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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 64 Documents
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Search results for , issue "Volume 10 Issue 07: (2018) July 2018" : 64 Documents clear
Synthesis, Structural and Biological Studies of Chromium(III) ,Manganese(II),Cobalt(II),Nickel(II),Copper(II) and Zinc(II) Complexes with Tere Dentate N2O Donor Azo-based Coumarin Ligand MAHMOOD NAJM ALOTHMAN; HIBA YOUSIF ALAZAWI
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The present work describes the synthesis and characterization and biological studies of new transition metal complexes derived from Azo ligand(LH) of 6-hydroxycoumarine. The new azo LH was synthesized from condensation the diazonum salt chloride of 5-methylmercapto-2-amino-1,3,4-thiadiazole with alkaline solution of 6-hydroxycoumari at 0 C temperature. The octahedral geometry was adopted fpr the prepared complexes in 2:1 mole ratio of L/M up on CHNM analyses and other spectroscopic methods. The ligand LH and metal complexes were confirmed their structures with the help of CHNM analyses, NMR, MS, UV-Visibel spectra and magnetic and molar conductivity measurements. The biological assays of the solutions of LH and it s metal complexes in DMSO solvent were screenec against some positive, negative grams bacteria and some fungal organisms. The observed results from diffusion method revealed that almost metal complexes have higher activity rather than the free solutions ofv LH due to the chelation theory of inhibition zone
Red Blood Cell Alloimmunization among the Transfusion Recipients at Sanglah General Hospital, Denpasar, Bali: A Preliminary Study Sianny Herawati; Usi Sukorini; Teguh Triyono
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Background Red blood cell (RBC) alloimmunization is the formation of alloantibodies among the recipientswhich is related to the frequency of antigen-positive blood transfusion received by the recipient. The difficultyto obtain compatible RBC and a higher risk of hemolytic transfusion reactions due to alloimmunizationbecome a challenge in clinical practice. Objectives: This study aims to analyze the characteristics of RBCalloantibodies in the recipient following transfusion at Sanglah General Hospital, Bali, as a preliminary study.Methods A cross sectional study was conducted among 40 recipients with a history of RBC transfusion atleast 3 times and willing to participate in this study from December 2016 to March 2017 at Sanglah General Hospital. Data were analyzed using SPSS ver. 16 software to determine the prevalence of study. Resultsmost recipients were 46 – 65 years (55%). In addition, most recipients were caused by hematology disorder (57.5%), female (52.5%), and O-Rhesus D positive (52.5%). RBC alloantibodies detected in 5% of recipients,all of them were multiple alloantibodies, such as anti-K antibodies (5%), anti-Kp a (5%), anti-E (2.5%), anti-C w(2.5%), anti-Lu a (2.5%) and anti-M (2.5%). Those alloantibodies only found in 46 – 65 years age group.Conclusion the first preliminary study regarding RBC alloimmunization in Bali was found contributed by anti-K,anti Kp a , anti-E, anti-C w , anti-Lu a , and anti-M. The results suggest that erythrocyte antigen phenotypes can beperformed further, particularly the Kell antigen to prevent alloimmunization. However, future studies withbigger samples are needed to determine the incidence of RBCalloimmunization among transfusion recipients in Bali.Keywords: Alloimmunization, Red blood cells, Transfusion recipients.
Morphological and Histological Study of the Pancreas of quail (Coturnixcoturnix) Dhaferah Jaafar A. Al Fatlawi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Study was carried out on  seven pairs of adult quail ((Coturnixcoturnix), The pancreas was excised from the duodenum rapidly after slaughter of the birds, the observations showed that there's no difference of structure features between sex (male and female of quail pancreas. The Pancreas is situated on the right side of abdominal cavity in the area between the ascending and descending duodenal loops, attached with the alimentary tract covered with capsules, the parenchyma of pancreas divided it to lobules by fascicles of connective tissue extended from capsule. The parenchyma of pancreas divided in to two kinds of glands exocrine and endocrine gland, the exocrine composed of serous acini cells and ductal cells, the duct system composed of intercalated duct attached to the centroacinar cells inside the lumen of serous acini, followed by intralobular duct, interlobular duct, and main duct (pancreatic duct) Endocrine gland divided in to two types of islets, the large one Alpha islets, and the small types Beta islets, supplied by rich network of blood vessels. Each ofducts, aggregation of lymphatic tissue and blood vessels can be seen in section of parenchyma. No clear boundaries between the exocrine portion and Islets of Langer hans. In conclusion the Anatomical features and histological structure of quail (Coturnixcoturnix) pancreas was found to be similar to that of other avian speciesKey words: Morphological. Histological. Pancreas, Adult. Quail. Coturnixcoturnix.
