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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Synthesis and Identification of New Macrocyclic Ligand and Study its Pharmaceutical Properties as Anti-bacterial Reagent by Using Molecular Docking Study Ali M. Mohamed
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The macrocyclic ligand (5, 7, 12, 14-tetraisobutyl-5, 12-dimethyl -1, 4, 8, 11-tetraazacyclotetradeca-7, 14-diene) was prepared by the reaction between ethylene diamine and 4-methyl pentan-2-one with the help of the perchloric acid as a precipitant reagent. It characterized by FTIR, 1HNMR and UV –Visible techniques. The prepared macrocyclic ligand combine with protein by the application of molecular docking study and it compared with a well-known and standard drug which is gentamycin. The results indicated that the recorded compound is very effective against the toxic bacteria on its cell area and may be in the future become an effective treatment regent by conduct further studies.Keywords: Macrocyclic ligand, Molecular Docking, Gentamycin, Staphylococcus aureus.
The Role of IL-6 and TGF-β1 in Iraqi Women with Recurrent Abortion Roua Jamal Abdulkhaliq
Journal of Global Pharma Technology .
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Abstract

The alteration in the cytokines stability synthesis by Thelper1 cells with a rise of interleukin 6 (IL-6) and Thelper2 cells with the increase of TGF-β1 secretion is measured critical for retaining of usual pregnancy and increased risk of recurrent spontaneous abortion (RSA). This study was designed to measure some cytokines and affect these cytokines in the case of recurrent spontaneous abortion and healthy pregnant. Blood samples were collected from 210 women 180 women with the recurrent pregnancy loss (three or more abortions), and 30 women with normal pregnancy to three or more birth and without a previous abortion in the first trimester Based on clinical examination and diagnostic laboratory findings for TORCH of ELISA examination measured serum levels of immunoglobulin (IgM and IgG (for Toxoplasmosis, cytomegalovirus, herpes, and rubella in normal pregnant and in aborted women. Depending on the results of the test, the patients were divided into four groups: group one included 30 women with recurrent abortion with seronegative for TORCH test was (23.8%), group two recurrent aborted with seropositive for anti-toxoplasma antibodies was (20.9%), group three included recurrent abortion suffering from infected with different causes such as (cytomegalovirus, Rubella or Herpes) ratio was (41%). while group four women with a healthy pregnancy promise as a control group was (% 14.3). Then taking thirty serum samples of women from the first and second group with recurrent abortion and compared with control group then measured serum levels of pro-inflammatory cytokines Interleukin-6 (IL-6) and anti-inflammatory marker Tumor growth factor-beta1 (TGF-β1). The results presented that the serum levels of (IL-6) were highest in group1 and 2 (474.50 pg/ml and 629.60 pg/ml) respectively compared with control group (247.03 pg/ml), there was a significant difference. While TGF-β1 was the highest level in group1 (217.63 pg/ml) followed by group 2 (171.06 pg/ml) then control group (109.97 pg/ml) with the significant difference between three groups. The results indicated that the serum levels of pro-inflammatory and anti-inflammatory marker found with high level in recurrent abortion compared with healthy pregnant.
Effect of Frying And Storage on the Quality and Shelf Life of Fried Sweet Potato (Ipomoea Batatas) Chip Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Sweet potato is the seventh most important crop in terms of global production. Sweet potatoes are rich in antioxidants, such as phytophenolics and carotenoids which also provide distinct flesh colours. The high perishability of sweet potato roots during storage remains a major constraint. It is widely cooked by deep frying and consumed in forms of French fries and chips. Consumers are increasingly health conscious and trends are moving toward foods with low oil content. This research has been focused on different parameters of drying for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and carotenoid; extending product shelf life during packaging and preservation. Results revealed that frying 2.0 cm of sweet potato chip in soybean oil heating at 150oC in 2 minutes was appropriated. Fried sweet potato chip could be preserved for 12 weeks under vaccum at 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried sweet potato products. Frying of sweet potato bars is carried out to convert the roots to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability.Keywords: Sweet potato chip, Frying, Shelf life, Carotenoid, Flavonoid, Vaccum.
Effect of Adding Zirconia and Alumina Nanoparticles on the Tensile and Flexural Properties of Polymer Blend Based on Polypropylene Teeb Adnan Mohameed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Polypropylene is an important material used in many structural applications, including automotive and aircraft parts as well as machine parts.  In this paper, the properties of polypropylene were improved by blending it with 5% ratio of poly methyl methacrylate (PMMA) and adding nanoparticles powders of zirconia (ZrO2) and alumina (Al2O3) in different ratios (0.3, 0.5 and 0.7%) to polymer blend, which consists of [PP: 5% PMMA and adding 1% of (polypropylene-grafted-malic anhydrated (PP-g-MA) as compatibilizing agent)]. Polymer blend and its nanocomposites were prepared by melt blending technique using twin screw extruder. Investigation of some mechanical properties and the morphology structure test of the nanocomposites samples was studied. The results illustrated that the mechanical properties increased when adding nanoparticle (ZrO2 and Al2O3) to polymer blend (PP: 5%PMMA: 1%(PP-g-MA)) and the highest values were obtained for tensile strength, modulus of elasticity, flexural strength and flexural modulus, at 0.3% ratio of (ZrO2 and Al2O3) nanoparticles in the blend. The fracture surface morphology showed that the addition of nanoparticles led to reduce the micro pores that exist in the morphology structure of polymer blend.Keywords: Polymer blend, Nanocomposite, PP, PMMA.
Assessment of Heavy Metals in Some Ground Water Wells at Baghdad City /Iraq Husam Saleem Khalaf
Journal of Global Pharma Technology .
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Abstract

