cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 70 Documents
 2   3   4   5   6 
Search results for , issue "Volume 10 Issue 05: (2018) May2018" : 70 Documents clear
Purification and Characterization of Laccase Extracted from Cladophora sp. and Its Role in Decolonization of Dyes Bahjat Fakhri Mahmood
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The Laccase enzyme belongs to the oxidoreductases containing copper atoms, and it has an ability to oxidize a wide range of phenolic compounds. Laccase was extracted from local green algae Cladophora sp. and partially purified using 80% ammonium sulfate and ion exchange chromatography. The specific activity of Laccase in precipitation step was 11583.1 unit /mg protein, and was 33733.5 unit /mg protein after the washing step of ion exchange chromatography technique using DEAE- cellulose ion exchanger. The optimal pH of the partially purified enzyme was 5.5 and for the stability was 6.0 . The optimal temperature of the activity was 35 °C and the enzyme remained at full activity at temperatures ranging from 25-45 °C. The enzyme also had a large tendency towards the Orthotolidine compared to the other reaction materials (Catechol, Guaiacol and Para ansidine). It was observed that the activity significantly reduced when the partially purified enzyme was incubated with substrates of reaction (EDTA, L-Cysteine and 2- Merecaptoethanol) at concentrations of 5mM and 10mM separately. While, the enzyme was still active after the incubation with SDS solution. The enzyme activity increased in the case of incubation of the partially purified enzyme with solutions containing ions of Cu, Fe and Zn at concentrations of 5mM and 10mM individually. The enzyme has retained its activity with ions of Na and Ca, while the enzyme inhibited with ions of Ag, Hg and Mn. The partially purified enzyme has a suitable ability to decolorize four types of textile dyes compared with the crude enzyme, especially the black dye. The percentage of decolorization of the black dye was 91.6% after incubation of the partially purified enzyme for 28 hours at 35 °C.Keywords: Oxidoreductases, Algae, Orthotolidine, Temperature, PH.
Molecular Study for Association of ABCB1 Gene Polymorphism with Leukemia Patients Ali H. Al-Marzoqi
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Yield of ABCB1 quality diversions of the advocates as an efflux particle spat that ship a gigantic sort of substrates and is an escapement of single adaptable cell security against xenobiotics. An ontogenesis (prenominal), incremental tally of weigh have demonstrated that some ABCB1 polymorphisms may expand Pgp wording and agility, and in addition influencing the advancement and feeling to illnesses and pharmacologic answer. High gayety of Pgp has been finding in established myeloid Leukemia patients. Genotyping of outstanding 12 was impact by PCR examination utilizing particular ground works. The subsequent DNA parts were conceived on agarose gels.Keywords: ABCB1; MDR1; P-glycoprotein; Polymorphism; Exon26 & 21.
Building Design and Performance Test of Vibration Beds with Whole Body Vibration Desak Ketut Indrasari Utami
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Vibration is a mechanical motion that oscillates around a fixed point. Whole Body Vibration (WBV) can be defined as vibrations that pass through the surface, backrest, or the floor, either in standing or reclining position. WBV has been proved to lower the level of awakening, inducing sleepiness by providing sense of comfort, and improving insomnia. This study aims to construct a bed with Whole Body Vibration (WBV) which was expected to provide comfort, lowering sleep onset, as well as inducing sound sleep, thus becoming a non-pharmacological treatment option for sleep disorders. Method: This study was conducted in two stages which began with designing and manufacturing of the vibration bed and followed by a performance test. Assesment was conducted based on subjective interviews. Performance test results were presented descriptively. Result: According to the functionality testing, the vibration bed could produce vibration frequency between 1-4 Hertz and displacement 0.094-0.397 mm on vertically directed vibration. According to performance test, as many as 94.1% of subject’s preferred 1 Hertz frequency compared to other frequencies. Furthermore, 88.23% felt comfortable using the vibration bed, 76.47% experienced improvement in onset of sleep and also more soundly sleep. There were only 23.52% of subjects that experienced no change from previous sleep pattern. No side effects were found during the performance test. Conclusion: Lower frequency Whole Body Vibration (WBV) bed with vertical vibration effectively enhanced the subjects’ sense of comfort and improved sleep quality with no observed side effect.Keywords: Whole Body Vibration, Vibrating bed design, Insomnia, Performance test.
