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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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The Effect of Special Vital Exercises to Force the Opposing Team to Commit Mistakes and Legal Irregularities in Handball Thaerah Abdul Jabbar Saleh
Journal of Global Pharma Technology .
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Abstract

That the multiplicity of skills and plans offensive individual and collective handball players was also accompanied by the development of defensive aspects, which led researchers to use and experimenting methods that are highly influential on the performance of individual defense and collective and offensive, so the importance of research by finding some exercises, The ball directly, but also affect the competitor and push him to commit errors and legal irregularities to benefit from the contribution studied in the increase of penalties and progressive suspension cases . In this case, the problem of research was not to exploit the imposition of individual and individual punishments imposed by the law, but to limit the interest in directing the players not to make these irregularities and mistakes to avoid penalties. Therefore, exercises were put in place for forcing the players of the opposing team to commit violations and legal errors. The effect of some exercises in forcing the opposing team players to commit mistakes and legal irregularities the researchers hypothesized that there were significant differences between the tribal and remote tests of the two groups and for the benefit of the remote tests. There were also significant differences between the tests of the two groups of research and for the experimental group. The researchers used the experimental method. The research community was determined by the players of the Karbala University team for the academic year 2011/2012 and for the Karbala youth handball players for the handball at the age of 18-20 years. A sample of (30) players from this society were selected and divided equally into two control groups. The results came in favor of the experimental group, and the researchers concluded that the special exercises used were of interest to the players in forcing the opposing team to commit legal errors and irregularities. This type of exercise has a great positive impact on the outcome of the game and thus achievement especially for players of age groups. The researchers recommended that trainers adopt this type of exercise in their training and use it for younger age groups, which are likely to have greater results because they are less aware of the law and its applications.Keywords: Vital exercises, force, opposing team, commit mistakes and legal irregularities.
Isolation, Screening, and Identification of Bacillus sp. Produced L- Glutaminase and Optimization of its Production by Submerged Fermentation Hameed Abbood Jebur
Journal of Global Pharma Technology .
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In this study L-glutaminase produced by locally Bacillus sp. isolated from different local of Iraqi soil.  Fourteen isolates were selected to produce L-glutaminase by submerged fermentation. The isolate C13     showed a maximum L- glutaminase activity (28.08 U/ml). This isolate was identified according to morphological, cultural, Vitek 2 system and genetic analysis using 16srRNA gene. The microorganism was closely related to Bacillus subtilis according to gene bank database in NCBI, and signed as Bacillus subtilis MH049477.1. The L-glutaminase production pattern was studied under submerged fermentation and increased their yield after optimization of fermentation parameters. The highest L-glutaminase activity (61.12 U/ml) was achieved by using  3 % of galactose as the carbon source and 2% of yeast extract as nitrogen source at pH = 8, after 48 h of incubation at  37o C  by using 2ml of inoculum contains 1x106   cfu /ml of Bacillus subtilis MH049477.1  . Fermentation was achieved in an incubator shaker at 120 rpm.Key words: Identification, Bacillus sp., L- glutaminase, Optimization, Submerged Fermentation
Efficacy, Safety, Quality Assurance of Isomers of Non-Steroidal Anti-Inflammatory Drugs: Dexketoprofen and Dexibuprofen Elena Litvinova; Mariya Zarichkova; Svitlana Kovalenko; Olga Posylkina; Olena Tkachenko; Anastasiia Lisna
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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The aim of this work is to analyze and systematize data on efficacy, safety, and quality assurance for NSAID isomers – dexketoprofen and dexibuprofen. Studies were conducted using databases on the Internet: PubMed; Food and Drug Administration, European Medicines Agency. It has used retrospective, logical, systematic and analytical methods. The results of a multifaceted analysis of sources of data of clinical use proved the high analgesic efficacy of dexketoprofen and dexibuprofen in acute and chronic pain of various etiologies, such as toothache, dysmenorrhea, pain after surgery, muscle pain, headache, back pain, pain from bone metastases, etc. To achieve the effect obtained with the use of 1 dose of racemic NSAIDs, half the dose of their active isomers is sufficient. The high clinical effectiveness of dexketoprofen, dexibuprofen combines with their relative tolerance, in particular from the gastrointestinal tract. In large part, the safety of dexketoprofen is due to the presence of only the active S (+) - enantiomer of ketoprofen, dexibuprofen is due to the presence of only active S (+) - ibuprofen, which eliminates the side effects associated with the influence of the R (-) - enantiomers. The results of the analysis of quality assurance of generic dexketoprofen (class 1 of biopharmaceutical classification system) and dexibuprofen (class 2 of biopharmaceutical classification system) during the biowaiver procedure are systematized. It has been shown that not only high permeability and high solubility, but also the composition of the drug excipients are important for pharmaceutical equivalence in vitro. Based on the results research findings presented, it is possible to optimize the technological process and analytical methods, which allows taking into account critical factors and ensuring the quality of the medicine and its bioequivalence to the reference drug.
