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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 69 Documents
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Search results for , issue "Volume 10 Issue 10: 2018" : 69 Documents clear
Molecular Identification of Entamoeba Histolytica In Amoebiasis Patients Ali Hassan Al-Timimi
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Infection is the third-greatest parasitic disease responsible for death in the world. Amoebic infections result either in a harmless colonization of the intestine, or in an amoebiosis with invasion and damage of the intestine, liver, lung, and brain. These distinct manifestations are due to the existence of Entamoeba Histolytica alone or with Entamoeba Dispar as a complex of two different, but morphologically identical species. One that is a nonpathogenic commensal in the intestine of humans, E. Dispar, and the other that is capable of inducing cell and tissue damage. Due to genomic DNA differences between pathogenic and nonpathogenic of these protozoan infections, we used a polymerase chain reaction (PCR) method that diagnosed and differentiated the two conditions. DNA extraction protocol using non-fixed stool samples.about60 of 65 stool specimens from patients with amoebiosis was characterized. Among them, 45 (75%) were infected only with the nonpathogenic species, E. Dispar, while 15 (25 %) displayed a mixed infection with the pathogenic nonpathogenic species, E. Dispar and E. Histolytica. The PCR protocol showed a specificity of 1.00 and a sensitivity of 0.95. The molecular approach is therefore reliable and applicable in the identification of pathogenic E. Histolytica infection. Present results provided tha importance data for the Iraqi Health Care System and   addressed the emerging problems of amoebic infection in Iraqi.Keywords: Entamoebahistolytiac, Molecular characterization, E. dispar, Stool sample.
Build and Standardize the Organizational Commitment Scale for the Administrative Authority of Iraqi Football Clubs Mohsen Mohammed Hassan
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The weakness in the administrative aspects was reflected on the players in the stadium during the competitions and competitions, and this also reflected the ability of the effective leadership of the coach in the coordination of work and follow-up and direct supervision and organize the efforts of the players, which gave the impression of the lack of effectiveness, which extends to the level and the extent required for players, Failure to achieve team goals and success. Building and standardizing the organizational commitment scale for the administrative authority of Iraqi football clubs to recognize the organizational commitment of the administrative authority of Iraqi football clubs. The researchers used the descriptive approach in the survey method and the standard, because of the relevance and nature of the current study. The information and data of the research community were collected (280) administrative members distributed among the clubs of the first class football in Iraq. The sample of the research was randomly selected. The sample of the building of the scale was (127) administrative members. Through the results of the results, the researchers reached the following conclusions:The members of the administrative body of Iraqi football clubs have shown a good organizational level, which has increased their level of ambition in the administrative process. Members of the administrative body of Iraqi football clubs have shown their football at an average level of organization, increasing their level of ambition in the administrative process. Set three standard levels of members of the administrative body of Iraqi football clubs. The possibility of using the scale applied in the current research by the administrative authority to measure the level of organizational commitment to them. Conduct studies similar to all workers in the federations and youth centers to find out the practical and scientific situation of workers in this field.Keywords: Organizational Commitment, Administrative authority and football.
Ferric (III) Chloride-Catalyzed Synthesis of 3, 4-Dihydropyrimidine-2(1H) Ones / Thiones for Biginelli Reaction and Characterization of Their Anticancer Activity Mahmood Shakir Magtoof
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

We describe the syntheses of  3,4-Dihydropyrimidine-2(1H)Ones/Thiones by a one-pot cyclocondensation of urea or thiourea, aldehydes and ethylacetoacetates using Ferric (III) Chloride as catalyst, this method has the advantage of excellent yields (55–93%) and short reaction time (6-7 hours). Furthermore, we have studied the antioxidant activities of these synthesized 3,4-Dihydropyrimidine-2(1H)Ones/Thiones. Some the synthesized compounds appear the Important antioxidant properties, these properties studied by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays. The cellular toxicity of the compound 1 was studied on (MCF7) cell lines using MTT assay that revealed the presence of a toxic effect of the cells with the highest activity of the compound 1 on (MCF7) cell lines. This indicates that compound 1 has an antioxidant and anticancer effect and can be used as a new chemical compound but this needs further investigation in vivo to confirm our results in vitro. The compounds were established on the basis of the spectral studies using IR,1H-NMR, 13C-NMR, and Mass spectra.Key words:  Aldehydes, urea/thiourea, Ethyl acetoacetates, Anticancer, Antioxidant, MCF7.
