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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 70 Documents
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Search results for , issue "Volume 10 Issue 05: (2018) May2018" : 70 Documents clear
Synergistic Effects of Bleomycin and Hypericum Triquetrifolium Extract on Bone Marrow and Germ Cells of Albino Mice Bushra Mohammed Amin Mohammed
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The aim of this study was to explore the cytogenetic effects of Bleomycin (BLM) and the aqueous extract of Hypericum triqutrifolium  each alone and their interaction (pre-treatment, post-treatment, co-treatment) on bone marrow and germ cells of Swiss albino mice depending on  Chromosome aberration assay, Micronuclei test , Mitotic index assay in addition to sperm abnormal morphology assay .The result showed  that the administration of a single dose of Bleomycin (80mg/kg) and of H. triqutrifolium (17mg/kg) each alone, for three consecutive days  have the ability to increase the total abnormal chromosomes, total micro nucleated cells and reduce the percentage of mitotic index value in bone marrow cells, in addition to enhancing the total number of abnormal spermatozoa .While their interaction revealed that the co-treatment (the mixture of Bleomycin and H. triqutrifolium ) amplify  significantly the total aberrant chromosomes  ,the most frequent types were ;chromatid break with fragment, ring chromosome, dysenteric chromosome , and  chromatid gap. Similar reduction in the percentage of cell proliferation but with a non-significant value was observed in pre, post and co-treatment.  Moreover the co-administration had increased the total number of micro nucleated cells and enhances significantly the frequency of abnormal sperm cells such as bent mid piece, irregular head, coiled tail and corkscrew types compared with the treated and untreated animals. Overall, those results herein found suggest an herb-drug interaction between H. triqutrifolium extract and Bleomycin, which clearly increase the drug bioavailability, with the lowest acute cytotoxicity .To reliably assess the clinical impact of these findings appropriate human studies should be conducted.Keywords: Bleomycin, Chromosome aberration, H.triqutrifolium, Micronuclei test, Mitotic index sperm abnormalities.
Application of Edible Coating by Carboxymethyl Cellulose, Chitosan, Konjac Glucomannan and Their Synergistic Effect on Storage of Mango (Mangifera Indica) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Mango (Mangifera indica) is a tropical fruit that has economic importance in Central Highland of Vietnam. It has good nutritional values such as vitamins, carotenoids, polyphenols, fibers and antioxidants. Mango fruit is very perishable and considerable postharvest quality defect is occurred due to ripening and senescence. Major obstacles of mango during preservation and shipping are weight loss, ripening, and formation of brown spots resulting in decreasing of its value. Mango is very susceptible to chilling injury. The use of the edible coating materials for prolonging shelf-life of mango is essential. The present study aimed to identify the effect of carboxymethyl cellulose (CMC), chitosan, CMC + glucomannan, chitosan + glucomannan as edible coating in storage of mango fruits. Results demonstrated that 0.5% chitosan: 0.25% konjac glucomannan as edible coating could be used to coating mango fruit and maintaining its shelf life to 15 days.Keywords: Mango, CMC, Chitosan, Glucomannan, Coating, shelf-life.
Organizational Culture as a Function of Predicting Administrative Competencies and Decision-making among the Top Leaders in Faculties of Physical Education and Sports Sciences from the Point of Teaching View Jassem Jaber Mohammed
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The importance of this study is that it is concerned with the human resource, which is the secret of the success of any institution, especially the educational institution, which is the leadership of the senior leadership positions that are supposed to give the institution sufficient attention in all aspects, especially cultural ones, which affect the behavior of individuals in decision-making and their competence to work and thus influence On the work of the institution, as defined by the research community, which is represented by the top leaders of the faculties of physical education and sports sciences, and the total vocabulary of (40) single, was chosen from this community in a comprehensive manner.The researchers used the measure of administrative competencies, decision making and organizational culture, which was built by the researcher Talal bin Abdullah Hussein Al-Sharif in 2014. The scale consists of (38) paragraphs distributed as follows:The first dimension (planning): includes (11) paragraph, namely paragraphs: (1 to 11).The second dimension (organization): includes (9) paragraph, namely paragraphs: (12 to 20).The third dimension (communication): includes (9) paragraph,The fourth dimension (calendar): includes (9) paragraph, namely paragraphs: (30 to 38).It is possible to arrive at the following conclusions: The results of the efficiency of the model to predict the organizational culture of the top leaders of the faculties of physical education and sports sciences in management competencies and decision-making.Keywords: Organizational culture, Administrative competencies, Physical education and sports sciences.
