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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 17 Documents
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Search results for , issue "Vol. 9 Issue 7 : 2017" : 17 Documents clear
Religiosity and its Impact on the Family Life Framework According to Imam Reza (Peace Be Upon Him) Ayatollah Zarmohammadi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Those who are familiar with religion and its evolutionary teachings endorse its extraordinary effect on individual and social life of human being; although there is difference of opinion regarding the scope of this influence. Some believe in the maximal role of religion and some believe in its minimal role, but what has been accepted by both groups is the very involvement of the religion in all human affairs. The current essay deal with human expectation of religion and at the same time discusses the influence of religiosity on the family life according to Imam Reza (peace is upon him). Moreover, it also debates the necessity of formation of family and its functions in the production and preservation of generation, providing peace, sense of integration and purity of generation and also such factors strengthening family foundation as generosity, good manner, adornment, and satisfaction of sexual instinct.Keywords: Life Framework, Religiosity.
The Relationship between Phylogenic Typing and Antimicrobial Susceptibility Patterns Forescherichia Coliisolatedfrom Utis in Many Hospitals at Baghdad City Eman Natiq Naji; Eptisam Younam Pirko; Munim Radwan Ali
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Objective In the currentsearch , E.coli  isolated from UTIs in many Baghdad hospitals. The study concentrated on phylogenic groups and this was done based on triplex PCR method by primers besieged to three genetic markers, chuA, yjaA and TspE4.C2. Evaluate the relationship of phylogenic groups of E.coli isolates with the antibiotic-non sensitive patterns.Methodology Four hundredof E.coli bacteria inaccessible from urine samples from  five hospitals in Baghdad city includes : Ghazi AL-Hariri, Iben- Beledi , AL-Iskan , AL-Nooman and AL-Yarmoke hospitals. Phylogenetic categorization of E. coli isolates was completed by by means ofearlier reported triplex PCR-based on  phylotyping procedure using primers besieged at three markers, chuA, yjaAand TspE4.C2. Phylogenetic combination was done on the starting point of the existence or nonexistence of the3 DNA fragments as follows: chuA–, TspE4.C2–, group A; chuA–, yjaA–, TspE4.C2+, group B1; chuA+, yjaA+, group B2; chuA+, yjaA–, group D. Because two possible profiles can be obtained for the groups A, B2, and D. Fifteen antibiotics second-hand for all foremost groups and their individual generations were used in this paper adjacent to all bacterial isolates. Results The isolates ofE.colifrom UTI  were distributed within thephylogroups B2 (43%); phylogroups D (28.25%); phylogroups A (24%) and B1 (3.5%), so phylogenic group B1 was prevalent among  male patients of AL-Yermouk hospital ( 14%), followed AL-Iskan (3.75)% so, isolation rate of E.coli were higher among age (11-20 ) years (31.75 %), also(11%) were sensitivity to antibiotics, whilst (75.25%) were classified as extensive drug resistance pathogens, but  13.75% were multidrug resistance  and in Qarkh areas, the frequency of phylogeneticB2 was (59.88%), followed phylogenetic A and D were ( 68.75 and 48.78%) respectively as  compared to Rusafa areas were prevalence phylogenetic B2(40.12%),followedphylogenetic D and A were (51.22 and 31.25 %) , as well as most of these phylogenetic groups occurred more frequently in both groups B2 or D (43, 28.25) % respectively, also ( 2.75, 2.5 )% of phylogenic A were antibiotics sensitivity in both AL-Iskan hospital and Ghazi AL-Hariri hospital respectively whilst these phylogenic was multidrug resistance as percentage (9, 3.75) % respectively in both AL-Yermouk hospital and AL-Iskan hospital, Whilst in these hospital this phylogenic A was founded with extensive drug resistance (1, 0.75) % respectively, also most of phylogenetic group  B2 occurred more frequently in AL-Yermouk hospital, so the sensitivity; multidrug resistance and extensive drug resistance as (2.25, 15 and 3.5) % respectively, also all  phylogenetic groups E. coli isolates from UTI patients of five hospital weregrouped  in two or three major group as  A , B group contain major sub groups .RecommendationsThe study recommends additional studies of the correlation  between the Phylogenic group  with antibiotic-resistance pattern  for other bacterial  types  isolated from  UTIs or the same bacteria isolated from other types of infections. We suggest to applicate our study on bacteria Vibrio colerai  isolated from the infected patients stool who submitted to  the same hospitals  or in the other provinces of the country, because of our country suffering frome  epidemics infections  in the last two years. Keywords: Urinary tract infections, Enterobacterial repetitive intergenic consensus PCR (ERIC-PCR), E. coli, Antibiotic resistance, MDR.
