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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 63 Documents
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Search results for , issue "Volume 09 Issue 12" : 63 Documents clear
Effect of Growth Regulators and Irradiation and Methyl Jasmonte in the Induction and Production of Flavonoids in Callus of Vitis Vinifera In-Vitro Sarab, A. Almukhtar
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Plant tissue culture technology was used in the induction of callus from the node of the Vitis vinifera and thus stimulated to increase the production of flavonoids. The study was carried out in three stages after the sterilization of the explant: The first consisted of the establishment of callus cultivars by culturing the node on the MS medium, which is equipped with different concentrations and types of growth regulators. The second stage was performed by exposing the induced callus tissue to different doses of gamma radiation, while the third stage was performed by Cultivation the irradiated and unirradiated callus on the MS medium which was provided with different concentrations of methyl Jasmonate. The results of the study showed that auxien 2, 4-D had the highest wet and dry weight of (1817.20 and 94.38) mg respectively, while NAA achieved a wet and dry weight of (677.02 and 71.16) mg respectively, The concentration of 2.5 mg / L of auxien resulted in the highest rate of wet and dry weight of callus of (1991.75 and 124.75) mg, respectively. The irradiation treatment was significantly higher in the concentrations of Gintestnic, Rutin, Quercetin, Proanthocyanin, Nargnine, and Hesperdine of (133.08, 149.44, 157.82, 48.03, 89.42, and 72.75) and μg / g respectively were significantly higher than those obtained from the comparison treatment which achieved the lowest concentration rates. Keywords: Callus, flavonoids, grapes, methyl Jasmonte, irradiation.
Synthesis Conditions of Ag Core@ Aushell System by Laser Ablation with (1064, 532, 355) nm Wavelengths as a Suitable Model for care Skin Enhancement Ghaleb Al-Dahash
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Laser ablation in liquid technique (PLA) has become a more important for the preparation of NPs. Metal targets were laser ablated in liquid for preparation of spherical Ag @ Au core @ shell NPS colloidal solution for refractive index sensing. In our research was prepared Core-shell Nano colloid system of Ag @ Au by using pulses of Nd-YAG laser with (1064, 532, 355) nm wavelength and (80 @ 60) mJ energy in ethanol liquid. The Surface texture, topography and morphology studied by Transmission Electron Microscopy (TEM) and Scanning Electron Microscope (SEM).Our structural analysis indicated the grains show spherical shape, where TEM images showed formation of Core-Shell clearly, UV-Visible spectroscopy has been employed for the optical properties measurements, Absorption peaks shifted to lower wavelength (blue shift) (UV). The effect of (Ag -core) was more effective than the (Ag - shell), and so by the sliver core effect (Ag -Core), and this confirms clear evidence that the effect of the (Core) influential, which dominates the effect of (shell).
Evaluation of Antimicrobial Activity of the Aquatic Extract against Bacterial isolates from URTI in Babylon Province, Iraq Ayad F. Alkaim
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Background, The other infections of patient in the hospitals may be occur resulting   from high drug résistance bacteria and causes mortality. The study have been aimed to investigate the antibacterial activity of aqueous extract Borago officinalis L., Cydonia oblonga., Matricaria chamomilla against most prevalence pathogenic bacteria. Methods; the aqueous extract  Borago officinalis L., Cydonia oblonga., Matricaria chamomilla were used to investigate the antibacterial activity pathogenic bacteria by Agar well diffusion method. Result; the Result showed that the crude of all plants extract have potential antibacterial activity. Conclusion; Based on the results it can be concluded that plants extract can inhibit bacterial colonization and adherence to upper respiratory tract infection, and provide production against different human pathogens and this may have clinical relevance.Keyword: Borago officinalis L, Cydonia oblonga, Matricaria chamomilla, Pathogenic bacteria.