Occurrence the heavy metals in water is one of the most important concerns. may cause savior health problems. In this work we made an attempt to know the quantity of six heavy metals in groundwater in different locations of Baghdad city. Examinations were made on groundwater of the review region to assess the heavy metals. Groundwater samples were gathered and analyzed utilizing Atomic Absorption Spectrophotometer for their Manganese, Iron, Zinc, Cadmium, Copper and Lead content and their levels compared with World Health Organization (WHO) specified maximum contaminant level. In order to accomplish this, water samples were obtained from 10 randomly selected wells in the region, in February and August, 2016. The study showed that the groundwater in the study area were generally alkaline (moderate) and contained Cu+2, Fe+2, Pb+2, Cd+2, Cu+2 and lead concentrations that are higher than the permissible limits suggested by the (WHO). The study can then be concluded to be contaminated with some heavy metals because of the effect of many activities in the survey area. Decreased the operation of Industrial treatment, laws and the integrated management led to deteriorating the groundwater quality. Also the study inclusion the TDS and EC in the groundwater in these locations.Keywords: Determination, Heavy metal, Atomic absorption, Groundwater wells.
Synthesis, Spectral Characterization and Studies of New Heterocyclic Azo Dye Compound Derived From Imidazole with Some Transition Metal Complexes Zainab. J. Mohammed
Journal of Global Pharma Technology .
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Abstract

A new heterocyclic azo ligand (E)-2-((4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl)diazenyl) benzoic acid, (CPMI=HL) was prepared by coupling diazotized of anthranilic acid with 4,5-bis(4-methoxyphenyl)-1H-imidazole in alkaline ethanolic solution. Eight complexes with Mn(II) , Fe(II), Co(II) ,Ni(II) ,Cu(II) ,Zn(II) ,Cd(II) and Hg(II) ions. These complexes and ligand were characterized by elemental analyses, IR, U.V-Vis spectra, mass spectra, (ligand and its Copper (II) complex), magnetic moments, Atomic absorption and molar conductance measurements. The IR data show that, the azo molecule behaves as a mono negative tridentate(N, N,O) ligand and linked through the carboxlicoxygen atom, azomethanic nitrogen of heterocyclic imidazole molecule and nitrogen atom of azo group, produces colored chelates with transition metal ions.The molar conductance data for all complexes are nonelectrolyte. Based on analytical and spectral data we proposed a monomeric octahedral geometry for all chelate complexes and d2sp3 or sp3d2 hybridization.Keywords: Azo imidazole, Chelate complexes, Characterization. 
Quality of Life of Hypertensive Patients with Candesartan and Candesartan-Amlodipine Combination Therapy at a Governmental Hospital in Yogyakarta, Indonesia Faridah Baroroh
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Many types of antihypertensive drugs produce different efficacies, and their use in therapy is often associated with unpleasant side effects that diminish the quality of life. This prospective cohort study intended to compare the impacts of two different treatments, namely candesartan and the combination of candesartan and amlodipine, on the quality of life of hypertensive outpatients at a government hospital in Yogyakarta, Indonesia. Starting with preliminary data survey, the analysis continued to measuring the quality of life of 100 respondents, which had met the inclusion and exclusion criteria, after three months of therapy. In the EQ5D questionnaire on quality of life, the EQ5D dimension was converted to EQ5D Index. The data analysis involved chi-square and correlation tests. The EQ-5D index ranged from 0.540 to 0.933 with an average of 0.819. Based on gender and complications, the quality of life of the patients who underwent candesartan therapy was not significantly different from those who took candesartan and amlodipine (p> 0.05). Meanwhile, based on age, occupation, income, and education, a significant difference was detected (p <0.05). The quality of life significantly correlated with age, employment, income, and education (p <0.05) but insignificantly with gender and complications (p> 0.05). As a conclusion, candesartan and candesartan-amlodipine therapies do not affect the quality of life of the patients differently, and the type of treatment is a factor that does not significantly affect the quality of life of the patients (RR; 95% CI = 1.135; 0.812-1.587). Keywords: Quality of life, Candesartan, Candesartan-Amlodipine, Hypertension, Outpatient.
Synthesis and Characterization of Cadmium-Copper Oxide (CdCu2O4) Nanoparticles by Chemical Co-Precipitation Method in the Presence of Oleic Acid as a Surfactant Abouzar Tahkor
Journal of Global Pharma Technology .
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Abstract

