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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 70 Documents
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Search results for , issue "Volume 10 Issue 05: (2018) May2018" : 70 Documents clear
Synthesis, Characterization and Biological Activity of New Ester Containing Azo Group Derived From 2-Amino-1, 3, 4-Thiadiazoline Derivatives Ammar H. Al-Dujaili
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

New azo compounds derived from 2-amino-1,3,4-thiadiazolines were synthesized. The cyclization reaction of thiosemicarbazones [I]a,b with the acetic anhydride lead to formation of 1,3,4-thiadiazoline compounds [II]a,b. Compounds[II]a,b were converted to 2-amino-1,3,4- thiadiazolines [III]a,b by hydrolysis of amide group using hydrazine hydrate. The new azo compounds [IV]a,b were synthesized via converted  the amino group of [III]a,b to diazonium salt, follow by the reaction with 4-hydroxyphenol. Finally the ester compounds [V]a-f was synthesized from the reaction of azo compounds with suitable carboxylic acid chloride. The synthesized compounds were characterized by elemental analysis, FTIR, 1HNMR and mass spectroscopy. All these compounds were evaluated for antibacterial activity against Staphylococcus aureus, Bacillius Subtilis, Escherichia coli and Pseudomonas aeruginosa by disk diffusion method and for antifungal activity against Aspergillus niger in Sabouraudʼs dextrose agar medium. Amoxicillin and fluconazole were used as standard drugs for Gram positive, Gram negative and antifungal activity, respectively. Most of the compounds have shown significant antibacterial and antifungal activity when compared with the standard antimicrobial agents.Keywords: 1, 3, 4-Thiadiazoline; Ester compounds; Azo compounds; Antibacterial activity; Antifungal activity; Disk diffusion.
A Forensic Study of Mycosis and its Relation ‎with Amphetamine Addiction Tests Suhailah M. Wahhoodee
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The abuse of amphetamines is of national concern from a public health perspective. This issuing a nowadays important subject, because the problem of amphetamine drugs has recently been raised toa very dangerous level. Amphetamines are generally prescribed as a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. The present study aimed to test the ability of Fungi to bio-convert methamphetamine that may change the metabolite pattern and / or concentration of the drug. Total of 53 blood samples were collected (10 samples from drug addict prisoners at Al-Samawa prison, 30 samples from healthy (non-symptomatic), 13 sample phlegm of respiratory system patients). Samples were cultured on Blood agar then purified on Sabouraud dextrose agar. Thereafter, each isolate was cultured in 5ml Sabouraud dextrose broth containing 6mg/ml methamphetamine drug and incubated at 37ºC. Samples were tested periodically, by thin layer chromatography (TLC) using methanol and ammonia (100:1.5) as a mobile phase. The separated spots were visualized by spraying with iodoplatinate or Marquis Reagent the results revealed that 11 sample was able to convert the drug after 14 days of incubation. The TLC method found more advantageous in detecting drug bio-conversion. Add to that, it is inexpensive, fast and easy to manipulate in forensic labs.Keywords: Methamphetamine, Fungi, TLC.
Correlation Study of HbA1C and Kidney Failure in Children of Iraq during Dialysis Nawal M.J. Al- Shammaa
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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AbstractDiabetes is the major risk factor for end-stage renal disease (ESRD) worldwide. In advanced chronic kidney disease (CKD), less is known about the predictive value of HbA1c. We enrolled 2401 diabetic patients with stage 3–4 and stage 5 CKD, who were classified into 4 groups according to their baseline HbA1c values (<6%, 6%–7%, 7%–9%, and >9%). During the median follow-up of 3 years, 895 patients developed ESRD, and 530 died. In linear regression analysis, higher HbA1c correlated with higher eGFR in patients with stage 5 CKD but not in stage 3–4 CKD. In Cox regression analysis, a trend toward worse clinical outcomes existed when the HbA1c level exceeded 6% in stage 3–4 CKD, but the significance was only observed for >9%. The hazard ratios (HRs) for ESRD, all-cause mortality and combined CV events with mortality in the group of HbA1c >9% were 1.6 (95% CI, 1.07 to 2.38), 1.52 (95% CI, 0.97 to 2.38) and 1.46 (95% CI, 1.02 to 2.09), respectively. This study demonstrates that the higher HbA1c level is associated higher risks for clinical outcomes in diabetic patients with stage 3–4 CKD but not in stage 5 CKD.Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD) worldwide, accounting for approximately 45% of end-stage renal disease (ESRD) cases in the Iraqi children dialysis population. This study was performed on 50 human females aged rang (6-12) years with on diagnosed by examining the patients by Alkademia Teaching Hospital ,also 50 males in addition to 50 healthy were enrolled in the study as control group. Measuring glycated hemoglobin (HbA1c) has been suggested as a means of assessing glycemic control in patients with diabetes, while HbA1c decrease in patients group before and after treated with mixtard. Current guidelines recommend a target HbA1c of approximately 7% for preventing or delaying microvascular complications, including diabetic kidney disease.Patients with DM and in later stages of CKD, whom were mostly excluded from clinical trials. HbA1c levels both appeared to associate with poorer clinical outcomes regardless of the baseline estimated glomerular filtration rate (eGFR). Another study showed that, in dialysis-dependent people with DM, patients with higher HbA1c levels, particularly those without anemia, exhibited poorer survival rates than did patients in the HbA1c range.To elucidate these equivocal results, we analyzed the relationships between HbA1c and the risks of ESRD and mortality in the advanced stages of diabetic CKD and tested whether different CKD stages affected these relationships. Keywords: HbA1c, DM, FBS, Albumin, creatinine, S. urea, CKD.
