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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Various Technical Aspects in Herbal Tea Production from Alisma Plantago-Aquatica Leaf N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Alisma plantago-aquatica is abundant weed on thinned crops of rice. A. plantago-aquatica is resistant to flood, but being very susceptible to shade; therefore the thickened rice crops shade the weeds and detain their growth. Leaves green; lower ones only sessile, widely linear, and swimming; the other ones aerial, long-petiolate; their plates big, ovoid or widely ovoid, with cordate base usually, with pointed apex. The use of medicinal herbs as a source of antioxidants is significant because they are often utilized to heal chronic diseases. Objective of this study focused on the effectiveness of blanching temperature and time; oven drying temperature and storage condition to total phenolics (mg/g), total flavonoids (mg/g), ferric reducing/antioxidant power (FRAP, mg/g), radical-scavenging activity (DPPH, mg/mL) of the dried Alisma plantago-aquatica tea. Results showed that Alisma plantago-aquatica should be treated in hot water at 95oC within 8 seconds in the present of citric acid 1.0% and then being dried by drying oven at 45oC until 7.5% moisture. The final herbal tea could be preserved under vacuum in aluminum bag at 28oC to maintain total phenolics, total flavonoids, antioxidant power and radical-scavenging activity for 12 months.Keywords: Alisma plantago-aquatica, Phenolic, Flavonoid, Herbal, FRAP, DPPH, Blanching, Drying.
The Impact of Iron Deficiency Anemia on Histomorphological Features of Placenta and the New Born Infants Rafah Hady Lateef Al-Mamouri
Journal of Global Pharma Technology .
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Abstract

 Iron deficiency anemia during pregnancy is  mutual heamatological disorder that happens in pregnancy, it affects maternal blood , leading to hypoxia, which cause changes in the structure of the placenta . Aim of study to explore the changes occurres both   in gross morphology and in histology of the placenta in anemic mothers. Methods: A fifty placentas were taken from mothers (full term) delivered at hospital constituted the material for the  present study. Full term placenta  was collected with case history and investigated after delivery of fetus. Two cm pieces were removed from both anemic and normal  group of placenta fixed in 10% formalin and used for processing and staining.  The microscopic study revealed histomorphological abnormalities as increased capillaries per villas, thickening of capillary basement membrane , trophoblastic basement  membrane, cytotrophoplastic proliferation,syncytial knots and fibrosis. All these changes occurred maintaining sufficient efficiency of placenta, to fulfill demand of oxgen in the fetus.Key words: anemia, histology, placenta,pregnancy.
Rationality and Prescribing Pattern of Antimicrobials on Female Lower Genital Tract Infection in a Tertiary Care Hospital of Odisha Ginia Agasti; Rasmita Jena; Dipti rani Rath; Trupti Rekha Swain; Goutam Ghosh; Durga Madhab Kar
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
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Abstract

Objective: Current study is based on the pattern analysis of various antimicrobial prescriptions for the treatment of female lower genital tract infection and its validation of rational use in a tertiary care hospital of Odisha. Methods: The current prospective investigation was carried out in outpatient department of Obstetrics and Gynaecology department at a tertiary care hospital over a period of six months.   A suitable data collection was carried out from female lower genital tract infection patients who were of 11-55 years of age group. Results: The study result found that most commonly prescribed antimicrobials were antifungal (azoles derivatives) and its combination with other antimicrobials. The other antimicrobials include, topical (8.4%)/single antimicrobial oral (2.8%)/ combination (intravaginal as well as oral- 50%) followed by other antimicrobials like linozolid (4.8%). Our study reveals that, antifungal agents are the most common antimicrobial drugs prescribed on the basis of laboratory diagnosis report, which revealed that, staphylococcal infection in majority of the patients (42%). Conclusion: Hence, present study shall definitely provide a small initiative towards control of emergence of antibacterial resistance, its side effects and cost of therapy worldwide.Keywords: Prescribing pattern, Antimicrobials, Lower genital tract infection, Tertiary care hospital.
Brown, White and Blue Bagging in Special Pharmacy: An Emerging Trend to Minimize Medication Error Sharad Chand
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Advancement in the sector of specialized pharmacy evolved a new concept of bagging system beyond the scope of traditional pharmacy service. Managed care organizations (MCOs) bring up the healthcare system in the network where the services are made available for the betterment of treatment and secure documentation system for reimbursement. Certain models namely brown bagging, white bagging, and blue bagging system are promising models for this system. These models generally cover expensive and high-risk medication to minimize the wastage and related drug related problems. In these models, all the prescribed medications reach to the health professionals, which meticulously review all the medications before its administration. This potential system has several advantages over the conventional pharmacy practices, despite several advantages many associated risk and disadvantages are equally challenging. But it can be concluded that benefits are outweighing the risk associated with these models, which may have more impact on patient wellbeing. Hence, this system of special pharmacy service can be recommended in the scope of hospital pharmacy and pharmacy practice.
Nurses' Attitude Toward Mental Illness in DhiQar, Iraq Ahmed Hassan Hussein
Journal of Global Pharma Technology .
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Abstract

Stigma against mentally ill patients is highly prevalent among nurses. High rates authoritarianism and social restrictiveness, low rates of benevolence and community mental health ideology were noticed among nurses. Recommendations: These findings raise the importance of learning the nursing students and nurses about the stigma and the right attitudes towards mentally ill patients. Future studies need to be inclusive of larger samples and need to study other aspects of the problem like the etiology and impact on patients.Keywords: Nurses, Attitude, Mental illness
Biosynthesis of Copper Oxide Nanoparticles using Starch of Maize and It’s Antimicrobial Activity against Opportunistic Pathogens Mouruj A. Al-Aubydi
Journal of Global Pharma Technology .
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Abstract

Copper oxide nanoparticles were synthesized by thermal green synthesis method using basically starch of maize, CuSO4.5H2O, with an abundance quantity of ammonia solution as stabilizing and alkalinity agent, the reaction was completed at 200 ͦC. The formation of black solution was represented the creation of CuO nanoparticles. Finally, after precipitation, washing by deionized water and ethanol and drying, CuO nanoparticles are obtained as black powder. The synthesized copper oxide nanoparticles were characterized via various techniques, included ultraviolet –visible (UV-visible) spectrophotometry, X-ray diffraction (XRD), fourier transform infrared spectroscopy analysis(FTIR) and transmission electron microscopy (TEM).All the analysis showed that the nanoparticles were very constant, pure, globular shape as well as average crystallite measure is 9.8nm. The particles diameter size was ranging from 47.41nm to 109.49nm. However, the average distribution (d50) is71.17nm.Antibacterial CuO nanoparticles activity of different concentrations were tested against four strains of pathogenic Gram-negative  bacteria Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Gram-positive bacteria Staphylococcus aureus. The results showed that different concentration of CuO nanoparticles have been significant increasing effect in inhibiting of a bacterial growth compared with the control for both types of bacterial isolates. Also,it was found that all isolates appeared high level of resistance against most usable antimicrobial agents, while these resistance were decreased in case of combination with CuO NPs. Thus there is a synergistic effect between CuO NPs and antimicrobial agents. Keywords: Copper oxide nanoparticles, X-ray diffraction, Starch, Antibacterial activity.
Expression of Adipocyte Binding Protein-2 (AP-2) on the Adipogenic Differentiation of Mesenchymal Stem Cell after Pulsed Electromagnetic Field (PEMF) Exposure Umiatin U
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Obesity is a health condition that can cause serious health problems in developing countries such as Indonesia and still a major health concern worldwide. Obesity increasing the risk of a number of pathological disorders including certain cancers, heart disease, stroke, and diabetes. It has been reported that Pulsed Electromagnetic Field (PEMF) have an inhibitory effect on adipogenesis of MSCs. However, it is not clear if this effect is direct or indirect. Various genes are involved in the development of obesity include adipocyte binding protein 2 (AP-2) which is associated with inflammation and the metabolic syndrome. In the present study, we investigated the effect of PEMF exposure with frequency 75 Hz and magnetic field 2 mT on the adipogenic differentiation of mesenchymal stem cells (MSCs). In the present study we used the MSCs second passage. The cells were stimulated by PEMF of 75 Hz/2mT for 14 days 10 in/day. The relative expression of AP-2 was measured on days 2, 4, 7 and 14 by using quantitative reverse transcription polymerase chain reaction (qRT-PCR) method. The PEMF significantly inhibited adipogenic differentiation by down regulating the expression of AP-2 on days 2, 4 and 7. This result indicated that PEMF exposure may have potent effect to inhibit adipogenic differentiation. Keywords: Pulsed electromagnetic field, Adipogenic, Mesenchymal Stem Cells, AP-2
Association of Different Body Mass Index with Vitamin D Receptor Gene in Females with Deficiency of Vitamin D Maha F. Smaism
Journal of Global Pharma Technology .
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Abstract