The Impact of the Design of Cooled Suit in the Recovery and Get Rid of Lactic Acid in the Handball Players in Karbala Club Hassim Abdul Jabbar Saleh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The game of handball rely heavily on anaerobic energy production system, and many of the sediments produced when working within the system to produce the necessary muscular contraction of energy, the most important (lactic acid), so the return of the player natural state has become one of the important things to familiarity with them from Before coaches and sports workers. Here lies the importance of research in the design of the suit refrigerated and their impact in the process of healing, which helps restore the player to its natural state, and as soon as possible. The research aimed to design suit refrigerated, and to identify the extent of the efficiency of the suit cooled in the speed of recovery and get rid of lactic acid after the first half and the game players Karbala club handball, and to identify the advantage experimental and control groups in the speed of recovery and get rid of lactic acid after the first half and the game players club Karbala handball. It was the use of the experimental method with the two groups equalizers experimental and control, and select the research community my players Karbala Sports Club handball category of applicants and the number 16 player, "was chosen as a sample of them-style comprehensive inventory after excluding (4) players who are goalkeepers and injured, were divided into Two equal groups Each group includes (6) players. The researchers concluded that the cooled suit is suitable for the recovery process and the elimination of the accumulation of lactic acid. The use of the cooled suit after the first half and the second run hastened the elimination of the accumulation of lactic acid and the healing, and the use of cooled formula is much better than the procedures used by the players and trainers in the process of recovery quick.Keywords: Design, Cooled suit, Recovery, Lactic acid and handball.
Evaluation of Disincentive Effects of 70% Isopropyl Alcohol and 10% povidone-iodine Safety Antimicrobial Agents of Skin Iman Fadhil Abdul-Husin
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Background: Many disinfectants were used clinically in both single and mixture applications, however there had been few research on disincentive electricity according to sterilization series when the use of an aggregate of disinfectants. Aim: the purpose of present study was to evaluate the antimicrobial of two disinfectants each one alone and when the usage of a combination of them on skin isolates bacteria. Methods: One hindered and eight healthy volunteers were recruited. first groups were treated with a70% isopropyl alcohol on forearm, second groups were treated with 10% povidone-iodine on forearm and third groups were treated with  combination of 70% isopropyl alcohol and 10% PVP-I on forearm included disinfections on the both forearm with isopropyl alcohol first followed by 10% PVP-I. Skin cultures have been acquired the usage of cotton swabs three minutes after application of each disinfectant, and then had been inoculated on blood agar plates for bacterial lifestyle Result: There was no significant difference in the number of positive cultures between subject treated with single disinfect  (first groups, 150bacterial isolates for subject  treated with a 70% isopropyl alcohol; while in the second group 108bacterial isolates for subject  treated with10% povidone-iodine (P < 0.01)).Third groups was more effective than disinfection with a single agent  since there were only 48 bacterial isolates  suggesting that there is relationship between disincentive power of mixed two disinfectants that  used in present study. Conclusion: The combination of 70 % isopropyl alcohol and 10% PVP-I was more effective than disinfection with a single disinfects of them with either 70% isopropyl alcohol or 10% PVP-I disinfect.Keywords: Antimicrobial agents, 70% isopropyl alcohol, and 10% povidone –iodine.
Immunohistochemical Evaluation of Growth Factors in the Peripheral Blood Vessels of Patients with Severe COPD and Osteoporosis Igor V. Manzulo
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The expression of vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGFβ) in the blood vessels of striated muscle specimens of 20 severe chronic obstructive pulmonary diseases (COPD) with osteoporosis and healthy subjects were assessed by immunohistochemistry method with using immunoperoxidase reaction with monoclonal and polyclonal specific antibodies. The serum levels of VEGF and TGFβ were studied in 74 severe COPD patients and 36 healthy individuals using immynoenzyme (ELISA) methods. Elevated level in TGF-β and reduced serum VEGF were associated with low bone mineral content and muscle mass in the COPD patients. Increased expressions of TGF-β2 and VEGF were observed in the vascular wall in the severe COPD group with osteoporosis. Intensities of staining in the arterial structures were higher in the COPD group, which were primarily presented in the endothelial and muscular layers. Thus, our study strengthens the hypothesis that change tissue and serum markers of the vascular remodeling are involved in pathophysiology of bone damage in severe COPD.Keywords: Chronic Obstructive Pulmonary Disease, Osteoporosis, Vascular Endothelial Growth Factor, Transforming Growth Factor Beta, Vascular Dysfunction.
Production of Bio-Ethanol from Various Lignocellulosics Using High Yielding Isolate of Saccharomyces Cerevisiae Apn07: Mathematical Approach G. Narendra Kumar
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Bio ethanol is increasingly being used as fuel additive in automobiles and the maximization of its production from alternative renewable substrates like lignocellulosic materials are gaining significance. The present study attempts to optimize the media using 0.5% acid hydrolysates from rice husk, rice straw, and sugarcane bagasse and groundnut shell with sugarcane molasses for the production of bio ethanol using RSM analysis with CCD design. The strain of Saccharomyces cerevisiae APN 07 isolated from coconut toddy that yielded 9.6% ethanol when 1.5 ml of all five substrates were mixed in the combination of 15 ml each. Mathematical analysis of the results determined the correctness of the prediction. The coefficient of determination (R2) was 0.997034 signify that the response model could revealed 99.19 % of total difference. The value of (R2pred = 0.994989) indicates high accord between the experimental and predicted value. The high value of adjusted determination coefficient (R2adj¬= 0.993) indicated the significance of model. FTIR confirms the presence of alcohol (OH group). Batch kinetic studies agreed with the model for ethanol production.Keywords: Saccharomyces cerevisiae APN 07, RSM-CCD, Alcohol production.
