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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Investigation on Light Structural View by Using of Reinforced Concrete with Nanoparticles Seyyedeh Fatemeh Khoshkalam Soleymandarabi; Raheleh Rostami
Journal of Global Pharma Technology .
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Abstract

The fibrous concrete is widely used in the construction industry, especially physical appearance industry. In this technical paper has been investigated concrete contained with nanomaterial and their properties.Spraying and pre-mixing techniques for the production have been introduced. If the fiber content is high then trapped air will increase and the density will decrease and thus the weight of parts will reduce. The dimensions of nanoparticles can play the role of filling cavities. Nano crystalline formation can also improve concrete strength. In this paper are introduced self-cleaning concrete, self-monitoring concrete, Nano-reinforced concrete and concrete Nano-coatings and glass Nano-fibers. Finally, in this paper has been paid to the application of fibrous concrete at the international conferences center of Esfahan in Iran and feature of Marriott hotel in San Francisco and the view of the Jubille church in Roma, Italy.Studies have shown that fiber concrete has use in the construction industry because of high-speed production, installation and high flexibility. Kiywords: Fibrous concrete, Nanoparticles, architecture, Self-cleaning concrete, Self-healing concrete, self-monitoring concrete.
Liquisolid Lipid Based Liquisolid Compacts of Olmesartan Medoxomil with Improved Oral Bioavailability: In Vitro and In Vivo Evaluation Dhiraj Chopra
Journal of Global Pharma Technology Volume 11 Issue 02 (2019) Feb. 2019
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Abstract

The main objective of the current research work is to evaluate the potential of lipid based liquisolid compacts (OLC) to enhance oral bioavailability of Olmesartan Medoxomil (BCS Class II molecule).OLC have been prepared using Capmul MCM and Captex as non-volatile vehicles, Pearlitol SD 200, Avicel PH 102 and Flowlac 90 as carrier’s materials and Syloid® 244FP as a coating material. Liquisolid compacts were prepared by premixing the non-volatile liquid and drug in equal ratio, converting the resulting wet mass into free flowing powder using carrier and coating material (5:1 ratio). Prepared LBLC’s were evaluated for their micromeritics properties, solubility, dissolution and in vivo bioavailability in selected rats. Among the formulations prepared, formulation (OLC1) containing Capmul MCM as vehicle, Pearlitol SD 200 as carrier has shown enhanced drug release (99.7 ± 5.4 release in 30 minutes) and solubility (72.54mg/mL) compared to other formulations. Hence, this formulation is evaluated for comparative in vivo bioavailability in rats along with pure drug and marketed formulation (Olmezest). It was found that relative bioavailability of OLC 1 was increased by 4.86 times compared to pure drug and increased by 1.42 times compared to marketed formulation. Hence, the study demonstrated that lipid based liquisolid technology can lead to improve the bioavailability of poorly soluble drugs like olmesartan medoxomil significantly.
Investigation of Antibacterial Activity and Cytotoxicity of ZnO nanoparticles Synthesized by a Novel Biological Method Shurooq S. Mahmood
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

This research explains the biosynthesis, characterization, evaluation of the antibacterial activity and cytotoxicity of zinc oxide nanoparticles (ZnO NPs) prepared by a low-cost and simple procedure. Bio-inspired ZnO NPs were synthesized with the aid of a novel, non-toxic, ecofriendly biological material namely; Banana peels extract (BPE). Qualitative phytochemical screening of the aqueous fruit peels extract of Banana revealed the presence of many phytocomponents in it. The structural, morphological and optical properties of the synthesized nanoparticles have been characterized by using UV–Vis spectrophotometer, XRD, FE – SEM with EDX analysis, AFM, and FTIR. The synthesized ZnO NPs were characterized by a peak at 373 nm in the UV–Vis spectrum. The XRD of the sample revealed the hexagonal wurtzite structure with an average grain size 11.98 nm. Particle shapes and sizes were determined by FE-SEM. Surface morphology of the sample was studied by AFM. FT-IR confirmed the presence of functional groups of both leaf extract and ZnO NPs. The results showed the antibacterial activity of the ZnO NPs against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). The cytotoxicity of ZnO NPs was tested against vero101 normal cell line and skin A431 cancer cell line by Crystal violet (CV) assay. Banana peels mediated ZnO NPs showed no evidence of toxicity against normal cell line, the nanoparticles are biocompatible and are non-toxic and effective cytotoxic effect against cancer cell line. These results clearly support the benefits of using a biological method for synthesizing ZnO NPs with anticancer activities.Keywords: Zinc Oxide NPs; Biosynthesis; Banana peels extract (BPE); Phytochemical; Antibacterial; Cytotoxicity
Molecular Investigation of E.dispar in Terms of Virulence Factors CP1, CP5 Khalid Thamir Mattar AL-Shaibani
Journal of Global Pharma Technology .
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Abstract

