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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
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Articles 65 Documents
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Search results for , issue "Volume 10 Issue 08: (2018) August 2018" : 65 Documents clear
Low Serum 25- Hydroxyvitamin D among Beta-Thalassemia Patients in Iraq Riham Hussein Noor Almosawi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

This study aimed to investigate characteristics of patients like type of Beta-Thalassemia,  age, gender, and estimation of vitamin D level in the serum of patients with β – thalassemia. Samples of blood were collected from 98 β-thalassemia patients and 32 healthy controls. The quantitative assays of 25-hydroxy vitamin D were detected by using the quantitative sandwich ELISA technique. Serological experimental analysis found that the mean 25-hydroxy vitamin D was significant decrease in patients group in comparison to control subjects (P<0.001).Keywords: β-thalassemia, Patients, Serum, 25-Hydroxyvitamin, Iraq.
The Brain Management of Time and it's Correlative to the Creative Leadership of The Heads Of Scientific Departments in the Faculties of Physical Education and Sports Sciences in Iraq Jassem Jaber Mohammed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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The current research problem was identified by answering the following question:Is there a relationship between the effectiveness of time management, and the level of creative leadership of the heads of departments, in the faculties of physical education and sports sciences from the perspective of the members of the faculty and the objectives of the research was to identify the effectiveness of time management and creative leadership of the heads of departments in the faculties of physical education and sports sciences and identify the Iraqi The relationship between the degree of effectiveness of time management and creative leadership of heads of departments in the faculties of physical education and sports sciences in Iraq. The researchers used the descriptive approach in the two methods of surveying and inter relationships. The research community was determined by the professors of faculties of physical education and sports sciences in Iraq. The sample was randomly selected from the (Universities of Muthanna, Babel, Kufa, Karbala, Dhiqar, Missan, Kut, and Qadisiyah) as indicated in the table below. Characterization of research measures Since the current research aims to define the management of time and its relationship to the level of creative leadership of the heads of the scientific departments in the faculties of physical education and sports sciences of Iraq, it was necessary to achieve the objectives of the research tool to develop time management, by defining time management areas from the perspective of members of the Commission Teaching, and preparing a tool for the level of creative leadership by defining its areas from the point of view of faculty members as well .Defining the concept of the study variables: time management and creative leadership. Defining areas of time management and creative leadership as follows: The brain management of time: Planning - Organization - Human Relations - Decision Making - Follow-up and Evaluation .Creative Leadership Scale. The most important conclusions: The philosophy of department heads and their approach to time management and creative production as important elements in the management process is weak. There is a correlation between time management and positive creative leadership through the answers of faculty member’s .The main reasons that limit the professional level of the departments of the academic departments where the recommendations are the limited training courses in the field of management. And the need to prepare a guide to knowledge and guidance in the field of time management, and the creative capabilities of employees in the university institution .The availability of spatial and physical facilities to help prepare for the change process to ensure the sustainability and continuity of the work of faculties of physical education and sports sciences.Keywords: Brain management, Time, Creative, and leadership.
Application of Carrageenan, Guar Gum as Biodegradable Coating on Storage of Persimmons (Diospyros Kaki) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Persimmon (Diospyros kaki) is fleshy fibrous tropical, deciduous fruit belonging to Ebenaceae family. Persimmon is classifed as a low-acid fruit, presenting titratable acidity. Persimmon is popular and widespread fruit that is enriched with many bioactive compounds, including polyphenols, terpenoids, steroids, flavonoids, carotenoids, minerals and dietary fiber. Although consumed fresh, losses that occur during persimmon storage are, to a large extent due to excessive ripening, loss of firmness, rot and the incidence of fruit peel browning. The fresh fruits are highly perishable and there are several problems related to their conservation, originating at harvest time when a series of processes begin that influence the quality of the product and its consequent loss. One way to increase the availability to the consumer, and even provide more value to the end product, is edible coating. An investigation on coating of Persimmon by using carrageenan and guar gum was investigated. Persimmon fruits which were coated with 0.75% carrageenan still maintained shelf-life until 30 days of preservation.Keywords: Persimmon, Coating, Carrageenan, Guar gum, Preservation, shelf-life.
