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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 39 Documents
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Search results for , issue "Volume 10 Issue 12." : 39 Documents clear
Impact of Pharmacokinetic Modification of Controlled Release Floating Tablets of Ranolazine B. S. Venkateswaralu
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

The present study outlines a systematic approach for design and development of oral controlled release floating tablet formulation of Ranolazine. Floating tablet Ranolazine have been shown controlled release there by proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate, Eutragit L 100 and HPMC Polymer combination, respectively. Five batches of tablets were prepared by the direct compression method. The physicochemical properties of different formulations, their Buoyancy lag time and total floating time and swelling index were evaluated. It was found that the hardness of the tablets were effects the Buoyancy characteristic of the dosage form. All five formulations possessed good floating properties with total floating time between 8 – 10 hrs. The in vitro release studies indicated that the floating dosage forms containing Eutragit L 100showed slower release. The cumulative % of in vitro drug release of formulation FR1, FR2, FR3, FR4, and FR5 were 49.36%,58.98%,72.22%, 98.88% and 76.89. Drug release to be enhanced by formulation F4 in compared with the marketed product. Accelerated stability study revealed that optimized formulation was stable for one month without any major changes in assay, dissolution profile, floating lag time and other physical properties. Based on best fitting method, optimized formulation was found to follow Higuchi Model release kinetic.
Hepatitis B Virus Surface Antigen Subtype in Positive HBsAg Subjects in Mengwi District, Badung, Bali-Indonesia Made Agus Hendrayana
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Indonesia is a country with a high prevalence of hepatitis B virus infection and can develop into chronic hepatitis in the community. Indonesia is a multiethnic country with a vast territory, so it is estimated that the prevalence of each hepatitis B virus subtype varies greatly in different regions. Sequences in the S region gene encoding amino acids can show hepatitis b virus subtypes through exclusive variations in subtype determinants of HBsAg. This hepatitis B virus subtype is epidemiologically important, because it can show differences in geography and ethnicity in its spread. This study aims to analyze the hepatitis B virus subtype in HBsAg positive subjects in Mengwi, Badung, and Bali-Indonesia. The subjects of the study were 75 patients who came to the Mengwi I Badung Primary Health Center. All serum samples were examined for HBsAg by the ELISA method. In HBsAg positive serum samples, hepatitis B virus subtypes are determined. The DNA is extracted from serum samples that are HBsAg positive. Amplification of portions of DNA S gene from serum HBsAg positive was performed by polymerase chain reaction first-round and second-round. The nucleotide sequence of the hepatitis B virus is converted into amino acid sequences and multiple alignments are performed. The hepatitis B virus subtype was determined by amino acid substitution analysis at positions 122, 127, 134, 159, 160 and 177 in the S gene assisted by using a computer program. The subjects with HBsAg positive were obtained from 11 out of 75 samples (14.7%). The results of hepatitis B virus subtype analysis found that almost all samples, 10 of 11 samples (90.9%) had adw2 subtypes, while one sample (9.1%) had adrq + subtype.Keywords: HBsAg, Subtype, HBV, Mengwi.
