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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
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Divergent Genetic Selection for Body Weight at Four Weeks Age in Japanese Quail M. A. Fadhil
Journal of Global Pharma Technology .
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Objective: The study conducted to measure the selection response of divergent genetic selection for body weight at four weeks age and its effects on other traits. Materials and methods: The experimental flock consist of 300 one day old chicks of black Japanese quail variety which divided into two groups, the first group (100 chicks) represents the control, and the second group (200 chicks) represents the base population for divergent selection. The selection procedure performed by select 30 females and 15 males for each of highest body weight (HBW) and lowest body weight (LBW) at four weeks of age, and the control line (CL) leaved without selection. The eggs of each line incubated to get the first generation, and the hatching procedure replicated three times. Results: The results showed that the average body weight at four weeks of age of unsexed birds, males and females for the base population 124.52, 129.89 and 127.21 gm. respectively. The average body weight at four weeks of age in the first generation for unsexed birds, males and females in the HBW line 147.60, 145.29 and 150.59 gm. respectively, and for LBW line 122.42, 120.26 and 125.25 gm. respectively. The selection response in the HBW group for unsexed birds, males and females 20.39, 20.77 and 20.70 gm. respectively, and for LBW line -4.80, -4.27 and -4.64 gm. respectively. There is significant difference between HBW and LBW in the body weight at six weeks of age while there is no significant difference between HBW and CL. Conclusion: There is significant improvement in HBW at six weeks can be achieved by selection for HBW at four weeks, and the natural selection assist the selection for HBW.Keywords: Japanese quail, Divergent selection, Body weight, Selection response, Realized heritability.
In-silico Screening of Compounds Contained in Wera (Malvaviscus Arboreus Cav.) Leaves as Anti-alopecia with Androgen Receptors R. Mustarichie
Journal of Global Pharma Technology Volume 11 Issue 6.
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Objective: Baldness (Alopecia) is a serious problem at this time because it is caused by stress, genetic factors, pregnancy, inadequate hair care, and less balanced nutrition. Previous studies have shown that ethanol extracts of Wera leaves (Malvaviscus arboreus) have anti-baldness properties. Research study was undertaken to investigate the potential of chemical compounds contained in the leaves of Wera as hair growers using androgen receptors with comparative drugs Minoxidil. Methods: This type of research is in silico where the results obtained are free energy values and hydrogen bonds that connect ligands with receptors. Results: From the 7 compounds contained in the Wera leaf, the results showed that trifolin compounds gave the lowest energy -7.08 kcal/mol and amino acids that were bound were Thr (877), Asn (705), and Phe (764) where more than the comparative drug Minoxidil namely Leu (873) and Asn (705) with free energy is -5.81 kcal/mol. In predicting pharmacokinetic properties and toxicity tests, compounds that are predicted as candidates for hair growth drugs do not meet pharmacokinetic parameters and are non-mutagenic and not carcinogenic so they cannot be administered orally. Conclusion: It is found that molecules with compounds 2- [2- (5-methyl-2-propane-2-ylphenoxy) ethoxy] naphthalene-1-carboxylate provides the lowest energy, which is -9.47 kcal/mol so that it has the potential to be a candidate for a new drug in the treatment of hair growth, namely alopecia either oral or topical usedKeywords: Wera leaves, In-Silico, Hair growers, Androgen receptors, Malvaviscus arboreus.
Social Capital, Family Support, Behavior Use of Personal Protective Equipment (PPE) as the Alternative to Improve the Performance of Employees Exposed to High Intensity Noise Budi Yulianto; Bambang Sunarko; Nurlailis Saadah; Uswatun Khasanah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Introduction: Many previous studies have shown that noise intensity in weaving of the textile industry exceeds TLV (> 85dBA) which is difficult to avoid and impossible to reduce. Employees who are exposed to noise and do not use PPE with a long duration of exposure will get an effect in terms of both physical and psychological health. This results in a decline in their performance. This study aims to examine the social aspects of the workplace (social capital), social aspects of the family (family support), and the attitude of employees towards PPE to the performance of those working in weaving exposed to high intensity noise for a long time through work stress. Methods: This study used an observational analytic design with a cross-sectional approach. The location of this research was the textile industry of PT Dan Liris in Banaran, Grogol, Sukoharjo, Central Java. The population of this study was 343 employees working in the weaving department of PT Dan Liris, who met the criteria. The sample size was 170, taken by proportional simple random sampling technique. Exogenous variables in this study included: social capital, family support, employee attitudes toward PPE, and work stress. Endogenous variables in this study included: employee performance, social capital variables, family support, employee attitude towards PPE, work stress, and performance which were measured using a questionnaire. The data were analyzed using path analysis. Results: There was a positive direct effect between social capital and employee attitudes towards PPE on employee performance, meaning that the social environment of employees who had good social capital could improve their performance by 0.085 points. In addition, good employee attitude towards PPEcould also improve their performance by 0.376 points. Keywords: Social capital, Employee Attitude towards PPE, Performance
A Model to Evaluate Content Dimensions in Educational Institutes in order to establish a Knowledge Management System Dorsa Didehvar
Journal of Global Pharma Technology .
