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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Effect of Prebiotic Plus Xylanase Enzymes in Reduced-Energy High Wheat Midd Diets on Broilers Subjected to Bursa Vaccine and Clostridium Perfringens Challenge under Heat Stress Y. J. Jameel
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

This study was designed to evaluate the effect of chronic heat stress (CHS) and pathogen challenge on broilers fed reduced energy, high wheat Midd (WM) diets with or without a mixture of yeast cell wall (YCW) and xylanase enzyme (XE) on performance, carcass fat percentage and the evaluation of diet and meat cost. Two hundred forty (1- day old) chicks (Ross 308) were distributed within 2 Petersime battery brooder units (48 pens: 5 birds per pen). For this experiment, treatments were assigned as an incomplete randomized block design with 6 treatments arranged as a factorial 3 × 2 with 3 levels of energy (3000, 2900, and 2800) and 2 treatments with or without supplementing mixture of (YCW 250 ppm plus XE 25/mg per ton) were used. Chronic heat stress CHS was induced by setting the HVAC system at 36± 2ºC from day one until the end of the study (day 24). Birds were vaccinated with a commercial IBD vaccine via eye drop at 10 days of age, followed by Clostridium perfringens challenge on day 16 and 17 of the study by 3/mL oral gavages 106 cfu/ml. Results revealed that the body weight (BW), body weight gain (BW gain), Productivity Index (PI), and feed conversion ratio (FCR) of chicks fed low energy (2800 Kcal with YCW and XE; PVL) then (2900 Kcal with YCW and XE; PL) respectively, were improved numerically but not significantly (P˃0.05) at days 10, 16, 21, and 24 as compared with chicks fed high energy (3000 Kcal with (PC) or without (NC) YCW and XE. Also, no significant differences were found by dual energy X-ray absorptiometry (DEXA scan) among the treated groups, but % fat of birds fed low energy (2800 Kcal plus YCW and XE; PVL) were decreased (P˃0.05) as compared with chicks fed high energy (3000 Kcal with (PC) or without (NC) YCW and XE). However, average cost of the feed and meat were lower of treatment administration diet have 2800, and 2900 Kcal as compared with 3000 Kcal diets. In conclusion, reduced energy diets did not affect under HS may be low energy decrease heat increment. Chicks fed low energy with or without YCW and XE led to enhance performance and lower carcass fatpercentage. In addition, low energy diet led to lower the cost of diets and meat. Keywords: Broiler, performance, reduced energy, heat stress, xylanase, prebiotics.
EPSTEIN BARR VIRUS AND CYTOMEGALOVIRUS CORRELATION WITH ORAL SQUAMOUS CELL CARCINOMA PATIENTS BY USING IN SITU HYBRIDIZATION METHOD IN THE CITY OF BAGHDAD. Zaid A Saeed; Noor Al-Huda Ali A.H. Saeed; Samar Abdul Raheem Al-Gharrawi
Journal of Global Pharma Technology .
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Abstract

Worldwide, the most prevalent cancer related deaths, poses one of the most risk cancers globally in many countries, is the oral cancer. There are some important factors associated with many human cancers, for example viral agents, which are involved in the spread of tumors, including the Oral Squamous Cell Carcinoma.So, this study was resolved to determine the relationship between Epstein Barr Virus and Cytomegalovirus with some Iraqi patients who suffer from Oral Squamous Cell Carcinoma by using In Situ Hybridization Technique, related to their age, gender, site distribution, histological grade and the tumor stage.According to sixty OSCC biopsies randomly collected during the period between July 2015 and September 2016, EBV was detected in (71.6 %) 43 out of 60 patients, whereas CMV was detected in (36.6 %) 22 out of 60 patients, the mean age was 38 years old and ranged between ( 27-72) years old, male to female ratio was (1.3 : 1) with 34 men and 26 women, most of the cases were tongue SCC 39, followed by gingiva 13 and 8 were at the floor of the mouth. Histological grades involved were 37 well differentiated, 5 were moderately differentiated and 18 were poorly differentiated. Staging of the tumor included 43 patients who fell in stage I and II, while the rest 17 patients fell in stage III and IV. Regarding to the positive results, EBV correlates in highly significant association with each of (age, gender, grading, tumor stage and site distribution at p<0.01), also CMV correlates with each aspect mentioned above in highly significant association at p<0.05. 
Assessment of IL17BR Serum Concentration in Females with benign & Malignant Breast Tumors Haider Abed Ali Alshawi
Journal of Global Pharma Technology .