Study the Effect of Ceylon Cinnamon (Cinnamomum Zeylanicum) Powder on Some Physiological Parameters in Broiler Chicks Sura Safi Obayes Khafaji
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The current study aimed to investigate the effects that could be caused by ceylon cinnamon (Cinnamomum  zeylanicum) powder addition to diet of broileron some physiological parameters. A total of 150 one-day-old mixed-sex broiler chicks were distributed into 3 treatments, comprising 5 replicates per treatment, with 10 chicks for each replicate. 1st group (control) fed on the standard diet during the experimental period (42 days), 2nd group (T1) and 3rd group (T2) fed on standard diet mixed with 500&1000 mg/kg of CNP, respectively. On 1st and 42nd day of experiment, body weight was recorded. As well as, blood samples were collected at the end of experiment, for assessment of RBC and WBC counts, PVC, Hemoglobin concentration (Hb) and heterophils/lymphocytes ratio (H/L). Total protein, Albumin, globulin, Triiodothyronine (T3) and Tetraiodothyronine (T4) concentrations in blood serum were determined. The statistical analysis registered the significant (P<0.05) elevation in the body weight on 42nd day of experiment inT1 and T2 groups comparing with the control. The results revealed that the second and third groups recorded significant (P<0.05) increase in RBC and WBC counts, as well as, PVC and HB concentration. While H/L significant (P<0.05) decline in T1 and T2 groups comparing with the control. At the same time, the result of total protein, globulin, T3 and T4concentrations revealed a significant increment (P<0.05) in two treated groups when compared with control. Therefore, it was concluded that the use of cinnamon powder can affected positively on some physiological traits and broiler performance.Key words: Cinnamon powder, Physiological parameters, Broiler chicks.
Green Synthesis of Silver Nanoparticles by Mentha Spicata Aqueous Leaf Extract Najeh Hashim
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Silver nanoparticles which were synthesized by Mentha  spicata aqueous leaf extract were characterized by UV-Visible Spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Atomic Force Microscope. Antifungal activity tests were done against dermatophytes Microsporum canis, Trichophyton mentagrophytes, the result showed that silver nanoparticles was efficient in highest inhibition rate at 5 mg/ml. The antioxidant properties of the obtained biomaterial were assessed in vitro, using ABTS as free radical; the result suggests that silver nanoparticles present promising antioxidant activity; the effect of silver nanoparticles on human red blood cells hemolysis was investigated.  Keywords: AgNps, Nanoparticles, Antifungal, Antioxidant.
Application of Carrageenan, Xanthangum as Biodegradable Coating on Storage of Cherry Tomatoes (Lycopersicon Esculentum) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Cherry tomatoes (Lycopersicon esculentum) have been popularly consumed as functional food by their antioxidants as well as good apperance with bright red color and delicious flavor. But cherry tomatoes are prone to desiccation shrinkage and fruit softening during storage, resulting in the decrease of their commodity value. The major postharvest losses of tomatoes are due to fungal infection, physiological disorders, and physical injuries.  The prevalent method of preservation of postharvest cherry tomatoes is the use of moderately low temperatures and high humidity. However, low temperatures induce chilling injury. Application of edible coating on tomatoes is able to reduce quality changes and slow down moisture loss by controlling and modifying the internal atmosphere of the individual fruits. The great benefit conferred by edible coatings is that these are natural biodegradable products. An investigation on coating of cherry tomatoes by using carrageenan and xanthan gum was investigated. Cherry tomatoes which were coated with 0.75% carrageenan still maintained good quality until 30 days of preservation.Keywords: Cherry tomates, Carrageenan, Xanthangum, Biodegradable, Coating, Storage, Shelf-life.
Structural, Spectral and Thermal Studies of New Bidentate Schiff Base Ligand Type (NN) Derived from Mebendazol and 2-Aminobenzothaizol and its Metal Complexes and Evaluation of their Biological Activity Shaimaa A. Hassan
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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In this study, a new Schiff base [methyl (E)-(6-((benzo[d]thiazol-2-ylimino)(phenyl)methyl)-1H-benzo[d] imidazol-2-yl)carbamate] (L) was  prepared and it's complexes with metal ions MII=VO, Mn, Co, Ni, Cu ,Cd,Zn and Hg in ethanol and ace ton with mole ratio (M:L) (1:2). All complexes have general composition [M (L) 2 Cl 2].H2O, [(VO) (L) 2(SO4)].H2O. The ligand and all complexes were characterized by modern spectroscopic (FT-IR, UV_Vis, 1HNMR, 13CNMR, Mass spectroscopy, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses, chloride content and molar conductance. In addition to evaluated their biological activity against two type of bacterial and one type fungus. Based on date for all techniques we suggested that all the prepared complexes have octahedral geometry, the value of antibacterial activity of this prepared complexes showed higher inhibition activity compared to the free ligand and starting material.Keywords: 2-Aminobenzothaizol, Mebendazol, Metal complexes, Biological activity.
