of damaging effects. Averrhoa bilimbi Linn (AB) known as Belimbing Wuluh in Indonesia, it contains phenolic compounds such as flavonoids, where the compound has the potential as a sunscreen. Objective: the study was to determine the Total Phenolic Content (TPC), Total Flavonoid Content (TFC) and investigate Sun Protection Factor (SPF) activity from different solvent for fractionation of AB among N Hexane (NH), Ethyl Acetate (EA), and Water. Methods: TPC, TFC, and Sun SPF were investigated using in vitro assay with spectrophotometric UV-Vis coupled chemometric using principal component analysis (PCA). In this study, TPC was determined using Folin-Ciocalteu reagent, the outcomes were expressed in (mg of gallic acid equivalent (GAE)/g sample), TFC content was determined by colorimetric using AlCl3 methods, the results were expressed in (mg of rutin equivalent (RE)/g sample), and SPF using Dutra calculation. Result:  EA showed the highest SPF (15, 38±1, 3).The similar fraction having the highest TPC (56, 87±1, 5212) mg (RE)/g of EA) and the highest TFC (24, 99±3, 2895) mg (GAE)/g of EA). When principal component analysis (PCA) was applied, high correlation among TFC and SPF activities was found. Conclusion: Hence, AB potential as sun screens.Keywords: Averrhoa bilimbi, Total Flavonoid Content, Total Phenolic Content, Sun Protection Factor, Chemometric.
A Comparative Assessment Study on Natural Coagulant and Regenerated Coagulant Alok Suman
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Surface water brings impurities in the form of suspended and colloidal solids. Coagulation and flocculation followed by filtration and disinfection process involved in the treatment of surface water. This process generates large quantity of waste generally known as water treatment sludge (WTS). A typical Water Treatment Plant (WTP) produces about 100,000 tons/year of sludge whereas, on a global scale, available literature estimates that at present the daily production of sludge exceeds 10,000 tons (Babatunde and Zhao, 2007). Increase in demand for milk and dairy products, dairy industries in most of the countries of the world, including India will lead to enhanced productivity, as a result increase in wastewater generation and environmental pollution. The objective of the present study is to determine WTS characteristics obtained from WTP and to investigate the reuse of recovered/regenerated coagulant in synthetic dairy effluent and compare with natural coagulant (Moringa Oleifera Seed Powder (MOSP)). The characterization of WTS shows the maximum amount of SiO2   at 67.75% by using Energy-Dispersive X-Ray Fluorescence (ED-XRF). The other oxides also observed by ED-XRF such as Al2O3 (16.76%), Fe2O3 (5.52%) and MgO (3.33%). For the optimum recovery of the coagulant, WTS acidified with the different normality of sulfuric acid. The RC produced similar turbidity removal efficiency (94%) at 25ml/l dose as compared to natural coagulant at 60 ml/l dose. It also has been observed that the removal of TSS, TDS, BOD and COD efficiently by RC. CPCB [3] reported that some of the WTPs are cleaned once in a year and in the lack of sludge disposal management it disposed off on nearby open lands or drain. Proper handling WTS from WTPs in an economical and environmentally friendly manner remains a very important issue. The recovery, recycling and reuse may provide a sustainable solution to the WTS management.Keywords: Water Treatment, Sludge, Recovery of coagulant, MOSP, SEM, ED-XRD, FTIR, and XRD.
Polymorphisms in micro RNA Genes and Humoral Immune Response to Hepatitis B Vaccine in Iraqi Children and Adolescents Qasim Sharhan Al-Mayah
Journal of Global Pharma Technology .