A Comparative Study of Oxidation in the Preparation of Lacton and Bislacton Compounds and Biological Activity Study of Product Compounds Marwan Mohammed Farhan
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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The Oxidation of five Compound Pyrylium salts with Potassium Permanganate were carried out at different temperature (room temperature, 0c0, 50c0). The reaction proved to be Complex, giving rise to multiple products. However, several major products were isolated at different temperature and identified, unsaturated, five-member ring Lacton, Bislacton and other by-products like Benzoic acid and it is derivatives and diagnosing them Spectroscopically (I.R., 1H-N.M.R.) in addition to the quantitative analysis to its elements. Biological activity of the three types from product compounds was detected on nine pathogenic bacterial species E. coli, Shi. sonni, Ps. areguginos, K. pneumoniae St. pyogenes, St.  Pneumoniae, S. aeureus, Sal. Typhi, and P. morganella. It was found that the product compounds had a good effect to inhibit growth of some pathogenic bacterial species. The best effective concentration of the products compounds against the bacterial growth of most species was 8000 g /mL Also; the results showed that the best compound of three types in an inhibition process was Bislacton, whose prepared concentrations had large impact.
Application of Central Composite Design Method to Oxidative Coupling Spectrophotometric Determination of Metoclopramide Hydrochloride in Pure form and Pharmaceutical Preparations Mohanad HN Halboos
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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A rapid, simple, and sensitive spectrophotometric method was developed for the quantitative determination of metoclopramide hydrochloride (MCP.HCl) in its pure form and in pharmaceutical formulations. The recommended method is based on the coupling between MCP.HCl (after oxidized with a NaIO4) and ellagic acid (EA) to form a colored product which shows a maximum absorption at 422 nm. In addition to univariate one factor a time optimization, chemometric central composite design (CCD) and response surface method were applied to design the experiments for three factors viz volume of oxidant, the temperature of oxidant, and temperature of coupling and to find out their optimum conditions. Under the best achieved experimental conditions, the analytical characteristics of the method were obtained. The linearity range of (MCP.HCl) is (0.1-15) μg.mL-1 at with molar absorptivity (40248.48) L.mol-1.cm-1, Sandell's sensitivity (0.00880) μg.cm-2, LOD (0.00835) μg.mL-1 and LOQ (0.02783) μg.mL-1. The results showed there are no significant interferences of additives (Exclusions) on the determination of the drug. The method proposed in this study was compared with the reference method classified in the British Pharmacopoeia and calculated F-test (0.1394) for 6 degrees of freedom and t-test (0.4517) for 12 degrees of freedom, the proposed method was found to be similar to the reference method in accuracy. The proposed method has been successfully applied for the determination of (MCP.HCl) in pure and pharmaceutical preparations (tablets, oral drops, syrups and injections).Keywords: Chemometric, Metoclopramide hydrochloride, Ellagic acid and oxidizing coupling.
Comparative Laboratory Study: Phytoremediation Ability for Lead, Cadmium, and Copper Using Three Aquatic Plants from the Tigris River in Baghdad City/Iraq ZR Taha
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The present study was investigate carried out to investigate the possible use of three aquatic plants Hydrilla SP, Vallisneria sp. and Polygonum sp A group of the Tigris River within the Baghdad area to remediate polluted water with lead, cadmium, and copper. after exposure to the concentration (10, 20, 30) ppm of Pb, Cd and, Cu Both individually and for 10 days laboratory, the percentage accumulation of these elements within the plant tissue has been measured as the results showed high efficiency of the Polygonum sp. in Pb accumulation of 55.3, 58, 171.5% in the three respectively and copper accumulation by (52, 65.8, 60.2) % for the concentration (10, 20, 30) Compared to other plants, while the Hydrilla SP exceeds.  In the cadmium accumulation of the three concentration (28, 31.1, 40.2)% respectively compared to other plants, as the results prove to be a factor, Pb Cd and cu in the samples of the water from the Tigris River during 2017 within the study area have exceeded the limits allowed by the World Health Organization,  Therefore, Hydrilla sp, Vallisneria sp, and Polygonum sp, which are naturally spread in the Tigris River, Which can be used in the Phytoremediation of the river's polluted water by heavy elements.Keywords: Polygonum, Vallisneria, Hydrilla, Phytoremediation.

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