Immunological Changes Associated with Rheumatoid Arthritis Mohammed Abd Jwad
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Rheumatoid factors (RF) are IgM autoantibody directed against the Fc portion of IgG. Rheumatoid factor is a well-established distinguishing and prognostic test in Rheumatoid Arthritis. High titer IgM RF is relatively specific for the RA diagnosis in the context of chronic poly arthritis, and was for decades the sole serologic criterion widely used in diagnosis of RA. Those, whom likely to assume a more prompt destructive form of disease in particular, are subject to early identification, It is vital to because the benefits gained in laying early aggressive mediation with disease modifying agents. A variable disease course is to be followed by patients where outcome measures are to be calculated such as functional status and radiological assessment of joint damage. An increasing risk is manifested for those patients with an established RA diagnosis. Positive testing results, anti-CCP antibodies or both are placed in a category of developing an erosive joint damage and impairment of function. As a result, patients should receive an anti-rheumatic therapy that could suppress the disease early stage activity. Patients, who are RA and anti-CCP diagnosis both be considered. Rheumatic factors are the conspicuous markers for patients with RA. Those markers are useful clinically .Antibody Rheumatic factors and anti-CCP testing is necessary for predicting and diagnosing of functional and radiographic outcomes. Patients with early diagnosed arthritis and who are anti-CCP and RA antibody positive considered being at higher and increasing risk of manifesting development of erosive joint disease. While those patients with neither markers are less likely to be develop the like symptoms, thus, symptomatic treatment (e.g. with non-steroidal anti-inflammatory drugs) may be appropriate for those lacking both anti-CCP and antibodies RF. From June 29th to October 1st (2016) this research was conducted during the mentioned period at Baghdad teaching hospital consultation clinic, which involved (47)patients with RA, they were 13 male and 32 female , this data was then subjected to statistical assessment by the IBM SPSS program 20th version which comprised of the arithmetic mean, Standard deviation, SEM, the study is aiming to identify the factor of rheumatoid in the diagnosis of RA and the value of biologic markers that have been assessed for disease activity assessment and for the prognosis of rheumatoid arthritis, particularly the use of anti-CCP antibodies test in diagnosis and predicting the prognosis of rheumatoid arthritis.Keywords: Predictive and prognostic values of Rheumatoid factor, Rheumatoid factor Titer, anti-CCP antibodies.
Study of Prevalence of Toxoplasma Gondii among Heamodialysis Patients in Thi-Qar Province Bassad A. Al-Aboody
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Toxoplasmosis is a widespread zoonotic disease caused by one of opportunistic parasite called Toxoplasma gondii .The current study was conducted in Thi-Qar province to investigate the parasite Toxoplasma gondii among heamodialysis patients using Enzyme Linked Immunosorbent Assay test and study some of the factors that may affect in the prevalence of infection, such as age, sex and a number of heamodialysis. 100 was collected samples of blood  from heamodialysis patients  from Hussein Teaching Hospital for the period from October 2015 to the end of  March 2016 and prepared a questionnaire form for each person to get their information, as well as the collection of 50 blood samples from healthy persons for the purpose of comparison between them with the current study. The results of the current study showed that the prevalence of toxoplasmosis in Thi--Qar province in renal dialysis patients and a comparison group of 28% and 24% respectively. Recorded results of Enzyme Linked Immunosorbent Assay ELISA test results for a positive antibody IgG in heamodialysis patients and a comparison, 25 % 22% respectively. As for the IgM antibody study did not record any positive result in heamodialysis patients group while in comparison group was 2%. The ratios antibodies IgG & IgM together in heamodialysis patients and comparison group 3%, 0.0% respectively. The highest infection rates for heamodialysis patients was in the age group (40-49 years) was 26.67% and the lowest rates of infection in the age group (>60years) 23.08 %  and reported significant differences P <0.05 to infection rates in males highest compared to females where it was 35.18% and 19.56% respectively. For factor number of heamodialysis show high infection rates in patients who have been exposed to more than>6times of heamodialysis 25.53% as for those who were exposed to 1-6 was ratios have 16.67%.Keywords: Toxoplasma gondii, Toxoplasmosis,   Heamodialysis patients, Prevalence, ELISA, risk factors.
