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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 73 Documents
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Search results for , issue "Volume 10 Issue 06: (2018) June 2018" : 73 Documents clear
Newly Developed Method for Determination Indomethacin using Potassium Hexacyanoferrate (III) by using ISNAG-Fluorimeter Homemade via CFIA Proph Nagam Shakir Turkie
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

A new, simple, sensitive and fast developed method for the determination of Indomethacin in pure form and drugs (capsule) by continuous flow injection diverged light. The method based on the reaction of the Indomethacin with Potassium hexacyanoferrate (III) to form off-white precipitate, using homemade ISNAG- fluorimeter. Optimum parameter has been studied to increase the sensitivity for developed method. The linear dynamic range for the instrument response versus Indomethacin concentration was 0.01- 5mmol/L while the L.O.D was 320.222ng/sample from the step wise dilution for the minimum concentration of lowest concentration in the linear dynamic range of the calibration graph. The correlation coefficient (r) was 0.9952while percentage linearity (R2%) was 99.05%. RSD% for the repeatability (n=7) was lower than 0.5% for the determination of Indomethacin, with concentration of 1, 5 mmol/L respectively. The methods: developed method was applied successfully for the determination of Indomethacin in pharmaceutical tablets. A comparison was made between the newly developed methodology and the classical method (turbidometry) of analysis using the standard addition method via the use of paired t-test. It shows that there was no significant difference between the quoted values of each individual company with calculated t-value at 95% confidence interval from developed method.Keywords: Indomethacin, flow injection diverged light, homemade instrument.
Synthesis and Characterization of Some New Derivatives of 8-Chlorothiophyllìne by Microwave-Assist Suzuki-Miyaura Coupling Reaction Salwa R. Abdul-Ameer
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Some new derivatives of 8-Chlorothiophyllìne (8-CTh) synthesized by Suzuki reactions when react 8-CTh with hydrazine to give 8-hydrazinyl thiophyllìne. This compound reacts with 4-bromo benzaldehyde to give imine compound. The microwave-promoted Suzuki-Miyaura coupling of the latter compound with different aryl boronìc acids gave (3-9) compounds with good to excellent yields. This reaction was checked by thin‐layer chromatography (TLC) method. All new compounds were characterized by melting points, elemental analysis, and FT‐IR, 1H, 13C-NMR and 2D-NMR spectroscopy. The antibacterial action of these derivatives was also determined.Keywords: 8-Chlorothiophyllìne, Suzuki reaction, Microwave, Antibacterial, Antifungal.
Film and The Public According to the Biology of Communication and Expression Ban Jabbar Khalaf
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The research titled "The film and the public according to the biology of communication and expression" deals with an important issue that characterized our current world, namely, the relationship between means of communication and expression and its relation to the recipients as goals and functions, if the corner of the title of the research share some of the features in that art is a means of communication and vitality, but they diverge greatly if we know that the fine arts are the means of expression that affect the normal composition of the functional person through the link to the core aspect, while the means of communication are public means aimed at influencing for specific interests. If the film is a shroud of the question of looking for divorcees, the means of communication are looking for partial and specific ones, and on this basis we do not accuse the media of being inferior or praising them for being taller. A qualitative difference between what McLuhan says: The cold media and the warm means of communication. As cinema is not aesthetically engaging, communication is on the sidelines, whether classical cinema (which McLuhan prepares as a warm communication medium) because it follows automatic rules in plotting and montage, for example, or the Godard Cinema because it violates rules. Everything related to communication and its means emanated from McLuhan, who believed that he had the final word in this and forgot that many waters passed in the river, and we are about a changing water and so is the world, what has ceased to be sent and what is sinking but the basis between them calls McLuhan warm and cold is: All awareness Hence, the problem of research was: "When is the film purely aesthetic expression and does not lose its role as a means of communication?" The importance of the research came from the importance that the film emphasizes its aesthetic authenticity, so as not to lose its fans. , While the objectives of the research has been manifested in the search for the values of the aesthetic value of the film when combined with the value of proliferation and public success. The limits of the research objective boundaries that relate to the subject of research, and temporally the second decade of the twenty-first century, either spatial limit includes the entire world cinema. The theoretical framework consisted of three investigations, the first of which was McLuhan and the theory of modern communication, it talked about McLuhan's ideas. The second topic is the film and the new era,it talks about the fate of the film in the era of electronic and biological explosion. The third topic was about the aesthetics of the film as a means of communication. The research covered the third chapter, where the research procedures were included. The fourth chapter also included findings, conclusions and a list of sources.Keywords: Film, Public, Biology, Communication and expression.
