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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Study of Proximate and Nutritional Composition of Leaves of Grewia tiliaefolia Vahl Rajesh Kumar Vaspri
Journal of Global Pharma Technology Volume 11 Issue 02 (2019) Feb. 2019
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Abstract

ABSTRACTObjective: The present study was aimed to assess nutritional value of the leaf of Grewia tiliaefolia Vahl belonging to the family tiliaceae. The parameters included proximate analysis of the leaves of Grewia tiliaefolia Vahl for carbohydrates, proteins, moisture, ash, and crude fiber. The determination of minerals of the leaves of the plant were magnesium, calcium, copper, iron, zinc, sodium and potassium. Methods: The methods employed for determination of proximate and nutritional value of leaf of Grewia tiliaefolia was according to standard procedures (AOAC). The instrument used was spectrophotometer. Results and conclusion: The results concluded that the proximate analysis of Grewia tiliaefolia Vahl leaf showed presence of carbohydrates, proteins, moisture, ash and crude fiber. Mineral contents like calcium, magnisium iron, zinc, copper, sodium, potassium was present. It is concluded that leaves of this plant is rich in nutritional components. Keywords--- Grewia tiliaefolia Vahl, Proximate analysis, Minerals, AOAC, Spectrophotometer. 
Polymorphisms of IL-4 Gene in Iraqi Behçet’s Disease Pat Israa Harjan Mohsen
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present research was carried out to reveal the correlation of IL-4 gene polymorphisms with Iraqi Behçet’s Disease patients. The technique that used in the present study is PCR-SSCP technique. DNA was extracted from blood. The results show that there was strong association between IL-4 gene and Behçet’s Disease there were two patterns (A and B), polymorphisms show significant differences(p>0.05) between patients and control where pattern (A) was occurred with percentage (2%) and (39%) while in the control and patients respectively .The pattern (B) was occurred with percentage (98% ) and (61%)  in the control and patients respectively .The results concluded that IL-4 gene polymorphisms were involved in  pathogenesis of Behçet’s Disease , our finding require more exploration to use this result as early hint of Behçet’s Disease  prevalence.Keywords: IL-4 .PCR-SSCP technique, Haplotypes, Polymorphisms, Behçet’s Disease 
A Comparative Study on In-vitro Nitric oxide scavenging activity between Zonegran and Levetiracetram Manish Babbu UG; Karthik V P
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Zonegran and Levetiracetram are two new range of anti-epileptics available in the market. Studies have been made earlier to demonstrate the antioxidant activity of the drugs Zonegran and Levetiracetam. Both have a good antioxidant property but there was not any comparative study for both the drugs. This study is to compare the anti-epileptic drugs Levetiracetam and Zonegran and demonstrate which drug has higher antioxidant property through Nitric Oxide radical scavenging activity.Methods: Nitric oxide scavenging activity was determined according to GriessIllosvoy reaction, with the help of Griess reagent. Ascorbic acid is used as positive control for the study. Conclusion: The study done suggests that both Zonegran and Levetiracetram possess antioxidant properties. At lower doses, Zonegran shows higher antioxidant potential over Levetiracetram and at higher doses, Levetiracetram shows slightly higher antioxidant property.
The Impact of the Plan and PDEODE Strategies in Developing Awareness of Cognitive Processes and Reducing Psychological Pollution Among Students of the Faculty of Physical Education and Sports Sciences Raed Abdulameer Abbas Al-Mashhadi
Journal of Global Pharma Technology .
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The Research Aims toTo identify the psychological awareness of cognitive processes and pollution of the students of the Faculty of Physical Education and Sports Science.To know the impact of strategies and PDEODE in PLAN Transgender search.Any previous two strategies realized more development in the variables of the students.Use the descriptive approach in the method of normative studies and comparative studies in the measurement of psychological pollution and awareness of cognitive processes, and the experimental method of the two equal groups in the tribal and remote tests in the variable PLAN and PDEODE strategies. And select the community and the research sample students the second phase of the Faculty of Physical Education and Sports Science - University of Babylon in the academic year (2014-2015), was the number of educational units (28) units divided into 14 units at each strategy, by one lecture each week and the number of ( 7) topics for each variable, are executed in the order, and repeated to increase the absorption of interaction and students about the importance of topics in their lives, and after the use of statistical methods were reached conclusions:1.The arithmetic mean of the variables of research within the standard level when the moderate sample.2.The PLAN and PDEODE strategies have an effect on the two search variables.The PLAN strategy has a greater impact than the PDEODE strategy in developing awareness of cognitive processes and reducing psychological pollution among students.Keywords: Strategy PLAN, PDEODE strategy, awareness of cognitive processes, psychological pollution.