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Abstract

The remarkable reduction in the incidence of hepatitis B virus (HBV) is mainly attributed to the vaccination regime. However, some individual variations in immune response to this vaccine do exist which may be actually referred to as genetic factors. This study aimed to evaluate the role of three single nucleotide polymorphisms (SNP) in microRNA genes, that is, miR-146a G>C, miR-149 C>T and miR-196a2 C>T in the humoral response to HBV vaccine. A total of 86 children and adolescents who had completed the vaccination program from Al-Zahraa Health Center during the period between October 2016 to January 2017 were recruited for this study. Serum levels of anti-HBs IgG was measured with enzyme linked immunosorbent assay (ELISA), DNA was extracted from blood sample and specific primers were used for the amplification of gene fragments corresponding to the SNPs. According to the instructions of the ELISA kit, among the investigated 86 subjects, only 58 (67.44%) had good immune response. Direct sequencing was used for genotyping. In recessive model, the frequency of GC+CC genotypes of miR-146a G>C was significantly higher in responders than non-responders (OR = 2.598, 95% CI = 1.008-6.698, P = 0.046), and the minor allele (C allele) was more frequent among responders than non-responders (OR = 2.16, 95%CI = 1.029-4.532, P = 0.039). The wild homozygous genotype (CC) and miR-196a2 C>T was more frequent in responders than non-responders (OR = 2.881, 95% CI = 1.044-7.953, P = 0.041) with significant effect of dominance model in responders against non-responders (OR = 3.143, 95% CI = 1.210-8.161, P = 0.016). Furthermore, the major allele (allele C) was more frequent in responders than non-responders (OR = 2.724, 95% CI = 1.253-5.922, P = 0.013). These data indicate the important role of miR-146a G>C and miR-196a2 C>T in immune response against HBV vaccine.Key words: Mi RNA, Hepatitis B vaccine, Single nucleotide polymorphisms.
Histomorphological Study and Scanning Electron Microscopy of the Duodenum in the Iraqi Black Partridge (Francolinus francolinus) Ola Al-Bhadly
Journal of Global Pharma Technology .
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Abstract

Objective: This project aimed to study the Morphological description and histological structure by using light and scanning electron microscope of duodenum in both male and female Iraqi black partridge (Francolinus francolinus) Methods: To conduct this investigation, 20 healthy Iraqi black partridge were collected from local suppliers. Birds were euthanized, dissected and then specimens were processed for histological and histochemical staining techniques. Results: Morphological study showed the duodenum consists of descending and ascending limbs forming (U) shaped tube called duodenal loop extend from the right side of the dorsal surface of the gizzard. The pancreatic and bile ducts opened in the end of the ascending limb. Male had significantly higher than Female in the mean length and weight of duodenum. Histologically, the wall of the duodenum was consisted of four tunicae mucosa, submucosa, muscularis and serosa. The mucosa had a distinctive feature by the presence of villi had finger shape and the crypts of lieberkuhn which covered by simple columnar epithelium with goblet cells. The goblet cells gave positive reaction with PAS stain. Duodenal villi appeared by SEM very long and finger-like shaped with two organized orientations, primary and secondary villi. No significant differences between sexes in the villi height, crypts depth and the number of goblet cells but significantly difference in the mean thickness of tunica. Conclusion: the results showed that the significant difference in the mean length, weight of duodenum and thickness of tunica between two the sexes may be related to differences in food intake amounts. Goblet cells neutral mucopolysaccharide secretions; in fact, the latter stain is an indicator mucin substance which are very important in digestion and absorption and subsequent body growth of the bird.Keywords: Duodenum, Histomorphology, IRAQI Black Partridge, Scanning electron microscope.