Effect of Blanching and Probiotic to Eggplant (Solanum Melongena) Fermentation Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The eggplant (Solanum melongena, L.) is a good source of minerals and vitamins. Being rich in fiber and having low lipid content, it contains a variety of phytochemicals, such as polyphenols, which provide important health benefits. However, the short shelf life of eggplant can be a major cause of postharvest losses especially during peak harvesting season. Fermentation is one of the most convenient technologies for the production of shelf stable food product. The objective of this study was to evaluate different aspects affecting to the fermentation of eggplants such as concentration of CaCl2, temperature and time for blanching; effect of ratio Lactobacilus acidophillus to the antioxidant of fermented eggplant. Results showed that eggplants should be blanched in hot water 95oC in 10 seconds with the present of 2.0% CaCl2. Moreover, the fermentation process for pickle eggplants had the best antioxidant by Lactobacilus acidophillus at ratio 1.5 x 108 cells/ml. Blanching and fermentation had significantly affected to antioxidant capacity and firmness of pickle eggplants.Keywords: Eggplant, Pickle, Fermentation, Blanching, Lactobacilus acidophillus, Antioxidant.
A Study of the Effect of the Use of Magnetised Water Technology to Increase the Hatching Rate of Common Carp (Cyprinuscarpio) in Hatching Incubators Abdulhusein Hamzah Jawdhari
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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This study was conducted in the fish hatchery of the Middle Euphrates Fish Production Company in Babylon Governorate on 1/4/2017 and used in three different strengths of magnetised water, known as tensile (700, 1400. 200) gauss, respectively, for five days, using four glass incubators (Zucker). The fertilised fish eggs were placed in four treatments with 100 g in each incubator. 1-2-3-4 The first incubator contained normal non-magnetised water. The second buffer was highly magnetised water 700, the third was 1400, and the fourth was 2000 gauss. Measure Percentage of oxygen, Electrical conduction, and Salinity by using a device YIS (conductivity meter) and Use the mercurial thermometer to measure the temperature. Was noticed that the incubator exposed to an intensity of 1400 gauss increased the proportion of oxygen in it and reached 10 while the lack of electrical conduction rate reached 40 and achieved a hatch rate 90% higher than those of the other treatments, with the hatching time beginning about8 hours before the others.Keywords: Magnetised Water, Hatching, Fish eggs, Magnetism intensity.
Association between GNB3 C825T Polymorphism and Sex in Iraqi Patients with Myocardial Infarction Ayat K. Taher
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Objective: The C825T polymorphism of the GNB3 gene is associated with hypertension, obesity and diabetes, while the association between the polymorphism and MI has been poorly explored. The aim of present study was to investigate the frequency distribution of C825T polymorphism of GNB3 gene in three study groups (G1, G2 and healthy controls) and its association with sex in Iraqi patients with myocardial infarction.  Methods: the study consist of 120 subjects (40 healthy individuals, 40 patients with only MI and 40 patients with MI and hypertension); genomic DNA extracted from whole blood, and C825T polymorphism was detected by polymerase chain reaction- Restriction fragment length polymorphism (PCR-RFLP). Results: the results show that most of patients were males it was (77.5 %) in G1 patients, while it was (70 %) in G2 patients, the difference was significant (P < 0.01) between males and females in both groups. the frequency of homozygous (CC) genotype G1 was (19.35 %) in males and (22.22%) in females and it was (28 %) for males, (16.67%) for females in G2. The heterozygous (CT) genotype for G1 in males and females was (61.29 %, 11.11%) respectively, for G2 it was (28 %, 16.67%) respectively. While, homozygous (TT) genotype in G1 was (19.35 %) for males and (66.67%) for females, and for G2 it was (14.29 %, 50.00%) in males, females respectively. The C allele frequency in G1 patients was (0.50) in males much higher than females (0.28), while T allele frequency was higher in females (0.72) than males (0.50). The frequency of C allele in G2 was (0.55, 0.33) for male and female respectively, and T allele frequency was (0.45) in male and it was higher in female (0.67). Odds ratio in both groups (G1and G2) was more than one according to (CT) genotype so it consider as a risk factor to MI for males while, (TT) genotypes consider as a risk factor to MI for females, while (CC) genotype can consider as a protective factor from MI since OR was more than one in both patient groups (G1 and G2). Conclusion: the polymorphism C825T of GNB3 gene in Iraqi population associated with myocardial infarction but more often in females.Keywords: Myocardial Infarction, G protein, GNB3, C825T polymorphism.
