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I Wayan Sudarsa
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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Analytical and Theoretical Studies of Some Diazo Dyes Hanan M. Ali
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Analytical studies were carried on diazo dyes that characterized 4,6-bis((E)-(3-nitrophenyl)diazenyl) benzene-1,3-diol (1), 4-((E)-(3-nitrophenyl)diazenyl)-6-((E)-(4-nitro phenyl)diazenyl)benzene -1,3-diol (2), 4-((E)-(2-nitrophenyl) diazenyl)-6-((E)-(3-nitro phenyl)diazenyl)benzene-1,3-diol (3) and 4,6-bis((E)-(2-nitrophenyl) diazenyl)benzene-1,3-diol (4). The results of the solvents effects and the pH effects were showed high solubility of these dyes in ethanol and the suitable pH values were found to be in the pH 12. Three isopiestic points were gained in the results of the azo dyes (2), (3) and (4). Add to which, the ionization (pKa) and the protonation (pKb) constants were calculated by using the half height method. The results were showed that the pKa1 values were absence intheresults ofdiazo dyes (3) and (4). Theoretical studies also approved the structures of diazo dyes (1), (2), (3) and (4). These studies were focused in the relation between the structure and the properties of these molecules. Due to the internal coordinate mechanics (ICM), the conformational analysis, the molecular mechanics (MM2) and the optimal minimization were attended for each azo dye.Keywords: Azo dyes, Internal coordinates, Conformational analysis, Molecular mechanics, Ionization constant and Protonation constant.
Think Pair Share (TPS) Method Improves Knowledge and Attitude of School-Age Children in Vegetable Consumption Praba Diyan Rachmawati
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

School-age children need vegetable consumption to meet optimal growth and development needs. However, it remains a challenge to ensure the need of adequate quantities of vegetable consumption. The Think Pair Share (TPS) method may offer the solution of this problem. The aim of this study was to analyze the effect of applying health education with a think pair share on the knowledge and attitudes of school-age children in vegetable consumption. This study used a pre-experimental research design. The population in this study was  40 students at a fourth-grade elementary school and employed total sampling technique. The independent variable was health education with a think pair share learning method, while the dependent variables in this study were knowledge and attitudes. Instruments in this study were questionnaires of knowledge and attitudes. The data were analyzed using Wilcoxon Sign Rank Test statistical test  with significance α≤0.05. The results of the statistical tests showed significant effect on knowledge (p=0.000) and attitude (p=0.000) of children in consuming vegetables. Think Pair Share method can increase the knowledge and attitude of children in vegetable consumption. Future studies may consider using this method as a medium of health education to increase vegetable consumption in school-age children.Keywords: Attitude, Knowledge, Think pair share, Vegetable consumption.
Chemical Modification of Chitosan for Metal Ion Removal Zakia S. Mohsin
Journal of Global Pharma Technology .
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Abstract

This study is interested with a significant application of surface chemistry in the fields of treatment of pollution. It deals with adsorption systems of chemical pollutants(some heavy metal ions) on surface (modified chitosan).Atomic absorption spectrophotometry technique have been used to results adsorption data at different conditions of (contact time, pH).Chitosan were modified from benzoyl chloride reaction with ammonium thiocyanate and then its resulting composite reactor with carboxylic acids at room temperature, the  chemical structures  of modified polymer was to elucidated using FTIR and 1HNMR. Chitosan modified compounds have been evaluated as a good material for adsorption of heavy elements in water solutions.
Designing Boardgame Media for Child Growth Stimulation Through Children’s Games Nurlailis Saadah; Budi Joko Santosa; Budi Yulianto; Uswatun Khasanah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Educating children requires interesting and safe media. Childhood is a period of growth and development of various aspects which include fine motor, gross motoric, language, and social personal. Social interaction can use technology that is not limited to space and time through gadgets. If there is no control over the use of gadgets, children can become addicted to them, indifferent to those around them, and rarely communicate with people around them. To anticipate this, alternative media that are safer than gadgets is game board. Methods: This research method included 2 phases. Phase I was Research & Development model research, Phase II was the implementation of the model using Pre-Experimental Design research that applies non-randomized One-Shot Case Study. Data were collected by using interview, questionnaire and observation. The data was processed using the visual comparison matrix analysis method. An attractive game board must be supported by a good mechanism and visibility. Results: Children can grow and develop well if a healthy lifestyle is implanted like healthy food is. The solution to this problem can be achieved by designing educational board games as a medium for learning and playing. The reason is that board games have rules, goals, problems, players, procedures, etc. It can also train psychomotor, emotional, moral, cognitive, artistic, children’s language aspects with fun. The board game is expected to make children interact well so that all aspects of a child’s development run well. Keywords: Board games, Stimulation, Types of Children's Games
Investigating the Effect of Muscular Relaxation Technique on Sleep Quality in Children with Leukemia Treated with Chemotherapy in Educational Hospitals of Zahedan Zeinab Poodineh
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Abstract

Introduction and objective: Sleep has long been considered as an important factor in human health. Sleepless clinically causes stress and the inability in performing social and job functions and it leaves considerable negative effect on quality of life and health status of people. Therefore, this study was conducted to determine the effect of muscular relaxation technique on sleep quality of parents of children with leukemia treated with chemotherapy.Methods this study is a randomized controlled intervention study in which 120 parents of children with leukemia were assigned in two groups of intervention and control. The intervention group received Benson's relaxation technique. Data collection tool included demographic information questionnaire and Pittsburgh Sleep Quality Index (PSQI). Data were analyzed by SPSS version 18 software, Paired Samples t-test, Wilcox on test, and t-test tests, Pearson correlation test, and One - Way ANOVA test.Results The mean score in the intervention group before and after intervention in the sleep quality was obtained 13.5 ± 60.5 and 5.7 ± 3.43, respectively, and significant difference was found between the quality of sleep in the two groups of intervention and control after intervention, and the relationship between quality of sleep of parents, education, gender, and their living place was not statistically significant.Conclusion The findings indicate that presence at hospital to care for the child could affect the sleep quality, because it disturbs the normal life conditions of the person. To improve their sleep status, is better that health care and management and personnel to take necessary steps to improve the quality of their sleep.Keywords: Muscular relaxation, Sleep quality, Leukemia, chemotherapy.