A Security Conceptual On Android Platform for Mobile Health Applications Kanaan Jalal Brakas Kaky
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Mobile Health application are readily accessible to the average uses of mobile devices, and despite the potential of mHealth applications to enhance the availability, affordability and effectiveness of delivering healthcare services, that take care of touchy medical data, or as such, have also the strength to carry enormous gambles according to the safety and privacy concerning their users. Developers on applications are commonly unknown, yet users are ignorant over what their data are animal managed and used. The proliferation of mobile phones together with built-in sensors makes large-scale sensing viable at low cost. During cellular sensing, information hourly includes user-sensitive facts certain as much its real-time location. We analyzed 40 downloaded apps beyond the Google Play save and confirmed that of run-on in accordance with health reasons, the outcomes were 100% successful, certain namely blockading traffic, revealing touchy consumer information, and affecting the heartbeat. Toughness Based on the composition comment that advised the need because the supposed protection framework, three-distinct or according to phases are presented, each concerning which is described among a resolve section. First, discussed the layout system about the preceding segment according to increase a protection frame for m Health apps to ensure the safety or privateness concerning sensitive medical data. The 2nd section is mentioned whoever in accordance with acquiring the implementation concerning a prototypic proof-of-concept version over the framework. Finally, the third segment finish mentioned the comparison procedure of terms on usefulness then efficiency for the proposed framework.Keywords: Mobile Heath, Health Effects, Android Security
Investigation of Herbal Tea Production from Perilla (Perilla Frutescens) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Perilla is an edible plant and has medicinal properties. The leaves have a very pleasant sweet taste and are used as a spice. Perilla seed and oil are rich sources of phenolic compounds, antioxidants, polyunsaturated fatty acids (α-linolenic acid, linoleic acid, oleic acid, and palmitic acid, omega-3 and omega-6 polyunsaturated fatty acids) and minerals. Perilla is commonly used to flavor the foods. Objective of the present study was focused on the effect of blanching, drying and storage of herbal tea produced from Perilla. Optimal results found that herbal tea would have stable antioxidant capacity while blanching at 95oC in 4 seconds with the presence of 4% CaCl2 submersed in blaching solution; drying at 40oC with 2.0 cm in dimenstion of Perilla; storage under vaccum in PET/AL/PE bag within 6 months without any deterioration.Keywords: Perilla, Herbal tea, Blanching, Drying, Storage, vacuum.
A Brief Review Self Nanoemulsifying Mouth Dissolving Film: Formulation and Applications in Herbal Medicine Lusi Nurdianti
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

The use of herbal medicines is increasing, because of the belief that natural medicines have fewer side effects than synthetic drugs. But many herbal products show low therapeutic action due to problems with solubility and improper molecular size which have an impact on low bioavailability despite having good potential. The development of self nanoemulsion (spontaneous nanoemulsion) in fast-dissolving intraoral film preparations is one alternative formulation that can be used, to improve the limitations of bioavailability and increase patient acceptance and compliance because the application of developments is effortless, given through the oral cavity, so that direct absorption occurs in the cavity mouth and enter the systemic circulation without experiencing the effects of the first cross metabolism. This study aims to explain the concepts and techniques of self nanoemulsion formulation in intraoral (mouth dissolving film) preparations to increase the bioavailability of natural active compounds in extracts with low solubility in water and their characterization and evaluation.Keyworlds: Self nanoemulsifying, Mouth dissolving fim, Herbal medicine, Bioavailability.
E-Prescription in Nigeria: A Survey Adebayo Omotosho; Justice Emuoyibofarhe; Peace Ayegba; Christoph Meinel
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Electronic prescribing or Electronic prescription (EP) is the computer-based electronic generation and transmission of a prescription.  EP systems help to increase accuracy and safety of patient prescription and reduce costs through improved legibility and electronic delivery. The motivation for EP is greater safety of drug use and to counter the current unacceptable levels of adverse drug events. This study evaluated the feasibility of hospitals in Nigeria to adopt an EP system. A survey was conducted in four hospitals in Nigeria to determine the economic, technical and organisational feasibility of adopting e-prescribing. Respondents included 42 medical practitioners - doctors, pharmacists, pharmacy technicians and assistants - working at the hospitals at the time of the survey. Respondents felt that implementation of an EP system is economically feasible (p=0.031) and organisationally feasible (p=0.032) but were ambivalent as to whether it is technically feasible (p=0.446). However, inadequate funding by the government does not provide for the health sector to acquire the necessary resources and training skills.
Effect of Faba Bean (Vicia Faba) in Growth Performance, Feed Utilization, Muscle Hardness and Crispness of Red Tilapia (Oreochromis Sp) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Among phytochemicals, phenolic compounds are gaining an increasing interest for their health promoting properties. Faba bean has a large variability of the levels of total polyphenols in seeds. Red tilapia (Oreochromis spp.) is an abundant freshwater fish with a white flesh meat. Customers prefer to fish fillet with more hardness and chewiness. Objective of this research focused on the effect of faba bean (Vicia faba) replacement in growth performance, feed utilization, muscle hardness and crispness of red tilapia (Oreochromis sp.) during rearing. The finding revealed that 30% faba bean in fish meal could improve the hardness and chewiness of red tilapia muscle while compromising to growth rate and feed utilization. This investigation was potentially applied not only for red tilapia but also for other aquaculture species so that the added value of fish cultivation could be enhanced.Keywords: Faba, Red tilapia, Hardness, Chewiness, Growth rate, Feed utilization.
