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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Impact of Folic Acid and Cyanocobalamin on Growth, Milk Yield and its Components of Awassi Ewes and their Lambs Mozhir K.K. Almahdawi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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The aim is to knowledge of vital role of folic acid and B12 vitamin on growth, milk production, milk components of Awassi sheep and their lambs.This experiment was carried out on 24 head of pregnant Awassi ewes with lambing of them in one of the private farms at Altagia village in southern of Hilla city. The experiment was included two phases, the first phase were dosage to Awassi ewes with two vitamins by mouth during experiment periods through estrus, gestation and parturition. The animals were randomly distributed into four treatments, the first treatment (control) without vitamins, second treatment was daily treated by 5mg/ewe of folic acid and third treatment was dosage of cyanocobalamin (B12 vitamin) with 225 μgm per ewe at twice time every week and fourth treatment were combination treated of folic acid and B12 vitamin as the same concentrations above. The second phase of the experiment, which began from birth of lambs and lasted weaning age ( 90 days).The lambs were dosage with two vitamins by mouth method after four hours of their born as the same mentioned of ewes in the first phase of experiment .The lambs were randomly distribution into four treatments, the first treatment was called control treatment without treated any vitamins and the second treatment were dosage with 1mg of folic acid to twice time per week, as well as the third treatment were treated with 125 μgm of B12 vitamin for twice time per week, As either fourth treatment the animals were mixture dosage of two vitamins (folic acid, cyanocobalmine) in the same concentrations. The results of statistical analysis of the first phase indicated the existence of significant differences (P≤0.05) on the averages of ewe’s weights at parturition and weaning, amount of daily feed intake, proportion of milk sugar, total protein and triglycerides of blood. As well as the results indicated high significant differences (P≤0.01) on the average of weights of ewes at the end of gestation, feed conversion , daily milk production , moisture, crude protein, crude fat non fats , total solids of milk and concentrations of cholesterol and albumin in blood of ewes. As for the second phase the results were shown significant differences (P≤0.05) on average amount of daily feed intake, total protein, albumin, triglycerides and cholesterol in the blood of lambs and another beside ,the results indicated high significant differences (P≤0.01) on average of live weight of lambs at birth and weaning, amount of daily feed intake and daily and total weight gains, and cholestrol concentration in the blood of Awassi lambs. We conclude that animals were dosages of folic acid with B12 vitamin were improving of health status and to improve significantly in most of traits of productive performance, growth and blood characteristics of ewes and their lambs as compared to the control treatment. Keywords: Folic acid, B12 vitamin, Milk yield, Milk components, Blood proteins.
The Reconstruction Procedure Using Osteocutaneous Vascularzed Fibula Graft in Limb Salvage Surgery for Recurrence Adamantinoma of Tibia Ade Martinus
Journal of Global Pharma Technology .
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Introduction Adamantinoma is a very rare malignant bone tumor. The recurrence case seems to have more rapid enlarges and more aggressive invasion of surrounding soft tissue. Recently limb salvage has become the primary method of bone tumor treatment due to oncologist orthopaedic surgical advancement and more accurate imaging techniques. The osteocutaneous fibula graft is one of the advance option for intercalary reconstruction of the defect after bone tumor resection. The objectives of this case report are to present the reconstruction procedure of recurrence primary bone tumor using osteocutaneous fibular graft. Case Report.22 year’s old male with mass on right leg that gradually increased in size. He was previously diagnosed to have an adamantinoma, excised in other hospital 5 years ago. Radiograph and MRI examination support a recurrence adamantinoma of tibia and was confirmed by histopathologic result. Discussion we performed a limb salvage procedure via wide excision and reconstruction using osteocutaneous fibular ­graft. We were able to preserve the anterior tibial and posterior tibial neurovascular bundle. The recipient anterior tibial artery and vein was chosen to anastomose to donor vessels. The flap is vital and the patient discharged on 5th day. Conclusion: The limb salvage surgery with reconstruction procedure using osteocutaneous vascular zed fibula graft is a feasible surgical treatment in case of recurrence adamantinoma of tibia. Osteocutaneous fibula graft has been proven to be an ideal choice due to very high bony union rates, provide well-perfused bone, the capability of osteogenesis, and improved regional circulation. Keywords: Adamantinoma, Recurrence, Intercalary reconstruction, Osteocutaneous fibula graft, Limb salvage surgery.