Anti-diabetic Activity of Dry Extract of Gymnema Sylvestre Sanna Sboeva
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The purpose of the study was to study the mechanism of antidiabetic action and compare the hypoglycemic effect of taking extracts of different concentrations of gurmar in a laboratory rat population. Studies were conducted in 2018 in a population of 400 laboratory rats based on the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) (Moscow, Russian Federation). 300 animals made up the experimental group, 100 - the control. We used 25, 50, and 75% gurmar extract and diabeton, which were given orally to animals from the experimental group at a dosage of 70 mg to 1100 mg per 1 kg of body weight and 10 mg per 1 kg of body weight, respectively. Tests for glucose digestibility were performed by administering extracts of gurmar after fasting, dosage of 270 mg per 1 kg of body weight. The hypoglycemic effect of gurmar-based drugs activates enzymes associated with the inhibition of absorption of glucose from the intestine, as well as with its breakdown. Studies have established 25% as the most optimal dose of gurmar extract. The dosage in this case is 270 mcg per 1 kg of body weight. The maximum hypoglycemic effect is observed 2 hours after taking the drug. For high concentrations of the drug, a 25–30% lower hypoglycemic activity was recorded. Another drug, taken for comparison-diabeton, is superior in its effect to 25% gurmar extract by 20%. A 30% increase in beta-endocrinocyte nuclei may indicate an increased physiological activity of these cells.Keywords: Gurmar, type 2 diabetes mellitus, Extracts, Diabeton.
The Effect of Qualitative Exercises (Physical - Skill) in the Development of Rapid Strength and Lay up Scoring of Basketball Players Mazen Kadhim Nassif
Journal of Global Pharma Technology .
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Through the follow-up of the researchers of most educational and training units, they noticed that most players aged 13-15 suffer from weakness in the strength and speed of the strike of the arms and legs, which negatively affects the performance and difficulty of scoring points during the performance of lay-up scoring, since the way to achieve the ideal performance that aims to win requires the compatibility of many requirements, including a high level of performance interrelated and overlapping physical and skill capabilities among them, as physical capacity is the cornerstone on which to build the development of the skill, so researchers have considered this problem Through the preparation of exercises qualitative (physical - skill) and trying to overlap them to serve the skill performance attempt to develop the rapid force and lay-up scoring of basketball players. The objective of the research was to identify the effect of specific exercises (physical - skill) in the development of rapid strength and lay-up scoring of players in basketball. The imposition of research is a positive effect of the physical exercises (physical - skill) in the development of fast power and lay-up scoring of basketball players. The researchers used the experimental method in designing the one group to suit the nature of the problem to be solved, and represented the research in all members of the research community; the young players aged 13-15 years in the club sports fans - Kerbala, the 10 players. The most important conclusions were of specific exercises (physical - skill) and clearly affected the development of rapid power and the skill of lay-up pacification of basketball players. The recommendations are the need to pay attention to the specific exercises and the link between the physical and skill aspects during the exercise and the single training unit. And the need to pay attention to the training of the force of the fast because it described the physical task is needed basketball player effectively and continuouslyKeywords: qualitative exercises, Rapid strength and lay up scoring.
Cycloyvoltammetry, ATR-IR of AlCl3/Amide and Thioamide DES and the Morphology of Deposited Aluminum at Variable Potential and Temperature Hadi M. A. Abood
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Aluminium was successfully electrodeposited from mixtures of aluminium chloride with two amides and two thioamides. Structure identification by ATR-IR spectroscopy suggested the interaction of   (AlCl2+) species with oxygen, sulfur and nitrogen respectively which influence the cyclovoltammetry behavior of the mixtures. Morphology of electrodeposited aluminium from the protected mixtures by decan layer examined by SEM and EDX showed variable shapes and microsize due to the effect of  variable temperatures (30°C to 60°C) and potentials (-0.6V to -1.6V), this in part is related to mass transport limitation and coordinating ligands.   Keywords: DES, Electro-deposition, Aluminium, AlCl3-amide, AlCl3-thioamide.
