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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Religiosity and its Impact on the Family Life Framework According to Imam Reza (Peace Be Upon Him) Ayatollah Zarmohammadi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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Abstract

Those who are familiar with religion and its evolutionary teachings endorse its extraordinary effect on individual and social life of human being; although there is difference of opinion regarding the scope of this influence. Some believe in the maximal role of religion and some believe in its minimal role, but what has been accepted by both groups is the very involvement of the religion in all human affairs. The current essay deal with human expectation of religion and at the same time discusses the influence of religiosity on the family life according to Imam Reza (peace is upon him). Moreover, it also debates the necessity of formation of family and its functions in the production and preservation of generation, providing peace, sense of integration and purity of generation and also such factors strengthening family foundation as generosity, good manner, adornment, and satisfaction of sexual instinct.Keywords: Life Framework, Religiosity.
The Effect of Organizational Cynicism and Injustice on Counter Productive Behaviors of Staff Considering Demographic Factors Rahim Rouzbahani
Journal of Global Pharma Technology .
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Abstract

In recent years, scientists have sought to show a decreasing trend in civil and citizenship behaviors; whereas, unfair and counterproductive interactions and behaviors are increasing. Counterproductive behaviors of a collection include a various range of behaviors such as rudeness, being carefree, robbery and aggressive behaviors towards colleagues and other clients. Meanwhile, counterproductive behaviors are increasingly rising in staff's organizational life. The present research aims to study the effect of organizational cynicism and injustice on counterproductive behaviors of staff in a public hospital considering demographic factors. This is an applied research in terms of objective and a descriptive-survey in terms of nature. Lisrel software and path analysis model were used to test the research hypotheses and to obtain results. According to the hypotheses testing results, the increase of employees' organizational cynicism increases their counterproductive behaviors in a public hospital; the increase of organizational injustice increases employee's counterproductive behaviors; as well as, the increase of organizational injustice increases staff's organizational cynicism in a public hospital.Keywords: Organizational cynicism, Organizational injustice, Counterproductive behaviors, Hospital.
The Investigation of the Stability of the Granules Based on Arginine and Tincture of Ginseng Katerina Romas
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The article presents the stability studies of the granules based on arginine and tincture of ginseng with neuroprotective (nootropic) action for the treatment of various disorders of the functional activity of the brain. For determining stability and shelf life of the developed medicine, several series of granules were stored at a temperature 15-25 °C in a dark, light protected place. Based on the research, it can be concluded that within 24 months from the date of manufacture, granules remain stable in all respects that have been studied.
Evaluating the Reality of University Sports from the Point of Players View in Iraqi Universities Hassanine Juma Assery
Journal of Global Pharma Technology .
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Abstract