The Relationship between the HPV Cervical Infection and Intraepithelial Colorectal Lesions in Women Olga S. Alyautdina
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

A histological structure of anal epithelium shows obvious parallels with the structure of cervical epithelium including the presence of a transformed zone at the border between two types of epithelial cells.  In this connection, a process of anal benign tumor pathogenesis is similar to cervical cancer. In the present work, with the use of liquid cytology, a comparison of colorectal HPV infection in women patients with cervix dysplasia and control group of patients with no cervix pathology has been performed. The cytological investigation was performed with the use of a method of liquid cytology BD ShurePath based on a system of automatized scanning of preparations BD Focal Point. Identification of high oncogenic risk HPV was made with the use of a hybrid capture method (HPV digene-test hybrid capture II). Using cytological investigation of colon scrapings, we revealed intraepithelial damages of colon epithelium most probably associated with HPV infection in 24% of patients from the high risk group. In the same time, there were no similar changes in the control group of patients. Our results show that HPV-associated cervix pathology is a risk factor for colon intraepithelial HPV-associated damages development.  These patients are in the high risk group for colorectal cancer development and they must experience a regular corresponding medical examination. Keywords: HPV infection, Cervical cancer, Colorectal cancer, Liquid cytology.
The Impact of Training Sessions in the Development of Social Behavior to Reduce the Phenomenon of Delinquency among Young People Fadel Kurdi Shalakha
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The research comes in an attempt to reveal the effect of counseling sessions on the methods of parental treatment and its role in the development of social behavior and to reduce the deviation of a sample of young people belonging to the centers and forums of youth and sports. And that the adolescent lives in a sensitive stage of his life needs to be understood and take his hand in order to be a positive and social community and integration with others and be able to take realistic goals consistent with their tendencies and potential because the social behavior The role of the sessions and the extension programs contribute to the development of social behavior and thus contribute to building a better society free of deviation and crime among young people. The study sought to identify the effect of instructional sessions on parental treatment methods in developing social behavior and reducing the phenomenon of deviation among young people. The researchers hypothesized that there are differences of statistical significance for the experimental group in the development of social behavior and reduction of Majeure deviation among young people, researchers have identified the research community, members of youth and sports forums in Najaf and researchers chose the youth forum (Ansar) as a control and the number (25) and Youth Forum (Black Rivers) as a pilot group and their number (25). After the application of the main they experiment were analyzed and the results are processed using (SPSS), has reached researchers to results, including the need for the use of extension programs and to increase awareness and use of appropriate methods of parental treatment of parents of good treatment and urged their children to integrate with others, have recommended the researchers emphasize the use of methods Democracy and desirable in dealing with their children and the impact of those methods in the development of the personality of children and the need to conduct surveys to detect the spread of positive social behavior because of its impact in reducing the phenomenon of deviation and reduce crime.Keywords: Training sessions, social behavior, phenomenon and delinquency.
Detection of Resistance Mutations in Chronic Hepatitis B Patients Using Antiviral Drugs in Iraq Abeer Ali Marhoon
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

In this study, it is aimed to determine the mutations responsible for drug resistance in patients with chronic hepatitis B virus (HBV) infection received/receiving antiviral treatment at our hospital and to examine the patients in terms of the treatment applied and their HBV-DNA levels. One hundred and eighty-one samples taken from patients diagnosed with chronic hepatitis B infection and follow them between February 2017 till January 2018 at Hepatology and Gastroenterology Teaching Hospital and Central Public Health Laboratory in Baghdad were studied with reverse hybridization principle-based INNO-LiPA HBV DR v2 method and the results were evaluated retrospectively. Mutation was determined in 80 samples (44.1%). and a decrease in DNA level was observed in 101 patients. In INNO LipA reverse hybridization the rtL80V/I mutation was highly frequency among patients 76/80(95%) and followed by rtS202GCI (75%), rtM204V/I/S (72.5%) and rtM250V/I/L (72.5%), rtA194T (67.5%), rtL180M (63.75%), rtT184SCGA (58.75%), rtT184ILFM (31.25%), rtN236T (25%), rtA181T/V (17.5%) and rtV173L (12.5%). This mutation was point mutations a result occurs substitution one nucleotide to another, causing antiviral drugs resistance.  Since a limited number of mutations can be examined via INNO LiPA method, it is concluded that different mutation patterns causing drug resistance cannot be determined and it will be beneficial to use an additional method such as sequencing that enables to determine these genes. Additionally, as a result of treatment failure due to drug resistance, if the treatment will be continued with a novel drug that is not used before, it is considered that the possibility of the presence of mutations causing a resistance against this antiviral should not be neglected.