Synthesis, Characterization and Antibacterial Studies of Some New Imidazole Derivatives Saif M. Ali
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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In this work, imidazole derivatives were synthesized by the reaction of benzoyl thiourea with ethyl chloro acetate (1). Hydrolysis of ester for compound (1) was synthesized by reaction of Imidazole derivative (1) with KOH give 2-((1-benzoyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)thio)acetic acid (2),compound (1)treatment with aldehydes gave ethyl 2-((1-benzoyl (Arylidene)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)thio)acetate(3a-e). Hydrolysis of ester forcompound (3a-e)with KOH gives ethyl 2-((1-benzoyl (Arylidene)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)thio) acetic acid (4a-e),Compound (3a-e)reaction with thiourea and HCl concentration gives ethyl 2-((9-benzoyl-6-(phenyl)-2-thioxo-2,5,6,9-tetrahydro-1H-purin-8-yl)thio)acetate (5a-e). Compound (3a-e)reaction with hydrazine hydrate gives 2-((6-benzoyl-3-(phenyl)-3a,6-dihydroimidazo[4,5-c]pyrazol-5-yl)thio)acetohydrazide (6a-e).All imidazole derivatives have been characterized by 1H-NMR, IR, and mass spectroscopy.Keywords: Imidazolederivatives, Hydrolysis, Pyrimidine, Hydrazide.
Investigation of the Mechanism of Action of New Hepatoprotective Herbal Drugs in the Experiment Larysa V. Iakovlieva
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Introduction. Rational pharmacotherapy for liver disease remains one of the most urgent medical and social problems. The purpose of the study was to determine the mechanism of action of new hepatoprotectors of plant origin in the model of acute toxic lesions of the liver of rats (tetrachloromethane, 0.8 ml / 100 g body weight, once, intragastric). Materials & Methods. Animals were divided into 8 groups of 7 animals in each group: 1 group - intact control; group 2 - control pathology (CC14); 3-6 groups - animals that received capsules Hepafisan (108 mg / kg), Fitovenol (150 mg / kg) against the background of СС14; Granules Gepatrombin (900 mg / kg) and Polygerbagastrin (900 mg / kg), respectively; 7-8 groups - animals that were given drug comparisons capsules Silibor (100 mg / kg) and Gepabene  (88 mg / kg). The investigated preparations were administered to animals in the treatment-and-prophylactic mode: 1 hour before administration and 1 hour after tetrachloromethane administration and on the next day. On the 3rd day after the simulation of the pathology in the blood serum of animals were determined the activity of alanine, aspartate aminotransferase (AlAT and AsAT) of alkaline phosphatase (ALP), the content of circulating immune complexes, C-reactive protein (CRP), proinflammatory (interleukin 1, (IL1) and tumor necrosis factor (TFN-α) and anti-inflammatory cytokines (interleukin 10 (IL10), the content of total and direct bilirubin in the blood serum. The absolute mass of the liver was determined. The content of the secondary products of LPO-TBC-reactants was determined in blood serum and in the biological substrate (liver tissues) activity of superoxide dismutase (SOD) and catalase (CAT), pyruvic acid (Pyruvate), lactate in serum - activity of succinate dehydrogenase (SDG), the content of glycogen in the liver, the liver detoxification function was investigated using a functional test called "Thiopental sleep" (thiopental in dose 35 mg / kg, intraperitoneally). Research results. It has been established that Hepafisan, Fitovenol, Gepatropin and Polyherbagastrin stimulate of reparative and regenerative processes in a liver, eliminate inflammatory processes. Under the action of biologically active substances that are part of the plant, there is a normalization of the processes of phosphorylation, the restoration of the cytochrome P-450-dependent monooxygenase system. By enhancing the utilization of glucose, they contribute to the synthesis of glycogen and provide a high level of energy supply to cells, which is likely to stimulate synthetic processes and improve hepatobiliary system function.Conclusions. A crucial role in the mechanism of hepatoprotective action of investigated means plays antioxidant properties that reduce in the damaging effects of lipid peroxidation processes, which contributes to regeneration of hepatocytes and functional reactivation of the liver.Keywords: Model of acute toxic damage of the liver, Tetrachlorolmethane, New hepatoprotective plants preparations, Hepatoprotective action.