Various Parameters Affecting to Production of Dried Jasminum sambac Flower Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Jasminum sambac is one of the most cultivated species in Vietnam. The plant is much valued for its exquisitely fragrant flowers. Flowers of Jasminum sambac have been utilized as traditional medicines to treat many diseases. Objective of this study focused on on the effectiveness of different parameters of freeze-drying such as pressure (0.06, 0.08, 0.10, 0.12 mbar), primary drying temperature (-3oC, -5oC, -7oC, -9oC) and secondary temperature (26oC, 28oC, 30oC, 32oC) to the total phenolic (mg GAE/100 g) and total flavonoid (mg QE/100 g) of dried Jasminum sambac flower. At the end of drying process, we also monitored the stability of dried Jasminum sambac flower during 6 months of preservation. Our results showed that the optimal drying process should be conducted at 0.08 mbar, primary drying temperature -7oC, secondary temperature 28oC to achieve the best dried Jasminum sambac flower. From this production, shelf-life of dried Jasminum sambac flower could be last for 6 months without any deterioration.Keywords: Jasminum sambac, Dried flower, Freeze-drying, Total phenolic, Total flavonoid, Shelf-life, preservation.
Estimation of Serum Levels of Testosterone and Estrogen in Vitiligo Patients Sherief Mahdy Hussein
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Vitiligo is an idiopathic systemic autoimmune disorder affecting skin, hair and oral mucosa. This genetic moreover acquired disease distinguished by melanin absence causes morbidity over all races. Although thyroid disorder has been known as a key trigger of this pathology, arange of other factors plays serious role in its presentation. Several hormones such as, testosterone and estrogen have been suspected as drivers of this disorder. The present study aimed to determine the levels oftestosterone, estrogen and the ratio of testosterone/ estrogen in serum of patients with vitiligo compared to matches control group .The study included50 patients from Egyptian population with lesions of generalized vitiligo (29 males and 21 females; median age 35.0 years; range 28–40 years and 50 healthy volunteers as control group (22 males and 28 females; median age 36.1 years; range 25–40years). All patients of vitiligo were recruited from Medical research center of excellence of National Research Centre, Egypt, during a period of 4 months (February 2019 to May 2019). The mean duration of the disease in the vitiligo group was 5.00years.Vitiligo diagnosis is based on if areas of patient's skin, hair or eyes lose coloring and confirmation is done using Wood’s lamp. Blood samples were obtained from both the patient and control groups, testosterone, estrogen and the ratio of testosterone/ estrogen. Results:  The present results declared significant elevation of testosterone (+144.5), estrogen (+116.048) as well as testosterone/ estrogen ratio compared to control subjects. Conclusion: Some endocrine markers play a principle role in pathogenesis and/or consequences of vitiligo. The abnormally disturbed levels of these markers lead to melanocyte damage and/or depigmentation.Keywords: Autoimmune disease, Melanin loss, Oxidative stress, Vitiligo, Estrogen, Testosterone, Testosterone /Estrogen ratio.
Synergistic Effect of 1-MCP Fumigated with Chitosan Coating on Shelf-life and Physico-Chemical Quality of Marian Plum (Bouea macrophylla) Fruit Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Marian plum fruit has high nutritional and functional components which are beneficial for human health. However it has a short shelf-life owing to its high respiration and ethylene production. 1-methylcyclopropene is an inhibitor of ethylene action even at low concentration to hinder ripening and improving storage stability on variety of fruits. Chitosan has strong antimicrobial and antifungal properties that could effectively adjust the permeability of gas exchange, slow down respiration rate, hinder fruit decay. Objective of this study focused on the evaluation of 1-MCP fumigation at different levels (20 ppm, 40 ppm, 60 ppm, 80ppm, 100 ppm) in combination with chitosan coating (0.1%, 0.15%, 0.2%, 0.25%, 0.3%) on shelf-life and quality of marian plum during 14 days of storage at ambient temperature. Our findings will provide better insights for manufacturers in postharvest management.Keywords: Marian plum, Chitosan, 1-MCP, Fumigation, Coating, Posthavest
Synthesis, Characterization and Antibacterial Studies of New Metal Complexes of α-Aminonitriles Derived from P- Chlorobenzaldehyde with 2-Aminopyrimidine Mohammed H. A. Al-Amery
Journal of Global Pharma Technology .