Mathematical Design of the Experiment in the Development of Technology of Beeswax obtaining from Propolis Oleg Shpychak
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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In present material the development of the technology of purified beeswax obtaining from propolis, which meets modern physical-chemical and therapeutic requirements, using a various models of mathematical design of the experiment has been shown.In this work a petroleum-ether fraction of propolis containing a beeswax products was used. While analyzing of the obtained fraction, lipids and some other high-molecular compounds of unqualified structure are extracted in parallel, as well as an insignificant number of the γ-pyrone derivatives.In this connection, the development of the condition of beeswax obtaining from this fraction, which is maximally purified from the related substances was reasonable. For this purpose a series of classical methods of fractionally differentiated extraction followed by fractions evaporation in a vacuum was used. In addition, methods of precipitation using a some organic solvents were used.The optimal conditions of the technology of purified beeswax obtaining from propolis have been determined by methods of mathematical design.Keywords: propolis, beeswax, technology, methods of fractionally differentiated extraction, precipitation, methods of mathematical design.
Electrochemical Determination of Tetracycline at SPCE modified with Nanocomposite Sundus H. Merza
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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An electrochemical sensor based on manganese dioxide nanorodMnO2and Graphene oxide (GO) functionalized with 4-amino, 3-substituted 1H, 1, 2, 4 Triazole 5(4H) thion  (FGO)/MnO2Nanocompositewas developed for voltammetric determination of Tetracycline (TET).The working electrode WE of SPCE was modified bya drop casting method. X-ray powder diffractometer (XRD), scanning electron microscopy (SEM) and FT-IR were employed to characterize the synthesized FGO/MnO2.  The determination of TET at the modified electrode was studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) in the phosphate buffer solution (PBS).TET  show sharp increase in the oxidation peaks  in the pH 2.Voltammetric characteristics of TET (Epa, Ipa) were estimated. From effect of scan rate, the average surface coverage ( ) of TET on the surface of  SPCE modified with FGO/MnO2 nanocomposite, the electron transfer coefficient and electron transfer constant rate ket was obtained as  10.56×1014 molecule cm-2, 0.5, and 10.41 cm.s-1respectively.  Under the optimal conditions, the peak current shows  linear relationship with concentration of Tetracycline (TET) ranges 1–9 µM with the detection limit of 0.2  M. The modified SPCE was successfully used to detect TETKeywords: SPCE, Functionalize graphene oxide, Cyclic voltammetry.
Sequencing of GTFD Gene among Biofilm Genes (GTF) in Streptococcus Mutans Isolated from Dental Caries Hala Hussein
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Objectives: Streptococcus mutans has been implicated as a primary etiologic agent of humans dental caries. An important virulence properties of this bacterium is its ability to form biofilm known as dental plaque on tooth surfaces, these bacteria also produces glucosyltransferases, multiple glucan-binding proteins, collagen-binding protein, and protein antigen c, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. This study aimed to detect gtfB, gtfC and gtfD genes in Streptococcus mutans isolated from dental caries patients in Babylon Province, Iraq. Methods: Out of 150 samples were collected from patients with dental caries35 isolates were diagnosed as Streptococcus mutans. The bacterial isolates were identified by standard laboratory protocols. Polymerase chain reaction (PCR) was used for detecting gtfB, gtfC and gtfD genes and Sequencing of gtfD genes confirmed of the results. Results: Out of, 35isolatesof Streptococcus mutans, 30(85.7%) isolates had gtfB encode GtfB with 80 bp, 27 (77.14%) had gtfC encode GtfC with 81 bp, and 31 (88.57%) had gtfD with 324 bp which explain their potential of biofilm formation. Conclusion: Our study results showed presence of High frequency of gtf genes among the clinical isolates of S. mutans isolates in Babylon Province, Iraq.
Cleavage of Mucin and Salivary Agglutinin by Partiallypurified Protease from Native Strain of Streptococcus Mutansan67 Mayssaa E Abdalah
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Streptococcus mutansAN67 is olatecommensal species of the human oral cavity and their role as a major causative agent associated with dental plaque.S.mutansAN67 was selected as the most active isolate for protease production. Separation and purification of Streptococcusmutans AN67 proteolytic enzyme was done by 0-70% (w:v) saturated ammonium sulfate and ion-exchange chromatography on the DEAE-cellulose column. Partiallypurified protease by ion-exchange chromatography was given an activity of 24 Unit/ml, protein concentration of 0.038 mg/ml, specific activity of 631.5 Unit/mg with purification fold of 2.8and a yield of42 %. Determination of molecular weight for partially purified protease from S. mutans AN67 was elucidated by the use of gel filtration on Sepharose-6B column, which determined as 134000Da.Partially purified protease was tested for cleavage of mucin and agglutinin proteins by gel filtration chromatography on Sepharose-6B column. Partially purified protease was able to cleave mucin protein substrate into three fractions; also it’s cleaving agglutinin protein into three fractions.Keywords: Streptococcusmutans, Protease, Mucin, Agglutinin.

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