cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
 43   44   45   46   47 
Search results for , issue "." : 1,093 Documents clear
Synthesis and Characterization of Some New Quinolinic acid Derivatives Haneen Nazar Wahab Al-Issawi
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Preparation of some non-homogeneous cyclic compounds starting with Quinolic acid .A different N-heterocyclic substituted derivative of quinolone has been synthesized. The nitrogen atoms have been alkylated first to form N-carboxymethyl followed by cyclization reaction to form heterocyclic/substituted aryl groups. All the synthesized compounds have been identified using FT-IR, 1H NMR spectrum.Keywords: Quinolinic acid, 1, 3-Oxazole, Imidazol, 1, 2, 4-Triazole, 1, 3, 4- thiadiazol, diazetidin, diazepines.
The Effectivity of Clonidine Addition to Levobupivacaine 0.25% for Scalp Block in Patients Underwent Craniotomy Surgery Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The scalp nerve block technique is a relatively simple and safe technique. Clonidine is well-known as an agent that extends the analgesia effect of local anesthetic drugs. The goal of this study was to evaluate the effectiveness of clonidine addition as adjuvants in levobupivacaine 0.25% in scalp nerve block in craniotomy procedures. Patients and Methods: This was a clinical trial with a double-blind, randomized study using consecutive sampling technique. Inclusion criteria include patients underwent craniotomy surgery due to brain tumor using general anesthesia with endotracheal tube in 18-60 years of age. As an addition to general anesthesia, group a received levobupivacaine 0.25% and clonidine 2 µg/kg as a regiment for scalp block. Group B received levobupivacaine only for the same purpose. All other treatments were similar for both groups. Results: The intraoperative fentanyl requirement (100 (50-150) vs. 150 (75-200) mcg, p <0.001), the period to the postoperative first PCA dose (822.5±129.7 vs. 387.8±69.6 minutes, p <0.001), and the total need of postoperative morphine by PCA (2.0 (1.0-3.0) vs. 3.0 (2.0-7.0) mg, p <0.001) were lower in the clonidine-added levobupivacaine groups compared to levobupivacaine alone. 3 Conclusions: The addition of clonidine to levobupivacaine 0.25% on scalp block is effective in reducing the need for intraoperative and postoperative opioids, reducing postoperative pain, extending the duration of scalp nerve block, and delaying the first PCA dose.Keywords: Clonidine, Levobupivacaine, Fentanyl, Morphine, Pain, Requirements.
Spectrophotometry UV-Vis Technique Combined with Chemometrics for Determination Phenylbutazone and Acetaminophen In Herbal Medicines Rollando Rollando
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: Indonesia is known with its natural resources, one of them is abundant herbs. The herbs are basic ingredients of herbal medicine which is called jamu. Jamu started to develop since hundred years ago and passed through generation which is trusted to cure many diseases without giving any side effect. Lately, there are many cases of combining jamu with some chemical substances. The most common chemical substances used in jamu are acetaminophen and phenylbutazone. Methods: This research develops method to detect acetaminophen and phenylbutazone by using spektrofotometric UV-Vis which is combined with chemometrics. The most common chemometrics multivariate calibration used is Partial Least Square (PLS) and Principal Component Analysis (PCA). From this method, the data analysis used is R Studio software. This research generates a regression equation. Results: Based on this research, the regression equation indicates that the result is significance which can be seen from the value of P < 0.05. Besides that, the value of correlation coefficient of acetaminophen as 0.9889, and phenylbutazone as 0,9728. Conclusion:  This method can be considered as qualified and meet the requirement.
