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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 65 Documents
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Search results for , issue "Volume 10 Issue 08: (2018) August 2018" : 65 Documents clear
Application of Chitosan Coating for Quail (Coturnix Coturnix) Egg Preservation Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Quails are becoming more popular as a source of meat and egg because of their small body size, rapid generation turnover and high egg production. Quail eggs are the good source of nutrients for human health, being one of the best and most economical sources of high quality protein. Although quail eggs are small in size, their nutritional value is three to four times greater than chicken eggs and is packed with vitamins and minerals. Quail eggs are becoming more and more popular as they fulfill the criteria of a product with traits of functional food. Objective of this research focused on the effect of different chitosan concentrations (0%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0%), effect of storage temperature condition (4oC, 28oC) to quail egg quality. Results showed that coating 2.5% of chitosan and preserving at 4oC could extend quail egg quality for 60 days.Keywords: Quai egg, Coating, Chitosan, Concentration, Temperature, Preservation.
Synthesis, Characterization and Study of Electrical Properties of Some New Aromatic Polyester Basma. J. Ahmed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

This research discloses the synthesis of various polyester resins, the polyesters containing homoring aromatic and others heterocyclic were synthesized by the condensation polymerization of suitable monomers (which are containing variety function groups in different structures) with phthalic anhydride. The main objective is synthesis of new polyester with keeping a reasonable electrical insulating behavior. The structural of polymer was characterized by Fourier Transform infra-red spectroscopy FTIR and HNMR. The dielectric constant (real ε' and imaginary parts ε") and AC conductivity (σAC) for all the polyester samples are studied by varying the frequency (30, 50, 70, 90, 120, 300, 500Hz and 1KHZ) at 25⁰C. Indeed, study of the electrical behavior of various polyesters revealed that the cross-linked polyesters presents higher insulating behavior at room temperature than linear polymers. Thermo gravimetric analysis (TGA) and differential scanning calorimetry (DSC) were employed to study the thermal stability for these polymers.Keywords: Aromatic polyester, Condensation polymerization, Heterocyclic, Phthalic anhydride, Thermal stability.
Synthesis and Characterization of Some Metal Complexes of [1-(4-Bromo-2-Methyl-Phenyl)-3-(4-Methoxybenzoyl)-Thiourea Taghreed B. Alwan
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

A new ligand [1-(4-Bromo-2-Methyl-Phenyl)-3-(4-Methoxy benzoyl)-Thiourea) (BMT) was synthesized by reaction of (4-Methoxyibenzoyliisothiocyanate) with (4-bromo-2-methyl anline). The Ligand was characterized by elemental micro analysis (C.H.N.S), (FT-IR) (UV- Vis) and (1H,13CNMR) spectra. Some transition metals complexes of this ligand were prepared and characterized by (FT-IR, UV-Vis) spectra conductivity measurements magnetic susceptibility and atomic absorption. From the obtained results the molecular formula of all complexes was suggested to be [M (BMT) 2Cl2] (M+2i=Cu, Mn, Co, Ni, Zn, Cd and Hg), the proposed geometrical structure for all complexes was an octahedral.Keywords: 4-bromo-2-methyl anline, 4-Methoxy benzoyl isothiocyanate, complexes.             
Investigation of Chitosan as Edible Coating on Storage of Star Apple (Chrysophyllum Cainino) Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Star apple or milk fruit (Chrysophyllum cainino) is a non climacteric fruit and is considered exotic. It has a very pleasant flavor and nice appearance because of its star shape when cut in half. It’s widely cultivated in South of Vietnam. The fruits are shining apple-sized berries. The immature fruits are astringent and contain sticky white latex. The fruit is bright green and greenish-yellow to red violet when ripe, and should be eaten when fully ripe. It has excellent health and medicinal benefits. Despite its food benefits, star apple is highly perishable due to its high moisture content which is susceptible to microbial action. Objective of this study focused on the chitosan edible coating affected to weight loss, protein, total soluble solid, vitamin A and vitamin C in star apple (Chrysophyllum cainino) fruits. Different concentrations of chitosan (0%, 0.25%, 0.5%, 0.75%, and 1%) were examined. Results demonstrated that star apple fruits which were coated with 0.75% chitosan still maintained shelf-life until 15 days of preservation. So the use of chitosan coating was one promising method to improve stability of star apple (Chrysophyllum cainino) fruits during storage and distribution.Keywords: Chrysophyllum cainino, Edible coating, Chitosan, Stability, Storage, distribution.