Synthesis, Characterization and Antibacterial Studies of Some Transition Metal Complexes Containing New Dithiocarbamate Ligand Ahmed Thabitnuman Dhuha
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The synthesis of some transition metal complexes with dithiocarbamate as a ligand of general formula [M (L) 2] where M = Mn (II), Co (II) and Ni (II). The dithiocarbamate ligand and its complexes were described by FT-IR, UV-Vis and 1H, 13C-NMR, Mass spectra, elemental micro analysis C.H.N.S., magnetic susceptibility, molar conductivity, melting points, and atomic absorption. The antibacterial Studies of synthesized compounds were studied versus [Escherichia coli (gram negative) and Staphylococcus aureus (gram positive)]. The conductivity data affirm the nonelectrolyte nature of the complexes.Keywords: Dithiocarbamate (Dtc), 4-aminophenazone, Transition metal.
The Cognitive Achievement of the Physical Management Material and its Relation to the Organizational Deviations of the Training from the Point of View of the Students Jassem Jaber Mohammed
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The introduction and the importance of research included that the level of sport needs to be built on and the most important of these foundations is the administrative aspect which is the cornerstone of the sport process in all its aspects and this aspect needs an in-depth study that adopts the researcher and the university professor to communicate it to the students and the extent The relationship of the student's cognitive achievement to this information with the organizational deviations of the teacher the problem was formulated in the form of several questions. The most important of which was to remove the organizational deviations of the teacher as a function of predicting the educational achievement of students of the fourth stage of the Faculty of Physical Education and Sports sciences at the University of Babylon Sports management, and there are several objectives, the most notable of which is the prediction of the achievement of the students of the fourth stage of the material of sports management in terms of the organizational deviations of the material teacher from the point of view of the students and the researcher used the descriptive curriculum for the suitability and nature of the study and through the results of the research was Several conclusions, including that the ratio of organizational deviations of the teacher from the point of view of students varies among them where there were several directives and proposals, the most important of which was to rely on the predictive equation produced by this study in other samples.Keywords: Cognitive achievement, Physical management, Material, Training and point of view
The Estimate of Heterosis Effects of Sheep Body Weights in Different Ages Abdullah Hameed Salim
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The current study was carried out at the Radwaniyah station / Ministry of Agriculture, which included analysis of data of local awassi sheep, Assaf and crossing Assaf (local Awassi ×Assaf). Records included weights at birth and weaning and in ages of 6, 9 and 12 months for the three genetic groups above. We aimed to study the effect of the genetic group on the lamb’s weights at different ages and the effects of the hybrid vigor resulting from the crossing of local awassi sheep with Assaf sheep to the traits of the weights in ages from birth to one year old. The results showed that the genetic group had a significant effect (p˂0.01) in all the studied traits while the effect of hybrid vigor was not significant for all studied traits, but it was similar to some previous studies, with 10.36, 12.20, 5.80, 6.49 and 4.92 % for weights at birth, weaning, 6 months, 9 month and 12 month respectively.