Synthesis and Characterization of New (2-(((5-(3, 5-Dinitrophenyl)-1, 3, 4-Thiadiazol-2-yl-2,5 Dihydroxy Benzalidine))) Metal Complexes Ali T. Bader
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

New  complexes  compounds of some metal ions such as [VO(IV)), Co(II) Ni(II),Cu(II),Zn(II) and Cd(II)] are synthesized with  ( 2-(((5-(3, 5-dinitrophenyl)-1, 3, 4-thiadiazol-2-yl-2,5dihydroxy benzalidine. The ligand Schiff base was synthesized by condensation of 2-amino -5-(3,5dinitro phenyl )1,3,4-thiadiazole with 2,5dihydroxy benzaldehyde .The suggested structures of new complexes are characterized by elemental micro analysis (C.H.N), FT-IR, UV-Vis spectra, Thermal gravimetric analysis (TGA-DTA), flame atomic absorption, molar conductivity, magnetic susceptibility and Mass Spectra.  The suggested theses complexes according to the results data the probable coordination geometries are octahedral complexes   excepted C1 was pyramidal. The all complexes were found to be non-electrolyte.Keywords: 1, 3, 4-thiadiazole, Schiff base and metal ions
Larvicidal Effect of Pure and Green-Synthesized Silver Nanoparticles against Tribolium castaneum (Herb.) and Callosobruchus maculatus (Fab.) Fatima S. Jafer
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Silver nanoparticles seem to be an excellent alternative option to control insect’s pests due to their unique characteristics. In addition, the plant mediated synthesized silver nanoparticles have important applications in the field of biology, agriculture and environmental due to their safety. The present work aims to study the activity of pure and green-synthesized silver nanoparticles (Ag NP’s) against Tribolium castaneum and Callosobruchus maculatus. The biosynthesized Ag NP’s by N. olrander were characterized by UV-visible spectra, X-ray Diffraction (XRD), Energy dispersive spectroscopy (EDS) and Scanning electron microscope (SEM). Larvae of T.castaneum and C. maculates were exposed to different concentrations of pure and green-synthesized silver nanoparticles and Nerium oleander leaf extract (500, 1000, 1500 and 2000 ppm). Although the Larvicidal effect of pure silver nanoparticles against larvae of T. castaneum (mainly first larval instar with LC50 value 2.019) and C. maculates (with LC50 value 3.366) , the green-synthesized silver nanoparticles have more larvicidal effect. while Nerium extract have a less effect on all larval instars of T.castaneum (LC50 value against first instar 3.853) and larvae of C. maculates (LC50 value 4.332),  The green-synthesized silver nanoparticles have more Larvicidal effect than pure silver nanoparticles and N. oleander leaf extract.Keywords: Callosobruchus maculatus, Tribolium castaneum, silver nanoparticles, and Nerium oleander.
Water Quality Assessment of Some Rivers in Al-Qadisiyah Province, Middle Euphrates/ Iraq Hazim A. Walli
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The assessment of water quality of some rivers has been intensively studied, however, a number of problems remain to be solved in order to enhance the assessment. The Present study was undertaken with aim of obtaining information about Hamza River, Diwaniya River, and Al-Shamyia River. The investigations were carried out to understand the present status of Rivers-water quality. The primary objective of the study is to find out quality of water from different sampling stations regarding composition of water from Rivers of Al-Qadisiyah city. The quality of determination by making the measurements and physical - chemical testing was examined. The study area consists of following Rivers located in different parts of the metropolis. The current study basically examines some physical and chemicals parameters for various samples that were taken from AL-Shamyia, Hamza, and Al-Diwaniya Rivers for various characteristics including: Temperature, pH, Electrical, Conductivity, Chloride, Sulphate, Phosphate, Turbidity, Hardness, total alkalinity, Dissolve oxygen, Chemical oxygen demand, and Biological oxygen demand. All samples had been collected in three locations: south of Shamyia River, Hamza River, and Al-Diwaniya River in November, December, January and February of 2016. In general, the pollution of Hamza River was more than Al-Diwaniya, Shmyia Rivers in terms of Temperature, PO4, SO4 and Chloride. While Al-Diwaniya River shows high value more than Hamza and Shamyia represented in pH and Chemical oxygen demand.Keywords: Water Quality Assessment, Temperature, pH, Electrical, Conductivity, Chloride, Sulphate, Phosphate, Turbidity, Hardness.