The Biological Action of Some Natural Additives Rajaa K. Baqir
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Since ancient times humans have been keen to improve their food taste by using natural or processed additives for example in Iraq people used to add stachys pseudopinardii to legumes and use of seidlitzia rosmarinus instead of sodium bicarbonate in the preparation of legumes and add Rhus coriaria to entremets and meat. This study investigated the anti-microbial activity of aqueous extract of the three plants against some bacteria and fungus 100, 500, 1000 mg/mL were the concentration which used in this study, Rhus coiaria has the highest activity than stachy pseudopinardii finally Seidlitzia romarinus.Keyword: Natural additives, biological, activity, bacteria, fungus.
Morphological Component of Uterine Leiomyoma Pathogenesis Andrey Gayday
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

It was shown that the pleonasm of myoma myocytes is one of the main processes that cause an increase in the mass of the tumor. In spite of the fact that momentous cells show similarity with cells of the myometrium, differences in the structure and metabolism of these tissues were unearthed. The paper presents an analysis of the morphological structure of uterine leiomyoma with a view to establishing its pathogenesis. 93 in-treatment patients diagnosed with uterine myoma took part in the research. 60 extirpated uteruses were morphologically investigated. The statistical processing of data included estimation of the arithmetic mean (M), the average error of mean (m) as well as the frequency of the occurrence of features with discrete values. Student’s t-test was used as well as Pearson’s chi-squared test and Fisher’s exact test, the method of multiple intergroup differences, multiple regression analysis and linear discriminant analysis. The modern studies substantially expand our idea of the risk factors and the mechanisms of development of uterine leiomyoma. A comprehensive approach to the study of the myoma provides new data on the prevalence and causes of this disease. One of the main outcomes of the analysis of contemporary data on uterine leiomyoma is the fairly clear interdependence between the character of the growth and the enlargement the tumor as well as the development of multifaceted changes on the systemic and local levels.Keywords: Myoma, Uterus, Reproduction, Histology, Histochemistry, Etiology, Degeneration, Cell Necrobiosis, Denervation.
Equilibrium, Thermodynamic and Kinetic Study of the Adsorption of a New Mono Azo dye onto Natural Iraq Clay Alya Khider Abaas
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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In the present work, bentonite clay was used as an adsorbent for the removal of a new prepared mono azo dye, 4-[6-bromo benzothiazolyl azo] thymol (BTAT) using batch adsorption method. The effect of many factors like adsorption time, adsorbent weight, initial BTAT concentration and temperature has been studied. The equilibrium adsorption data was described using Langmuir and frundlich adsorption isotherm. Based on kinetics study, it was found that the adsorption process follow pseudo second order kinetics. Thermodynamics data such as Gibbes Free energy ∆Gᵒ, entropy ∆Sᵒ and ∆Hᵒ were also determined using Vant Hoff plot.Keywords: Adsorption, Azo dye, Bentonite, Isotherm, kinetic.