Preparation and Characterization of Nanohybrid Antioxidant from Propyl Gallate and Evaluation of its Antioxidant Activity Abeer Muhammedali Alnasrawi
Journal of Global Pharma Technology .
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In this study a nanohybrid antioxidant Mg/Al-PG-LDH was prepared by intercalating propyl gallate (PG) between magnesium/ aluminum layered double hydroxides. Identification of the prepared compound by the FT-IR revealed that some functional groups had been shifted either to higher or lower frequencies indicating the preparation of new compound. X-ray diffraction analysis confirmed the crystalline   nature of the prepared compound. The antioxidant activity of the nanohybrid compound was evaluated using three methods. In the ABTS cation radical scavenging assay the IC50 of PG and Mg/Al-PG-LDH were (50 and 100) µg/ml, respectively. By using ferric reducing antioxidant power (FRAP), analysis of the results allowed to rank the antioxidants used in this study as follows: Mg/Al-PG-LDH < Trolox< PG. The standard antioxidant butylated hydroxyl anisole exhibited the highest chelating effect in compare with the nanohybrid antioxidant and PG.Keywords: Propyl gallate, Nanohybrid antioxidant, FT-IR, XRD, ABTS, FRAP, and Chelating effect
The Role of Levan Produced from Pseudomonas fluorescens as Antipathogenic Substances and Phagocytic Enhancer against Some of Bacterial Isolates Alaa Raheem Kazim
Journal of Global Pharma Technology Volume 11 Issue 05.
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Levan is a natural substance that produced from many organisms, levan recognized as a homopolysaccharide with multi-functional features and a wide range of potential industrial applications. Pseudomonas fluorescens had the capacity to produce levan in the total absence of air which exhibited broad antibacterial spectra against foodborne pathogenic bacteria.  The results showed that three isolates of bacterial isolates were classified as a member of Pseudomonas fluorescens with antibacterial activity when tested against various pathogenic bacteria; levan has antibacterial activity against Staphylococcus. aureus, E.coli and Listeria but it had no activity against Salmonella  typhi, the results showed that levan increased phagocytic activity, The phagocytic index against S.aureus increased in the presence of levan in compared with control (without levan). The phagocytic index was (65%) when used levan in concentration (200µg ∕ ml|) while the phagocytic index was (40%) in control (without levan).Keywords: Levan, Antimicrobial activity, FT-IR, Pathogenic bacteria, Phagocytic index.
Production of Slime Layer by Staphylococcus Epidermidis Isolated from Hip and Knee Joint Infections during Revision Arthroplasty of Patients in Abn- Sina Hospital in Baghdad Hadi Abdulah Abd Ali Al-Zuhairi
Journal of Global Pharma Technology .
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This study was carried out to determine the ability of Staphylococcus epidermidis strains to produce slimelayer and biofilm formation during a period of study which extended from1 October, 2016 till 1 October, 2017.Analytic Profile Index (API) system for Staph (Bio-Merieux, France) was used to identify of bacteria to specieslevel. According to Kirby-Bauer (disk diffusion) technique, the antimicrobial susceptibility test was done.Frequency of Staphylococcus epidermidis strains isolated from hip and knee joint infections was higher inmale than female patients, 12(85.7%) vs. 2 (14.3%) (P-value ≤ 0.05).From antimicrobial susceptibility test, themost effective antibiotic was Vancomycin which showed 100% susceptibility rate and the highest resistancerate was to Benzylpenicillin (85.7 %.) followed by Erythromycin and Ampicillin (78.6%). Staphylococcusepidermidis strains were revealed different degrees of resistance towards remaining antibiotics. Out of 14Staphylococcus epidermidis strains under study, 11(78.6%) of Staphylococcus epidermidis strains were slimelayer production, while only 3(21.4%) of Staphylococcus epidermidis strains were non slime layer production(P-value ≤ 0.05) this indicate that Staphylococcus epidermidis strains from Hip and knee infections have theability to format biofilm.Key words: Staphylococcus epidermidis, Hip and knee infections, Osteomyelitis, Slime layer production andBiofilm formation.