Using Mathematical Models within the Cosmetological Aid Organization in the Context of Botulinum Toxin Therapy of Upper Face Skin Age-Related Changes Olga Nikolaevna Krasilnikova
Journal of Global Pharma Technology Volume 11 Issue 04.
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Mathematical modeling is the language of modern science. This paper describes the application of the mathematical evaluation of the clinical efficiency of botulinum toxin therapy of age-related changes in the skin of the upper half of the face on the example of correcting the three zones of the patient. For this purpose, we used the scoring scale; schedules that help the doctor get new information about the effectiveness and quality of the procedure throughout the observation period, and master practical skills of quality examination. Such an approach in cosmetology will make it closer to evidence-based medicine, contributing to the objectification and systematization of the accumulated data.Keywords: Cosmetological care, Botulinum toxin therapy, Evaluation of the efficiency of injection correction of age-related facial skin changes, Quality of medical care, Integral quality factor.
Antidepressant Effects of Cleistocalyx nervosum Extract Consumption in a Rat Model of Post Stroke Depression Wathita Phachonpai
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The aim of this study was designed to evaluate whether Cleistocalyx nervosum (C. nervosum) extract improved depression-like behaviors induced by middle cerebral artery occlusion (MCAO) in post-stroke-depression (PSD) rats. Right MCAO procedure was performed on day 1 in male Wistar rats. C. nervosum was thereafter administered (250, 500 and 750 mg/kg), daily for 28 days. Neurological functions after ischemia were determined by the forelimb grip force and the hot plate tests. Tail suspension (TST) and forced swimming (FST) tests were used to assess depression-like symptoms. Plasma corticosterone (CORT) level, and brain oxidative status, and scavenging enzymes were also investigated. Our results showed that three doses of C. nervosum treatment were able to diminish neurological impairments and exert antidepressant effects in PSD rats. This was accompanied by the decrease in stress hormone level and brain oxidation indices, and increase in antioxidant enzymes activities. It suggested that C. nervosum could improve the depression-like emotional status and promote recovery of motor and sensory functions in PSD, and can be applied as a complementary agent for treatment of PSD.
Effect of Physical Exertion in Some of Antioxidant concentrations for Young Player's in Handball Ahmed Kadhim Abdulkareem
Journal of Global Pharma Technology .
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The study aimed to identify the effect of physical effort in some concentrations of antioxidants for young handball players. The study also revealed that there are statistically significant differences in physical exertion in some antioxidant concentrations of young handball players. It has been shown that the importance of research helps to detect the degrees of emotional arousal and knowledge of its relationship with antioxidants that work to get rid of the free radicals causing fatigue for young basketball players. The researchers used the training curriculum to suit the nature of the problem on the players of Kufa Sports Club youth handball for the season (2017-2018) and the number of (12) players, was adopted method of comprehensive inventory in the selection of the sample were identified two players for the purpose of conducting the pilot, The main sample is (10) players. After the tests of pretest and posttest, data were collected and processed statistically to obtain the results through which reached the most important conclusions, the physical effort at the heart rate 180 beat/second was affected by the antioxidants taken by the researcher and the component of Selenium (Se) and (Vitamin E And C) was the result of good preparation and systematic training of young handball players. The rate of change of vitamin(C) was higher than that of vitamin (E) and the lower selenium was achieved after the physical exertion at 180 beat/second for youth players in handball.Keywords: Physical exertion, Antioxidants and handball.
Effect of Extract Cocor Bebek (Bryopyllum pinnatum) to the Amount of Th17 Cells Spleen and Levels of IL-17A Serum in Mice Balb/C Pregnant Model of Systemic Lupus Erithematosus Umi Kalsum
Journal of Global Pharma Technology Volume 11 Issue 6.