Pharmacokinetic Modification of Controlled Release Tablets of Antihypertensive Drug Palanisamy Vishnu
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The objective of the study was to pharmacokinetic modification of controlled release tablets  of Isradipine tablets designed to provide 24 hours drug release profile using varying proportion of Eudragit L – 100 and HPMC Phthalate; Lactose monohydrate as matrix-forming material. The prepared matrix tablets showed satisfactory physicochemical properties where drug content was 99.19 % to 103.78 %, thickness was 3.23 mm to 3.36 mm, hardness was 3.37±0.13 to 3.51±0.20 kg/cm2 , friability was less than 1% and % weight variation was within the standard pharmacopoeial limits of ±10% of the weight. Mathematical analysis of the release kinetics of the optimized formulation (F15) was best fitted in zero order kinetics (R2 = 0.982). The dissolution profiles of formulation FI4 and innovator product in multi media were compared in Phosphate buffer pH 6.8.Several kinetic models respectively. The stability data reveals that the FI4 showed a negligible change in drug content thickness, weight variation, hardness, friability and in vitro drug release for three months according to ICH guidelines.
The Effect of Papain Enzyme Against Collagen Density in Keloid Tissue Culture Herman Y. L. Wihastyoko
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objective: Papain enzyme in Papaya sap has the ability to increase collagen degradation, thus, it can be used for the treatment of keloid. Therefore, the aim of this study was to determine the effect of this enzyme on keloid tissue. Methods: Randomized Controlled Trial Post-Test Only Design using ten human keloid tissues was applied in this research. Each of the tissue was divided into four treatment groups. The histological preparation was conducted by Masson’s trichrome staining. All of the samples were observed using a microscope. The collagen density was determined through the use of Olyvia software. The hydroxyproline level was measured by total collagen kit assay using a spectrophotometer. All the results were analyzed using a one-way ANOVA test. Result and Discussion: The mean value of collagen density in group K = 193,273+4,099; P1 = 188,765±3,598; P2 = 187,217±2,839; and P3 = 185.143±2.871. The results of statistical tests (p <0.05) on collagen density mean value showed that there is a significant difference between groups K, P1, P2, and P3. The mean value of hydroxyproline levels in group K = 268.5±69.43; P1 = 389,1±43,58; P2 = 454.8±85.81; and P3 = 559.8±167.57. The results of statistical tests (p<0.05) on hydroxyproline groups also showed a significantly difference in the groups. Conclusion: The papain enzyme can decrease the collagen density in keloid tissue culture.Keywords: Collagen density, hydroxyproline, keloid, papain enzyme
Different Parameters Influencing to Extraction and Drying of Anthocyanin Powder from Magenta (Peristrophe Roxburghiana) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Leaves of magenta (Peristrophe roxburghiana) have a good source of anthocyanin. They have potential health benefits for human consumption. Objective of the present study to examine various aspects affecting to anthocyanin extraction including blanching, solvent, solvent: solid, extraction time and temperature under ultrasound, carrier and temperature for drying. Optimal results were clearly shown that the panda leaves should be blanched under 95oC in 10 seconds; extraction should be conducted by ethanol 90%, ethanol: solid (2.0:1.0), 60oC, 8 minutes; vaccum drying should be executed at 60oC with the support of carrier (0.5 maltodextrin: 0.5 gelatin: 1.0 magenta fluid). Ultrasonic had positive effect on anthocyanin extraction and this method could be utilized to optain the most anthocyanin powder.Keywords: Magenta, Anthocyanin, Ultrasonic, Blanching, Solvent, Extraction, Carrier, Drying.

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