Rheumatoid Factor Isotypes in a Sample of Iraqi Rheumatoid Arthritis Patients Raghad Hassan Hussein
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Rheumatoid arthritis is a chronic inflammatory disease with an autoimmune origin. This disease primarily involves the small joints with subsequent systemic involvement. Rheumatoid factor is one of several biomarkers that characterize this disease. The prevalence of rheumatoid arthritis has increased in Iraq in recent decades. This study aimed to investigate the level of three RF isotypes in a sample of Rheumatoid arthritis patients. The study involved 100 Iraqi rheumatoid arthritis patients aged 5-72 years. The mean age for the patients included in the study was a 41.04 ±14.25 year with the majority of patients (42%) being in the age group 40-59 years. A highly significant difference in the prevalence of rheumatoid arthritis was found between female (82%) and male (18%) patients included in the study (p<0.01). Qualitative estimation of RF isotypes showed that the highest positivity was for RF-IgG (42%) followed by RF-IgA (29%) and RF-IgM (28%).Quantitative estimation of RF-isotypes showed that the mean value for serum IgA, IgG and IgM in patients included in this study was 41.04 U/ml, 39.6 U/ml and 48.6 U/ml respectively. An interrelation was found between RF-IgG and RF-IgM titers (r=0.54). The results of this study confirm the importance of measuring multiple RF isotypes in rheumatoid arthritis patients.Keywords: Rheumatoid arthritis, Rheumatoid factor isotypes, RF-IgM.
Ni (II) and Cd (II) Complexes Derivatives from Heterocyclic Schiff Base; Synthesis, Spectroscopic and Biological Studies Fawzi Y. Waddai
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Ni and Cd complexes of new Schiff base derived from 5-Amino-2-phenyl-2,4-dihydro-pyrazol-3-one with 4-chlorobenzalaldehyde (A) , 2-Hydroxy-benzalaldehyde (B) and 4-Hydroxy-benzaldehyde (C) have been prepared and characterized by elemental analysis ,molar conductivity measurements, FTIR, UV-vis, 1HNMR, mass spectrometer and magnetic susceptibility. Analytical data revealed that six complexes were a distorted tetrahedral geometry and exhibited (1:1) metal: ligand ratio. The biological activity for the three ligands and its complexes were studied.
Effect of Cranberry in Enhancing Oral Hypoglycemic Agents in Uncontrolled Type-II Diabetic Patients Atheer Majid Rashid Al-Juhaishi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Diabetes mellitus (DM) is one of the most common metabolic disorders associated with morbidity and mortality. Type II diabetes may be due to peripheral insulin resistance, defected insulin secretion or both. Cranberries are an evergreen class of midget sapling in the subgenus Oxycoccus of genus Vaccinium and have many pharmacological effects including antibacterial, antioxidant, cardio protective activity, anticancer, and hypoglycemic effects. The aim of this study is to assess the effect of cranberry in enhancingoral hypoglycemic agents in uncontrolled type II diabetic patients. The population sample consists of 60 type II diabetic patients aged between 35 and 63 years who met the diagnostic criteria of type II DM. Each patient was assessed individually using a case sheet that including age & sex, medical history and medication history. They were divided into two groups; the 1st group was treated with metformin and sulfonylurea alone, the 2nd group were treated with those agents plus cranberry capsules as add on treatment. The results showed significantly decline in blood glucose & glycated hemoglobin (HbA1c) which was changed from uncontrolled level 9.51% to controlled level 6.97% with aid of cranberryin group 2 in comparison with its change from 9.38% to 7.65% with oral hypoglycemic agents alone in group1 (p-value <0.0001). In conclusion, cranberry has a good hypoglycemic effect in treatment of type II DM and enhancing the effect of oral hypoglycemic agents.Keywords: Cranberry, Type II diabetes, FBS, HbA1c.