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Abstract

New metal ion complexes of some transition metal ions [Mn(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)] of previously prepared ligand 2-(4-Chlorophenyl)-2-(Pyrimidin-2-Ylamino)Acetonitrile was synthesized. The ligand was prepared by Strecker's procedure which included the reaction of P-Chlorobenzaldehyde with 2-Aminopyrimidine and the structures of the new metal ion complexes were characterized by Elemental Micro Analysis (C.H.N), Chloride Content, FT-IR, UV-Vis spectra, Thermal Gravimetric Analysis (TGA-DTG), flame atomic absorption, molar conductivity as well as magnetic susceptibility measurement. According to the obtained data the probable coordination geometries of these complexes were suggested as octahedral. All complexes were found to be non-electrolyte. The antibacterial activity of the ligands and their metal ion complexes have been studied by screening against various microorganisms, Staphylococcus aureus, Bacillus subtilis (Gram-positive), Escherichia and Pseudomonas aeruginosa (Gram-negativre). Agar (well-diffusion method) was used to determine the activity. The metal ion complexes gave the formulae: [ML2Cl2].nH2O.Keywords: 2-(4-Chlorophenyl)-2-(Pyrimidin-2-Ylamino)Acetonitrile, Transition metal ions.          
Variable Parameters Affecting to Nile Tilapia (Oreochromis Niloticus) Fish-Paste Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Tilapia has emerged as one of the most cultivated and marketed species in Vietnam. There is not much research mentioned to processing of fish-paste of this valuable fish. In order to improving the added value of this fish, we investigated a production of fish-paste from Nile tilapia (Oreochromis niloticus). By investigation different parameters probably affecting to gelation, the results was noticed that the best physicochemical properties and sensory characteristics of fish-paste would be obtained by the addition of modified starch 1.5%: guar gum 1.5%. These results demonstrated that the addition of modified starch and guar gum in the formulation of Nile tilapia fish-paste increased the nutritional value of the product without reducing its sensory preference.Keywords: Nile tilapia (Oreochromis niloticus), fish-paste, Modified starch, Guar gum, Physicochemical properties.
Prescription of Antihypertensive and Antianginal Medications within the Conditions of Outpatient Treatment of Patients with Ischemic Heart Disease Along with Hypertension Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Abstract Cardiovascular morbidity leads the world in the morbidity rate structure. An arterial hypertension and a stable angina are widely occurring among the population and, in terms of medical and social significance, stand at the head of the circulatory system diseases. The combination of these diseases is observed in 2/3 of patients. An important challenge for cardiology is to ensure a rational approach to the choice of medications for effective antianginal and antihypertensive therapy, its compliance with accepted treatment quality standards, the development of clear and scientific-based criteria for the use of medications, improvement of the patients’ quality of life while reducing the economic costs for medications supply. Purpose. To develop an approach to the optimization of medications supply for patients with ischemic heart disease in combination with arterial hypertension in inpatient and outpatient practice, based on the use of pharmacoeconomic and pharmacoepidemiological researches. Materials and methods. To assess the prescription structure of the various groups of antihypertensive and antianginal medications, an analysis of the past medical history in patients with ischemic heart disease in combination with arterial hypertension was carried out. Variation statistics methods have been applied in mathematical data processing. Results. Beta-blockers prevailed, followed by angiotensin-converting enzyme inhibitors, calcium channel blockers, and diuretics were found in the structure of medicinal benefits when prescribing pharmacotherapy to patients with stable angina pectoris with arterial hypertension. Conclusions. As a result of the research, it was revealed that the combination therapy in most cases was based on beta-blockers, angiotensin-converting enzyme inhibitors, diuretics in various combinations with each other.

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