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This study aims to determine a way to reduce the number of Th17 cells spleen and serum levels of IL 1A heart in mice Balb /C pregnant models with Systemic Lupus Erythematosus. This was studied, using mice Balb / C pregnant models with SLE. This study is divided into 5 groups: negative control, positive control, and treatment provision Bryophyllum Pinnatum dose of 10.5 mg/day, 21 mg/day and 42 mg/day.  The Th cell number 17 was measured through flow cytometry. Levels of IL 17A were measured using the ELISA method. The data was analyzed using the Kruskal Wallis test. Giving bryophyllum Pinnatum dose 21mg / day (2.79 ± 1.484) has been proven to reduce the number of Th17 cells in mice Balb / C pregnant models with SLE when compared to the other dose treatment. Although, it did not significantly affect (p> 0.05).There was no difference with the increased levels of IL bryophyllum Pinnatum 17A in Balb / C mice pregnant models with SLE (p> 0.05). Conclusion: Giving bryophyllum Pinnatum has been proven to reduce the number of Th 17 cells in mice pregnant models with SLE.Keywords: Systemic Lupus Erythematosus (SLE), Bryopillum Pinnatum, Th17, IL 17A.
Pharmacoeconomic Analysis - The Way to Optimization of Using the Health Budget Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Reforming the drug supply system requires the introduction of modern scientific approaches to quality management of pharmacotherapy, the main principle of which is the individual selection of the drug taking into account its effectiveness and safety. Introduction: To analyze the literature on the need and feasibility of using pharmacoeconomic methods to provide medicines. Materials and methods: The basis for research is the methods of pharmacoeconomics. Results: The analysis of the data of literature sources was carried out and the necessity of using pharmacoeconomic methods in the field of health care was determined. Conclusions: As a result of the review, it was determined that pharmacoeconomic analysis is an effective method that facilitates the adoption of optimal decisions in the field of drug supply. Keywords: Arterial hypertension; Health care, Antihypertensive drugs; Form system.
Assessment Effective Factors on Clinical Application of Nursing Continuing Education from the Viewpoints of Nurses Mohsen Hojat
Journal of Global Pharma Technology .
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Introduction Ongoing continuing education program with the present methods and conditions is inadequately helpful and applicable. There are various factors, which influence the efficiency and efficacy of such programs for nurses. The present study aimed to investigate the effective factors in application of continuing education from the viewpoints of nurses. Methods This is a cross- sectional descriptive study. Sampling was census, conducted on nurses in Jahrom, Iran in autumn 2015. Data were collected by Dehghan Nayeri and Khosravi checklist with reliability of α=0.949. Data were analyzed by descriptive statistical tests (frequency distribution and mean), independent t- tests and Spearman correlation coefficient. Results In the present study, 176 subjects were recruited of whom 72.7% were female. Subjects' mean age was 21.64 (14.18) years. From the viewpoints of the nurses, the most effective factors for application of continuing clinical education were "the scientific characteristic of the training nurse" and " enough accountability in applications of the learned materials" while the lowest effective factors were" financial reward of the organization for newly learned materials" and "application of distant learning in the ward". Mean overall score of factors effectiveness was 3.07(0.53). Conclusion The level of various factors effectiveness in use and application of continuing education programs should be considered. The most important goal of administration of continuing education programs is improvement of nurses' knowledge and awareness to promote the quality of the given services.Keywords: Continuing education, Nurse, Clinical application.
Biochemical Study in Rats Hepatotoxicity with Carbon Tetrachloride and Treated with Camel Milk Alyaa Majid
Journal of Global Pharma Technology .
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Objective: Carbon tetrachloride (CCl4) is a highly toxic chemical agent. Therefore, the present study was carried out to investigate the protective effects of camel's milk against CCL4 induced toxicity in male rats. Materials and methods:  Albino male rats (150-200 g) were divided into four groups of 6 rats: a control group fed only with diet and tap water for two weeks, the second group fed with standard diet and camel milk, the third group intoxicated with CCl4 on first two days of the experimental 14 days and fed with tap water and diet, and the fourth group intoxicated with CCl4 on first two days of the experimental 14 days and then treated with camel milk. Results: The results indicated that the CCl4 caused a significant increased in the level of  serum total cholesterol(TC) , triglycerides(TG), very low density lipoprotein (VLDL)and low density lipoprotein(LDL), lactate dehydrogenase(LDH), creatine kinase(CK)and aspartate aminotransferase (AST). Also, there was a significant decreased in the level of serum high density lipoprotein (HDL).Protective activity of camel's milk against toxicity of CCl4  observed in decreasing of TC, TG, VLDL, LDL, LDH, CK, AST and increased in the HDL levels. Conclusion:  These findings strongly prove that beneficial effects of Camel Milk clearly shown through the reduction of the CCl4 induced related damages and oxidative stressKeywords: Camel milk, Carbon tetrachloride, Lipid profile, Rats.

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