Synthesis, Identification, Theoretical and Experimental Studies for Carbon Steel Corrosion Inhibition in Sea Water by Some New Schiff base Derivatives linkage to 5-Nitro Isatin Moiety Athraa H. Ahmed
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This research includes synthesis of new 5-Nitro isatin derivatives started from 5-Nitro-3-(Ethyl imino acetate)-2-oxo indol, namely 5-Nitro-3-(imino acetohydrazide)-2-oxo indole (1); 5-Nitro-3-[(iminoacetyl) phenylsemi carbazide]-2-oxo indole (2); 5-Nitro-3-[(imino acetyl) phenylthiosemicarbazide]-2-oxo indole (3); and 5-Nitro-3-[(imino aceto) N,N-di methyl urea]-2-oxo indole (4). The derivatives were characterized by using FTIR, 1H-NMR, 13C-NMR and C.H.N.S analysis with the measurement of some physical properties. Quantum mechanical method of the Density Functional Theory (DFT) of B3LYP with a level of 6-311++G (2d, 2p) were used for calculating the geometrical structure, physical properties and inhibition efficiency parameters, all were studied at the equilibrium geometry in four media (vacuum, DMSO, ETOH and H2O). The theoretical results showed that compound (2) is the best corrosion inhibitor among the others. Finally, the corrosion protectiveness, kinetics, and thermodynamics of the prepared compound (2) effect on C-steel in 3.5% NaCl solutions had been studied using the potentiodynamic polarization, SEM (Scanning Electron Microscopy) and AFM (Atomic Force Microscopy) measurements.Keywords: 5- nitro isatin, Schiff bases, Corrosion inhibitors, Quantum chemical calculations, electrochemical measurements.
Determination of TNFR1 Level and its Association with ACR and eGFR in Iraqi Patients with Different Stages of Diabetic Nephropathy Sabreen Ali Mezil
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: recently, studies have been focused on diabetes complications, such as neuropathy, retinopathy and nephropathy. Attempts were conducted to diagnosis diabetic complication cases to determine the relevant proper markers that can be employed for early detection purposes to prevent the development and progression to final disease stage. The aim of this study is to determine TNFR1 in diabetic nephropathy and its relation with renal function under various stages of this disease.   Materials and Methods: 90 patients (45 male and 45 female) with T2DM, aged (40-60), who attend to Baghdad Teaching Hospital /Medical City, were classified into three groups according to albumin-creatinine ratio (ACR) in urine. The first patients group consists of 30 diabetic patients with ACR less than 30mg/g (normoalbuminuria). Whereas; the second patients group includes 30 diabetic patients with ACR range 30-300 mg/g (microalbuminuria). The third patients group comprises 30 diabetic patients with ACR more than 300 mg/g (macroalbuminuria).In addition to 30 healthy subjects as control group. Fasting blood glucose, serum creatinine and blood urea were assayed by enzymatic methods. Soluble TNFR1 was estimated by ELISA. Modification of diet in renal disease (MDRD) formula was used to calculate of eGFR. Results: There are significant differences between values of TNFR1, ACR and eGFR. A high significant increase of TNFR1 (p˂0.001) was noticed in macroalbuminuria patients group in comparison with normoalbuminuria and control groups. Also, there is a significant increase in ACR level in macroalbuminuria group than other studied groups. In contrast, a significant decrease in eGFR was recorded in macroalbuminuria group in comparison with other patient and control groups. A high significant increase in of both Creatinine and blood urea levels were recorded in macroalbuminuria patients group than other patient and control groups. Conclusion: sTNFR1 associates with renal function in the case of diabetic nephropathy. Consequently, it considers a better predictor of renal function for patients with diabetic nephropathy. Keywords: T2DM, Nephropathy, TNFR1, ACR, EGFR, Microalbuminuria, Macroalbuminuria.