Evaluation of the Effectiveness of Olive (Olea europaea) Leaf and Pomegranate (Punica granatum) Flower Extracts in the Viability of the Protoscolices of Echinococcus granulosus In Vitro Zainab Ali Hussein
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The present study was conducted for the period from 1/10/2017 up to 1/3/2018 at the Department of Biology - College of Education for Girls-Kufa University. It aims to assess the effectiveness of ethanolic extracts for olive (Olea europaea) leaf and pomegranate (Punica granatum) flower in the viability of protoscolices of Echinococcus granulosus parasite in vitro. The results demonstrated that the ethanolic extracts for olive leaf and pomegranate flower are very effective in the devastation of the protoscolices, and that the mortality rate increases with concentration and duration of exposure to both extracts .The results showed that the ethanolic extracts for olive leaf was more powerful than the ethanolic extracts for pomegranate flower in the mortality of protoscolices, where the LC50 for the mortality of the protoscolices was (9.7) mg/ml and (11.1) mg/ml, respectively, following 15 minutes of exposure to the extracts, while the LC50 for the mortality of the protoscolices (5.9) mg/ml and (6.6) mg/ml respectively, after 60 minutes of exposure to the extracts. The results also showed that the ethanolic extract for olive leaf led to the decimation of the protoscolices in less time than the ethanolic extract for pomegranate flower when exposed to the concentration of (4) mg / ml, where the LT50 of the protoscolices of (44.6) minutes and (79.4) minutes, respectively, while exposed to the concentration of (16) mg/ml, where the LT50 of the protoscolices of (15.7) minutes and (18.3) minutes, respectively. The conclusion from this study that leaves of olive plant and pomegranate flowers as natural materials can be used to kill the protoscolices of the E. granulosus parasite before a surgical procedure to remove the hydatidcysts .Keywords: Olive leaf, Pomegranate flower, Ethanolic extracts, Protoscolices, Echinococcus granulosus, In vitro.
A Comparative Study of the Level of Depression among Students in the Hostel at Anbar University Marwan Abdullatif
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Depression is one of the most common psychiatric diseases in the world, confirmed by global research. The World Health Organization (WHO) sees it as the second most important cause of death and disability in the world after heart disease by 2020. Depression is defined as "a temporary or permanent emotional state in which the individual feels constricted, sad, and distressed, and is characterized by feelings of concern and grief. This condition is accompanied by specific symptoms related to mood, cognitive, behavioral and physical aspects. This study is intended to highlight a very important subject for university students as it is a scientific attempt to study the level of depression they have, especially as this study focuses on an age group with hopes for the renaissance of the society. The problem of depression may be greater than it may come to mind, which is likely to be treated as an attempt to vent the excitement and enjoyment of the most important. For these reasons, depression has been the subject of continuous follow-up and study, and has been written about in many different cultures and different languages. Therefore, the current study is a preliminary step to understand this phenomenon and propose appropriate preventive and curative solutions to mitigate their powers and the associated problems. The research community included the students of some of the (117) faculties of internal departments in Anbar University, represented by three different faculties: College of Engineering, College of Science and College of Physical Education and Sports Sciences. The sample of the study was affected by (60) students, and by percentage (51.28%). They were chosen randomly, with 20 students per college.After collecting the information, they were unloaded in special tables, and the most important conclusions were reached:There are statistically significant differences between the students of some colleges residing in the internal departments at Anbar University in the level of depression.Students of the College of Science resident in the internal departments at Anbar University more students are prone to depression.Students of the College of Physical Education and Sports Sciences resident in the internal departments at Anbar University less students at the level of depression.Keywords: Depression, Students and hostel.
Synthesis, Characterization and Study of Liquid Crystalline Behavior of New Compounds Containing Thiazolidin-4-one, 1, 2, 3-Triazole and Benzimidazol Rings Tareq K. Ibraheem
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

All new compounds synthesized by many reactions starting from a product the compounds [I]a,b from reaction of 3-phenylenediamine  or 4-phenylenediamine  with chloroacetyl chloride, then the compounds [I]a,b reacted with potassium thiocyanate to yield compounds [II]a,b. While  the compounds[III]a,b yield from  reacted the compounds [I]a,b with sodium azide then the compounds [III]a,b reacted 1,3-dipolar cycloaddition reaction  with   acrylic acid to give compounds [IV]a,b and the later compounds reacted with phenylene diamine to product benzimidazole  compounds [V]a,b . In addition to synthesized acid chloride compounds [VI]a,b  by reacted the compounds  [IV]a,b with   thionyl chloride .Finally reacted the compounds [VI]a,b with  different aromatic amines to give amide compounds[VII-X]a,b . The synthesized derivatives characterized viamp. , FTIR, 1HNMR in addition to mass spectroscopy .The liquid crystals properties were studied by using polarized optical microscope (POM) and differential scanning calorimetry(DSC).Keywords: liquid crystal; benzimidazol; thiazolidin-4-one.

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