The current study included the detection of  existence the Parasite E.dispar in 180  samples of feces  for  stricken patients with diarrhea from revisers  to  public hospital of Al -Shamia  and three primary health centers in the district of Al- Shamia which is subsidiary to Al- Qadisiyah governorate  for period of  July 2016 till the end of December 2017, only 48 samples containing the Parasite of amoeba with it nourished  ,sacked  state  or both out of 180 sample of  feces for stricken   patients with diarrhea, the incidence rate of the Parasite of amoeba recorded 26.22%, and the obligation results are submitted to microscopic examination for  Molecular examination  to Real Time PCR (Taq Man Probe) to specific  investigate  to the   E. dispar and indicate the existence this kind in 31 samples ,with  64.58% rate  of the total of 48 obligation samples, after then the obligation samples  underwent to  molecular testing for E. dispar to investigate  about each of  the two the predation virulence factors, CP1 and CP5 using SYBER Green Real Time PCR. the current study has shown that  the possession E. dispar  for the virulence factors malign factor  of CP1 using  the initiators  concern the genes,  then proved existence of the CP1 factor  in  18 samples of total  31 positive   samples for parasite with 58.06% rate . While did not prove existence the gene of the CP5 in the type of E. dispar. Some studies to be positive about  that E. dispar coexisted  in the intestines  of human , while other studies pointed to a lack of clarity about the  fact  of  this type has   pathogen or no , because of  its ability to bring about (causation ) some focal lesions and harming  and make damage in the laboratory  living tissues . from this standpoint, the current study  come to investigate about two virulence factors of the virulence factors   as a step  of steps the  study  which consider the most comprehensive study of the Species E. dispar to show  the reality of living of this kind.Keywords: E. dispar, CP1, CP5.
Variables Factors in Wax Apple (Syzygium Samarangense) Wine Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Wax apple (S. samarangense) fruit is crispy, juicy and tasty with apple aroma. Fruit flesh contains spongy tissue. It represents potential benefits for human health because they are rich source of polyphenolic antioxidants. This fruit is also highly perishable. Its economic potentials have never been exploited. During its harvesting season, a considerable percentage of the fruits are not harvested due to lack of demand and inadequate storage facilities, therefore leading to wastage. The surplus could be used for fruit wine. Effect of primary fermentation duration (4, 6, 8, 10 days), sugar to pulp ratio (5, 10, 15, 20% w/w), Saccharomyces cerevisiae inoculation (2.0 x 106,4.0 x 106, 6.0 x 106, 8.0 x 106 cfu/g) on anthocyanin (mg/ 100 mL), total phenolic content (mg GAE/ 100 mL) and total flavonoid (mg CE/ 100 mL) content of fermented wax apple fruit drink were thoroughly investigated. The secondary fermentation (1, 2, 3, 4 weeks) was also examined to improve the turbidity (mJ/cm2) and sensory score of the final fermented drink. The optimal conditions for fermentation of wax apple juice should be conducted at 8 days of primary fermentation with 15% of sugar supplementation inoculated with 6.0 x 106 cfu/ml of Saccharomyces cerevisiae and 4 weeks of secondary fermentation (aging) to get pleasant physico-chemical characteristics of fermented wax apple drink. Fermented Syzygium samarangense drink was red-pink, clear and transparent. This present study revealed that horticulture farmers would get more added values from wax apple fruits not only by local commerce but also processing. It could be processed by fermentation and conversion into high valued wineKeywords: Wax apple, Wine, Fermentation, Sacchromyces cerevisiae, Anthocyanin, Phenolic, flavonoid
Study MetheletetraHydrofolatredctase (MTHFR) Gene Polymorphism in Myocardial Infarction Patients in Babylon Province/ Iraq Mona Al-Terehi
Journal of Global Pharma Technology .
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Abstract