Comparison of Three Phenotypic Methods for Detection of Extended-Spectrum β-Lactamase (ESBL) Producing Klebsiella Pneumoniae Jumaah Dakel Hussein
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Through a period extended from October to December, 2016. Fifty six of Klebsiella pneumonia isolates were collected from some hospitals in Baghdad. The isolates of K. pneumonia were obtained from various clinical specimens including: 39(69.65%) isolates from blood, 6(10.71%) isolates from urine,6(10.71%) isolate from burns, 3(5.36%) isolate from sputum and 2(3.57%) isolates from ear swabs. Our result shows a high level resistance of K. pneumonia clinical isolates towards most of the antibiotics under test, all K. pneumonia isolates had the highest resistance rate 100% to Ampicillin followed by (87.6%) to Cefazolin, while the lowest level resistance of K. pneumonia isolates was to Imipenem which had 17.86% resistance rate. Three methods were used for phenotypic detection of ESβL producing Klebsiella pneumoniae, first one was done by Vitek-2 system and the results showed that out of 56 isolates, 45 (80.35%) isolates were gave positive results for ESβL producing while 11(19. 65%) isolates of K. pneumonie were gave negative results. While in second method (disc combination method) the results showed that out of the 56 K. pneumonia isolates, 48(80.35%) isolates were positive ESβL producing, while 8(19. 65%) isolates of K. pneumonie were negative by two sets of cartridges (D52C) discs. In the third method the results of CHRO Magar technique, 51(91.07%) of the 56 isolates gave positive result which suspected ESBL producers while only 5(8.93%) isolates gave negative result. Eventually, CHRO Magar technique was recorded a high percent of ESBL detection while method by using Vitek-2 system was recorded a low percent of ESBL detection. From study we noticed that a high percent of ESBL producing K. pneumoniae isolates compared with non ESBL producing K. pneumoniae isolates under test by all previous confirmatory methods used in this study.Keywords: Klebsiella pneumoniae, Extended-Spectrum β-Lactamases (ESBL), phenotypic detection
Morus alba and Morus rubra alleviate hepatic disorder, oxidative DNA damage and gene expression profile change in obese rats Howaida Ibrahim Abd-Alla
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: To examine the impact of Morus rubra and Morus alba extracts on physiological and metabolic functions of obese male rats induced by high fat diet. Methods: Orlistat was used as standard drug. Seventy Wistar male rats (weighing 150-160 g) were fed for 12 weeks with high fat diet to induce obesity. The obese rats were randomly assigned to three groups (10 rats each) and treated with Morus rubra and Morus alba extracts or orlistat for 6 consecutive weeks. The level of visfatin was measured by enzyme-linked-immunosorbent. The suppression impact of extracts against DNA adducts 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 2-deoxyguanosine (2-dG) generation was measured by high-performance liquid chromatography. Expression of genes including ATP- citrate-lyase, peroxisome-proliferator-activated receptor-γ and HMG CoA reductase in liver tissues were also measured by quantitative real time-polymerase chain reaction. Results: Treatment with the Morus rubra and Morus alba extracts and orlistat significantly decreased visfatin level. Morus rubra and Morus alba extracts significantly decreased the levels of mRNA expression of ATP-citrate-lyase, HMG CoA reductase genes, and peroxisome-proliferator-activated receptor-γ compared with high fat diet rats. In addition, Morus rubra and Morus alba extracts decreased the level of 8-OHdG/2-dG ratio. Conclusions: The ameliorating effect of Morus rubra and Morus alba extracts on visfatin levels  reducing fat may be attributed to the rich content of polyphenolic which suppresses lipid synthesis in liver tissues. Moreover, anti-DNA damage effect of Morus rubra and Morus alba extracts suggests their role as natural antioxidants against diseases such as obesity associated with genetic damage.
Obestatin (OB), Calprotectin (FCP) and (SIgA) in Patients Infected with Entamoeba Histolytica in Al-Najaf Governorate, Iraq Raja Jawad Mohamed Al-Saeedi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The study included the identification of changes in biomarkers to determine the effect of E. histolytica on the level of calabrotectin, obstobestatin and SIgA in patients parasites, 250 patients were collected from AL-Hakeem Hospital in Najaf from (May 2018) to (October 2018), The number of  patients with amoeba was 115(46%), 65(26%) males and 50 (20%). females and compared with a control group of 50 healthy subjects The results showed sig significant increase(p≤ 0.05) in the level of obestatin, calprotectin, SIgA control groub.
Genotype and Phenotype Detection of E. coli Isolated from Children Suffering from Urinary Tract Infection Zahraa Hameed Oda Alquraishi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One hundred clinical urine samples were obtained from patients suffering from UTI during the period from 1, August, 2017 to 9, October, 2017. Methodology: The identification of the E. coli isolates was depended on colonial morphology, microscopic examination and biochemical tests as a primary identification. The final identification was performed by PCR technique with Mdh. In addition antibiotic genes were used such as (bla-CTM, blatem-1, aac (6) - Ib-crandsul-1). Result: Rendering  to  the  results  obtained  according to the morphological ,cultural and biochemical characters from 100 sample  only   80 (80%) isolate was  identify as  E. coli. According  to  the  results  obtained  by  PCR, Mdh gene  that  encode  was found in 56 (70%) isolates in  E. coli. The results of PCR revealed that the percentage of bla-CTX-M gene among tested isolates reached to 30/56(53.57%), 10/56(17.85%)   for blaTEM-1, 13/56(23.2%) for aac (6’)-Ib –cr and 33/42 (78.57%) for Sul-1gene. Conclusion: The  study  investigated  the  antibiotic resistance genes  of  E. coli which  play a major  role  in pathogen city .Keywords: E. coli, Urinary tract infection and antibiotic resistance genes.

Page 45 of 110 | Total Record : 1093

 43   44   45   46   47 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue