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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Association between Fragmented QRS Complex before Operation and a Trial Fibrillation after Coronary Artery Bypass Graft Surgery in Seyyedolshohada Hospital of Urmia Reza Faramrzzadeh
Journal of Global Pharma Technology .
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Introduction FQRS is defined as different patterns of fragmentation in wave R or wave S in narrow QRS complex and more than two R waves or more than one R wave in wide QRS complex. In various ischemic and non-ischemic diseases and non-hereditary and hereditary conduction diseases, FQRS has been examined. The predicting role of FQRS for a trial fibrillation (AF) after CABG that high incidence and associated with serious side effects in these patients has been examined only in one study. Methodology In this two-group study, 200 qualified patients who underwent CABG were included in the study. These patients were divided into two groups. One group received AF and other group did not receive AF. The incidence of AF after CABG and its association with FQRS were examined. In addition, the association of other variables with AF after CABG was examined using statistical software. Results Poet-operative AF was seen in 63 patients (25.2%) out of 250 patients. Patients with postoperative AF with had older age (P = 0.001) and larger left atrium (P =0.001). In patients with COPD, AF had more prevalence (P = 0.001). In addition, the extubation time of patient (P = 0.001) and heart on pump connection (0.001) were significantly associated with postoperative AF. FQRS (P = 0.001) and number of leads with FQRS (P = 0.001) were significantly associated with AF after CABG. However, patient gender, anemia, hypertension, diabetes mellitus, early detection of patients, number of vessels involved, the number of grafts, and graft to the right coronary artery, and the left main involvement were significantly associated with AF after CABG. Discussion In our study, postoperative AF is associated with presence of FQRS in ECG before operation in patients. In addition, FQRS has higher predictive value for postoperative AF. Keywords: AF, FQRS, CAB.
Awareness, Attitude and Practice of Infection Control Among Clinical Year Medical Students of a Private Medical School in Malaysia Sandheep Sugathan
Journal of Global Pharma Technology Volume 10 Issue 12.
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Objectives: The current research was planned to evaluate the awareness, attitude and practice of infection control among the clinical year medical students of a private medical school in Ipoh city, Perak State of Malaysia. This study was also aimed at any need for improving the curriculum in relation to infection control measures with an eye on reducing hospital acquired infections in future. Methods: This cross-sectional descriptive study on the awareness, attitude and practice on infection control was conducted among clinical year medical students from a private medical school in Malaysia, using a self-administered questionnaire. Results: Our study revealed that those clinical students with higher levels of attitude showed a significantly higher level of practice (p-value <0.001). The respondents having good knowledge, good attitude and correct practice were 66.7%, 57.6% and 51.5% respectively. Conclusion: Awareness of clinical medical students on infection control was quite good in this research, but it was not reflecting on attitude level and practice levels of students. There was a significant association between attitude level and practice. Gender and years of exposure in clinical practice were not significant predictors.
Evaluation of the Effects of Different Solvents Extracts of Tribulus Terrestris Obtained Via Ultrasonic Extraction on Human Asthenozoosperm Activation In Vitro Hikmat Fakhri Wassef
Journal of Global Pharma Technology Volume 11 Issue 05.
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Objective: This study was designed to evaluate the activity of different fractions of Tribulus terrestris Tt obtained via 20KHZ ultrasonic technique for different periods of extraction time and different solvents on different asthenozoospermic parameters in vitro. Material and method: The study was conducted on seventy-five asthenozoosperic patients. The sperm samples were activated in vitro (after liquefaction) with different doses of the extracts by using a direct simple layer method (DSLM) technique. Grades of sperm movement and sperm morphology were the main parameters tested. Results: Aqueous extract for 15 min. at a dose 0.02% showed the highest activity. Less activity was obtained by exposure of the sperm samples to a dose 0.002% aqueous acetonitrile (AA) extract for 15 min., 0.0002% dose of Ethanol (EtOH) and Methanol (MeOH) extracts for 15 min., 0.002% dose of (AA) extract for 15 min. and 0.002% dose of (EtOH) and (MeOH) extracts for 60 min. Exposure of asthenozoospermic samples to a dose of 0.0002% of (AA) extract for 60 min. gave the lowest activity. Conclusion: These finding indicated that the use of ultrasonically assisted extraction can obviously improve the activity of Tt extracts on asthenozoospermic patient’s parameters including the grades of sperm motility and sperm morphology.Keywords: Asthenozoospermia; Ethanol (EtOH); In vitro activation; Methanol (MeOH); Tribulus terrestris Tt; ultrasound extraction.
Optical and Morphological Characterizations of Element Oxides Compound (Y2O3 / SeO2) Nano-Composite Structures Synthesized Via Chemistry of Laser Ablation Ayad F. Al-Kaim
Journal of Global Pharma Technology .
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The elements Oxides compounds S1(Y2O3) & S2(Y2O3/SeO2) are prepared chemically as an initial stage and affected by Laser Neodymium –YAG ablation  energy (200 mJ), pulses (200 pulse) and  frequency (6Hz) at temperature (65°C) with distilled water as a second stage. (XRD) showed that the oxides compounds were Polycrystalline to the two samples with a difference in the intensity values by increasing crystallization in the first sample and the appearance (Y (OH) 3, PLA) of the) Cubic) , (Monoclinic) forms of the yttrium oxide (S1) and in the second sample (S2) confirmed the formation of SeO2 based (Y2O3) in a quadrilateral and Monoclinic. The Field Emission-Scanning Electron Microscopy(FE-SEM)  images of the two samples (Y2O3) & (Y2O3/ SeO2) showed nanoparticles of Yttrium Oxide & Selenium Oxide as multi-shapes (sheets & rods) with (Y2O3: 82nm) and (Y2O3/ SeO2: 91nm) in grain size  showed long nanotubes distributed on the nanoparticles spread more widely (S1), and the sample (2S) showed the presence of selenium as well as SeO2 in varying proportions and in spherical forms spread over the surfaces of the Y2O3 nanoparticles. This was reinforced by the EDX analysis with the presence of these oxides. The results of the optical properties showed the value of absorbance increased in the S2 than in the S1, energy gap for the indirect electronic transmission were observed. They showed that they were semi-conductive materials with values of (3.5 eV) for the first sample & (3eV) in the second sample.Keywords: Laser ablation, Y2O3/SeO2 nanostructure, Optical & structural properties.
Ruthenium (II) and Platinum (II) Complexes of 4, 5, 6- Triaminopyrimidine; 2-Hydroxy-4, 5, 6-Triaminopyrimidine and uric Acid: Synthesis, Characterization and Physicochemical Studies Suha Y. Nassar
Journal of Global Pharma Technology .
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Six Ru(II) and Pt(II) of uric acid; 4,5,6-triaminopyrimidine and 2-hydroxy-4,5,6-triaminopyrimidine complexes were prepared and identified by elemental analysis, conductivity measurement, melting point records, U.V.-visible, FTIR, 1H-NMR, 13C-NMR and HSQC spectroscopy. Some physicochemical properties of the prepared complexes were studies such as their luminescence characters and nanonature, using XRD and SEM techniques. Four biological activities of these complexes, such as antibacterial, antioxidants and cytotoxic activities have been studied besides their interaction with bacterial DNA.
Relationship between Lipid Profile and Some Physiological Markers in Pre and Post-Menopausal Type II Diabetic Females Noora M. Hameed
Journal of Global Pharma Technology .
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This study aimed to compare lipid profile level rates in pre and post-menopausal type II diabetic females. The hormones including (Estradiol and Insulin) and the physiological parameters (Cholesterol, high density lipoproteins, Triglyceride, Low density lipoproteins, Very low density lipoproteins , Hemoglobin A1c, Fasting Blood Glucose, insulin resistance, insulin sensitivity, systolic and diastolic blood pressure). This case-control study was done in a period of March 2016 to October 2016, where the samples collected from Al-Sadr Teaching Hospital in Najaf Province. The number of samples was (80) patients with type 2 diabetes with an average age (36-65 year), all of them were with type 2 diabetes are divided to premenopausal and post menopause, Also, the study included 40 apparently healthy people with an average age ( 36-65 year) , as control matched with disease group. The results showed that patients with type 2 diabetes , had significantly( p ≤ 0.05 )  higher cholesterol, Triglyceride, Low density lipoprotein, very low density lipoprotein, Hemoglobin A1c, insulin, insulin resistance and Fasting blood glucose levels rate than control group, while the levels rate of insulin sensitivity is decreased significantly (p ≤ 0.05)  in type 2 diabetic patients when compared with control group . The Estradiol levels rate was significantly (p ≤ 0.05) higher in premenopausal females while it decreased in postmenopausal females of both control and type 2 diabetic patients. Systolic and diastolic pressure showed significant difference between patients with type 2 diabetic and control. According to the comparison of premenopausal and postmenopausal women in both diabetic patients and in control group, the results showed significant ( p ≤ 0.05) elevation in Estradiol hormone level rates, Insulin hormone level rates and insulin resistance in both groups. On the other , the comparison of premenopausal patients with diabetic and  premenopausal control groups the statistical analysis showed significant elevation (p ≤ 0.05) in cholesterol levels rate, Low density lipoprotein (LDL), HemoglobinA1c  levels rate (HBA1c), fasting blood glucose (FBG), Estradiol hormone level rates, Insulin hormone level rates, insulin resistance ,insulin sensitivity and diastolic blood pressure. According to the comparison of postmenopausal diabetic patients and postmenopausal control group, there were significant differences (p ≤ 0.05) in cholesterol levels rate, Low density lipoprotein (LDL), HemoglobinA1c levels rate (HBA1c), fasting blood glucose (FBG), Estradiol hormone level rates, Insulin hormone level rates, insulin resistance and insulin sensitivity.Keywords: lipid profile, Diabetes mellitus, Pre and Post-Menopausal, estradiol    
The Association between Plasma Soluble ICAM-1 and Adiponectin with Over Nutrition in Pediatric Patients with Dengue Infection Ni Kadek Elmy Saniathi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Introduction: Dengue Hemorrhagic Fever (DHF) is one of the urgent health problems in tropical countries, including Indonesia. On the other hand, the prevalence of overweight is also increasing among children even in developing countries. Recent studies proved that adiponectin has significant influence toward immune system. Therefore, this study aimed to provide a preliminary data about the relationship between overweight and DHF with sICAM-1 as the biomarker. Method: An analytic observational study with nested case control study design was conducted using 78 subjects. The DHF status was established using 1997 WHO criteria while the sICAM-1 and Adiponectin were assessed using ELISA technique. All of the data were statistically analyzed. Result: The baseline characteristics of the subjects between the groups were considered homogenous. The Odds ratio of overweight toward the risk of dengue shock syndrome (DSS) was found to be quite high at 2.89 (95% CI: 0.81 – 12.25) while the adiponectin level was also significantly different between overweight and normal subjects in DHF group. However, no significant difference was found in sICAM-1 level between the groups. Conclusion: It can be concluded that sICAM-1 and adiponectin level was differ between patient with over-nutrition than normal counterparts with over-nutritional patients tended to have higher sICAM-1 and lower adiponectin level. But the difference was not statistically significant.Keywords: Dengue hemorrhagic fever, Overweight, sICAM-1, Dengue shock syndrome.
Development of Instruments to Measure Disaster Preparedness Hery Sumasto
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: Indonesia is called a disaster supermarket due to any disaster exists. The community preparedness in Indonesia is still low. The university academic community needs to be prepared so that it has enough capacity during disasters. The purpose of this study was to develop an instrument to measure disaster preparedness at a university in Indonesia. Method: Research and Development method was used in this study. The participants were directorate officers, lecturers/staff, and students. The development of the instrument was carried out by literature study, Focus Group Discussions (FGD), and expert consultation. The instrument development steps were instrument assessment, formulating strategic problems, instrument trials, and analysis. Results: The instruments produced in this study had five parameters, including knowledge, attitude, and practice (KAP); the university policy; resource mobilization capacity; early warning system; and emergency response planning. The result of an instrument trial showed that the University had high disaster preparedness (97%). Discussion: The instruments produced in this study can be used to measure disaster preparedness in the University.Keywords: Research and development, Disaster preparedness, Disaster instruments
Effect of Magnetized Water on Reducing the Histological and Physiological Effects of Experimental Infection with Ascaridia galli in Domestic Chicken Sukayna Jabbar Mushattat
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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The current study was carried out to determine the effect of magnetized water in reducing the damage of Ascaridia galli parasites. 45 local chickens were divided randomly in to three groups G1 control group, G2 infected group, and G3 infected and treatment with magnetized water. In all groups 15 lacal chickens. Results showed a significant improvement in the blood parameters of RBC, WBC, MDA.SOD, Ca, CL, Na in G3 treated with magnetized water compared with the rest of the groups G1 and G2, where the results showed significant decrease in RBC measurement and significant increase in measurement WBC in G2 compared with the rest of the groups and with a potential P <0.05. The histological study of the intestinal tract showed a significant improvement in the magnetized water treatment group. The histological study of the intestinal tract showed significant improvement in the treated group with magnetized water G3 Where the histological sections showed re-spawning in the vesicles and epithelial layer lining the intestines and the lack of necrosis in the intestinal wall and the lack of lymphocyte infiltration in addition to the number of larval stages of Ascaridia galli in the intestinal epithelium.Keywords: Infiltration, chicken.
Quantum-Chemical Study For Some β-Lactam Drevatives by using Hyper Chem Calculations Zainab Y. Kadhim
Journal of Global Pharma Technology .
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In the present research, we studied the properties of   three β-lactam derivatives(C18H12N2OS3 , C25H17FN2O3S and C22H19ClN2O5S2). The study was carried out by using semi-empirical methods (ZINDO/1, ZINDO/S, and PM3), to identify the binding energy ∆Eb, heat effect of ∆Hof formation, and dipole moment for some β-lactam derivatives.   Inaddtion, the electronic transitions and vibration modes were computed for these compounds. HOMO and LUMO energies were calculated to determine the reactive sites of these compounds.Keywords: β-lactam, Semi-empirical methods, Heat the formation.

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