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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 39 Documents
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Search results for , issue "Volume 10 Issue 12." : 39 Documents clear
Application of Agar/ Glycerol as Biodegradable Coating on Storage of Star Apple (Chrysophyllum Cainito) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Star apple (Chrysophyllum cainito) is a non climacteric fruit, with high antioxidant capacity and high nutritional and health benefit. The flesh of star apple is very sweet with glucose as the main sugar. The fruit is very susceptible to water loss so they are easily shrinkage and fruit softening during storage, resulting in the decrease of their commodity value. The major postharvest losses of star apples are due to fungal infection, physiological disorders, and physical injuries. The prevalent method of preservation of postharvest star apples is the use of moderately low temperatures and high humidity. However, low temperatures induce chilling injury. Edible film is environmentally friendly and safe for human health since it is made from natural ingredients. One of the marine polysaccharide used as base material for edible film preparation is agar. Glycerol is also the most widely used plasticizer in edible film making. An investigation on coating of star apples by using agar/glycerol was investigated. Star apples which were coated with 2.75% agar and 6.8% glycerol still maintained good quality until 30 days of preservation. Application of edible coating on star apple is able to reduce quality changes and slow down moisture loss by controlling and modifying the internal atmosphere of the individual fruits. The great benefit conferred by edible coatings is that these are natural biodegradable products.Keywords: Star apple, Agar, Glycerol, Biodegradable, Coating, Storage, Shelf-life.
Pharmacokinetic Modification of Controlled Release Matrix Tablets of Balsalazide Palanisamy Vishnu
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Balsalazide is used to treat a certain bowel disease (ulcerative colitis) and it also helps to reduce symptoms of ulcerative colitis such as diarrheal, rectal bleeding and stomach pain.  It has a short half life and under goes extensive first pass metabolism. In the present study, balsalazide  600mg controlled release matrices were prepared by wet granulation method and in vitro drug dissolution studies were performed to find out the drug release rate and patterns. Eudragit L-100, Eudragit RSpo, lactose and their combination were used as rate controlling polymer. Tablets were formulated using different polymers ratios. As In vitro drug releaser was carried out using USP type II (paddle method ) at 50 rpm in 900ml of acetic dissolution medium(pH 1.2) for 2 hrs, followed by 900ml alkaline dissolution medium (Ph7.4) upto 12 hrs. Mean dissolution time is used to characterize drug release rate from a dosage form and indicates the drug retarding efficiency of polymer. When Eudragit L 100 and Eudragit RSpo were used alone as the only retarding polymer, a sustained drug release pattern were not absorbed while, combination in the matrix almost doubled the time required for releasing the drug. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics.
A Retrospective Study of Erythema Nodosum Leprosum in Dermatology and Venereology Outpatient Clinic of Sanglah General Hospital, Bali-Indonesia I Gusti Nyoman Darmaputra
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Introduction: Erythema nodosum leprosum (ENL) or type II reaction in leprosy is acute inflammation in the chronic disease of multibacillary leprosy. Clinical manifestation of ENL on the skin such as painful cutaneous nodule, commonly found on the face and extremities accompanied by nerve inflammation, systemic involvement, and other extracutaneous symptoms which possibly caused disability if it is not treated appropriately. Aim: To find out the ENL pattern in the Department of Skin and Venereology, Sanglah General Hospital for three years. Methods: This study was a retrospective study from the medical record of ENL new cases treated in the Skin and Venereology Outpatient Clinic, within period January 2013-December 2015 classified by the number of patients, age, sex, and type of leprosy. Result: Starting from January 2013-December 2015 there were about 39 new leprosy patients with ENL (36% of all new patients in the leprosy division), 64% are male, 82% aged 17-45 years, and 69% of patients suffer from borderline lepromatous (BL) leprosy. Conclusion: Most leprosy patients with ENL are male, aged 17-45 years with BL type leprosy. Complications that arise due to ENL or the side effects of corticosteroids could cause a large socio-economic impact.Keywords: Erythema nodosum leprosum, Leprosy reaction, Sanglah General Hospital.