The present study was aimed to investigate MetheletetraHydrofolatredctase (MTHFR) gene which related to acute myocardial infarction (MY) patients using restriction fragment length polymorphism (RFLP-PCR) technique, the results show that the homozygote TT genotype was (23.3%) in patients and (30.0%) in control with non-significant variation (OR 1.41). while CT genotype was (30.0%) and (33.03%) in patent and control respectively  with not significantly with OR (14.414) , CC genotype was (46.7%) in patients and (36.70%) in control. The allelic frequency was T patient vs. controls; 38% vs. 47% while allelic frequency was C in the patient vs. controls; 62% vs. 53%. we have concluded that  the MTHFR 677T allele hasn’t  been contributed as a risk factor for myocardial infarction .Our findings raise the possibility that novel genetic defects and/or environmental  factors  may  influence  homocysteine  metabolism  in  this  ethnic  group.Keywords: MetheletetraHydrofolatredctase, Acute myocardial infarction, RFLP-PCR.
The Validity Assessment of E-Cadherin Expression to Differentiate Ductal and Lobular Type Invasive Breast Carcinoma I Gusti Ayu Sri Mahendra Dewi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Introduction: Currently, breast cancer is one of the leading causes of cancer related death in women worldwide. The diagnosis of breast cancer still depends on biopsy to determine the histopathological subtype and the nature of the cancer. However, the subtypes alone could not differentiate between lobular and ductal carcinoma. Therefore, this study aimed to evaluate the validity of E-cadherin expression as biomarker to differentiate ductal and lobular invasive breast carcinomas. Methods: An analytic observational cross sectional study was conducted using 47 biopsy samples of ductal and lobular type invasive breast carcinoma examined at Anatomical Pathology Laboratory Faculty of Medicine, Udayana University/ RSUP Sanglah Denpasar in 2017. The samples were evaluated using H & E staining while E-cadherin expression was examined by using Immunohistochemistry technique (IHC). Pearson chi-square was performed to analyze the data with p-value less than 0.05 was considered significant or valid. Result: Descriptive statistics showed that the samples were homogeneous in term of age between ductal and lobular types (p=0.668). Breast cancer was found to be more prevalent on the left breast compared to the right one in both in ductal and lobular types. IHC staining showed that E-cadherin expression was significantly lower in lobular types (9.1% positive) compared to ductal (60.0% positivity) and, thus, can be used to differentiate them (p=0.000). Conclusion: E-cadherin expression was a valid biomarker to differentiate ductal and lobular type invasive breast carcinoma. More comprehensive study with larger number of samples is required to assess the generality of this findingKeywords: E-cadherin, Breast carcinoma, Ductal type, Lobular type.
Self Care Behavior As An Indicator Of Psychological Adaptation In Patients Undergoing Chemotherapy Awatiful Azza
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Chemotherapy is one of the medical actions taken to treat cancer and kill cancer cells using cytostatic drugs. This treatment not only has positive effects but also the negative effects of sufferers. This study aims to analyze the relationship of self-care behavior with the psychological adaptability of patients undergoing chemotherapy Methode: This study used a cross-sectional design. The Sample was 120 patients in the chemotherapy treatment unit at the hospital in Jember-Indonesia district, with purposive sampling. The independent variables were self-care behavior (include self-care confidence, self-care management, Self-care maintenance). The dependent variable was a psychological adaptation. Data were obtained through a modified Self Care Heart Failure In-dex (SCHFI) instrument which has been modified for patients undergoing chemotherapy. Data were analyzed by using Chi-square with a significance level of p < 0, 05. Results: of this study indicate there was a relationship between self-care behavior with the psychological adaptability of patients with chemotherapy, the p-value was 0.00 <0.05. Conclusion: Self-care behavior is one form of nursing service that can be applied to patients undergoing chemotherapy. The ability to engage patients independently during chemotherapy can increase patient self-esteem and will help improve patient adaptation due to the side effects of chemotherapy. Further study recommends developing the intervention to improve the adaptation of patients undergoing chemotherapy.Keywords: Adaptation, Self Care Behavior, Chemotherapy.
Hemopoietic Activity of the Beetroot Ethanolic Extract of Beta Vulgaris (Shamandar) in Albino Rats Shahbaa M. Al-Khazraji
Journal of Global Pharma Technology .
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Abstract

Beta vulgaris known locally as shamandar, the aim of this study is to demonstrate the hem biotic effect of the ethanolic extract of beetroot of the plant, The study was prepared to investigate the effect on hemoglobin (Hb), red blood cell count (RBC) “, packed cell volume (PCV) “, mean corpuscular hemoglobin (MCH) “, mean corpuscular volume (MCV)”, and mean corpuscular hemoglobin concentration (MCHC) “by using 50 albino Swiss rats. Five groups of rats (each 10) were fed orally with different doses of beetroot extract of Beta vulgaris (200, 400, 800, 1600 mg/kg body weight and control), for sixteen days. Blood samples were collected from the rats by ocular bleeding, and analyzed for the determination of the hem biotic parameters. It is concluded from the study , that the beetroot ethanolic extract of beta vulgaris elevate the blood parameters in a dose dependant  manner , which support the folklore  use of the juice of the shamandar to treat anemia.Keywords:  Beta vulgaris, Shamandar,   Beetroot, Albino Rats, Blood Picture, anemia.
Analytical Method Validation for the Determination of Tetrabutylammonium Bromide Content in Daclatasvir Dihydrochloride by LC-Ms/Ms Suresh Reddy. Yellampalli
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
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Abstract

Objective: A rapid, sensitive and selective analytical method was developed and validated for the determination of Tetrabutylammonium bromide content in Daclatasvir dihydrochloride. Method: Chromatographic separation was achieved on a Kinetex biphenyl 150X 4.6 mm, 5µm column using isocratic elution with the mobile phase consisting of acetonitrile and ammonium formate buffer with flow rate was 0.7 mL/min. Results: The retention time of Tetrabutylammonium bromide was found 4.65 min. The method was validated according to ICH [1] guidelines. The calibration curve was linear over the concentration range of 0.0310–0.1530 % (r = 0.9999). The intra- and inter-day precision (RSD %) was 3.8 % and the accuracy (%) was LOQ (91.8 %) to 150 % (101.6 %). Conclusion: The proposed method was simple, precise and accurate. The method can be used for the testing of content of Tetrabutylammonium bromide in Daclatasvir dihydrochloride API during routine quality control and stability testing.Keywords: LCMS/MS, Tetrabutylammonium bromide, Method validation, ICH guidelines and Daclatasvir dihydrochloride.

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