Preparation and Evaluation of Hydrogels Containing Methanolic Extract of Brassica Oleracea ver. Italic Tahir Ansari
Journal of Global Pharma Technology Volume 11 Issue 01.
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Objective: Herbal medicine usage is increasing nowadays because their usage is acceptable by most people to be safe and produce fewer side effects than synthetic drugs. This present study has been undertaken with the aim to formulate and evaluate herbal gel containing Brassica oleracea ver. italica methanolic extract.  Method: The gel formulation was designed by using methanolic extract of Brassica oleracea var. italica, Carbopol 940, propylene glycol, methyl paraben, propyl paraben and required amount of distilled water. PH of skin was maintained by adding tri-ethanolamine drop wise. The prepared herbal gel formulation was subjected to preliminary evaluation such as pH, total phenolic content and total flavonoid content, viscosity, drug diffusion study and anti-inflammatory study.  Result: The result of anti-inflammatory study showed that the gels with extract concentration of 1000 µg/ml have comparable anti-inflammatory activity with the Diclofenac sodium (100 µg/ml).Conclusion: Formulation of gel containing B. oleracea var. italica extract is a good attempt as herbal formulation has high demand in the market.Keywords: Brassica oleracea var. italica, Carbopol 940, Hydrogel.
Spectral and Linear Optical Characterization of Organic Laser Dyes Mixture Solution Noor K. Abdulmutalib
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Spectral and linear optical properties for mixture of compounds Aurintricarboxylic Acid after polymerization (H1) and  Aurintricarboxylic Acid after closer ring (H2), were determined at different concentrations (3* 10-4, 6*10-4 and 9*10-4 ) M in Dimethyl sulfoxide (DMSO) solvent at room temperature. The intensity of absorption range is towards longer wavelengths (red shift); organic laser dyes have a spectrum within range (240-600) nm. Results demonstrate that mixture of laser dyes are effective optical materials when contrasted with single laser dyes. It can be utilized as resonator in cavity lasers.Keywords: Linear and nonlinear properties, Mixture dyes, Optical limiting, And organic laser dyes.
Determination Levels of Anxiety for Patients Undergoing Endoscopy at Marjan Teaching Hospital in Al- Hillah City Ali Ahmed Zghair Al-Khafaji
Journal of Global Pharma Technology .
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Background: Upper and lower endoscopy are commonly used to identify and treat numerous gastrointestinal illnesses. These procedures may reason some difficulty for patients such as ache, tachycardia, and in some cases, even a provisional desideration; these difficulties might have unaffected psychological impaction up on the patient health state and may reason a rise in anxiety levels (Previti et al., 2016 Aim of the study: To determine the levels of anxiety for patients undergoing endoscopy. Methodology: Quantitative – Cross sectional design was selected to determine the anxiety levels for patient undergoing endoscopy from the period between 11-October 2016 to 31 August 2017.The digestive system center at Marjan teaching hospital was selected as a risk area to collect the data, purposive sample from (150) patient who scheduled for upper and lower endoscopy were selected. After their agreement to participate in the study. Special anxiety scale adopted after modification. Results: The majority of the study sample 79 (52.7%) were male, 44 (29.3%) between age group (18-27) years old and 50 (33.3%) were with primary education. Most of the study sample 77 (51.3%) recorded moderate anxiety level. Conclusion: Most of the participants recorded moderate anxiety level.  Recommendation: Training program may be helpful of the health personnel who work in the clinical area which content all the necessary information related to this procedure, which may prepare them to play their role as education providing the patient with all information, answer all questions and using different educational strategies such as audiovisual taps.Keywords: Determination, Endoscopy, and Anxiety Levels.
Effects of Thiopurine Methyltransferase (TPMT) Polymorphism on Red Blood Cells and Plasma Concentration of 6-Mercaptopurine: Clinical Study Mohammed Khudair Hasan
Journal of Global Pharma Technology .