The Effectiveness of A Reproductive Health Active Learning Process Model in Improving Teen's Knowledge and Self-Trust in the First Middle School Teresia Retna P; Wahyuningsih Triana Nugraheni
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Adolescence is a transitional period between childhood and adulthood, which begins at the time of sexual maturity, namely between the ages of 11 or 12 years to 20 years, namely before young adulthood (Soejiningsih, 2004). To be ready to enter adulthood, adolescents begin to get acquainted and deal with various adult problems. Biologically, adolescents already have the ability like adults, but psychologically they have not got the right to use these abilities. The occurrence of psychological changes causes confusion among adolescents. They experience emotional turmoil and mental stress so that they easily deviate from the rules and social norms that apply in society. The design of this study was an experiment with a Posttest Only Control Group Design approach. In the experimental design of this study, there were two groups selected randomly. One group acts as a control group and the other group acts as an experimental group. The population in this study were students of health cadres at SMP Negeri 1 Merak Urak, Tuban Regency in 2019/2020, with a sample size of 36 students. The sample of this research was some students of health cadres at SMP Negeri 1 Merak Urak, Tuban Regency, with a sample size of 33 students. The sampling technique used was simple random sampling. The independent variable of this research is the active learning process of adolescent reproductive health, the dependent variable of this study is the level of knowledge and self-confidence of adolescents. The research instrument used in this study was to use a modified adolescent reproductive health active learning process module and a questionnaire to measure the level of knowledge and self-confidence of adolescents in junior high school. Data analysis was used to determine the effect of the independent variable and the dependent variable with the Manova test, with an error rate of α 0.05. Hypothesis testing shows that the significance value for the treatment and control groups tested by the Pillai Trace, Wilk's Lamda, Hotteling's T and Roy's Largest Root procedures is 0.005
The Analysis of Organizational Learning and role of Knowledge Management Component to Improve its Hamid Tajdar
Journal of Global Pharma Technology .
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Abstract

In this study, we have tried to identify those factors among key success factors of knowledge management that their implementation increases the organizational learning of staff. The method of study was so that firstly eight key factors of success of 1. IT 2 human resource 3. Support of top managers 4.Training of staff 5.Motivating staff 6.Sharing 7.Organizational culture 8. Team work, and organizational learning were considered as the dependent variables. Then, the relationship between dependent and independent variables was investigated. The subject of knowledge management in the University of this is a new subject and investigating the success factors can play an important role in organizational learning of its staff. The population of this research is staff of Zabol University that their total number was 400 and a sample size of 190 was selected based on Morgan table. Data were collected by a standard questionnaire with Cronbach's alpha of 0.920, and t-test and SPSS software were used to analyze the collected data. The results show that the key success factors of knowledge management have impact on staff organizational learning. At the end of study, some recommendations have been presented to enhance organizational learning level and successful implementation of knowledge management systems to managers of Zabol.Keywords: Knowledge management, Organizational culture, Success factors, Organizational learning.
Pharmacodynamics and Hepatoprotective Properties of Drugs Affecting Metabolic Processes in Patients with Drug-Induced Liver Injury on the Background of Specific Antituberculosis Therapy Anna V. Berestova
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective. Data on pharmacodynamics and hepatoprotective properties of taurine, ursodeoxycholic acid and their combinations in the treatment and prevention of drug-induced liver injury on the background of specific anti-TB therapy is presented. In the study course, a retrospective analysis of primary medical documentation of 270 patients was carried out. Materials and Methods. These patients were undergoing antituberculosis therapy in regional clinical tuberculosis hospitals during 2013-2016. Clinical studies were conducted in the regional clinical tuberculosis hospital in 2016-2018. At the clinical stages, 100 patients were examined. Results and Discussion. A retrospective analysis showed that in a real clinical practice, anti-TB therapy is canceled even with a moderate increase of the transaminase level. Temporary cancellation and correction of specific therapy led to a slowed-down x-ray dynamics and an increase in the length of hospital stay. It also helped to reduce clinical manifestations of liver injury and decreased enzyme activity in most patients for 8-14 days, though the transaminases absolute values remained above the reference values. Conclusion. Taurine intake in dose of 1000 mg/day for the pharmacological correction and prevention of drug-induced liver injury showed high drug efficacy both in monotherapy and combination with ursodeoxycholic acid. Taurine shows an immunomodulatory effect in patients with tuberculosis, with increase of CD3, CD4, CD16, immuno-regulatory index and decrease of CD8, the level of cytokines IL-4, IL-6 and TNF-α.Keywords: Drug-induced liver injury, Specific antituberculosis therapy, Pharmacodynamics, Hepatoprotectors, taurine, Ursodeoxycholic acid.

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