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Abstract

Breast cancer is one of the most dangerous and most common malignancies  among women in the world, which affects different age groups of women, IL-17 plays an important role in chronic inflammation and cancer, Serum IL-17BR concentration which useful in early diagnosis and staging of breast tumors.  The aim of the study was to evaluate of IL-17BR serum concentrations in patients with benign and malignant breast tumors and study the relation between the above parameter and breast cancer development. The study population was composed of 120 samples 24 patients with recently diagnosed breast carcinoma, 6 patients with repetitive carcinoma, 40 patients with benign breast tumor (fibroadenoma) and 50 normal apparently health woman as a control.ELISA technique was applied for estimation of IL-17BR levels in patients as well as apparently healthy volunteers of women. The results revealed the mean age of malignant breast females was 52.8 ± 12.3 (Mean ± SD), while it was 26.9 ± 8.3 years for women with benign tumor with highly significant difference (P<0.001), IL-17BR level was determined and found that was a highly significant difference in its level among benign breast females subjects (72.48 Ng/ μL) and healthy control (50.87 Ng/ μL) P< 0.001), no significant difference in the mean of sIL-17BR level among the different patients‘ groups (49.83, 64.33 Ng/ μL) for recurrent and primary breast cancer respectively. Estimation of IL-17BR level showed significant elevation of the concentration among the sera of recurrent breast cancer in comparison with other groups which perhaps regarded as a prognostic marker.Keywords: IL-17BR, Fibro adenoma, Breast cancer, Carcinoma, ELISA.
Certain Blood Lipid Profile and Immunological Alterations Accompanied Vascular Inflammation in Hypertensive Patients Lamees M. Al-Janabi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The current study was conducted to examine certain blood biochemical and immunological changes associated with high blood pressure in hypertensive patients. Hundred blood samples were collected from normal and hypertensive people, at Al-Hussein teaching Hospital, for assessment of Fatty lipids such as total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein as well as the study of IL-1β and TNF-α genes expression levels. The results of hypertensive patients showed significant increase of T. Cholesterol , TG and LDL and significant decrease of HDL, whereas the molecular analysis revealed significant increase in the expression ranks of both IL-1ß and TNF-ɑ genes in comparison with normal people. In conclusion, hypertension could be accompanied by lipidemia and decreased immunity.Keywords: Hypertension, Lipid profile, Immunity IL-1β, TNF-α.
Pain Assessment for Adult Patients Admitted to Coronary Care Units in Al - hilla Teaching Hospitals, Babylon – Iraq Amina Abd Al Hassan Jabur
Journal of Global Pharma Technology .
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Background: Pain considered as a significant problem for critically ill patients, pain assessment is essential toreach optimal level of quality of care. Nurses play a critical role in managing and alleviating acute pain amongcritically ill adult patients. Objectives: To assess the level of pain of critically ill adult patients who wereadmitted to the coronary care units in Al-hilla teaching hospitals. Methodology: A descriptive cross-sectionalstudy design selected to assess pain for critically ill patients who were admitted to coronary care units in Al-hilla teaching hospitals was conducted from October 2016 through August 2017. Non-probability (purposive)sample consisted of 92 patients selected, structured questionnaire which consist five parts were prepared inorder to collect the data. The statistical package version 22 was used to analyze the data. Results: Malepatients were predominated, the majority age group of participants were (41 to 65) years constituted 62%most of them were married with low level of education, regarding smoking habit 52% of them were smokers.High proportion of patients 83.7% had frequent bouts of pain while 35.9% were suffering from persistent pain;the most associated symptom with pain was drowsiness (77.2%). About two third of the participants preferredto use medications to control their pain, according to McGill questionnaire the mean score of pain intensity forthe study sample was severe (2.50). Conclusion: Pain still unresolved problem among adult patients admittedto the coronary care units in Al hilla teaching hospitals who recorded severe pain, which accompanied withassociated symptoms such as drowsiness. Recommendation: There is a need for focused continuouseducation and training program to important the health personnel&#39;s practice and knowledge regarding painassessment and management.Keywords: Pain Assessment, Adults Patients, Critical care units, McGill Pain Questionnaire.
Production of Pickled Mustard Greens (Brassica Juncea) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Mustard greens are fresh during the harvesting season but perishable under the prevailing conditions of temperature and humidity as well as lack of adequate storage facilities. An alternative way of preserving surplus mustard greens could be fermented to pickle products. Preservation of the mustard green by fermentation can eliminate the undesired taste and improve flavor of the vegetable. Therefore we explored a lactic fermentation from mustard greens by focusing on the effect of different parameters such as blanching time and temperature as pre-treatment, salt concentration, fermentation time to physicochemical, microbial and sensory characteristics of pickled mustard greens. Experimental results revealed that blanching raw mustard green in water heated at 95oC in 10 seconds, 6% salt in 12 days of fermentation was appropriated to get a pleasant pickled mustard greens quality. Mustard greens pickles are considered as one of the health supplements.Keywords: Mustard greens, Lactic fermentation, Salt, blanching, Physicochemical, Microbial, Sensory.