The Impact of Special Exercises for the Development of a Deep Sense of Block Skill Accuracy in Volleyball for Player's Focal Youth Bassem Hassan Ghazi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The Aim of Research: Preparation of special exercises to develop the deep sense and the accuracy of block in the volleyball for focal young players and Learn the effect of special exercises in the development of deep sense and the accuracy of the block of the volleyball of focal young players. Hypothesis: Special exercises have a significant effect on the development of the deep sense and the accuracy of block of the volleyball of the focal young players. As for the research methodology, the researcher chose the experimental method as the appropriate method to solve the problem of research in the design of a single group with the pre and posttests. The sample of the research was chosen from the research community represented by the young players (17-19) years for the Kufa and Al Rawdatain 2016-2017 clubs. The number of players was chosen from them. The number of players was 4 players in each team. The total number of players was 8. The Researcher Concluded: An evolution in the deep sense of the young players for the movement of the parties to the experimental group, Exercises for deep sense and accuracy contributed to increase the accuracy of the wall of the ball of the volleyball players, The various special exercises developed by the researcher contributed to the development of deep sense and accuracy of the wall barrier.The Recommendations Were: The need to use special exercises in the development of deep sense and the accuracy of the wall of the block of the volleyball of young players, The need to develop a deep sense and accuracy of the skill of the wall of the young players to defeat the importance. The need to use exercises for the deep sense of other skills.Keywords: Special exercises, Deep sense, Block skill and Focal youth.
Nigella Sativa-Based Protection against Uterus and Ovary-Related Histological Damages Generated by Cimetidine in Mice Wafaa Sameer Abdullah
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

To generate protecting effects against the histopathological changes in uteri and ovaries in mice that are caused by cimetidine, this work was initiated using the aqueous suspension of Nigella sativa. In this experiment, 40 female mice were recruited that were randomly divided into 4 groups. Nigella sativa-cimetidine group (NCG) was given orally 1000mg/kg B.W of Nigella sativa-based aqueous suspension (NSAS) daily that was followed by administering cimetidine at 25mg/kg B.W. Nigella sativa group (NG) was administered orally 1000mg/kg B.W of NSAS daily. Cimetidine group (CTG) was exposed to 25mg/kg B.W of cimetidine daily. Control group (CG) received normal saline only. The experiment was run for 76 days. After the experiment was done, animals were sacrificed to obtain uteri and ovaries from all groups. These organs were subjected to histopathological-based processing and microscopically examination. The results of applying cimetidine alone in the CTG revealed harmful changes that interfered with the normal physiological activities in these organs that were ceased after using NSAS in the NCG. The study provides valued and important information about the use of Nigella sativa and its extracts in generating protection against the genital-based harmful changes induced by cimetidine.Keywords: Cimetidine, Nigella sativa, protection.
Immunomodulatory Effect of Ethyl Acetate Extract of Permot (Passiflora Foetida L.) Leaf against the Secretion of Antibody and Delayed Type Hypersensitivity in Vivo Andi Emelda
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The aim of this study was to investigate the immunomodulatory effect of ethyl acetate of extract of Passiflora foetida L leaves (EAEPL) on hypersensitivity response and antibody titer of immune cells. Hypersensitivity response test evaluated the swelling of the feet of mice, while antibody titer test evaluated the hemagglutination. Examination of antibody titer was performed in 5 groups of 25 wistar rats. All the test animals, except control group, induced by SRBC on the 3rd day intraperitoneally. The extract was given for 7 days. The hypersensitivity response test was performed in 5 groups of 25 mice (Balb/c). The groups, except control group, were given antigen (SRBC) on the 3rd day intraperitoneally and on the 7th day were administered intraplantarly. The thickness of the soles of the feet was measured using a plethysmometer before and after injecting the antigen at T4, T24 and T48. The data were processed statistically by Kruskal-Wallis then advanced test by Mann-Whitney. The group of negative control against the groups of EAEPL was significantly different (p<0.05). The antibody titer of the groups given the extract were higher than the antigen-induced group without the administration of the extract. The results show that the groups of EAEPL can increase antibody secretion. The test of hypersensitivity response showed that the group of negative control to EAEPL groups showed significantly different (p<0.05). The results showed that the swelling of the feet of mice decrease at T48. This research concludes that ethyl acetate extract of EAEPL has the immunostimulatory effect.

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