Synthesis and Characterization of (Five, Six) Hetrocycyclic Derivatives from Imidazole and Studying of their Biological Activity Lina Saadi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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This research involve synthesis (Pyrazol,isoxazole ,Oxazine, Thiazine, Pyridine, pyrimidine) derivatives by three different steps, The first step includes coupling reaction between 3-amino acetophenonediazonium chloride with imidazole in alkaline alcoholic solution to form (1-(3-((1H-imidazol-2-yl)diazenyl)phenyl)ethan-1-one) (1) ,while second step includes reaction(1) with (3,4-Dimethoxy benzaldehyde) to get chalcone derivative (2),while the third step includes reaction(2) with (hydrazine ,phenyl hydrazine ,2,4 dinitrophenyl hydrazine, hydroxylamine hydrochlorid, urea, tiourea, ethyl cyanoacetate, malononitrile, guanidine hydrochloride) to get (five and six ) hetrocyclicderivatives, heterocyclic compounds have been characterized by FT-IR, 1H-NMR and13C-NMR  analysis and study the biological activity for all derivatives to word two types of becteria.Keywords:  Azo, pyrazole, chalcone ,oxazine, thiazine,  pyridine, pyrimidine.                                                                                    
A Comparative Study of Tuberculosis Diseases in Diyala Province in 2010 and 2015 Raghad Ibrahim
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Tuberculosis (TB) is one of the concern worldwide public health threats. A retrospective study conducted during the period (2016/11/14) until (2017/4/7) to comparative the incidence of tuberculosis disease in Diyala province between 2010 and 2015 years, the study-included number of patients with the chest and respiratory infections visited the central treatments of tuberculosis infections in Diyala. The patients included males and females with   ages from (20-90) years, they had been done X-ray chest and laboratory tests, including: examination of the septum with Ziehl–Neelsen testand (E.S.R).Examination had been identified a positive cases of tuberculosis among them, the number of patients infection with TB in (2010) were (147) cases from (1429) and (405) cases from (5772) patients   in (2015). The study showed that tuberculosis infections were  decline in 2015 to 7%  compares with  2010 to10.3%  .The results showed that (44.89%) of male and 55.1% in female  with TB infections in 2010. Also 47.90% of males  and 52.09% of females infected with TB in 2015 , the high rate of infection among age group  (31-50) in 2010, and (51-70 years) in 2015  , while the age group (71-90years) are showed the lowest ratio  were infected with TB infections for both 2010 and 2015. The results  appeared urban area  were high   incidence of infection in  both 2010 and 2015 in contrast  with rural area  , was  85(52.82% ) in urban  and 62(42.17%) in rural area in 2010 ,   with 207 (51.1%) in urban area and 198 ( 48.9%) in rural areas in 2015.Keywords: TB, Seroprevelance, Diyala province, Iraq.
Effectiveness of Rota Vaccine among Children in Babylon Province, Iraq Mudher Hassen Noor
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Acute diarrhea is passing of watery stool > 10 ml / kg / 24 h. which stay less than two weeks. Diarrhea account for 9% of death in children and about 0.71 million deaths / year in the world .Gastroenteritis, also called as infectious diarrhea, It means infection of gastrointestinal tract by certain organism, it could be either viral, bacterial or parasitic. And the virus is considered the most common. Rota virus is common in children while Norvo virus more common in adult. Rota virus is RNA virus belongs to the Reoviridea family. Most of children up to the age of 5 years are infected with this virus at least one time .The immunity will develop after the infection or vaccination with Rota virus. The aim of the study is to evaluate the effectiveness of Rota vaccine in modification of severity and prevalence of rotavirus infection among children in Babylon province A total of (1041) stool samples were collected from child with age from six months to five years old suffering from acute diarrhea who are admitted to the emergency room or to the wards of Babylon teaching Hospital for maternity and children. And all these stool samples were submitted for detection of rotavirus by a strips containing specific rotavirus Ab. The prevalence of positive rotavirus infection was (231) from (1041) with (22.22%) of all children with acute gastroenteritis from the age (6 months-5 years). We conclude that, Rotavirus infection was decrease significantly in our province after routine introduction of rotavirus vaccination

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