Influence of Immune Engines in Iraqi Patients with Acute Myeloid Leukemia Muhammed A.H. Aldabagh
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Acute myeloid leukemia (AML) is heterogeneous disorders originated from the abnormalities in the proliferation and maturation of myeloid progenitors in bone morrow. There is a clinical correlation between immunity engines and disease progression, but this relationship is not completely clear yet. This study was designed to assess the full immune response in Iraqi patients diagnosed with AML. Patients and healthy volunteers were divided into three groups: newly diagnosed untreated, under chemotherapy treatment patients and control group. A significant reduction were seen in C4 and IFN-γ levels in both untreated and treated groups with no significant difference between untreated and treated groups. On the other hand, IL-2 and IL-8 levels increased in untreated and treated groups, whereas IL-4 elevated only in untreated group. Additionally, IL-1α levels were decreased in treated group. Moreover, no differences in IL-10 and GM-CSF levels were found between studied groups. Levels of IGG significantly elevated after treatment. However, no differences in IGA and IGM levels were found. In conclusion, immune engines may have substantial effects on the development of AML disease, and chemotherapy may negatively or positively affect the levels of immune components.Keywords: Acute myeloid leukemia, innate and adaptive immune engines, IL-8, INF-γ, IgG.
Detection of Metallo β-lactamase Class among Carbapenem Resistant Acinetobacter baumannii (CRAB) Isolates in Hilla / Iraq Rabeea Abdulelah Al-Hindawi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

During the period between April 2016 and January 2017, a total of 1100 clinical specimens (burns, wounds, throat, urine, blood) were collected from two hospitals in Babylon province Al-Hillah Teaching Hospital and Medical City of Mirjan Hospital. All specimens were cultured and 17 Acinetobacter baumannii isolates were obtained from clinical specimens in a percentage of (1.5%) distributed in burn 11 (2.8%), wound 1 (0.6%), throat 1 (2%), urine 3 (0.7%) and blood 1 (0.9%).This study was conducted to determine the presence of carbapenem resistance Acinetobacter baumannii (CRAB) isolates and the prevalence of Ampc gene responsible for carbapenem-resistance among clinical isolates of A. baumannii collected from two hospitals in Hillah City. Isolates were identified according to VITEK2 system and further confirmed using PCR technique depending on housekeeping genes. Antibiotics susceptibility was assayed by using disks diffusion method according to CLSI recommendations and it’s found 8 isolates was carbapenem resistant. The Carbapenem resistance Acinetobacter baumannii (CRAB) isolates were subjected to monoplex PCR targeting ampC gene, PCR experiments showed that seven (87.5%) isolates were harbored ampC gene. These results revealed that CRAB isolates constitute 47% of all A. baumannii that had been isolated from Al-Hillah Teaching Hospital and Medical City of Mirjan Hospital in Babylon province. This underlies the importance of their accurate identifications and reporting to prevent the emergence of complete resistance to the most potent drugs against A. baumannii in Babylon province.  Keywords:  CRAB, A. baumannii, Carbapenem.
Ultrasonic Synthesis and Anti-Microbial Screening of Some 1, 3, 4-Thiadiazole Derivatives Mustafa K. Shneshil
Journal of Global Pharma Technology Volume 09 Issue 12
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Some novel1,3,4-thiadiazole derivatives (1a-10a) were greenly synthesized by the reaction of substituted benzoic acid with thiosemicarbazide in the presence of phosphorus ox chloride (POCl3) under ultrasonic irradiation forming2-substituted phenyl-5-amino-1,3,4-thiadiazole (1-10). The later were reacted with benzoyl chloride under Schotten-Baumann conditions to give the target molecule 2-substituted phenyl-5(N-benzoyl)-amino-1, 3, 4-thiadiazole (1a-10a). The structures of the compounds synthesized identified by using spectral analysis methods (F.T-IR, 1H-NMR and13C-NMR). The compounds (1a-10a) screened for anti-microbial (Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa) activities using disc diffusion method. The minimum inhibitory concentrations (MICs) of the compounds also calculated by agar streak dilution Method the compounds (1a and 5a) were the most active compounds against the above strains of microbes.Keywords: Green chemistry, Ultrasonic, 1, 3, 4-Thiadiazole, Amide, Anti-microbial. 
Need for Non-Drug Treatment for Alzheimer's Disease Mainul Haque
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Need for Non-Drug Treatment for Alzheimer's Disease
Single Nucleotide Gene Polymorphism of Interleukin 1 Receptor Gene at Position-1970 in Type 1 Diabetes of Iraqi Patients Ibtesam Badday Hassan
Journal of Global Pharma Technology Volume 09 Issue 12
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The aim of this study was to evaluate the frequency of polymorphism of interleukin-1-R gene (IL1R) at position-1970 SNP) in T1D and in healthy controls subjects39 of Iraqi patients, (12 males & 27 females;1 5.65 ± 1.79 years) and 21 controls.(7 mail & 14femal ; 14.66 ± 3.43 years) were enrolled in this study the polymorphism of IL-1R-1970was data waved by polymerase chain reaction-specific sequence primer (PCR-SSP) assay. Results revealed that comparing IL1R-1970genotypes and alleles between T1D patients and controls frequencies of TC genotype and C allele (79.49vs. 68.05%;P =0.419respectively) were significantly rise in patients contrast to controls, (38.28vs. 40.62%; P =0.094) and the related RR rates were 21.3%and39.8%, respectively. And the associated EF values were 1.71and2.11.Similar observations were made in CC genotype. In contrast TT genotype and T allele (22.33vs. 38.95%, P =0.706respectively) frequencies were significantly decreased in patients, compared to controls (42.38vs. 49.38%; P =0.094), and associated PF values were 0.63and0.47, respectively. These findings suggest that IL1R-1970 SNP might have a role in the etiopathogenic mechanism showed associations (positive and negative) with T1Din the samples of Iraqi patients.Keywords: SNP IL-1R Diabetes.
Photo Catalytic Degradation of Reactive Blue 4 Dye using Hydrothermal Synthesized ZnO Nanoparticles Hassan A. Alshamsi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

The research reports the preparation of zinc oxide nanoparticles (ZnO NPs) using hydrothermal process. Several techniques  were used to characteristic ZnO NPs which included x-ray diffraction (XRD), scanning electron microscopy (SEM) ,transmission electron microscopy (TEM),atomic force microscope (AFM),and Fourier-transform I Infrared Spectroscopy (FTIR).Also, the research included photo catalytic activity of ZnO NPs for Reactive Blue 4 dye  removal from aqueous solution under light irradiation  from 100 W . It was shown that the use of ZnO as photo catalyst have acceptable photo catalytic activity for degradation of dye. It has been found that maximum percentage removal of dye was achieved at 0.8g/L ZnO mass, pH 6, temperature 303K and dye concentration 20 ppm. The photo catalytic degradation was monitored by measuring the absorbance of the dye at its λ max using UV-Vis spectroscopy.Keywords: Hydrothermal, ZnO, nanoparticles, Photo catalyst, dye, SEM.
Oculohypotensive Effect of Nitric Oxide Donor in Glaucomatous Male Rabbits Mustafa Ghazi Al-Abbassi
Journal of Global Pharma Technology Volume 09 Issue 12
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Objective: The aim of present study was to evaluate the effect of topical nitric oxide donor in lowering intraocular pressure of glaucomatous male rabbits. Method: Thirty two albino rabbits weighing (2.5-3.5 kg) were used in the study and allocated into four groups include: normal group, glaucoma induced group, sodium nitroprusside (SNP) group and timolol group. Glaucoma induction was done by single intravitreal injection of 50 units of freshly prepared alpha-chymotrypsin in 0.1 ml of sterile saline. The treatment was applied twice daily: at 9:00 a.m. and at 1:00 p.m. during 12 day. The intraocular pressure was recorded two times a day: at 9:00 a.m. and at 12:00 p.m. The parameters that measured include; the intraocular pressure, pupil diameter, corneal sensation, light reflex, conjunctival redness and cyclic guanosine monophosphate (cGMP) level in aqueous humor. Results: The results revealed a high significant decrease in intraocular pressure and a high significant increase in cyclic guanosine monophosphate level, also no variation in pupil diameter, positive pupillary response to light, no corneal sensation, and no conjunctival redness were observed. Conclusion: The findings suggest that sodium nitroprusside has oculohypotensive action and it may prove to be an additional effective for the management of glaucoma.Keywords: Glaucoma, Nitric oxide donor, intraocular pressure.

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