Detection of Some Virulence Factors Genes in S. Aureus Isolated From Different Clinical Cases Rawaa M. Mohammed
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

A total of 60 specimens (urine, burn swabs, and wound swabs) from different clinical cases were collected from patients (in different age groups) who admitted to several health centers in Al-Dewaniya General Teaching Hospital, during a period extending from October 2016 to January 2017. Some virulence factors was investigated for 30 isolates only of MRSA using Single and Multiplex PCR For detection virulence factor genes which both coa gene encoding  production of coagulase, clfA gene encoding for clumping factor, spa gene encoding for protein A, fnbA gene encoding for fibronectin binding proteins, luks gene encoding production of Panton Valentine Leukocidin (PVL), Results showed that all 30 isolates (100%) were possescoa, clfA, spaand fnbA genes, 13 (43.3%) were possesluks gene. Nanoparticle represented by gold and silver were tested in this study to defect their effect on viability of S.aureus. The results indicated that? Particle were more effective to inhibit the grow that of this bacterium (data are not showing in this paper).Keywords: virulence factors, MRSA, PVL, S.aureus, Nanoparticles.
Antidotal Therapeutic Trials of Induced Acute Sulphur Toxicosis in Male Rats Falah Muosa Kadhim Al-Rekabi
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objective: The current study is planned for treatment of sulphur acute poisoning as laboratory animals model in male rat. Method: Primarily, oral LD50 estimated by probit method and derived statistically by two different statistic programs, Microsoft excel and Spss version 25, the estimated LD50 was 4102 and 4060 respectively which exhibited no statistical differences. After that the toxic nonfatal dose 3000 mg/Kg.BW was chosen and administered through gastric gavag as a single dose to 18 male rats divided equally and assigned as, G1injected I.P by solution contain (0.6 % sodium nitrate + 6% sodium thiosulfate) plus 0.1 ml B-complex per each 100 gm BW, G2 also injected I.P by barium chloride 160 mg/kg.BW plus 0.1 ml B-complex/100gm .BW, while the third group didn’t receive any anti-dote and considered control group. Results: The result revealed that both anti-dotes have various efficiency to overcome acute sulphur poisoning in rat, but barium chloride plus B-complex was the more efficient one. Conclusion: Barium chloride plus B-Complex I.P antidote is capable to overcome sulphur acute poisoning in rat, but further studies are recommended in ruminantsKeywords: Treatment, Acute, Toxicity, Sulphur, Rat.
Administration of Topical Passion Fruit Extract Cream (Passiflora edulis) inhibits the Increase of MMP-1 Levels and Decreases the Amount of Collagen in Wistar Rats (Rattus norvegicus) Exposed to UV-B Rays Anak Agung Gde Putra Wiraguna
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Introduction: Aging skin is most prevalent due to exposure to sunlight, especially UV-B rays. UV-B rays which stimulate the formation of free radicals are highly reactive molecules with unpaired electrons that can cause elevated levels of MMP-1, causing a decrease in the amount of skin collagen. This study was an experimental animal study with a post-test only control group design.  Method: A total of 36 Wistar rat were divided into 2 groups, each consisting of 18 Wistar rat, the control group was smeared with placebo cream and the treatment intervention group was smeared with passion fruit seed extract cream 100%, all groups were exposed to UV-B with a total dose of 840 mJ / cm ² for 4 weeks, then an excision was carried out for the examination of dermis collagen amount and level of MMP-1.  Result: The results of the comparative analysis of the two groups using independent t-test showed that there were significant differences between the two groups, the mean level of MMP-1 and the mean amount of collagen with p <0.05. The mean level of MMP-1 and the mean amount of collagen treatment in intervention group were 2.32% and 70.32%, and control group showed the mean level of MMP-1 and the average amount of collagen at 2.99% and 63.63% respectively.  Conclusion: the administration of passion fruit seed extract cream inhibited the increase of level of MMP-1 and the decrease of total collagen level in Wistar rat skin was exposed to UV-B.Keywords: Passion fruit, MMP-1, collagen, Skin.