Evaluate Toxic Effect of Bisphenol A on Kidney of Male Mice and Mitigation Its Effect by Green Tea Extract Aamer. M. Ali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Bisphenol A is a substance for the synthesis variety of plastics, primarily epoxy resins and polycarbonates. Bisphenol can have severe effects on the type and might contribute to gradual cumulative renal injury over a lifetime. This study object to estimate toxic effect of bisphenol A on type of male mice also mitigation toxic effect of bisphenol A by using extract green tea. Healthy adult male albino laboratory mice (Mus musculus) treated for two doses of bisphenol a (20 mg/kg and 40 mg/kg body weight per day) for thirty days and green tea extract was co-administration orally as antioxidant. Bio-chemical parameter of serum creatinine and blood urea was calculated as indicator of kidney function. groups treated with bisphenol A showed increased in serum creatinine and blood urea also histopathological of kidney showed significant damage in groups that treated with bisphenol A whereas groups that treated with bisphenol A and co-administration  green tea extract showed mitigation toxic effect of bisphenol  A due to role of green tea as anti-oxidant compound.Keywords:  Evaluate, Bisphenol A, Green Tea, Antioxidant compound.
Synthesis, Physiochemical and Thermal Study of Some Transition Metal Complexes with Chelating Ligand and Study their Theoretical Treatments Israa H. Ibraheem
Journal of Global Pharma Technology .
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Complexes of Cr+3, Ni+2 and Cu+2 with the ligand 2-(p- nitrobenzoyl) thiobenzimidazol) (L) were prepared and characterized by FT-IR  ,UV-Visible, TG analysis ,Atomic absorption spectroscopy , Molar conductivity and magnetic moments measurements .The general formula has been suggested for all the prepared complexes [Cr(L)2Cl2]Cl.4H2O, [Ni(L)2(H2O)2]Cl2.2H2O and [Cu(L)2(H2O)2]Cl2.2C2H5OH to be an octahedral geometry. A theoretical treatment of these compounds in gas phase was done using HyperChem.8.7 program. Semi –empirical PM3 method was performed to evaluate the ∆H° ƒ, ∆ Eb and ∆ET for all compounds, also vibration frequencies, electronic spectra and electrostatic potential HOMO and LUMO energies for the ligand was estimated to determine the reactive position for this ligand .Keywords: Physiochemical study, Transition metal ion, octahedral structure, Theoretical study.
Synthesis and Characterization of Some New Oxazol, Thiozol, Oxazolidinone Derivatives from Quinazoline Nagham Majid Abdulhassan
Journal of Global Pharma Technology .
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Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2, 3-disubstituted-4(3H) quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, cyclization with ethyl chloro acetate and 4-phenyl-phenacyl bromid moiety afforded final compounds. The structures of compounds were confirmed by F IR, 1HNMR and.Keywords: Anthranilic acid, 4(3H)-Quinazolinone, Synthesis.
Teenager’s Thought is Related to Self-Control in Safe Smartphone Use During the Covid-19 Pandemic Rizki Fitryasari; Rr Dian Tristiana; Ah Yusuf
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: The use of smartphones in the Covid-19 pandemic era is an inevitable phenomenon, including for teenager who participated in online learning. The inability to control themselves independently in using smartphone-based devices is a risk factor for gadget addiction. This study aimed to analyze the relationship between teenagers' thoughts and self-control in safe smartphone use in the Covid-19 pandemic era. Methods: This study was a descriptive correlation design based on a cross-sectional approach. The population was teenagers aged 11-18 years in Surabaya, Indonesia who had participated in online learning during the Covid-19 pandemic. The purposive sampling was conducted and gained 185 respondents. The study variables were teenagers' thoughts and self-control in using smartphones. The instrument used was a questionnaire and the data were analyzed using the Spearmen Rank test. Results: The statistical test results showed that a good thought of teenagers was related to high self-control in using a smartphone (p = 0.000, r =0.371). Conclusion: The teenager’s thought in smartphone usage was formed based on benefits, barrier, beliefs, and the consequences of online learning activities. The teenagers’ awareness will lead to a good self-control for limiting the smartphones usage independently. Further research should be focused on the development of a safe smartphone usage guidance that can assist teens to be able to use the smartphone safely.

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