Aspects of Health-Improving and Sports-Mass Work Students Valery Panachev
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Currently sports-mass and health-improving work appears to be one of the most important directions in social students’ self-government as well as effective force of persuasion in necessity of students’ physical training and teachers’ professional activity improvement. New era states new innovative problems before all generations. These problems include improvement of life quality, of human health, active way of life, maintenance of peace in the world. One of the basic problems of future social development of state is the quality life improvement, improvement of people’s health and of demographic situation. Today the problems of population’s health, especially of students’ health are the most pressing ones. Up till now the problem of students’ health strengthening by means of physical culture remains acute. In this article we tried to study the peculiarities of dynamic improvement of students’ physical motion in the last decades. The results of students’ motive behavior received during our study predetermined the real interest to active physical culture and sports training. Special students’ interest was provoked by their own model of self-development during the education at university. The decisive role played the stimulation of students’ self-government in motive activity improvement, healthy life-style, systematic physical culture and sports training. All these facts were connected with greater independence in self-development and preparation to the future professional activity. Keywords: Healthy life-style, Students’ self-government, Health strengthening study, Development of physical culture and sport, Health-improving, Sports-mass work.
Virtual Screening of Sulphonyl Urea Derivative and In-silico, In Vitro Anticoagulant Evaluation of Lead Molecules K. Chaithanya Veena
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: The objective of present study is the virtual screening of sulphonylurea analogues followed by the insilico and in vitro evaluation for its anticoagulant activity. Method and result: the method of virtual screening selected is the structure based virtual screening using Ch EMBL database. The in silico analysis was performed using auto dock tools 4.2.The docking was performed using 1TA2 (thrombin) and 1FJS(clotting factor Xa) as the binding proteins which are drawn from the protein data bank. The sulphonyl urea analogues obtained from virtual screening are allowed to dock with the clotting proteins, the binding energies and docking positions were determined using auto dock tools 4.2.the in vitro evaluation of anticoagulant activity were performed, the prothrombin time(PT) and activated thromboplastin time(APTT) were determined. Conclusion: The sulphonylurea analogues are capable of producing the anticoagulant activity. Keywords: Virtual screening, Sulphonyl urea analogues, Anticoagulant activity, Gliclazide, glimepiride, War far in, In silico analysis.
Synthesis, Spectral and Biological Studies of Metal Complexes with Heterocyclic Ligand Derived from Thaizolylazo Dye Khalid J. Al-Adilee
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Metal (II) complexes have been synthesized with new azo dye ligand 2-[2--(4, 5-dimethyl thiazolyl) azo]-4-benzyl phenol (DMeTABP=HL) derived from coupling reaction between 4, 5–di methy thiazaolylazonium chloride and 4 – benzyl phenol in alkaline alcoholic solution. Azo dye ligand and metal complexes have been characterized by elemental analysis (C.H.N.S), 1H-NMR , mass, Electronic, IR , XRD spectral data , SEM ,thermal analysis (TGA,DSC and DTG) , magnetic susceptibility , metal contents and molar conductance .The elemental analysis of the metal chelate complexes confirms the stoichiometry of the type [ M(L)2 ] , where M =Ni(II) , Cu(II) , Zn(II) and [M(L)2]Cl and where M = Co (III) and L = azo dye ligand. The spectra and analytical data indicated that the ligand (DMeTABP) behaves as tridentate chelating agent with l: 2 [M: L] complexes and octahedral geometry.  Conductance measurement suggests the l:l electrolytic nature of Co(III) complexes but non- electrolytic nature of the rest metal complexes. The biological activity of azo dye ligand and its metal complexes against the pathogenic activities was tested against the sensitive organisms Escherichia coli (gram negative), streptococcus, staphylococcus (gram positive) as antibacterial and Alternaria spp as antifungal. The activity data show that the metal complexes were of higher antibacterial and antifungals activity than the free ligand. The results are discussed. The biological activity also conducted cells viability and cytotoxicity assay on Cu (II) and Zn (II) _complex by using the lines of cancerous liver cells of the type HePG2 and compared with line of the ordinary cellsKeywords: Thiazolyl azo ligand, Metal complexes Characterization, Antibacterial, Antifungal and anticancerious.

Page 4 of 7 | Total Record : 70

 2   3   4   5   6 

Filter by Year

2018 2018


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue