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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Men’s Attachment to Masculinity and Preference in Accessing Primary Health Care Service in URBAN Area of Surabaya, Indonesia Setho Hadisuyatmana
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Men’s attachment to masculinity is believed to contribute to the low access to health services. However, there is a paucity in the available literature to explain this further in Indonesia. This study aimed to narrow the gap by providing scientific evidence to explain whether a similar situation is occurring in Indonesia. We conducted a cross-sectional study involving 134 men aged 20-40 years old who lived in Surabaya as participants. The ideology of masculinity, masculinity norms and the gender role conflict were assessed for their correlations with men’s access to primary health care. Univariate analysis was employed to identify the studied variables; and bivariate analysis was conducted to the correlation with men’s use of the primary health care services, using Spearman’s correlation test. The men were moderately attached to the ideology of masculinity (52.2%), masculinity norms (56.7%) and have moderate gender role conflicts (53.7%), and used the primary health care center for services (54.5%). The bivariate analysis resulted that all the three studied variables did not correlate with men’s access to primary health care centers (p = 0.455, 0.654, 0.300 respectively). The results refute the widely accepted notion and suggest that the men’s attachment to masculinity did not contribute to their use of primary health care service. Instead, the men would access the primary health service as early as physical symptoms started to occur.Keywords: Health service utilization, Indonesia, Masculinity, Men, Primary health care.
Serine and Alanine as Corrosion Inhibitors for 5083 AA in Aqueous Solutions Zainab W. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

By means of potentiodynamic polarization methods, inhibiting the influence of serine and alanine on 5083 AA corrosion in 0.1 mol.dm-3 sodium hydroxide and 140.6 mol. dm-3 NaCl">  over temperature range (298-313) K was investigated. Potentiodynamic polarization results specified that these amino acids functioned as a functional inhibitor in an alkaline environment. The inhibiting efficiency raises as the inhibitor concentration raises. However, it drops as temperature rises. The maximum efficiency value found with alanine was 73 under 298 k and 1410-2 mol. dm-3">  alanine concentration. The adsorption of the amino acids complies with Langmuir adsorption isotherm. Some thermodynamic parameter 14∆Gads">  and activation energy 14Ea">  have been computed to demonstrate the process of corrosion inhibition. The kinetic limitations have been evaluated by means of Arrhenius theorem. An appropriate mechanism has projected for 5083 AA corrosion in alkaline medium. The surface morphology of uninhibited and inhibited samples was investigated using an optical microscope.Keyword: Corrosion inhibition, 5083AA, Amino acids, Free energy of adsorption, Adsorption mechanism.
Application of Proniosomal Powder Technology to Prepare Fast Water Dissolving Tablets for Dutasteride Nidhal K. Maraie
Journal of Global Pharma Technology .
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Abstract

Objective: The aim of the study is to prepare fast water dissolving dutasteride tablets containing a pronisomal powder that yield niosomal dispersion of dutasteride upon dissolving in hot water. The niosomes derived from dissolved tablets may improve the dissolution and permeability of dutasteride since it is loaded in the niosomal vesicles and avoid the high cost and other disadvantages of the soft gelatin capsules commercially available. Method: Ten formulas of dutasteride proniosomal gels were prepared by coaservation method and niosomes derived from them were evaluated for their loading capacity, particle size, particle size distribution , zeta-potential and in-vitro drug release in order to determine the optimum type and quantity of proniosomal contents that will be used to prepare maltodextrin based proniosmal powder formulas which were evaluated and the optimum proniosomal powder formula was used to prepare dutasteride tablet. Results: Thickness, , hardness, disintegration time and in-vitro drug release for the optimum dutasteride tablet T5 were 5.57±0.08 mm, 3.1±0.11 Kg/cm2, 2.9±0.03 and reaches 100% release after 30 min. Particle size, polydispersity index (PDI), and zeta potential of niosomes derived from dissolving dutasteride tablet (T5) were ~263±3.8 nm, 0.225, and -5.43±0.436 mV Conclusion: This results indicating the contribution niosomes derived from proniosomal powder in improving the dutasteride solubility and gave higher dissolution rate compared to the conventional soft gelatin capsule of the same drug . Therefore presenting an oral dosage form that is more convenient and having all the advantage of tablets. Keywords: Cholesterol, Dutasteride, Niosomes, Proniosomes, Span 60, and Tween 20.
Patterns of Mucocutaneous Disorders in HIV-seropositive Patients and Relations with CD4 Counts at Sanglah General Hospital, Denpasar, Bali Made Wardhana; Nila Wardani; Ivana Sugiarto; Made Puspawati; Elis Indira; Wiraguna, Swastika Adiguna
Journal of Global Pharma Technology .
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Abstract

Background: It is well known that more than 90% of HIV-infected patients will develop at least one type of dermatologic disorder during their HIV infection. As a result of the acquired immunodeficiency or the effect of the treatment, with an increased risk infectious skin condition which caused by viral, bacterial, and fungal infections, as well as inflammatory skin disease, have all been reported to increase as CD4+ T cells depleted.Objective: Our purpose was to evaluate the cutaneous manifestation in HIV/AIDS patients in dermatology-venerology polyclinic, Sanglah Hospital Denpasar. Subjects and Methods: Data was collected from medical records of HIV/AIDS patient whose came to the dermato-venerology department, Sanglah Hospital period 2007-2009.Results: During the three years period, noted 260 HIV/AIDS patients with cutaneous manifestation, 183 males, and 77 females. Those patients mostly in the age group 21-30 years old. Five most common cutaneous manifestation was condyloma acuminate for 59 patients (22,7%), dermatitis 27 patients (10,4%), drug eruptions 26 patients (10,0%), prurigo 24 patients (9,2%) and seborrheic dermatitis 23 patients (8,8%). Conclusion: Cutaneous manifestation in HIV/AIDS patients which dominated by males gender and age group 21-30 years old was very varied, in which the most common cutaneous manifestation is condyloma acuminate.Keywords: Cutaneous manifestations, HIV/AIDS.
Mathematical Modeling Applications in Medical Cases: An Essential Tool for Discovery: A Review Dunia Alawi Jarwan
Journal of Global Pharma Technology Volume 11 Issue 01.
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This paper discusses the important role that mathematics and mathematical models play in the current revolution of learning, together with the resource regarding science and computational power. The delivery note outlines the reasons in the back of thinking about the utility on mathematics after the field of Biology or Medicine namely an urgent need. The bill also highlights the ambitions or goals over its department over disciplines indicating that mathematics is a wealthy location regarding examination ranging out of coherent abstractions in imitation of concrete applications. The pointed out examples prove that: The sound over mathematics is remarkably powerful or flexible, then the modes of thinking discovered within mathematics perform spawn inconceivable insight within many phenomena as take up current life. In it review, we furnish quick records yet spotlight half concerning the necessary features regarding modeling between organic systems together with an emphasis over the lesson on excitable cells. We finish along with dialogue in relation to possibilities yet challenges because of mathematical modeling going forward. In a large sense, the comment is designed after help answer an easy however necessary query that theoreticians oft rear from interested however skeptical colleagues about the empirical side.Keywords: Mathematical modeling, Medical Cases, Biochemical signals
Effectiveness of Lactobacillus acidophilus as Probiotic in Cantaloupe (Cucumis Melo) Juice Fermentation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Cantaloupe is one of the most consumed fruit crops worldwide specially in Viet Nam due to its pleasant flavour and nutritional value. Cantaloupe is highly perishable, due to its high moisture content.  Lots of cantaloupes rot away in the farmland. The production of freshly cantaloupe juice is a best way to raise the merchandise rate of cantaloupe and to prolong its product shelf-life during consumption. Lactic acid fermentation increases the shelf life of cantaloupe juice and also enhances various beneficial properties, including nutritive value and flavours. Objective of this study focused on the effect of Lactobacillus acidophilus as probiotic in cantaloup (Cucumis Melo) juice production. Different technical parameters such as the initial soluble solid content (8.0, 8.5, 9.0, 9.5, 10.0 oBrix), Lactobacillus acidophilus innoculum size (1.0, 1.5, 2.0, 2.5, 3.0 g/L), fructo-oligosaccharide (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) were examined during fermentation at 37oC in 48 hours. Results showed that the best fermented juice quality would be achieved by the initial soluble solid content 9.5oBrix, Lactobacillus acidophilus innoculum size 2.0 g/L, fructo-oligosaccharide 2.0%.Keywords: Cantaloup, Lactobacillus acidophilus, Probiotic, Juice, Fructo-oligosaccharide, Innoculum.
Various Technical Parameters Influencing to Production of Polyscias Fruticosa Tea Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Polysicas fruticosa is available throughout Vietnam. This plant species contains large quantity of saponin. We have identified some basic chemical components of the leaf Polyscias fruticosa as moisture, ash and saponin content. On that basis, we chose the initial drying of the raw material with a vacuum drying method, the drying temperature of 50oC, for 6 hours to achieve a humidity of < 13% as required for medicinal herbs; The method of hot extraction in solvents is 70% ethanol with a solid/liquid ratio of 1/8, at a temperature of 70oC and extraction for a period of 1 hour limit affecting product quality. Examining the heavy metals and microbiological indicators of dissolved powders from Polyscias fruticosa, the product has produced standards for food safety as prescribed by the Vietnamese Ministry of Health.Keywords: Polyscias fruticosa, saponin, Drying, Extraction, Ethanol, Powder.
Influence of Blanching Temperature and Time on Quality of Minimally-Processed Mango during Frozen Preserva Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Mango (Mangifera indica L.) is one of the most important tropical fruits. It’s excellent source of nutrients, soluble fibres, bioactive compounds such as carotenoid, ascorbic acid and phenolic.  Mango pulp is very perishable with a short shelf life. It is very vulnerable to dehydration, discoloration, and decomposition. Objective of this study focused on the effectiveness of blanching (60oC in 4 minutes, 65oC in 3.5 minutes, 70oC in 3 minutes, 75oC in 2.5 minutes, 80oC in 2 minutes) to physico-chemical attributes of the minimally-processed mango during frozen storage for 6 months. Our results showed that minimally-processed mango should be blanched in hot water at 75oC for 2.5 minutes to maintain its shelf-life and physico-chemical characteristics during 6 months of frozen storage.Keywords: Mango; minimally-processed; blanching; physico-chemical; shelf-life; frozen storage
Adequacy of Magnetic Resonance Image versus Electromyography in Patients with Back Pain Ahmed Obaid Hossain
Journal of Global Pharma Technology .
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Abstract

This study included patients with back pain. The electromyography (EMG) test were done in the neurophysiology unit in Mirgan hospital in Babylon city and the magnetic resonance image (MRI) test done in the radiologist unit in Hilla surgical teaching hospital. The important results in this study the distribution of patients with back pain according to EMG 96% of patients diagnosed as lumber radiculopathy while according MRI 98% of patients diagnosed as lumber Radiculopathy. The distribution of patients with lumber radiculopathy according to MRI results including (severity and root affected) the (MRI) more accuracy than (EMG) in diagnosis of back pain and the most lumber radiculo pathy effected in EMG are L4 and L5 while the most lumber radiculopathy effected in MRI areL4 ,L5 and S1.Key words: MRI :( magnetic resonance image),EMG :( electromyography).
Application of Edible Coating to Extend Shelf Life of Custard Apple (Annona Squamosa) Fruit during Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Custard apple (Annona squamosa L.) is a climacteric fruit and highly perishable in nature. The fruit is well known for its sweet taste, specific flavour, and pleasant, aromatic creamy pulp. The fresh fruit pulp contains high nutritional value such as protein, carbohydrate, sugar, vitamin and mineral. Edible coatings are widely used for extension of shelf life of fruits and vegetables by reduction of moisture loss and gas exchange as well as reduction of the physiological disorders. The main problem of postharvest losses associated with custard apples is rapid loss of firmness. The objective of the present study was to identify the effect of different xanthan gum concentrations (1%, 2%, 3%, 4%, 5%) and storage temperature (8 oC, 12 oC, 16 oC, 20 oC) to the weight loss, firmness, total soluble sugar and ascorbic acid in custard apple (Annona squamosa) fruits during preservation. Moreover, shelf life (0 day, 7 days, 14 days, 21 days and 28 days) of custard apple (Annona squamosa) fruit in storage also clarified. Results demonstrated that xanthan gum 4% and storage temperature 8 oC could maintain custard apple (Annona squamosa) fruit quality for 28 days without any deterioration. This is an opportunity to develop value‐added products reducing the postharvest losses, improving nutritional value and generating additional revenue for custard apple growers.Keywords: Custard apple, Xanthan gum, Coating, Firmness, Shelf life, Preservation.

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