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Organizational knowledge is one of the most important assets of every organization; thus, its optimal management will lead to a comprehensive organizational improvement. Knowledge management is a powerful tool to achieve competitive advantages and it has been experienced that its use in academic environment has many advantages. However, the important issue prior to establishing a knowledge management system is to identify and determine the effective factors on the readiness of organizations to implement this project. Therefore, the main goal of this research is to provide a model to evaluate the readiness level of content dimension of educational centers in order to establish the knowledge management system. This research is a combination of quantitative and qualitative methods; and after exploratory studies, exploratory interviews with experts of knowledge management have been carried out. The data were coded and classified using the methods of grounded theory. As a result, four hundred and ninety two codes were obtained and the main model consisted of 7 main components and 18 sub-components. A questionnaire consisted of 54 questions was used in this research and its validity and reliability was calculated 0.929 through content method and Cronbach’s alpha coefficient respectively. Data were analyzed through confirmatory factor analysis and the final model consisted of six main content dimensions. These dimensions are as follows in terms of importance and priority: Development of educational departments in accordance with environmental knowledge estimated as 1.193, senior management supportive strategies estimated as 0.469, institutionalization of processes and technology knowledge estimated as 0.461, evident and caching technologies estimated as 0.344, knowledge-oriented behaviors estimated as 0.297, participative culture in knowledge creation estimated as 0.237. Furthermore, twenty-eight sub-problems will be extracted in terms of importance and priority.Keywords: Modeling, Content Dimensions, Educational Centers, Knowledge management system’s establishment.
Pharmacogenetic Testing: Effectiveness of the Use of the Indirect Anticoagulant Warfarin Oxana Bogaevskaya
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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There are some particularities of managing patients who have been taking anticoagulants for a long time and who need dental treatment. People who regularly receive oral anticoagulant therapy are at increased risk of bleeding during and after surgery in the oral cavity. Clinicians must constantly weigh the risk of postoperative bleeding with continued therapy, as well as the risk of thromboembolic complications when the drug is discontinued. The purpose of this study is to study the effectiveness and safety of the indirect anticoagulant Warfarin in patients with diseases of the cardiovascular system undergoing dental treatment. In 2017-2018, based on the Moscow dental clinic No. 2 (Russian Federation), studies were conducted in which 350 patients participated, of which 5 were excluded from the sample. Moscow cardiological dispensary No. 1 patients who applied for dental care were involved. The first group consisted of 30 people with a diagnosis of severe diseases of the cardiovascular system (coronary heart disease, etc.), the second - 65 people with an average risk of thrombosis, the remaining 250 people of the 3rd group are patients with a low risk of thrombosis. Instead of Warfarin, the first two groups received low molecular weight heparin, the third - continued the course of Warfarin. In addition to general clinical methods (ECG, maintaining the INR level (international normalized ratio), etc.), examinations used a selection of local anesthetics and vasoconstrictors. Significant differences in the INR level before and after the operation between the three groups were not found - all of them were within normal limits. The maximum number of bleeding cases in patients from the 1st group is 2.1 times higher than in the 2nd group (p ≤ 0.01), and 3.5 times higher than in the first (p ≤ 0.001). Between the 2nd and 3rd group the difference was 1.6 times (p ≤ 0.05). Regardless of the use or rejection of Warfarin, the maximum number of bleeding cases during dental procedures occurs in patients with severe cardiovascular diseases. Refusal from Warfarin is justified in case of severe diseases of the cardiovascular system, but in the case of a low level of thrombosis, therapy with Warfarin is possible. The risk of bleeding is evenly distributed within each group, regardless of the combined use of a vasoconstrictor and anesthetic or only anesthetic, while maintaining the difference between the groups. We have shown that the severity of diseases of the cardiovascular system can also influence the number of cases of bleeding during dental interventions. The complexity of the dental intervention determines the likelihood of bleeding. In the first group, for patients who had one tooth removed, bleeding was observed 5 times less compared with removal of the cyst (p ≤ 0.001), and 4 times less - compared with operations on the pulp (p ≤ 0.001). Pearson's correlation between the type of dental intervention and the number of bleeding in this group is the highest (0.91), 0.82 in the 2nd group, 0.56 in the 3rd. The type of dental intervention, regardless of the use of Warfarin, has a direct relationship with the number of bleeding. The maximum number of bleeding is observed in patients with severe pathologies of the cardiovascular system.Keywords: Effectiveness and safety of dental treatment, Warfarin, INR, Anticoagulants, Anesthetics, vasoconstrictors, Injection pain relief, Pharmacogenetic testing.