Background: Obesity is one of the well spread chronic condition that is affecting health and it is connected to many fatal chronic diseases like cardiovascular disease, diabetes mellitus and cancers. Vitamin D is shown to has a role in the pathogen city of obesity, and the Vitamin D receptor (VDR) gene polymorphism is shown to affect the obesity phenotypes like body mass index (BMI).Objective: is to assess the association between different variants of vitamin D receptor gene and the BMI in females with deficiency of vitamin D. Methods and Materials:  The study was conducted with the participation of 170      females who are having low vitamin D levels. The single nucleotide polymorphism Taq in the vitamin D receptor gene was detected by PCR-RFLP. Vitamin D level in the serum was measured by ELISA technique. Result: This study is resulted in that there is a positive correlation between the BMI and different biochemical measurements like the level of vitamin D(p < 0.001), calcium level [ both free Ca(p=0.01) and total Ca(p= 0.002)], urea level (p < 0.001), and bilirubin level (p < 0.001). It is also resulted in finding a positive correlation between the BMI and the genotype of the vitamin D receptor, as it is noticed that 44.7% of the patients who are carrying the TT genotype, while only 40.0% of the patients who are carrying the CC genotype. Conclusion From the result   the study show significantly negative correlation between Vitamin D and BMI that means the vitamin D deficiency could relate with increase BMI ,Also there is significantly negative correlation between vitamin D and cholesterol ,as well as this study indicate that significantly decrease of total bilirubin  with increasing BMI increased. From the results of genetic study for vitamin D receptor gene study, can conclude that the T allele is positively correlated to the obesity represented by the BMI, and that could lead to the conclusion that females who are having the TT genotype are of higher probability to get high  BMI and obesity. 
Pattern and Characteristic of Sports Related Injury in Emergency Department Sardjito Hospital Andreas Wahyu Wicaksono
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective. Sport activites have been encouraged to everyone due to its benefits to the physical fitness, improving the endurance, and has psychological good impacts. But, sport activites also carries risk of injury to the body. Sports-related injuries are not an uncommon cause of ED visit. The aim of this study was to identify the pattern and characterize emergency department (ED) visits that result from sports-related injuries across the Sardjito Hospital.Methods. The study took place retrospectively observational study over a period of two years from January 2014 to December 2015 and included people 3 years of age or over. Any patient presenting with an injury attributable to participation in organised sport had their details and phone number noted in the medical record form by the orthopaedic resident. The patient medical record were analysed retrospectively. Demographic trends, pattern and characterstic for each patient were recorded.Results. A total of 133 elligible patients were enrolled to this study, 98 were male with the mean of age was 17.5. The most common type of sport that cause of injury was cycling (22.6%), followed by running (21.8%) and then football (17.3%). The majority of the patient sustained upper extremity injury (75.9%). 108 patients sustained fracture, 15 dislocation, and 10 soft tissue injury. There was statistical differences between type of injury as compared with age group (p = 0,000), the age group of <10 years old, 11-20 years old, 31-40 years old and >40 years old suffered more fracture than dislocation and soft tissue injury. There was statistical differences between type of injury as compared with injured extremity (p = 0.03), the injury mostly affected superior extremity, but there was no statistical difference between type of injury as compared with type of sports, gender and side of injury (left or right) (p > 0.05). Conclussions. Sports can cause musculoskeletal injuries, good preparation must be taken to avoid severe injury. High percentage of upper extremity injury and lower extremity injury, the specific type and location of injuries of each sport should be known by health professionals.Keyword: sport injury, emergency department, age group, gender, location and types of injuries
Effectiveness of Pitaya Pulp Incorporated to Wheat Flour in Bread Making Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

 AbstractThere has a trend towards the consumption of functional foods beneficial for human health.  Bread is one of the most important staple foods in the world.  Pitaya pulp is a rich source of nutrition like carbohydrate, pectin, crude fibre, vitamin and minerals. It also contains a great amount of phytochemical constituents like phenolics, flavonoids. It would be of functional benefit if wheat flour could be substituted by pitaya pulp to utilize anthocyanin pigment in adherent as natural valuable colorant in bread-making. We have attempted in the application of composite flour through the incorporation of pitaya pulp into wheat flour to improve nutritional quality of bread. In this study, pitaya pulp was utilized to substitute refined wheat flour in bread-making doughs at 3.5%, 5.0%, 6.5%, 8.0%, 9.5% substitution levels. Various variables of texture firmness (g), specific loaf volume (cm3/g), water activity (aw), rancidity (meq O2/kg fat), total phenolic (mg GAE/ 100g), total flavonoid (mg GE/ 100g) and sensory characteristics of bread were carefully observed. The substituted bread-making with 8.0% pitaya pulp had the improved firmness, rich in total phenolics and flavonoids but low in rancidity. During 7 days of storage in OPP/LLDPE pouch at ambient temperature, the physico-chemical, microbial and sensory characteristics of bread still satisfied to acceptable level.Keywords: Bread, Pitaya, Firmness, Specific loaf volume, Water activity, Phenolic, Flavonoid, Rancidity.

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