The Relationship between Phylogenic Typing and Antimicrobial Susceptibility Patterns Forescherichia Coliisolatedfrom Utis in Many Hospitals at Baghdad City Eman Natiq Naji; Eptisam Younam Pirko; Munim Radwan Ali
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Objective In the currentsearch , E.coli  isolated from UTIs in many Baghdad hospitals. The study concentrated on phylogenic groups and this was done based on triplex PCR method by primers besieged to three genetic markers, chuA, yjaA and TspE4.C2. Evaluate the relationship of phylogenic groups of E.coli isolates with the antibiotic-non sensitive patterns.Methodology Four hundredof E.coli bacteria inaccessible from urine samples from  five hospitals in Baghdad city includes : Ghazi AL-Hariri, Iben- Beledi , AL-Iskan , AL-Nooman and AL-Yarmoke hospitals. Phylogenetic categorization of E. coli isolates was completed by by means ofearlier reported triplex PCR-based on  phylotyping procedure using primers besieged at three markers, chuA, yjaAand TspE4.C2. Phylogenetic combination was done on the starting point of the existence or nonexistence of the3 DNA fragments as follows: chuA–, TspE4.C2–, group A; chuA–, yjaA–, TspE4.C2+, group B1; chuA+, yjaA+, group B2; chuA+, yjaA–, group D. Because two possible profiles can be obtained for the groups A, B2, and D. Fifteen antibiotics second-hand for all foremost groups and their individual generations were used in this paper adjacent to all bacterial isolates. Results The isolates ofE.colifrom UTI  were distributed within thephylogroups B2 (43%); phylogroups D (28.25%); phylogroups A (24%) and B1 (3.5%), so phylogenic group B1 was prevalent among  male patients of AL-Yermouk hospital ( 14%), followed AL-Iskan (3.75)% so, isolation rate of E.coli were higher among age (11-20 ) years (31.75 %), also(11%) were sensitivity to antibiotics, whilst (75.25%) were classified as extensive drug resistance pathogens, but  13.75% were multidrug resistance  and in Qarkh areas, the frequency of phylogeneticB2 was (59.88%), followed phylogenetic A and D were ( 68.75 and 48.78%) respectively as  compared to Rusafa areas were prevalence phylogenetic B2(40.12%),followedphylogenetic D and A were (51.22 and 31.25 %) , as well as most of these phylogenetic groups occurred more frequently in both groups B2 or D (43, 28.25) % respectively, also ( 2.75, 2.5 )% of phylogenic A were antibiotics sensitivity in both AL-Iskan hospital and Ghazi AL-Hariri hospital respectively whilst these phylogenic was multidrug resistance as percentage (9, 3.75) % respectively in both AL-Yermouk hospital and AL-Iskan hospital, Whilst in these hospital this phylogenic A was founded with extensive drug resistance (1, 0.75) % respectively, also most of phylogenetic group  B2 occurred more frequently in AL-Yermouk hospital, so the sensitivity; multidrug resistance and extensive drug resistance as (2.25, 15 and 3.5) % respectively, also all  phylogenetic groups E. coli isolates from UTI patients of five hospital weregrouped  in two or three major group as  A , B group contain major sub groups .RecommendationsThe study recommends additional studies of the correlation  between the Phylogenic group  with antibiotic-resistance pattern  for other bacterial  types  isolated from  UTIs or the same bacteria isolated from other types of infections. We suggest to applicate our study on bacteria Vibrio colerai  isolated from the infected patients stool who submitted to  the same hospitals  or in the other provinces of the country, because of our country suffering frome  epidemics infections  in the last two years. Keywords: Urinary tract infections, Enterobacterial repetitive intergenic consensus PCR (ERIC-PCR), E. coli, Antibiotic resistance, MDR.
The Result of Taking Mare’s Milk for Nonalcoholic Steatohepatitis Bakytzhan Bimbetov
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) and is linked to overweight, obesity and metabolic syndrome. The main role in treating NAFLD is attributed to leading a healthy lifestyle, keeping a healthy low-calorie diet and high physical activity. In dealing with issues of healthy diets of patients with NASH, mare’s milk can be considered a pathogenically based, highly effective and affordable natural therapeutic dietary agent. The value of the product is defined by its similarity to the chemical components of women’s breast milk. This article reports a case of a successful treatment of NASH with the help of monotherapy using sublimated mare’s milk within a relatively short period of time, devoid of laborious dieting, physical activity or any side effects.Keywords: Non-alcoholic fatty liver diseases, Non-alcoholic steatohepatitis, Mare's milk, Sublimated mare's milk, Medical and dietary properties of mare's milk.

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