The Effect of a Learning Program According to the Felder and Silverman Model Using Assistive Aids to Develop Reflective Thinking and Learning Some of Basic Skills for Students in Tennis Makarim Aliawi Nasser
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The importance of the research is the need for the teacher to search for the best method that is appropriate to the nature of the student and his educational environment in a manner that motivates the student and to achieve the best performance, and this through the preparation of an educational program using the model Feldder and Silverman aims to develop their thinking and learn some basic skills in tennis as well as use The aids that contribute to and accelerate the acquisition of skills and facilitate their performance because they give a clear impact in learning the basic skills that represent the ultimate goal of the learning process. The purpose of the research is to: Prepare an educational program according to the Felder and Silverman model using the aids in the development of intellectual thinking and learning some basic skills for students, to know the effect of the educational program according to the Feldder and Silverman model in the development of thinking and learning some basic skills for students. According to the model of Felder and Silverman using the aids in the development of intellectual thinking and learning some basic skills in tennis for students.The Research HypothesesThere are statistically significant differences in the development of reflective thinking and learning some basic skills for students between the tests of pretest and posttest, there are significant statistical differences between the groups research in posttest tests. The researchers used the experimental program to design the equivalent groups with pre and remote testing because it fits in with the research problem. The research community determines the students of the third stage - the College of Physical Education and Sports Sciences / Karbala University for the academic year 2017-2018 (96) (A-B-C-D) The research sample was selected by lot. The sample of the research was the students of the (A-B) division, where the number of A (23) students and (B) (27) The Feldder and Silverman scale applied to the research sample of the students of the two divisions, and the researchers reached the following conclusions: The educational program developed according to the model of Felder and Silverman for learners has had a clear and effective effect in the development of intellectual thinking and learning some basic skills of tennis for students, the educational program helped to master each part of the skills and the emergence of development of the skill level of the two experimental groups in the development of contemplative thinking and skills. The recommendations were as follows: The need to focus on the use of methods Felder and Silverman through the use of teaching aids because it accelerates the process of learning, the need to rely on the principle of classification of students according to the model Felder and Silverman before embarking on any research, the need to conduct similar studies and the use of samples and other skills.Keywords: Learning program, Felder and Silverman model, Reflective thinking and tennis.
Antibacterial Activity of Nisin-Silver Nanoparticles on Staphylococcus epidermidis and Therapeutic Effects in Experimental Skin Infection in Mice Ahmed Qassim Al-Awadi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Today technology using nanoparticle when treatment pathogentic microorganism and we focused on this here .It was found that the species of Staphylococcus epidermidis used in present study were sensitive to Levofloxacin .The aim of report effect (Nisin-Silver Nanoparticles) on ability of complete healing injury comparing using Nisin only. In vivo study revealed that silver nanopasrticles treatment of S. epidermidis contaminated injured skin showed good healing process contain complete regeneration of the epithelial cells of the epidermis and good prognosis and increase of cellulartiy of the dermal content compared with untreated group. In conclusion, treatment of skin infected with S.epidermidis using silver nanoparticles at different concentration may limit the skin damage, localized the lesion to the incision site and enhance the healing process.Key words: Staphylococcus epidermidis, Nisin A, silver nano particles.
Detect Heat Shock Protein 70 and Tumor Necrosis Factor Alpha in Obese Breast Cancer Patients Moaed E. Al-Gazally; Alaa S. Al-Awad; Sheerin H. Abbas
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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This study include the measurement of heat shock protein 70 (Hsp 70) and tumor necrosis factor alpha (TNF-α) in breast cancer(BC) by Enzyme-linked immunosorbent assay(ELISA) method. In addition, study the relationship between both (HSP-70 and TNF-α) with obesity≥ 30 Kg/M2 for patients (No.58) and controls (No.30) with age (20-50 years).Hsp-70 elevated while TNF-α decreased in obese BC patients. BC incidence is very low before age 25 and increases in age up 40 years. Increasing of BMI lead to increasing in the breast cancer incidence. Result Hsp-70 elevated statically significant where mean of Hsp-70(56.32 ± SD =18.78, p-value= 0.0001) while TNF-α decreased significantly where mean of TNF-α (163.81pg/ml ± SD = 64.94, p-value= 0.0001) in obese BC patients. The concentration of TNF insignificant decreased where), there is significant the obesity significant with BC patients (p-value = 0.048).Conclusion: Obesity is risk factor for BC. Concentration of Hsp-70increased while TNF-α decreased after Chemotherapy. 
Factors Associated With Interprofessional Collaboration for Handling Stunting In Children Nursalam .
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: An estimated in every 4 (25%) infants and toddlers were stunted in Surabaya. With slow progress in stunting reduction in this many regions is not due to insufficient diet alone, it needs interprofessional collaboration (IPC) which will improve the performance of health workers in the management of stunting. The aimed of this study is to understand the knowledge, attitude, self-efficacy, collaboration, communication about interprofessional collaboration to handle children aged < 5 years were stunted. Methods: The research used a cross-sectional study. The population in this study was 128 health workers. Samples were taken by simple random sampling. Independent variables were knowledge, attitude, self-efficacy, collaboration communication. The dependent variable was interprofessional collaboration. The instrument used a questionnaire. Data were analyzed by using correlation and logistic regression with a significance level of p <0.05. Results: The focus of this study is to understand the knowledge, attitude self-efficacy, collaboration communication in interprofessional collaboration as a way to handle stunting aged < 5 years; for self-efficacy p=0,027. A health worker who had good knowledge, attitude self-efficacy, collaboration communication, impacted and improve interprofessional collaboration as a prevention effort against stunting. Conclusion: From this study, we can conclude that the knowledge, attitude, self-efficacy, collaboration communication improve interprofessional collaboration in handling stunting in children under five. The better knowledge, attitude and belief about interprofessional collaboration, the better the implementation of interprofessional collaboration.Keywords: Factor personal, Interprofessional collaboration, Stunting, Children.
The Effect of Intrathecal Fentanyl on Bispectral Index during Spinal Anesthesia in Patients with Lower Limb Orthopedic Surgery Shahryar Sane
Journal of Global Pharma Technology .
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Objective The addition of opioids to local anesthetics in spinal anesthesia modulates some aspects of anesthesia and analgesia. Accordingly, this study sought to evaluate the effect of adding intrathecal fentanyl on bispectral index (BIS) during spinal anesthesia. Materials and Methods According to prospective clinical trial studies, the patients undergoing lower limb orthopedic surgery were randomly divided into 2 groups. Group 1 received 12.5 mg of 0.5% hyperbaric bupivacaine (HBB), while Group 2 received 12.5 mg of HBB plus 20 µg of intrathecal fentanyl. After the induction of spinal anesthesia, a bispectral index (BIS) monitor was connected and baseline values were recorded for each patient. BIS, vital signs, nausea and vomiting and shivering were recorded for each group. Results A total of 54 subjects participated in the study and underwent analysis. The recorded BIS was different between the two groups at all the time points. At all the times, BIS values were lower in the fentanyl group compared to those in the other group. After spinal anesthesia, the changing trend of BIS reduced until the 45th minute for fentanyl group. In 30th and 45th minute after spinal anesthesia, BIS had the highest reduction in fentanyl group (P= 0.01).Conclusions Although the BIS scores began to decrease during spinal anesthesia using hyperbaric bupivacaine alone or with intrathecal fentanyl, the greatest reduction from baseline BIS values occurred adding intrathecal fentanyl. Moreover, maximum reductions of BIS scores appeared at 30 and 45minutes after the induction of spinal anesthesia.Keywords: Spinal anesthesia, Bispectral index, Fentanyl, Bupivacaine.

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