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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 4 Documents
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Search results for , issue "Volume 08 Issue 05" : 4 Documents clear
Adjusted Permutation Method for Multiple Attribute Decision Making with Pruning Solution Approach Ali Athari Beyragh
Journal of Global Pharma Technology Volume 08 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

Permutation method is one of the multi-critera decision making techniques which can get the best order of the given alternatives to have the best benefits. This method solves the decision making problem by calculation the benefit of each possible permutation with N Factorial calculations for N alternatives. In this paper, we presented a new method for improving the classical permutation method. It works with pruning the possible permutation sequences of the alternatives to reach the best solution. Our method can solve the problem by less than N(N-1)/2 calculations. It tries to find the best order by comparing the effect of switching the places of two nearby alternatives in the permutation sequences.Keywords: Multi-criteria Decision Making, Adjusted Permutation, Pruning.
Maintaining and Developing Ethical Corporate Culture Moslem Soleymanpor
Journal of Global Pharma Technology Volume 08 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

Of  all  the  issues  boards  of  directors,  executives,  and  managers  face,  one could  argue  that  unethical  corporate  activity  is  one  of  the  most  significant  in  terms  of its  potential  negative  impact  and  also  one  of  the  most  difficult  to  properly  address. This  article  argues  that  three  key  elements  must  exist  if  illegal  or  unethical  activity within  and  on  behalf  of  organizations  is  to  be  minimized  through  developing  and sustaining  an  ethical  corporate  culture.  The  three  elements  include  (1)  the  existence of  a  set  of  core  ethical  values  infused  throughout  the  organization  in  its  policies, processes,  and  practices;  (2)  the  establishment  of  a  formal  ethics  program,  including a  code  of  ethics,  ethics  training,  an  ethics  hotline,  and  an  ethics  officer;  and  (3)  the continuous  presence  of  ethical  leadership-that  is,  an  appropriate  ‘tone  at  the  top’  as reflected  by  the  board  of  directors,  senior  executives,  and  managers.  While  each  of these  three  elements  is  distinct,  they  also  overlap,  relate  to,  and  reinforce  each other.  This  article  discusses  each  of  the  three  key  elements  necessary  to  develop  and maintain  an  ethical  corporate  culture. Keywords: Ethical corporate culture; Ethical values; Ethics programs; Ethical  leadership. 
DFT Study of Alkyl-Substituted Morphine Molecules Vahid Moeini
Journal of Global Pharma Technology Volume 08 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

In this paper, (5α,6α)-7,8-didehydro- 4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) as well as alkyl-substituted morphines are studied using density functional theory (DFT) at B3LYP/6-311++g(2d,p) level. The calculated Hartree-Fock (H-F) energies ranged as -1018.0049 to -939.3950 kJ mol-1. Among the three studied molecules, C16H16NO3-CH2CH2CH3 system represents the minimum vibrational frequency, H-F energy as well as the minimum highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) energy gap with 49.939×1010 Hz, -1018.0049 kJ mol-1 and 0.11257, respectively. Keywords: DFT, Hartree-Fock, Morphine, HOMO-LUMO.
Bioinformatics Analysis of HSP90 in Amniotic Fluid and Amniotic Membrane Cells as A Potential Anticancer Drug Target Hakimeh Zali
Journal of Global Pharma Technology Volume 08 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

HSP90AA is a crucial protective chaperon protein in normal and cancer cell. It has been previously determined HSP90AA down regulate in tumor cell treated with extract of amniotic membrane (AM) stem cells. Aim of this study find out the pathways and molecules associated with reduction of HSP90AA by bioinformatics methods. Network analysis defined the principal functions of HSP90AA in cancer survival and proliferation through interaction with important proteins with different functions such as AR, AKT, HIF1A and P53 to promote tumor cell proliferation and angiogenesis. Gene ontology analysis released the regulation of nitric oxide synthesis activity. In sum up results distinguished the misexperssion of HSP90AA may due to down-regulation of its transcription factors or systemic changes in gene expression of cancer cell after treated with extract of AM cells and induce apoptosis in oxidation state.Keywords: Hsp90AA, Cancer, Amniotic membrane, Epithelialstem cells, Mesenchymalstem cells, Apoptosis

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