Musculoskeletal Problems Induced by the Cycling Activity Paramita Dyah Lasmana
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

ABSTRACTINTRODUCTIONThere are some musculoskeletal problems that may arise due to cycling. It may be related from overuse due to unproper bike settings. The aim of this study is to understand cycling related musculoskeletal problems.MATERIALS AND METHODSThis was an observational study conducted on 32 adult respondents who ride a bicycle at least once a week. The parameters used in this study was illeotibialband syndrome, patellar mallalignment sign, inseam frame size ratio and x ray-based measurement (insalsavati index and sulcus angle). Cross tabs and independent test were used to analyze the correlation of unusculoskeletal problems with the factors that may affect.RESULTSThere was 32 respondents with 30 readable knee x-ray. Cycling frequency and distance, apprehension test result, knee Q angle, Sulcus angle, and Insalsavati index were found to have no correlation with the occurrence of knee pain. Age, knee angle, and frame size-inseam ratio were found to have unrelation significantly with p value,0,06; 0,025,and 0,00, respectively.CONCLUSIONThis study showed that knee pain in cycling was correlated significantly with age, knee angle, and frame size-inseam ratio. These results may be used to define the best frame size of bike no prevent cycling-related musculoskeletal problems. KEYWORDSCycling; musculoskeletal problems
Methodology for Development of Pediatric Medicines for Complex Treatment of Diseases of Immune-Dependent Nature Olga Rukhmakova; Tatyana Yarnykh; Olexander Tykhonov; Galina Melnyk
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The objective of the work – is to substantiate methodology for development of pediatric medicines for complex treatment of diseases of immune-dependent nature.Materials and Methods: at the first stage of research, their objective was set, its significance for science and practical pharmacy was shown. At the information search stage, the need for new children’s medicines was identified. The second stage of research involves determining the main directions of achieving the objective. The third stage is the choice and justification of means aimed at achieving the objective, namely, the objects and methods of research. The fourth stage is devoted to the complex of experimental studies on the development of pediatric medicines for complex treatment of diseases of immune-dependent nature. At the final stage of research technical conditions, relevant sections of registration dossier and projects of quality control methods for proposed medicines were developed.Results: based on the created general methodological concept of the development of pediatric medicines for complex treatment of diseases of immune-dependent nature, we have compiled a plan of experimental research, which is given in the article.Conclusion: methodology for development of pediatric medicines for complex treatment of diseases of immune-dependent nature has been substantiated.
Technical Variables Affecting to Production of Pickle Ficus (Ficus Racemosa) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The plant Ficus racemosa occupies a vital place in the traditional system of medicines. It contains antioxidants which quenches free radical damage to cells and tissues. The short shelf life of ficus can be a major cause of postharvest losses especially during peak harvesting season. Fermentation is one of the most convenient technologies for the production of shelf stable food product. The objective of this study was to evaluate different variables influencing to the fermentation of ficus such as concentration of CaCl2, temperature and time for blanching; effect of ratio Lactobacilus acidophillus to the antioxidant of fermented ficus. Results showed that ficus should be blanched in hot water 95oC in 15 seconds with the present of 3.0% CaCl2. Moreover, the fermentation process for pickle ficus had the best antioxidant by addition of 15% sugar, Lactobacilus acidophillus at ratio 2.0 x 108 cells/ml. Blanching and fermentation had significantly affected to antioxidant capacity and firmness of pickle ficus. The pickle ficus had a high content of antioxidant as well as firmness. This plant holds a great prospective source for developing herbal products and thus a vital source of income for the pharmaceutical industry.Keywords: Ficus, pickle, fermentation, blanching, Lactobacilus acidophillus, antioxidant.

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