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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 5 Documents
 1 
Search results for , issue "Volume 10 Issue 09: (2018) September 2018" : 5 Documents clear
In Vitro Antioxidant Anti-inflammatory and Acute Toxicity Study of Root Extract of Asparagus Racemosus Ramesh L. Londonkar
Journal of Global Pharma Technology Volume 10 Issue 09: (2018) September 2018
Publisher : Journal of Global Pharma Technology

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Abstract

The purpose of the study is to investigate potential of antioxidant, Anti-inflammatory and acute toxicity study of ethanol root extract of Asparagus racemosus Linn (ASR). The antioxidant activities were evaluated using in vitro Ferric reducing power, Free radical scavenging activity by DPPH method, hydroxyl radical scavenging activity, Nitric oxide radical scavenging activity, Super oxide Anion Radical Scavenging Activity and total antioxidant capacity. The anti-inflammatory potential was also evaluated using Hyaluronidase inhibition assay. The effect was compared with a known antioxidant agent (BHA/Ascorbic acid). It was found that the extract at different concentration exhibited a significant dose dependent antioxidant and anti-inflammatory effect. Acute toxicity study was performed in Wistar rat and an OECD guideline 423 was followed, No sign of toxicity was observed after treating with 2000 mg/kg of ASR.Keywords: Asparagus racemosus, Free radical, acute toxicity, Hyaluronidase inhibition. 
Formulation and Evaluation of Herbal Antiperspirant and Deodorant Foot Powder from Mulberry Leaves Extract Ravindran Muthukumarasamy
Journal of Global Pharma Technology Volume 10 Issue 09: (2018) September 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Sweating is a normal physiological process occurs in the body, but excessive sweating (hyperhidrosis) indicates a significant adverse impact on the quality of life for individuals. Sweating can be considered to have stressful experience, reduces self-confidence and social acceptance as it interferes with daily activities. Excessive sweating on the foot provides optimum conditions for bacterial growth and subsequently leads to smelly foot. Objective: The objective of the current study was to formulate and evaluate antiperspirant and deodorant foot powder from mulberry leaves extract.  Methods: The formulated powder was tested for its antiperspirant and deodorant activity against Staphylococcus epidermidis by measuring its zone of inhibition using disk diffusion method. Furthermore, the formulated powder was tested for its physiochemical parameters as per standard procedures. Results: The study results proved that mulberry leaf extract showed considerable antibacterial activity against Staphylococcus epidermidis bacteria in concentration of 200 mg/ml and 400 mg/ml. Phytochemical screening on the extract confirmed the presence of alkaloids, reducing sugars, phenols, flavanoids, carbohydrates, proteins, etc... The invitro evaluation of  the formulated herbal foot powder was tested on the micrometric test parameters like angle of repose, bulk density, tapped density, hausner ratio, carrs compressibility index and sterility test. The results on the micrometric properties was found to have poor flow property. Conclusion:However, the formulated herbal foot powder from mulberry leaves extract can be used as a potential herbal antiperspirant and deodorant foot powder with further studies on improving the flow property of the powder and toxicity testing using suitable models.
Pharmacognostic Studies on Tradescantia Zebrina Gouri Kumar Dash; Mohamad Nur Aiman Fadrul; Allan Mathews
Journal of Global Pharma Technology Volume 10 Issue 09: (2018) September 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Tradescantia zebrina Heynh. ex Bosse (Family- Commelinaceae), is an important medicinal plant with several traditional medicinal uses. In Malaysia, the plant is recommended to be a remedy to improve kidney function. In the present paper, we report some pharmacognostic studies on the leaves since there are no standard parameters available for this plant in the literature. Presence of typical epidermis with multiple hypodermis layers, few chloroplasts scattered in the spongy parenchyma and red color in most parts of the upper and lower epidermis are some of the key features for the identification of the species. Preliminary phytochemical screening of leaves showed presence of sterols, saponins, flavonoids, tannins, carbohydrates, and proteins and amino acids respectively. The above findings together with physicochemical parameters can be useful in establishing pharmacognostic standards for the plant.
LOW CD8+ T LYMPHOCYTE/TUMOR BUDDING INDEX PREDICT POSITIVE NODAL STATUS IN BREAST CARCINOMA Ni Putu Sriwidyani; I Wayan Juli Sumadi
Journal of Global Pharma Technology Volume 10 Issue 09: (2018) September 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Death in breast cancer patients are mostly caused by the presence of distant metastasis and nodal status is the strongest prognostic factor of metastasis. CD8+ T lymphocyte/tumor budding index is a representation of the anti/protumor properties interaction. The purpose of this study is to prove the interaction between tumor cells and tumor microenvironment and its relationship nodal status in breast carcinoma. Methods: A cross sectional analytic study using 45 cases of breast carcinoma which were underwent mastectomy and radical axillary lymph node dissection at Sanglah Hospital Denpasar during 1 January until 31 December 2017 was conducted. Tumor budding was a small group of cells at the edge of tumor invasion which was evaluated at H-E slide. CD8+ T lymphocyte was evaluated on immunohistochemical slide and was calculated on the peritumoral stroma. Results: Using ROC curve, cut-off value was 4.05. Of all cases, 23 cases with low and 22 cases with high CD8+ T lymphocyte/tumor budding index. CD8+ T lymphocyte/tumor budding index had a significant inverse correlation with nodal status (p=0.000), meanwhile LVI has linier correlation with nodal status in breast carcinoma (p=0.006). Conclusion: there was an inverse relationship between CD8+ T lymphocyte/tumor budding index with nodal status in patients with breast carcinoma
Optimization the Mathematical and Computational Approaches to Understanding the Medical Science Applications Ali Jalal Ali
Journal of Global Pharma Technology Volume 10 Issue 09: (2018) September 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Computing is the backbone of modern healthcare systems, it not only cut-downs the associated treatment and medicine costs but also decreases the logistics requirements simple mathematics is used effectively by people in all walks of life to assist decision making. However, in this paper it is argued that many, so called, applied mathematicians affiliated with university mathematics departments all too often do not apply mathematics to anything in particular. Although there is the national appeal of relevance to an application for the equations under study, applied mathematics has come to mean something completely different than really applying mathematics to solve an important the problem in another discipline. Even ‘mathematical modeling’ is often observed to involve the development of ‘neat’ equations which are stated to be loosely linked to something people will care about but is presented with esoteric and obscure mathematics which is not accessible to stakeholders in the application of the problem. It is suggested that simple models that directly answer questions of relevance are always better than complex models that are not influential, unrealistic, or irrelevant and that experts in the area of application must have integral roles in the entire modeling process, including the design of research questions, ensuring realism of model structures, informing parameter estimates, and the presentation and communication of results.Keywords: Computing, Medical Applications, Medical Image, Polynomials.

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