Determination of Hormones profile and Semen Parameters for Infertility of Men at Al-Husain Hospitals, Thi-Qar City, Iraq and Effect the Age and Type of Diagnosis Enas Abdul Kareem Jabbar
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Male factor is responsible for the infertility in about 50% of cases. The people’s perception of infertility varies from culture to culture. So this work amid to determine the prevalence and pattern of endocrinological abnormalities and semen parameters in patients investigated for male infertility in our environment, and any associated between semen’s and hormones’ results. This work included 89 infertility men and 11 healthy as control group. Their age was ranged between 20-50 years old. The volume, concentration and movement of seminal fluid patterns were examined. Then patients were divided to four groups: Azospermia, Oligospermia, and Normospermia poor movement. Follicle-stimulating hormone FSH, luteinizing hormone LH, Prolactin, and Testosterone were determined. The endocrinological diagnosis was done.  The highest frequency % of cases was normospermia with poor movement and the lowest was azospermia. The mean of patients’ age was about 34.5 years. The frequencies% of infertility was significantly higher within 25-40 age group. The semen volume was significantly lower in Azospermia and Oligospermia groups. The normal shape sperm and the sperm concentration were lower in all patients groups. FSH, LH, and prolactin levels increased in Azospermia and Oligospermea groups compared to normospermia and control groups. The highest frequency of cases with high FSH, LH, and Prolactin was in Azospermea, and lowest in normospermia while the frequency of cases with high testosterone frequency was (0) in Azospermea and only (1) in Oligospermea, and Normospermea. In Azospermia and Oligospermia, the significantly highest endocrinological diagnosis was germinal epithelial failure. This study reported the significance of proper endocrinological work-up in evaluating patients with infertility where appropriate because these cases may be identifiable endocrine disorders that may be correctable, and that in our environment, endocrine dysfunction is common cause of male infertility. It also reported the frequencies of different endocrine abnormalities, some of which can be successfully processed. We conclude that hormonal evaluations should be performed in the assessment of infertility in males in our environment.
Structural Conformational Study of Isoflavon Derivatives in Soybean Using Semi empirical Methods Yuyun Yuniati
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Isoflavon was falconoid group which was a polifenolic compound. As a member of flavonoid groups, isoflavon was a bioactive compound that contains phenolic group reported to have an  ability as antioxidant and prevent free radical damage through two mechanism. The mechanism are donating hydrogen ions and directly acting as a free radical scavenger. One of the seed plants which contain isoflavon was soybean. Isoflavon derivatives in soybean are biochanin a, genistein, daidzein, equol, formononetin, dan glycitein. The compounds can be applied in medical and pharmaceutical. Generally the is of lavon derivatives in soy bean have been conducted to anti-allergic, antioxidant, dan anti cholesterol. These studies based on optimization and structural conformational to support QSAR and Molecular docking studies. In this study, semiempirical AM1 method was used for optimization all the structure. The distance of two nearby atoms affect the structure stability and the strain energy because the lower the strain energy, the more stable that compound The most stable structure for biochanin a, genwastein, daidzein, glycitein, formononetin was 40o while the most stable structure for equol was 280o.Keywords: Conformation, Derivatives, Energy, Isoflavon, Soybean.
Combination of Pandan (Pandanus Amaryllifolius) Extract and Dragon Fruit (Hylecereus Polyhizus) Pulp for Jam Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Leaves of Pandanus amaryllifolius are used as natural colourant due to presence of high chlorophyll content. Not only dragon fruits or pitayas (Hylocereus sp.) are believed to be rich in antioxidants but also they have high economic potential in domestic and foreign market. In order divesify different products from these sources, a research was conducted to combine pandan extract and pitaya pulp for jam production. The search focused on the effect of modified starch concentration, ratio of pandan extract: pitaya pulp, sugar supplementation, temperature and time during condensation to the shear stress and appearance of jam. Results showed that 1.5% modified starch, 3% of pandan extract: pitaya pulp, 10% sugar supplementation, 95oC and 10 minutes during condensation will give the best quality of jam.Keywords: Pandan, Dragon fruit, Modified starch, Sugar, Condensation, Jam.
Effect of Force Molting on Blood Parameters of Broiler Breeder Hens Khalid Hamid Hassan
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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The study was conducted in the poultry house of animal production Department, College of Agriculture, University of Diyala, during the period 1st Oct. 2016 to 22 June 2017. The aim of the study was to determine the effect of force molting by fasting program of Ross 308 and Arbor Acres broiler breeder hens on blood parameters. The experiment consists of four groups (each group consist of 15 hens) namely Ross molting (Rm), Ross control (Rc), Arbor Acres molting (Am), and Arbor Acres control (Ac). The blood samples performed with three replications. The results were indicated that there is a significant higher heterophil cell count of Am compared with Rm, while there is higher Base cell and H/L of Am compared with other groups. Also, there is a significant superiority of Am and Rm in PCV and Hb values compared with other groups. There is a superiority of Ac and Rc in blood glucose, protein and globulin compared with other groups. There is a significant increase of WBC, Heterophil, Basophils, H/L, Hb in molting groups compared with control group, while there is a significant superiority of control groups compared with molting groups in glucose, albumin, cholesterol, GPT, GOT and uric acid.                                                                                                                             Keywords: Force molting, Arbor Acres, Ross 308, Blood parameters.

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