Work’s Environment Effect on Metal and Male Reproductive Hormones Levels: Circulating Testosterone, LH, and FSH are Positively Associated with Cadmium, Lead, and Molybdenum Farha A.Ali Shafi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Objectives: The present study was carried out to investigate the concentration cadmium (Cd.), lead (Pb.), and molybdenum (Mol.) in blood samples of petrol stations workers and its relationships with the male reproductive hormones levels such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and Testosterone. Methods: This study included 31 workers in 4 petrol station in different sites of Thi-Qar city/Iraq, who were working since more than 5 year in the petrol station and spend more than 12h work time, and ten healthy in different sites of a same city. Both groups age were ranged from 23 to 45 years old. Heavy material (Pb, Mo, and Cd) were determined by atomic absorption method using Shimadzu AA-7000 Dual Atomizer system. Hormones level (FSH, LH, and testosterone) were determined by enzyme linked fluorescent assay (ELFA) using the Bio Mérieux VIDAS Automated Immunoassay System. Results: Our results found significantly higher Cd, Mo, and Pb levels in Petrol workers compared to control (p<0.05). While no significantly differences were detected between FSH levels in control and Petrol workers groups, significantly higher testosterone level was found in Petrol workers compared to control (p<0.05). Conversely, significantly lower LH level in Petrol workers group than it in control group (p<0.05). Conclusion: the petrol station workers exposure to Cd, Pb, and Mol which lead to increase its levels in their blood due to neglect the occupational safety instructions. Thus associated positively with the testosterone level and negatively with the LH level in their blood.
The Relationship between Three (Human, Perceptual, and Technical) Skills of Financial Managers and Their Effectiveness in Manufacturing Companies with the Intermediate Role of Empowering Managers Hossein Azimi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

The aim of this study is to investigate the effect of three (human, perceptual, and technical) skills of financial managers on their effectiveness in Gilan province's manufacturing companies with the mediating role of empowering managers. The research method was descriptive-correlational and the statistical population included managers and financial experts of 193 manufacturing companies in Rasht industrial town. Data collection tool was a researcher-made questionnaire which was distributed among 30 active companies by random sampling method. The reliability of the questionnaire was confirmed. Additionally, the content validity of questionnaire was confirmed by the opinion of the experts and its construct validity was confirmed by factor analysis. The results of the correlation test using spss16 software showed that there is a statistically significant effect between the studied variables. Moreover, structural equation modeling and path analysis technique were used to investigate the interactions of research variables. The results obtained from the seven examined hypotheses confirmed the impact of three (human, perceptual, and technical) skills of financial managers on their empowerment in manufacturing companies of Gilan province (P <0.05). Also, the results of this study indicated that the empowerment of managers affects the financial management effectiveness (planning, budgeting, control and assessment) in manufacturing companies of Gilan province (P <0.05).Keywords: Triple skills (Human, Perceptual, and Technical), Effectiveness of managers, Empowerment of managers.
Effect of Spraying Salicylic Acid and Collection Dates of Corn Silk (Zea mays L.) on Growth, Yield and Content of Some Antioxidant Compounds Maher H.S. Al-Mohammad
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

A filed experiment was conducted during the autumn season of 2016 to study the effect of foliar application salicylic acid (SA) at concentrations 0, 50, 100 and 200 mg.L-1 and collection dates (CD) at 14, 28 and 32 days after flowering and their interactions on growth parameters (plant length, total leaves number, leaf area and total chlorophyll), yield (Fresh and dry weight, plant yield and dry productivity) and some antioxidant compounds(total phenol compounds, flavonoids, anthocyanins, carotene, ascorbic acid and glutathione) of corn silk (Zea mays L.). Results of analysis of variance showed that SA affect were given increased   significantly impact (P<0.05)  when increased concentrations on all growth parameters of plant and yield, while late CD were increased leaf area, plant yield and dry productivity of corn silk, but the early CD decreased total chlorophyll and fresh weight of corn silk. The interaction between SA 200 mg.L-1×CD 14 days were given high amount of total phenol compounds, carotene, ascorbic acid and glutathione (140.53, 8.96 mg.Kg-1 DW, 115.34 and 16.71 mg.Kg-1 FW) respectively, and treat of SA 200 mg.L-1×CD 32 days were given high amount of total flavonoids and anthocyanin (48.57 and 5.93 mg.Kg-1 DW).  Keywords: Corn silk, Salicylic acids, Collection dates, Antioxidant compounds.
Inflammatory Response of Annona Muricata Linn Leaves Extract in Colorectal Cancer Patients Ingrid Suryanti Surono
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Annona muricata L (AML) is a member of Annonaceae with antioxidant, anti-inflammatory and anticancer properties.  A randomized double blind placebo controlled pre post-trial on twenty colorectal cancer patients who had undergone primary tumor resection were conducted in two groups, each group was supplemented with A. muricata leaves extract, and maltose as placebo. Inflammatory responses were assessed using ELISA method. There is no significant difference between pre and post on cytokine and cyclooxygenase serum level, also between two groups. A strong significant correlation between serum level of TNF-α and IL-10 cytokine (coefficient correlation = 0.64, p = 0.01) and significant correlation between IFN-g and IL-10 (coefficient correlation = 0.47, p = 0.05) was found after 8 weeks AML supplementation, as shown by increasing of IL-10 production, in response to  TNF-α and IFN-γ in an inflammatory condition. This study  is  registered  in Clinical Trials.gov ID:  NCT02439580Keywords: Annona muricata L, inflammatory response, colorectal cancer, cytokine, cyclooxygenase, TNF-α, Interleukin-10, Acetogenin. 
Investigation of Antioxidant Status in Iraqi Patients with Beta- Thalassemia Major Jamela Jouda
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Background: Oxidative stress is the most common complication in Beta-thalassemia patients due to ironover load that is resulted from long life blood transfusion leading to growth retardation, delay of sexualmaturation, and later involvement of the liver, heart, and endocrine system. Aim of study: Assess of someantioxidant parameter status in serum and saliva of patients with beta-thalassemia major in comparisonwith control subjects. Methodology: Total antioxidant (TAO), glutathione (GSH), uric acid (UA), urea (U)and albumin were investigated in serum and saliva samples of all subjects. Results: Albumin level inserum is significantly (P ˂ 0.00001) decreased in patients group (3.27 ± 0.17 g/dl) from that in controlgroup (3.59 ± 0.13 g/dl). However, TAO level was significantly elevated (P = 0.031) from (3.14 ± 1.38U/ml) in the saliva of control group up to (4.09 ± 1.76 U/ml) in the saliva of patients group as well assignificant difference (P = 0.02) in salivary fraction index (Sf) only for TAO which is elevated from 0.47 incontrol group up to 0.56 in patients group. Conclusion: The findings of this study indicated that theserum level of albumin can be used as a good marker to reflect the liver status in TM patient in additionto other conventional markers. Also this study suggested that saliva can be act as an alternative sampleto assess the antioxidant status in TM patients but need further investigation.Keywords: Beta thalassemia major, Iron overload, Antioxidant, Saliva.

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