The current study objectives at following:To identify the reality of sports university from the perspective of players of Iraqi universities.Evaluation of the reality of university sports from the perspective of players of Iraqi universities.The researchers used the descriptive method in the survey method. The research community identified the 156 Iraqi players in the Iraqi universities and then selected a sample of 70 randomly selected players. The researchers then selected and applied the measure of the reality of university sports on the research sample. Results and the use of appropriate statistical treatments to reach the results after the results were presented analyzed and discussed the researchers reached the most important conclusions of the following:Ability of the measure of the reality of Sports University, which researchers applied in measuring the reality of university sports in Iraqi universities.The reality of university sports in Iraqi universities is at the acceptable level.There is weakness in the reality of university sports in Iraqi universities.Keywords: Evaluating, University sports and Iraqi Universities.
Protective Role of Propolis against Iron Overload Induced Genotoxicity and Oxidant/Antioxidant Status Mjida A.J. Al-Qayim
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The current study designed to investigate the protecting role of propolis in DNA damage  and oxidaant / antioxidant imbalance caused by  iron overload. 24 adult male wister rats divided in to 3 equal groups and handled as following: 1st group(C) as control, 2nd group, IO) group IP iron dextran 100mg/ kg BW each 72 hr. 3rd (IOP) given IP iron dextran 100mg/ kg BW each72 hr. and orally Propolis crude extract (50 mg /kg body weight) daily for two months. Results revealed that administered rats with propolis showed enhancement in oxidant/anti-oxidant indicators, categorized by raise of GSH, and MDA reduction on the contrast with IO group. Propolis adiminstration to IO  rats  decreased the  DNA damage and fragmentation. Conclusion, the present results are established for the first time a new role for the Propolis, in counter and reduce the iron overload harmful effects on DNA mainly via modulation of oxidant status in IO.
Low Glutathione Peroxidase Plasma Levels Related to the Severity Degree of Vitiligo I Gusti Ayu Agung Praharsini
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Introduction: Vitiligo is a pigmentation disorder caused by damage to melanocytes which causes loss of pigment production on the skin and mucosal surfaces. The etiology of vitiligo is still unknown, but there are several theories regarding the occurrence of damage and death of melanocytes in vitiligo. One is a widely known theory is the theory of oxidative stress. The body has a defence mechanism against free radicals through the formation of antioxidants, one of which is glutathione peroxidase (GPx). Increased free radicals will result in decreased levels of glutathione peroxidase. This study aims to prove the correlation between plasma glutathione peroxidase and an increase in the severity of vitiligo. Method: The study design using an analytical study with a cross-sectional approach in vitiligo patients at Sanglah Hospital Denpasar. Sampling were done with consecutive sampling technique involving 40 vitiligo patients and 20 non-vitiligo controls that met the inclusion and exclusion criteria. Venous blood sampling was performed to measure GPx plasma levels and physical examination to measure the severity of vitiligo based on VASI scores. The collected data were analysed using SPSS version 23.0 with normality test, unpaired T test, correlation test and chi-square to get the prevalence ratio (PR).Result: The results showed a lower level of GPx plasma in vitiligo patients (72.3 ± 82.5 ng/mL) compared to non-vitiligo (160.63 ± 124.33 ng/mL) subjects (p<0.05), low GPx levels were a risk factor for vitiligo with a prevalence ratio (PR 1.57; CI 95% = 1.89-2.776; p<0.05) and plasma GPx levels have a strong negative correlation with the degree of vitiligo severity based on vitiligo area severity index (VASI) scores in vitiligo subjects (r=-0.60; p <0.05) Conclusions in this study there is a negative correlation between plasma GPx levels with vitiligo severity and low GPx levels are risk factors for vitiligo.Keywords: Glutathione peroxidase, Vitiligo, Vasi score.
Optimization of the Simultaneous Determination of Sitagliptin and Metformin, in Human Plasma by A Rapid HPLC Method Balamurugan K; Kirtimaya Mishra; Suresh R
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Simple, rapid and reproducible methods were established for quantitative determination of Sitagliptin (SIT) and Metformin (MET) spiked with plasma using an Onyx C18 Monolithic column  connected with an Onyx C18 guard cartridge.  and PDA detection at 210 nm. The mobile phase was MeOH, ACN, 0.01mM KH2PO4 (pH 3.5±0.5), adjusted with freshly prepared 10% orthophosphoric acid.  was pumped at 0.492 mL/min. The method was linear between 0.5-2.5 µg/mL, statistically validated for its linearity, precision and accuracy. The precision was found to be less than 1% showing high precision of the assay method. It was found that the excipients in the commercial tablet did not interfere with the method. Developed method can routinely use for the estimation of SIT and MET related compounds from the dosage form spiked with plasma.
The Association Between the Severity of Diabetic Peripheral Neuropathy and Diabetic Risk Factors in Diabetic Patients Type I and II. Sarah Ali Alkindy
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Back ground: The diabetic risk factors can effect on the severity of diabetic peripheral neuropathy (DPN). The most risk factors have an effect on the peripheral nervous system are duration of diabetic disease, glycocelated hemoglobin (HbA1C) and type of diabetes (DM type). Objectives: To determine the association between severity of DPN and duration of diabetes, HbA1C, the type of diabetes, age and sex of diabetic type I and II patients. Patients and Methods: Three hundred individuals were participated in cross sectional study. They divided to two groups labeled as A and B. Group A regarded as diabetic patients with abnormal neurological examination. Group B regarded as diabetic patients with normal neurological examination. About 68 male and 82 female were participated in this study for each group.  The age of participant are grouped as <18, 18-30 and 31-60 year. The full history was taking from participants including socio demographic data and duration of disease with type of diabetes. All participants with type I and II underwent clinical assessment and biochemical investigation. The clinical assessment used Toronto clinical scoring system (TCSS) for screening diabetic peripheral neuropathy (DPN). The biochemical investigation was done for determining the level of HbA1C. The study was carried out at Marjan teaching hospital and Al Sadeq teaching hospital in Babylon province during the period from Aug.2017 to Sep.2018.Results:TCSS used for scoring the DPN to mild, moderate and severe. The severity of DPN show significant association with duration of DM disease,  type of diabetes , the level of HbA1C and age of diabetic patients, the P value about o.oo1, 0.02 , 0.001 and 0.001respectively. The sex of  diabetic patients showed no significant association with severity of DPN, the P value 0.45.Conclusions: There is higly association between severity of DPN and DM duration, HbA1C , type of DM and age of diabetic patients. There is no association between sex of diabetic patients and severity of DPN.
In Vitro and In Vivo Effects of Silver Nanoparticles Biosynthesized By Serratia Marcescens Khawlah Jebur Khalaf
Journal of Global Pharma Technology .
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Abstract

Biosynthesis of silver nanoparticles by Serratia marcescens was demonstrated using the supernatant for extracellular biosynthesis. The formation of AgNPs was characterized by UV-Vis spectrophotometry, atomic force microscopic (AFM) and fourier transform infrared spectroscopy (FTIR).Antimicrobial activity of silver nanoparticles was performed by use well diffusion method and show that these AgNPs can be used as growth inhibitors against pathogenic isolates:  Salmonella sp. , Staphylococcus aureus. Staphylococcus epidermedis,   E. coli, Klebsiella sp, Candida albicans   .Antibiotic susceptibility of Salmonella sp. was determed by used disk diffusion method and found the most susceptible for amoxicillin, chloramphenicol, azithromycin, ampicillin and cefotaxime and resistance to flurmequine neomycin and colistin. The present study was designed to assess the effect of silver nanoparticles wich synthesized by serratia marcescens in modulating the salmonellosis in BALB/C mice. we found that in vivo the histological study for liver it was damage when compared with mice's liver treated with antibiotic  (amoxicillin ) .Keywords: Serratia marcescens, silver nanoparticles, pathogenic bacteria, liver.
Optical Nonlinearity of Thiazine Dyes Doped With Nanoparticles of Liquid Crystals Ban A. Naser
Journal of Global Pharma Technology .
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Abstract

The optical nonlinearity of several thiazine dyes such as(azure A and azure B) organic dyes doped with nanoparticles of liquid crystals in ethanol solvent has been studied using diode pump solid state laser at wavelength(457 nm) and power (56 mW) as the source of excitation. The optical responses were characterized by measuring the intensity dependent refractive index (n2) of the medium using the Z-Scan technique. The results indicate that the samples of organic dyes doped with nanoparticles of liquid crystals possess very large linear and nonlinear optical properties as compared with samples of pure organic dyes. This result showed that these organic doped dyes are very suitable for applications in optical devices and can be available for applications as active laser medium.Keywords: Organic laser dyes, Z-Scan technique, Nonlinear optical properties, Liquid crystals.

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