The Incidences of Use the Over Counter Drugs Abeerfadhil Ibraheem
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Importance of the study:  over-the-counter (OTC) medication is commonly used, among older, adults and children. They can be dangerous because their side effect, interactions with other medication and allergic reactions. The most OTC medications frequently utilized worldwide are Paracetamol (acetaminophen), Non-steroidal anti-inflammatory drugs (NSAID), stomach upset, antitussive, allergy and skin rashes and itching medications. Objectives:  To determine the misused practice of over-the-counter medications, to assess the common use of the over-counter medication and to assess patient's information about commonly used over-the-counter (OTC) medication. Design, Setting, and Participants:  Descriptive analyses study, the sample was (100) participants, conducted from community-dwelling from 21 to 61and over years old male and female. Using assessment tool instructed from literature review from1/2/2018-1/3/2018, the reliability of the questionnaire through the use of Cronbach's Alpha was (.846). Results:  the study revealed that the lowest mean score (1.53) for knowing how much weights before giving these medicines. The lowest mean score (1.73) for they check with care provider before taking an (OTC) when having a long-term medical problem or are taking prescription medicines, the lowest mean score (1.3) for they taking acetaminophen every 4 to 6  to relieve headache, fever & pain. Conclusions : the most  of study sample didn’t aware about the weight  and the dose of taking medication, check with care physician before taking an over-the-counter drugs when having a long-term medical treatment or dealing with prescription therapies and when they taking acetaminophen every 4 to 6  to relieve headache, fever & pain .Keywords:  Over counter medication (OTC), Misuse, Non-steroidal anti-inflammatory drugs (NSAIDs) and stomach upset.
Informed Consent to Clinical Trial as Factor Determining Participation Igor Mareev
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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The informed consent (IC) form and the doctor involved in the research are the major sources of information for participants in clinical trial (CT). Thereby, they are directly influencing the perception of possible participants and they decisions about participation. However, significance of these factors for the participants in the BE study remains unclear. The leading method applied was a questionnaire survey: a volunteer (n=137), who has already experienced the practice of participation in clinical trial and satisfies the selection criteria, was once asked to fill in the questionnaire on his own. As the research progressed, all the respondents were divided into two groups: participants who got acknowledged about the IC by a doctor and independently. In the group of respondents, who read IC independently, students dominated. The significance of factors influencing the decision to participate in clinical trial was assessed on a five-point scale. Respondents noted the following as the most significant motivators: a cash reward, regular health observation and observation by professional experts. Negatively colored factors were the risk of side effects, adherence to restrictions, and the use of a new drug. Thus, research results showed that volunteers adequately assess the risks of participation in clinical trial. Material affluence plays a key role in motivation and determines the ‘professionalization’ of volunteers in the BE study. This factor is undoubtedly the leading risk of ethics violation.Keywords: Clinical trials, Bioequivalence, Informed consent, Perception, Motivation, Decision-making.

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