The present study intended to synthesize cadmium-copper oxide (CdCu2O4) nanoparticles by chemical co-precipitation method in the presence of oleic acidC17H33COOH as a surfactant to control the size of particles. The spherical CdCu2O4nanoparticles were synthesized with an average particle size of 44.79 nm at the calcination temperature of900˚C for 4 hours. The chemical co-precipitation method was utilized as an easy and inexpensive method to produce high-purity mixed oxides. The morphology, network parameters and particle size of the product was studied and characterized by Fourier transform infrared spectroscopy (FT-IR), X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) techniques. The XRD analysis showed the pattern of CdCu2O4corresponded to Perovskite structure and monoclinic symmetry. The average particle size synthesized by XRD almost matched with the particle size observed in SEM image. The results indicated that the amount of surfactant, pH and stirring rate of solution had a crucial role in the homogeneity and particle size of the product.Keywords: Cadmium-copper oxide nanoparticles, Co-precipitation method, nanoparticles, oleic acid, Surfactant.
Comparison the Effect of Ewe and Goat Colostrum Extracts on the Hematological and Biochemical Profiles: Rat as a Model Afrah Sabeeh Mhyson
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

This study was generated to provide information about the hematological and biochemical changes affected by exposing female rats to colostrum extracts of ewes and goats. As a start, 30 female rats were classified randomly into 3 groups (10 rats/each). The experiment was lasted for 30 days. Until the end of the experiment, a group received ewe colostrum extract (ECE) as 0.1ml orally/daily, another group was given goat colostrum extract (GCE) at 0.1ml orally/daily, the control group (C) was provided with normal saline at 0.1ml orally/daily. After the experiment was done, sacrificing of the tested animals was performed, and blood-based samples were obtained. These blood samples were tested for changes in the blood profiles using certain features such as RBCs counting, hemoglobin (Hb) level, packed cell volume (PCV), WBC counting, glucose (Glu) level, cholesterol (Ch) level, triglycerides (TAG), alkaline phosphatase (AP), alanine transferase (ALT), basophils (B%), eosinophils (E%), monocyte (M%), lymphocyte (L%), and neutrophils (N%). The results recognized significant (p<0.05) effects of the extracts on the RBCs, Hb, PCV, Glu, Ch, and TAG when compared with those in the C group. Furthermore, no significant (p>0.05) differences were provided from such effects on the WBCs, AP, and the ALT when compared with those in the C group. There were significant (p<0.05) effects of the extracts on the L% when compared with that in the C group. However, no significant (p>0.05) differences were provided from such effects on the B%, E%, M%, and N% when compared with those in the C group. No differences were noticed from these effects between both extracts on all those parameters. The study provides very important data about the effects of ewe and goat colostrum extracts on the hematological and biochemical characteristics in female rats that could be further used as supportive information for future studies.Keywords: Blood, Biochemical, Colostrum, Ewe, Goat, Parameters, Rat.
The Emotional Sensitivity of University Student's Girls to the Practices and Non-practices of Sport Hind Salem Tayeh
Journal of Global Pharma Technology .
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Abstract

Their current research problem has focused on trying to answer the following question: Does exercise affect the emotional sensitivity of students in Iraqi universities? The objective of the study was to identify the level and fields of emotional sensitivity of both female students and non-sports practices, and to identify the differences between the level and fields of emotional sensitivity in both female and non-sports students. The researchers hypothesized the following: Of the emotional sensitivity between female students and non-practices of sport, and there are significant differences between the results of the negative field of emotional sensitivity between female students and non-practices of sport, there are differences of statistical significance between NTA The researchers used descriptive research method in the method of comparative studies on a sample of students of the third stage of the Faculty of Physical Education and Sports Sciences at the University of Baghdad (practices) for sport and the third phase students of the Faculty of Management and Economics at Mustansiriya University (Non-practices) for the sport, the number of (60) students who are 21 years of age in each of the two kidneys persisted for the academic year 2017/2018 by (30) students to exercise sports, and (30) non-sports student, Their stages of rain (SPSS). The researchers concluded that the level of emotional sensitivity in both the practices and non-practices of the sport was clear, that the level of emotional sensitivity in the practices was More than non-sports practices, female students need practices and practices to guide psychological counseling to reduce the level of emotional feeling they have, to recommend that researchers should pay attention to the measurement of emotional sensitivity to university students B Each league, interest in providing the educational atmosphere dominated by harmony and tolerance for students of Physical Education and Sports Science, it is necessary to work to enable the teaching staff in the faculties of Physical Education and Sports Science members to provide educational and psychological counseling programs and provide students with the state of love.Keywords: Emotional sensitivity, Practices and non-practices of sport.

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