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Objective: This study was  aimed to find out the proper dosing strategy for patients with ALL treated with 6-mercaptopurine with possible genotype polymorphisms and the relationship between genotype and toxicity.  Material and Methods:  Sixty ALL patients and sixty healthy subjects were enrolled. The subjects involved two groups; group A Includes 60 patients with acute lymphoblastic leukemia on maintenance (continuation) phase (2:1 Male: Female ratio); group B Includes 60 healthy subjects' adults and children without any medical illnesses (2:1 Male: Female ratio). DNA was isolated from whole blood and genetic polymorphism in thiopurine S-methyltransferase (TPMT) coding genes were detected by polymorphism chain reaction-restriction fragment length (PCR-RFLP) assay. Complete blood count, liver function tests, renal function tests and blood sugar concentration obtained at the same day of blood sampling for patient and control subjects were done. Results: TPMT polymorphisms were seen in 14 (23.33%) of the total study population. The number of patients with TPMT*2 was 8 (13.33%), whereas, patients with TPMT*3B was 6 (10.00%). As a comparison between patients with TPMT polymorphism to patients without TPMT polymorphism, Hepatotoxicity and nephrotoxicity increased significantly in patients with TPMT polymorphism. Random blood sugar was significantly higher in patients with TPMT polymorphism (p = 0.02894). Bone marrow suppression was significantly higher in patients with TPMT polymorphism. 6-TGNs concentrations were increased significantly in the patients with TPMT polymorphisms using 6-MP (p = 0.00667). A significant positive relationship was founded between 6- TGNs RBC concentration and serum creatinine concentration (r= 0.9340), serum concentration of ALT, AST, ALP plasma concentration and TSB (r= 0.7428, 0.6250 0.6509 and 0.435) Conclusions: In this study, we report a presence of the TPMT2 and TPMT 3B polymorphism in Iraqis population. Therefore, TPMT variants monitoring is important to avoid the development adverse effects in patients treated with thiopurine drugs.Keywords: TPMT gene, 6- Mercaptopurine, Thiopurine drugs, Polymorphisms, Acute lymphoblastic leukaemia.
Development of the Potential of Extrak Lidah Mertua (Sansevieria sp) and Lemongrass (Cymbopogon Nardus) in Lowering the Number of Air Germs of Space through Humidifier Modification AT Diana Nerawati
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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According to Regulation of the Minister of Health No.1077 of 2011, indoor air pollution especially houses are very dangerous to human health, because in general people spend more time doing activities indoors so that the house becomes very important as a micro environment related to the risk of air pollution. Efforts to deal with indoor air pollution caused by germs need to be carried out, especially indoor air pollution the danger level is greater than outdoors. The goal is to test the decrease in germ rate in the air of the room with humidifier modification using sansevieria and lemongrass extrak. The experimental design used in the study is One Group Pretest Posttest Design. As a humidifier modification material to lower the Air Germ Number of the Room. The achievement of this goal was done using pre-experiments with the form of One Group Pre- Post Test Design. The free variables are Sansevieria extraks with concentrations of 30%, 40% and 50% and the bound variables are germ numbers. Analysis of the data used in the form of a paired t test and Anova test. The results showed that the average extrak air germs of Sansevieria and Lemongrass concentrations were 30% before treatment of 15.6 CFU/dm3 and after treatment of 3.4 CFU/dm3, while the concentration of 40% of space air germs before treatment is 19.8 CFU/dm3 and after treatment 5.6 CFU/dm3 and the concentration of 50% of space air germs before treatment is 17.2 CFU/dm3 and after treatment is 6 CFU/dm3. The result of the paired t test showed that p < 0,05, means there is a significant difference in the decrease in the number of germs before and after treatment at all conditions. Extrak Sansevieria and Lemongrass are able to lower the number of air germs of space. at extrak concentrations Sansevieria 30% and lemongrass 0.1 % the average decrease in the germ rate is 78.2%, while for concentrations 40% the average decrease in germ rate is 74.24% and the average 50% concentration decrease in the germ rate is 65.11%. Anova test results obtained that tongue in-laws extract (Sansiviera,sp) concentrations of 30% 40% and 50%, have a p value of > 0.05, which means there is no meaningful or insignificant difference.The results of this study are extrak Sansevieria sp and Cymbopogon Nardus as humidifier fluid modification at concentrations of 30%, 40% and 50% have the same effectiveness in lowering indoor air germs. Recommendations for development and trials modify sansievera and lemongrass extrak solutions with other oceans that can also absorb air pollution. Keywords: Germ numbers, Humidifier, Extrak sansieveira and cymbopogon nardus, air spaces.

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